理学博士, 京都大学

Entomology

Physiology and anatomy of nervous system

Biophysics

Neuro Science in General

entomology

神経系の生理と解剖学

生物物理学

神経科学一般

Environmental science/Agricultural science, Entomology

Life sciences, Animals: biochemistry, physiology, behavioral science

Life sciences, Biophysics

Life sciences, Neuroscience - general

01 Apr. 2010
電気通信大学大学院情報理工学研究科, 教授

Oct. 2001
University of Electrocommunications, Professor

May 1989
University of Electro-Communications, Associate Professor

Apr. 1988
Monell Chemical Senses Center, University of Pennsilvania, Staff Scientist

Nov. 1985
Yale University School of Medicine, Postdoctrial Associate

Jun. 1984
University of Illinois, College of Liberal Arts and Science, Research Associate

Apr. 1980
Kanebo Cancer Reserach Institute, Researcher

Mar. 1980
Kyoto University, Graduate School, Division of Natural Science, 生物物理学専攻

Mar. 1977
Kyoto University, Graduate School, Division of Natural Science, 生物物理学専攻

Mar. 1975
Kyoto University, Faculty of Science, 生物系

2005 - 2007
会計監査, 日本味と匂学会, Society

2006
評議員, 日本比較生理生化学会, Society

2000 - 2003
評議員, 日本比較生理生化学会, Society

1994 - 1999
学会誌編集委員, 日本味と匂学会, Society

1996 - 1997
評議員, 日本比較生理生化学会, Society

1994 - 1996
会計監査, 日本味と匂学会, Society

Nov. 1990
味と匂の研究会(現味と匂学会)
中西研究奨励賞

Oct. 1987
東北医学会感謝状

キニーネ・ショ糖混合刺激に対するクロキンバエ味覚毛の応答インパルス
中村整; 磯部洋平; 瀬戸美星; 仲村厚志; 森田修司
日本味と匂学会誌, 日本味と匂学会, 21, 3, 265-266, Dec. 2014, Peer-reviwed, クロキンバエふ節の味覚毛より記録したショ糖応答のインパルス頻度はキニーネにより抑制されると考えられてきた。しかしショ糖またはキニーネそれぞれの単独刺激に対する応答はそれぞれの濃度の増加で振幅減少を示し，先の頻度抑制は振幅の変化であり頻度の現象ではない可能性があった。そこで各条件についてインパルスの振幅を検討したところ，糖応答の抑制の起きる範囲では振幅の変化は僅かであり，その影響はほとんどないことが認められた。
Scientific journal, Japanese

クロキンバエのフ節D4型味覚毛の各種アミノ酸に対する応答
中村整; 小川絵里; 小川洋史; 栗原隆一郎; 仲村厚志
日本味と匂学会誌, 日本味と匂学会, 20, 3, 257-258, Dec. 2013, Peer-reviwed
Scientific journal, Japanese

昆虫味覚毛糖感度の体表部位依存的な差異の解析の試み
中村整; 瀬戸美星
日本味と匂学会誌, 19, 3, 341-342, Dec. 2012, Peer-reviwed
Scientific journal, Japanese

Inhibition mechanism of chemosensillar response to sugars by bitter substances in the blowfly, Phormia regina
Tadashi Nakamura; Mihoshi Seto
The Japanese Journal of Taste and Smell Research, The Japanese Association for the Study of Taste and Smell, 18, 3, 287-290, Dec. 2011, Peer-reviwed
Scientific journal, Japanese

アカハライモリのリポカリンによる嗅電図の修飾
野海芳博; 高橋司; 澤田研; 岩佐達郎; 中村整
日本味と匂学会誌, 16, 3, 545-548, Dec. 2009, Peer-reviwed
Scientific journal, Japanese

Contribution of the inositol 1,4,5-trisphosphate transduction cascade to the detection of "bitter" compounds in blowflies
Qin Ouyang; Hiroyasu Sato; Yoshihiro Murata; Atsushi Nakamura; Mamiko Ozaki; Tadashi Nakamura
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, ELSEVIER SCIENCE INC, 153, 3, 309-316, Jul. 2009, Peer-reviwed, Bitter taste detection is very important for many species including flies, because it prevents the ingestion of toxic food. Although it has been known that flies have specific bitter-sensitive taste cells in their contact chemosensilla, the mechanism by which those cells transduce the chemical signal into electrical activity has remained elusive. In this study, we first confirmed that type D4 and D5 tarsal chemosensilla of the blowfly Phormia regina responded well to bitter substances. Then, recording impulses from type D4 chemosensilla, we examined the possibility that a G-protein-coupled inositol 1,4,5-trisphosphate (IP(3))-dependent transduction cascade is of importance in the bitter-sensitive taste cells. We found that the response to bitter substances was depressed by specific inhibitors of G-protein, phospholipase C, or IP(3) receptor in the tarsal taste receptor cells. These results suggest that G-proteins mediate the IP(3) pathway in the transduction cascade in bitter-sensitive receptor cells. (C) 2009 Elsevier Inc. All rights reserved.
Scientific journal, English

嗅細胞特異的なＧ蛋白質Ｇolfの細胞膜ラフトへの局在
中村 整; 仲村 厚志; 竹田 浩之
日本味と匂学会誌, 15, 3, 583-586, Dec. 2008, Peer-reviwed
Scientific journal, Japanese

Odour of limonene affects feeding behaviour in the blowfly, Phormia regina
Atsushi Nakamura; Tomoyuki Suzuki; Daiki Taniguchi; Atsushi Matsuda; Manabu Tobeta; Tadashi Nakamura
NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 446, 1, 36-39, Nov. 2008, Peer-reviwed, Experiences of odours at meals are thought to affect food preference in many animals. To study appetite modulation by odours, we established a new experimental system based on the modification of a previous method, where flies fed sucrose flavoured with D-limonene subsequently showed reduced appetite to plain sucrose. In this new experimental system, a fly population was divided into two groups: (1) the "simultaneous" group of flies was exposed to D-limonene and sucrose simultaneously for 10 min, and (2) the "separate" group of flies was exposed to sucrose alone for 10 min, and 1 h later, to limonene for 10 min. The appetite of flies in the "separate" group for sucrose was unaffected by the experiment, but the appetite of flies in the "simultaneous" group was significantly decreased, and this effect lasted for >= 3 days. To investigate if this appetite modulation by D-limonene was based on long-term memory formation (protein synthesis), we examined the effects of the protein synthesis inhibitor, cycloheximide. Injection of cycloheximide 1 h after exposure to limonene and sucrose inhibited the appetite suppression in the "simultaneous" group of flies. In addition, to exclude the possibility that D-limonene exerted its effect through taste, rather than odour, we examined the effect of removing of the olfactory organs, antennae and maxillary palps on appetite modulation by D-limonene. When the olfactory organs were removed, no reduction in appetite was observed in the flies in the "simultaneous" group, indicating olfaction. In our new and effective appetite-modulation system for flies, modulation of appetite by olfactory detection of D-limonene was shown. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Scientific journal, English

イモリ嗅上皮ボーマン腺に発現するリポカリンファミリータンパク質
岩佐達郎; 満都拉; 浦野和雄; 高橋司; 澤田研; 岡野恵子; 中村整
日本味と匂学会誌, 15, 2, 211-220, Aug. 2008, Peer-reviwed
Scientific journal, Japanese

クロキンバエ第5味細胞の情報変換機能の解析
佐藤博康; 欧陽琴; 勝沼祐介; 網谷拓郎; 村田芳博; 仲村厚志; 中村整
日本味と匂学会誌, 14, 335-338, Dec. 2007, Peer-reviwed
Scientific journal, Japanese

NO-cGMP signaling pathway in sugar receptor neurons in the blowfly
Tadashi Nakamura
Frontiers in Molecular Endocrinology of Invertebrates and Vertebrates, 2, 1-5, Aug. 2007
International conference proceedings, English

クロキンバエ培養味細胞における蔗糖刺激に誘発されるNO産生
後藤信太郎; 村田芳博; 尾崎まみこ; 中村整
日本味と匂学会誌, 13, 3, 287-288, Dec. 2006, Peer-reviwed
Scientific journal, Japanese

Primary culture of gustatory receptor neurons from the blowfly, Phormia regina
Yoshihiro Murata; Mamiko Ozaki; Tadashi Nakamura
CHEMICAL SENSES, OXFORD UNIV PRESS, 31, 6, 497-504, Jul. 2006, Peer-reviwed, Flies provide a powerful model system for exploring signaling systems in gustatory receptor neurons (GRNs). To elucidate the cellular and molecular bases of these signaling systems, we sought to develop techniques to dissociate GRNs. We developed a primary culture of GRNs isolated from the labella of the blowfly, Phormia regina, 4-5 days after pupation. Dissected labella were treated with papain in a low Ca2+ saline solution and shaken in Leibovitzs L-15 medium supplemented with 20-hydroxyecdysone, L-ascorbic acid, and trehalose with a test tube mixer. Released cells were plated and kept at 29 degrees C in a medium containing fetal bovine serum. After a minimum of 2 days in culture, we observed survival or growth of bipolar cells with the characteristic morphology of GRNs. We also examined taste responsiveness by monitoring intracellular Ca2+ with a Ca2+-sensitive fluorescent dye, fluo-3. For some bipolar cells, application of sucrose, NaCl, or LiCl for 5-20 s transiently increased the intracellular Ca2+ levels in cell bodies for 20-30 s. The primary cell culture described here is useful for functional analysis of GRNs.
Scientific journal, English

クロキンバエ味細胞の応答に対するl-cis-ジルチアゼムの阻害効果
村田芳博; 尾崎まみこ; 中村整
日本味と匂学会誌, 12, 337-340, Dec. 2005, Peer-reviwed
Scientific journal, Japanese

Guanylyl cyclase involved in taste transduction mechanisms of fly sugar receptor cells
Y.Murata; M.Mashiko; M. Ozaki; T. Nakamura
2005 Abstract Viewer/Itinerary Plannner. Washington, DC: Society for Neuroscience, Program No.280.7, Nov. 2005, Peer-reviwed
International conference proceedings, English

Nitric oxide may contribute the intracellular signal transduction pathway of sugar receptor cell in blowfly, Phormia regina
S.Goto; Y.Murata; M.Ozaki; T.Nakamura
2005 Abstract Viewer/Itinerary Plannner. Washington, DC: Society for Neuroscience, Program No. 280.8, Nov. 2005, Peer-reviwed
International conference proceedings, English

Anorexia due to associative learning of gustatory and olfactory cues in the blowfly, Phormia regina
T.Nakamura; M.Tobeta; A.Nakamura; M.Ozaki
2005 Abstract Viewer/Itinerary Planner, Washington DC: Society for Neuroscience, Program No. 888.14, Nov. 2005, Peer-reviwed
International conference proceedings, English

Biochemical and physiological evidence that calmodulin is involved in the taste response of the sugar receptor cells of the blowfly, Phormia regina
Keiji Seno; Tadashi Nakamura; Mamiko Ozaki
Chemical Senses, 30, 1-8, Jun. 2005, Peer-reviwed
Scientific journal, English

Preliminary analysis of the GABA-induced current in cultured CNS neurons of the cutworm moth, Spodoptera litura
H Satoh; H Daido; T Nakamura
NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 381, 1-2, 125-130, Jun. 2005, Peer-reviwed, Properties of GABA-induced current in cultured CNS (ganglion) neurons of cutworm moths (Spodoptera litura) were studied using a whole-cell patch-clamp technique. CNS neurons ranging from 10 to 20 mu m in diameter were cultured for 4-7 days in MGM-464 medium. GABA-induced a current response in these neurons in a sigmoidally dose dependent manner where the Hill coefficient and EC50 were 2.2 and 33.0 mu M, respectively. The reversal potential of GABA-induced current was -2.5 mV, which is close to the CI- equilibrium potential that was calculated from chloride ion concentrations in the present experimental environment. Furthermore, the GABA-induced current response depended on the extracellular chloride ion concentration, indicating that the receptor regulates the CI- permeability of cells. The GABA-induced current was completely inhibited by the GABA(A) antagonist, SR95531, and activated by the GABAA agonist, muscimol but not by the GABA(B) agonist, baclofen. On the other hand, the GABAc agonist, CACA, also induced a little smaller current than the GABA-induced response. The pharmacological behaviors of the GABA-induced currents suggest that these cells contain GABA receptors that belong to the GABA receptor family including the Rdl GABA receptors identified in Drosophila neurons. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Scientific journal, English

G(q)alpha subunit mediates receptor site-specific adaptation in the sugar taste receptor cell of the blowfly, Phormia regina
K Seno; K Fujikawa; T Nakamura; M Ozaki
NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 377, 3, 200-205, Apr. 2005, Peer-reviwed, The gustatory system is essential for almost all animals. The recent identification of G protein-coupled receptor proteins (GPCRs) has progressed molecular biological studies of gustatory systems, although the signal transduction mechanisms have not yet been fully elucidated. In vision and olfactory receptor cells, G(q) class G protein is known to be a major signal transducer. By functional blocking of intrinsic G(q) with an anti-G(q/11)alpha antibody, we investigated the roles of G(q) in the sugar receptor cell of the blowfly, Phormia regina. Before and after introduction of the anti-G(q/11)alpha antibody into the cell through the DOC-permeabilized cell membrane, we recorded the responses of the receptor cell to sucrose and D-fructose, which stimulate different receptor sites, respectively. The initial impulse frequency in response to either sucrose or D-fructose was not changed by antibody introduction, whereas the adaptation rate in sucrose stimulation, but not fructose stimulation, became slower after antibody introduction. These results indicate that: (1) G(q) is a regulator of adaptation in the sugar receptor cell of Phormia, rather than a transducer, and (2) different adaptation mechanisms are promoted by stimulations with sucrose and D-fructose. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Scientific journal, English

The nitric oxide-cyclic GMP cascade in sugar receptor cells of the blowfly, Phormia regina
T Nakamura; Y Murata; M Mashiko; K Okano; H Satoh; M Ozaki; T Amakawa
CHEMICAL SENSES, OXFORD UNIV PRESS, 30, Supple. 1, I281-i282, Jan. 2005, Peer-reviwed
Scientific journal, English

Intrinsic nitric oxide regulates the taste response of the sugar receptor cell in the blowfly, Phormia regina
Y Murata; M Mashiko; M Ozaki; T Amakawa; T Nakamura
CHEMICAL SENSES, OXFORD UNIV PRESS, 29, 1, 75-81, Jan. 2004, Peer-reviwed, The taste organ in insects is a hair-shaped taste sensory unit having four functionally differentiated contact chemoreceptor cells. In the blowfly, Phormia regina, cGMP has been suggested to be a second messenger for the sugar receptor cell. Generally, cGMP is produced by membranous or soluble guanylyl cyclase (sGC), which can be activated by nitric oxide (NO). In the present paper, we electrophysiologically showed that an NO scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl (PTIO), an NO donor, 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-1-triazene (NOC 7) or an NO synthase (NOS) inhibitor, N-G-nitro-l-arginine methyl ester (l-NAME) specifically affected the response in the sugar receptor cell, but not in other receptor cells. PTIO, when introduced into the receptor cells in a sensillum aided by sodium deoxycholate (DOC, pH 7.2), depressed the response of sugar receptor cells to sucrose but did not affect those of the salt or water receptor cells. NOC 7, given extracellularly, latently induced the response of sugar receptor cells; and l-NAME, when introduced into the receptor cells, depressed the response of sugar receptor cells. The results clearly suggest that NO, which may be produced by intrinsic NOS in sugar receptor cells, participates in the transduction cascade of these cells in blowfly.
Scientific journal, English

クロキンバエ唇弁糖受容細胞におけるNOの産生・作用機構
益子正史; 村田芳博; 尾崎まみこ; 尼川大作; 中村整
日本味と匂学会誌, 10, 3, 689-692, Dec. 2003, Peer-reviwed
Scientific journal, Japanese

Perception of noxious compounds by contact chemoreceptors of the blowfly, Phormia regina: Putative role of an odorant-binding protein
M Ozaki; T Takahara; Y Kawahara; A Wada-Katsumata; K Seno; T Amakawa; R Yamaoka; T Nakamura
CHEMICAL SENSES, OXFORD UNIV PRESS, 28, 4, 349-359, May 2003, Peer-reviwed, The blowfly, Phormia regina, has sensilla with four contact-chemoreceptor cells and one mechanoreceptor cell on its labellum. Three of the four chemoreceptor cells are called the sugar, the salt and the water receptor cells, respectively. However, the specificity of the remaining chemoreceptor cell, traditionally called the `fifth cell', has not yet been clarified. Referring to behavioral evaluation of the oral toxicity of monoterpenes, we measured the electrophysiological response of the `fifth cell' to these compounds. Of all the monoterpenes examined, d-limonene exhibited the strongest oral toxicity and induced the severest aversive behavior with vomiting and/or excretion in the fly. d-Limonene, when dispersed in an aqueous stimulus solution including dimethyl sulfoxide or an odorant-binding protein (OBP) found in the contact-chemoreceptor sensillum, the chemical sense-related lipophilic ligand-binding protein (CRLBP), evoked impulses from the `fifth cell'. Considering the relationship between the aversive effects of monoterpenes and the response of the `fifth cell' to these effects, we propose that the `fifth cell' is a warning cell that has been differentiated as a taste system for detecting and avoiding dangerous foods. Here we suggest that in the insect contact-chemoreceptor sensillum, CRLBP carries lipophilic members of the noxious taste substances to the `fifth cell' through the aqueous sensillum lymph. This insect OBP may functionally be analogous to the von Ebner's grand protein in taste organs of mammals.
Scientific journal, English

クロキンバエ唇弁から単離・培養した味細胞の応答特性
村田芳博; 尾崎まみこ; 中村整
日本味と匂学会誌, 10, 3, 685-688, 2003, Peer-reviwed
Scientific journal, Japanese

Patch clamp analysis of transduction mechanisms of the Browfly sugar receptor cells.
H.Satoh; M.Ozaki; T. Nakamura
2003 Abstract Viewer/Itinerary Planner, Washington, DC: Society for Neuroscience, No. 490.7, 2003
International conference proceedings, English

Primary culture of taste receptor cells dissociated from pupal blowfly labella
Y.Murata; K.Seto; M.Ozaki; T.Nakamura
2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Program No. 595.8., 2003
International conference proceedings, English

Phosphlipase C - coupled GTP - binding protein is involved in the adaptation mechanism of the sugar taste receptor cell in the blowfly, Phormia regina
K.Seno; T.Nakamura; M.Ozaki
2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Program No. 490.6., 2003
International conference proceedings, English

Intrinsic nitric oxide regulates the taste response of the sugar receptor cell in the blowfly, Phormia regina
T.Nakamura; Y.Murata; M.Mashiko; H.Suzuki; M.Ozaki; T.Amakawa
2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Program No. 595.9., 2003
International conference proceedings, English

脂溶性色素によるハエの脳味覚神経回路の可視化
夏蘭; 尾崎まみこ; 中村整
日本味と匂学会誌, 10, 503-504, 2003, Peer-reviwed
Scientific journal, Japanese

イモリ嗅電図(EOG)に対するCl-チャンネルブロッカーSITSの多重効果
加藤秀雄; 中村整
日本味と匂学会誌, 9, 3, 679-682, Dec. 2002, Peer-reviwed
Scientific journal, Japanese

ウシガエル嗅細胞におけるフロセミド感受性Cl-トランスポーターの作動様式
吉岡美佳; 中村整
日本味と匂学会誌, 9, 3, 683-686, Dec. 2002, Peer-reviwed
Scientific journal, Japanese

クロキンバエ唇弁味細胞の糖受容におけるNOの関与
益子正史; 村田芳博; 尾崎まみこ; 尼川大作; 中村整
日本味と匂学会誌, 9, 3, 537-540, Dec. 2002, Peer-reviwed
Scientific journal, Japanese

クロキンバエ(Phormia regina)唇弁から単離した味覚感覚毛に見出される新しい蛋白質
妹尾圭司; 中村整; 尾崎まみこ
日本味と匂学会誌, 9, 3, 545-549, Dec. 2002, Peer-reviwed
Scientific journal, Japanese

フロセミドに誘発されるウシガエル嗅繊毛内のCl^-^濃度の変化
吉岡 美佳; 中村 整
日本味と匂学会誌, 8, 3, 569-572, Dec. 2001, Peer-reviwed
Scientific journal, Japanese

イモリ嗅細胞培養の試み
松本 尚史; 中村 整
日本味と匂学会誌, 8, 3, 573-576, Dec. 2001, Peer-reviwed
Scientific journal, Japanese

Noninvasive measurement of chloride concentration in rat olfactory receptor cells with use of a fluorescent dye
Hiroshi Kaneko; Tadashi Nakamura; Ber; Lindemann
Am. J. Physiol. Cell Physiol. 280, C1387-C1393, May 2001, Peer-reviwed
Scientific journal, English

蛍光色素を用いたラット嗅細胞内のクロライド濃度の測定
金子 博; 中村 整; B.Lindemann
日本味と匂学会誌, 7, 3, 371-374, Dec. 2000, Peer-reviwed
Scientific journal, Japanese

蛍光色素を用いたラット嗅細胞内のクロライド濃度の測定
金子 博; 中村 整; B.Lindemann
日本味と匂学会誌, 7, 3, 371-374, Dec. 2000, Peer-reviwed
Scientific journal, Japanese

Chloride concentration in rat olfactory receptor cells measured with a fluorescent probe
H.Kaneko; T.Nakamura; B.Lindemann
259, Jul. 2000, Peer-reviwed
International conference proceedings, English

Cyclic AMP diffusion coefficient in frog olfactory cilia
CH Chen; T Nakamura; Y Koutalos
BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, 76, 5, 2861-2867, May 1999, Cyclic AMP (cAMP) is one of the intracellular messengers that mediate odorant signal transduction in vertebrate olfactory cilia. Therefore, the diffusion coefficient of cAMP in olfactory cilia is an important factor in the transduction of the odorous signal. We have employed the excised cilium preparation from the grass frog (Rana pipiens) to measure the cAMP diffusion coefficient. In this preparation an olfactory cilium is drawn into a patch pipette and a gigaseal is formed at the base of the cilium. Subsequently the cilium is excised, allowing bath cAMP to diffuse into the cilium and activate the cyclic nucleotide-gated channels on the plasma membrane. In order to estimate the cAMP diffusion coefficient, we analyzed the kinetics of the currents elicited by step changes in the bath cAMP concentration in the absence of cAMP hydrolysis. Under such conditions, the kinetics of the cAMP-activated currents has a simple dependence on the diffusion coefficient. From the analysis we have obtained a cAMP diffusion coefficient of 2.7 +/- 0.2 . 10(-6) cm(2) s(-1) for frog olfactory cilia. This Value is similar to the expected value in aqueous solution, suggesting that there are no significant diffusional barriers inside olfactory cilia. At cAMP concentrations higher than 5 mu M, diffusion slowed considerably, suggesting the presence of buffering by immobile cAMP binding sites. A plausible physiological function of such buffering sites would be to prolong the response of the cell to strong stimuli.
Scientific journal, English

Saarland大学医学部第2生理学研究所Lindemann研究室
中村整
日本味と匂学会誌, 6, 233-235, 1999
Japanese

イモリ嗅細胞内のCl^-^濃度分布とCl-ポンプの働き
金子 博; 中村 整
日本味と匂学会誌, 5, 3, 493-496, Dec. 1998
Scientific journal, Japanese

Direct measurement of the chloride concentration in newt olfactory receptors with the fluorescent probe
T Nakamura; H Kaneko; N Nishida
NEUROSCIENCE LETTERS, ELSEVIER SCI IRELAND LTD, 237, 1, 5-8, Nov. 1997, Peer-reviwed, Chloride (Cl-) current in the olfactory cell has been proposed to be excitatory and amplifying the receptor current. As an intracellular concentration of Cl-([Cl-](i)) is critically important for the proposed function, we tried to measure [Cl-](i) of the isolated newt olfactory receptors using chloride-sensitive fluorescent dye, N-(6-methoxyquinolyl)-acetoethyl ester (MQAE). We found that the average of Cl- concentration through the cell is about 40 mM. This value is fairly lower than 120 mM that was suggested from reversal potential of tail component of the olfactory response in the low Cl- bath solution. Because the reversal potential for the present [Cl-](i) is above the resting potential, opening of the Cl- channels may serve as a booster for the depolarizing odor-response. (C) 1997 Elsevier Science Ireland Ltd.
Scientific journal, English

Filtering effect of cone oil droplets detected in the P-III response spectra of Japanese quail
K Kawamuro; T Irie; T Nakamura
VISION RESEARCH, PERGAMON-ELSEVIER SCIENCE LTD, 37, 20, 2829-2834, Oct. 1997, Peer-reviwed, While absorption spectra of bird cone visual pigments have been well studied, physiological study of bird cone cells has been less advanced owing to their small sizes. We measured the P-III components of electroretinograms (ERG) from isolated retinas of Japanese quail. We recorded responses to monochromatic flashes of equal photon numbers, and found that the shape of the response spectrum is dependent on the incident direction of the flashes. The spectrum obtained with the flashes from the cornea side had a steeper peak around 500 nm than that with flashes from the receptor side. This is clear electrophysiological evidence of the filtering effect of the oil droplets in the cone cells, which has long been suspected. We analyzed these spectra with respect to the absorption spectra of cone pigments and transmittance spectra of oil droplets. (C) 1997 Elsevier Science Ltd.
Scientific journal, English

Ionic mechanisms of olfactory reception in vertebrate,
T.Nakamura
Internatl Congress on Cilia, Mucus and Mucociliary Interactions, 40, 1997
International conference proceedings, English

Direct Measurement of concentration of chloride in the newt olfactory cell
T.Nakamura; N.Nishida; H.Kaneko
Internatl. Sympo. Olfaction and Taste XII, 105, 1997
International conference proceedings, English

Gated conductances in native and reconstituted membranes from frog olfactory cilia
T Nakamura; HH Lee; H Kobayashi; TO Satoh
BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, 70, 2, 813-817, Feb. 1996, Peer-reviwed, Although cAMP is well established as a second messenger for olfactory transduction in vertebrates, the role of inositol 1,4,5-trisphosphate (IP3) in this process remains controversial. We addressed this issue by comparing currents evoked by cAMP and IP3 in native and reconstituted membranes from olfactory cilia. We detected only a cyclic nucleotide-gated conductance in the native membrane but both cyclic nucleotide-gated and IP3-gated conductances in the reconstituted membrane. The magnitudes of the cyclic nucleotide- and IP3-gated conductances were not correlated with each other in reconstituted membranes, suggesting that cyclic nucleotide- and IP3-gated channels originate in different cellular compartments.
Scientific journal, English

Ligand-gated ionic conductances in the olfactory cilia(共著)
Tadashi Nakamura; Tomo-Oki Satoh; Sio Miyamoto
Biophysics, 40, 193-199, 1995, Peer-reviwed
Scientific journal, English

Regulation of calcium concentration by second messengers in newt olfactory receptor cell
T.Nakamura; K.Tsuru; S.Miyamoto
First East Asian Symposium on Biophysics, 186, May 1994
International conference proceedings, English

Survey of gated conductances in frog olfactory receptor cells.
S.Noguchi; H.Kobayashi; T.Satoh; T.Nakamura
First East Asian Symposium on Biophysics, 187, May 1994
International conference proceedings

Ion channels contributing to the transduction in the olfactory receptor cell
T.Nakamura
ASB94 Workshops, program, 67, May 1994
International conference proceedings, English

Regulation of Ca²⁺ concentration by second messengers in newt olfactory receptor cell
Tadashi Nakamura; Kazunobu Tsuru; Sio Miyamoto
Neuroscience Letters, 171, 197-200, 1994, Peer-reviwed
Scientific journal, English

Calcium ions in the transduction current of the olfactory receptor cell. Molecular mechanism of generation of electric signals in sensory cells
T.Nakamura; S.Hirota; Y.Kurimoto
Proceedings of the 18th Taniguchi Intrntl. Sympo. Biophys. Division, ed. by F. Tokunaga, 282-299, 1992
International conference proceedings, English

Olfactory transduction, analogous mechanism to visual transduction
T.Nakamura; T.Satoh; S.Miyamoto
Symposium on Molecular Mechanism of the Photo-reception and Transduction in the Bio-Information Systems. Abstracts, 5, 1992
International conference proceedings, English

嗅細胞における情報変換機構の研究
中村整; 神原武志
Research Projects in Review, 14, 153-157, 1991
Research society, Japanese

Calcium influx induced by intracellular cyclic AMP in the newt olfactory receptor cell
T.Nakamura; S.Hirota
Proc. 2nd Japan-USSR Cooperative Symposium, Receptor : Structure and Function, 16, 1991
International conference proceedings, English

Study of cAMP and Ca++ in olfactory transduction
T.Nakamura
3rd Internatl. Congress of Comparative Physiology and Biochemistry, Abstracts, 43, 1991
International conference proceedings, English

HISTOCHEMICAL-STUDIES OF MITOCHONDRIAL ACTIVITIES OF CULTURED CORNEAL ENDOTHELIAL-CELLS OF CAT DURING WOUND-HEALING
Y OGITA; T NAKAMURA; S HIGUCHI; T MORI; M SHIMOOKU
JAPANESE JOURNAL OF OPHTHALMOLOGY, JAPAN J OPHTHALMOL, 34, 2, 200-215, 1990, Peer-reviwed
Scientific journal, English

Studies on the mechanism of olfactory transduction in vertebrates
G.H.Gold; G.Lowe; T.Nakamura
Neurosci. Res, 12, S127-S134, 1990, Peer-reviwed
International conference proceedings, English

Studies on the role of cyclic AMP in olfactory transduction
G.H.Gold; G.Lowe; T.Nakamura
Proceedings of the tenth Internatl. Sympo. on Olfaction and Taste, 295, Jul. 1989
International conference proceedings, English

Evidence that adenylate cyclase mediates olfactory transduction for a wide variety of odorants.
G.Lowe; T.Nakamura; G.H.Lowe
Proc. the 10th Internatl. Symplo. on Olfaction and Taste, 330, Jul. 1989
International conference proceedings

Conductive properties of olfactory cilia.
T.Nakamura; G.H.Gold
Proc. 10th Internatl. Symplo. on Olfaction and Taste, 344, Jul. 1989
International conference proceedings, English

ADENYLATE-CYCLASE MEDIATES OLFACTORY TRANSDUCTION FOR A WIDE VARIETY OF ODORANTS
G LOWE; T NAKAMURA; GH GOLD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 86, 14, 5641-5645, Jul. 1989, Peer-reviwed
Scientific journal, English

WAVELENGTH REGULATION IN IODOPSIN, A CONE PIGMENT
JG CHEN; T NAKAMURA; TG EBREY; H OK; K KONNO; F DERGUINI; K NAKANISHI; B HONIG
BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, 55, 4, 725-729, Apr. 1989, Peer-reviwed
Scientific journal, English

Monoclonal antibody specific to a cone pigment, chicken iodopsin. (共著)
J.G.Chen; T.Nakamura; H.Matsumoto; T.G.Ebrey
Vision Research, 29, 1267-1276, 1989, Peer-reviwed
Scientific journal, English

Studies on the role of cAMP in olfactory transduction.
T.Nakamura
Proceedings of USSR-Japan Symposium. Receptors: Structure and Function, 28, 1989
International conference proceedings

CYCLIC NUCLEOTIDE-GATED CONDUCTANCES - A NEW CLASS OF ION CHANNELS MEDIATES VISUAL AND OLFACTORY TRANSDUCTION
GH GOLD; T NAKAMURA
TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER SCI LTD, 8, 8, 312-316, Aug. 1987
Scientific journal, English

Cyclic AMP: an intracellular messenger for olfactory transduction. ,
G.H.Gold; T.Nakamura
Discussions in Neurosciences, IV Sensory Transduction, ed by A.J.Hudpeth et al., IV, 86-90, 1987
International conference proceedings, English

A CYCLIC NUCLEOTIDE-GATED CONDUCTANCE IN OLFACTORY RECEPTOR CILIA
T NAKAMURA; GH GOLD
NATURE, MACMILLAN MAGAZINES LTD, 325, 6103, 442-444, Jan. 1987, Peer-reviwed
Scientific journal, English

Light-regulation of intracellular calcium in the rod outer segment.
G.H.Gold; T.Nakamura
Proceedings of the international society for eye research, IV, 127, Sep. 1986
International conference proceedings, English

生薬のプラスミン阻害作用：有効成分の精製と合成阻害剤との比較
中村整; 岡本彰祐; 斎藤雄二; 桑木崇秀; 松本秀俊
血液と脈管, 15, 305-307, 1984, Peer-reviwed
Scientific journal, Japanese

凝固線溶酵素の阻害に関する赤芍エキスと合成薬剤の相互作用の解析
岡本彰祐; 中村整; 斎藤雄二; 桑木崇秀; 弓岡栄三郎; 横山育三; 松本秀俊
和漢医薬学会誌, 1, 48-49, 1984
Scientific journal, Japanese

赤芍の高分子性プラスミン阻害成分の部分精製
中村整; 岡本彰祐; 桑木崇秀; 横山育三; 斎藤雄二; 弓岡栄三郎; 松本秀俊
和漢医薬学会誌, 1, 98-99, 1984, Peer-reviwed
Scientific journal, Japanese

若干の和漢生薬、とくに赤芍エキスによるプラスミン及びトロンビンの阻害様式について
中村整; 岡本彰祐; 斎藤雄二; 桑木崇秀; 松本秀俊
血液と脈管, 14, 461-466, 1983, Peer-reviwed
Scientific journal, Japanese

Characteristic inhibition of thrombin and plasmin by active ingredients of chinese herbs. (IX Internatl. Cong. Thrombosis and Haemostasis)
T.Nakamura; S.Okamoto; Y.Saito; T.Kuwaki; H.Matsumoto
Thrombosis and Haemostasis, 50, 199, 1983
International conference proceedings, English

Early Receptor Potential and Production of Metarhodopsin ((]G0002[))in Frog Retina(共著)
Tadashi Nakamura; Fumio Tokunaga; Toru Yoshizawa
Annotationes Zoologicae Japanenses, 55, 3, 125, 1982
Scientific journal, English

Kinetic study of Regeneration of Cone Pigment in Frog Retina in vitro and in vivo Monitored by Early Receptor Potential(共著)
Tadashi Nakamura; Toru Yoshizawa
Annotationes Zoologicae Japonenses, 54, 2, 85, 1981
Scientific journal, English

Isolation of rod early receptor potential from frog retina. (共著)
Tadashi Nakamura; Fumio Tokunaga; Toru Yoshizawa
Vision Research, 18, 1978
Scientific journal, English

Isolation of rod early receptor potential from frog retina
Tadashi Nakamura; Fumio Tokunaga; Toru Yoshizawa
Third International Congress of Eye Research, 188, 1978
International conference proceedings, English

書評「サイボーグ昆虫，フェロモンを追う」
中村整
学会誌編集長からの依頼により，神崎亮平氏の著書の書評を行った。内容は神崎研における長年の，昆虫の機能を模した小型ロボットの開発とその応用による脳神経系の機能解析のモデルを提示しているというもので，工学と生物学の両分野の学生に一読を勧める。, 日本比較生理生化学会, 16 Mar. 2015, 比較生理生化学, 32, 1, 47-48, Japanese, Invited, Book review, 0916-3786

匂いと昆虫の巧みな世界-匂いに支配されている昆虫の不思議-，井濃内順著
中村整
日本味と匂学会, Apr. 2014, 日本味と匂学会誌, 21, 1, 83-84, Japanese, Invited, Book review, 1340-4806

ショウジョウバエの味覚受容メカニズム
仲村厚志; 中村整
ハエは体の複数の組織で味を感じることが可能である．例えば，肢のふ節と呼ばれる組織では食べ物の評価を行い，口吻を伸ばして摂食を行う．その他にも，羽やメスの産卵器官についても，味覚受容器が存在することが知られているが，それらの機能については，まだ明らかにされていない．それぞれの味覚受容器には味覚毛と呼ばれる毛が存在し，この先端部分で味物質を受容している．味物質を受容する候補分子は，これまでに 70個近くも得られているが，その多くは，どのような物質を受容するのかは明らかになっていない．これらの分子の機能が明らかになれば，ハエの体の様々な部位に存在する味覚受容器官の役割解明につながると期待される．, バイオメカニズム学会, Aug. 2007, バイオメカニズム学会誌, 31, 3, 138-142, Japanese, Peer-reviwed, Introduction other, 0285-0885, 110006838875, AN00334047

Nitric oxide-cyclic GMP cascade in gustatory receptor neurons of the blowfly, Phormia regina
Yoshihiro Murata; Shintaro Goto; Tadashi Nakamura
Apr. 2006, Comparative Physiology and Biochemistry, 23, 2, 3-10, Japanese, Peer-reviwed, Introduction other

嗅覚情報変換におけるcAMPシステム
中村整; 金子博
フレグランスジャーナル社, Feb. 2002, Aroma Research, 3, 1, 11-15, Japanese, Peer-reviwed, Introduction other, 1345-4722, 40005261221, AA11487412

嗅覚情報変換機構の研究動向：ｃAMP経路を中心に
中村 整
Dec. 2000, 日本味と匂学会誌, 7, 3, 323-326, Japanese, Introduction other

Cellular and molecular constituents of olfactory sensation in vertebrates
T Nakamura
Since the discovery of odorant-activated adenylate cyclase in the olfactory receptor cilia, research into the olfactory perception of vertebrates has rapidly expanded. Recent studies have shown how the odor discrimination starts at the receptor level: each of 700-1000 types of the olfactory neurons in the neural olfactory epithelium contains a single type of odor receptor protein. Although the receptors have relatively low specific affinities for odorants, excitation of different types of receptors forms an excitation pattern specific to each odorant in the glomerular layer of the olfactory bulb. It was demonstrated that adenosine 3',5'-cyclic monophosphate (cAMP) is very likely the sole second messenger for olfactory transduction. It was also demonstrated that the affinity of the cyclic nucleotide-gated channel for cAMP regulated by Ca2+/calmodulin is solely responsible for the adaptation of the cell. However, many other regulatory components were found in the transduction cascade. Regulated by Ca2+ and/or the protein-phosphorylation, many of them may serve for the adaptation of the cell, probably on a longer time scale. It may be important to consider the resensitization as a part of this adaptation, as well as to collect kinetic data of each reaction to gain further insight into the olfactory mechanism. (C) 2000 Elsevier Science Inc. All rights reserved., ELSEVIER SCIENCE INC, May 2000, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY, 126, 1, 17-32, English, Peer-reviwed, Book review, 1095-6433, WOS:000088270000002

デジタル記録”超”入門
中村整
1998, 日本味と匂学会誌, 5, 157-160, Japanese, Peer-reviwed, Introduction other

感覚器（嗅細胞）におけるトランスダクション
中村整
1993, 静電気学会誌, 17, 16-22, Japanese, Peer-reviwed, Introduction other

嗅細胞の環状ヌクレオチド感受性イオンチャンネル
中村整
Using ultramicro patch electrodes, we have shown that olfactory receptor cilia contain a cyclic nucleotide-gated ion channel which has low selectivity between monovalent cations and high sensitivity to divalent cations. Biochemical evidence of an odorant-activated adenylate cyclase supports the idea that this channel mediates olfactory transduction., The Biophysical Society of Japan General Incorporated Association, 1988, 生物物理, 28, 5, 236-239, Japanese, Peer-reviwed, Introduction other, 0582-4052, 130000722476, AN00129693

視細胞のイオンチャンネル
中村整
1987, 生体の科学, 38, 284-290, Japanese, Introduction other

光と生命の事典
秋山(張)秋梅; 安倍 学; 蟻川謙太郎; 安東宏徳; 飯郷雅之; 飯野盛利; 池内昌彦; 池田憲昭; 池田 啓; 池畑広伸; 井澤 毅; 石川大太郎; 石川 満; 石田 斉; 石塚 徹; 井上圭一; 井上幸次; 伊吹裕子; 今井啓雄; 今泉貴登; 今元 泰; 岩田耕一; 岩田達也; 上山久雄; 丑田公規; 内橋貴之; 浦野泰照; 海野雅司; 大石 正; 大内秋比古; 大内淑代; 大岡宏造; 大須賀篤弘; 太田信廣; 太田英伸; 大平明弘; 岡 義人; 岡島公司; 岡野俊行; 岡本晃充; 岡本秀毅; 小口理一; 小阪田泰子; 尾﨑浩一; 加川貴俊; 片岡博尚; 片岡幹雄; 加藤晃弘; 門田明雄; 鐘ヶ江健; 鎌田 堯; 嘉美千歳; 上久保裕生; 上出良一; 神谷真子; 唐津 孝; 川井清彦; 川田 暁; 川鍋 陽; 河村 悟; 川原 繁; 神取秀樹; 菊川峰志; 北山陽子; 木下俊則; 木下充代; 清末知宏; 久保達彦; 小泉 周; 河内孝之; 小島大輔; 児玉高志; 小塚俊明; 小林一雄; 小松英彦; 小柳光正; 酒井達也; 櫻井啓輔; 櫻井 実; 佐々木純; 佐藤公行; 佐藤良勝; 志賀向子; 鹿内利治; 直原一徳; 七田芳則; 篠原邦夫; 篠村知子; 嶌越 恒; 島崎研一郎; 沈 建仁; 末次憲之; 菅澤 薫; 須藤雄気; 關 隆晴; 園池公毅; 田井中一貴; 髙井保幸; 高市真一; 髙雄元晴; 髙木慎吾; 高田忠雄; 髙橋文雄; 高橋裕一郎; 髙橋勇輔; 竹内聖二; 立川貴士; 立花政夫; 橘木修志; 田中 淳; 田中 歩; 田邉一仁; 谷戸正樹; 崔 正權; 塚本寿夫; 柘植知彦; 筒井 圭; 出村 誠; 寺北明久; 寺島一郎; 寺嶋正秀; 寺西美佳; 手老省三; 土居雅夫; 藤堂 剛; 德富 哲; 鳥居雅樹; 内藤 晶; 永井健治; 中川将司; 永田 崇; 長谷あきら; 中谷 敬; 中津 亨; 長沼 毅; 中根英昭; 中林孝和; 中村 整; 中村光伸; 中村 渉; 錦織千佳子; 西出真也; 西村賢宣; 沼田英治; 野口 巧; 羽鳥 恵; 林 重彦; 林 文夫; 針山孝彦; 彦坂幸毅; 久枝良雄; 久堀 徹; 日出間純; 平野 誉; 深田吉孝; 福永 淳; 藤塚 守; 船坂陽子; 古川貴久; 古谷祐詞; 牧野 周; 真嶋哲朗; 増田真二; 松下智直; 松永 司; 松本 顕; 松山オジョス武; 万代道子; 三島和夫; 水上 卓; 皆川 純; 宮尾光恵; 宮嵜 厚; 村上明男; 望月伸悦; 森 俊雄; 森田明理; 森脇真一; 八木田和弘; 保田昌秀; 山﨑洋一; 山路 稔; 山下高廣; 山下(川野)絵美; 山中章弘; 山仲勇二郎; 山本興太朗; 吉原静恵; 吉原利忠; 吉村 崇; 和田正三; 渡辺正勝
Dictionary or encycropedia, Japanese, Contributor, 第3章 光の情報利用 3.2 視覚 130 チャネル, 朝倉書店, 25 Feb. 2016, 9784254171617, 化学,生物学,医学など様々な分野から選んだ約200項目の事項・現象を解説した事典。視覚における光受容細胞で最初に興奮するメカニズムであるイオンチャンネルとその開閉機構等を解説した。

研究者が教える動物実験 第１巻 感覚
中村整
Scholarly book, Japanese, Contributor, 第2章 嗅覚 ８．鼻はにおいで電気的な興奮をする ９．嗅細胞の情報変換機構に迫る, 共立出版, 25 Jul. 2015, 9784320057722, 日本比較生理生化学会として出版した3冊のシリーズの一つで、様々な動物実験の手法を各分野を得意とする研究者が紹介。嗅覚実験に関する章における脊椎動物の嗅覚の電気生理学の手法について記述した。読者として学部学生から第一線の研究者までを想定。

Insect Taste: Experimental Biology Reviews Vol. 62
Mamiko Ozaki; Tadashi Nakamura
English, Joint work, Chemosensory regulation of feeding in the blowfly: several studies after 'The Hungry Fly', Taylor & Francis Group, Oct. 2008

シリーズ21世紀の動物科学、９．動物の感覚とリズム
中村整; 尾崎まみこ
Japanese, Joint work, ４章 化学感覚, 培風館, Jul. 2007

Fronteirs in Molecular and Endocrinology of Invertebrates and Vertebrates Vol.II
Tadashi Nakamura
English, Joint work, NO-cGMP signaling pathway in sugar receptor neurons in the blowfly, Department of Animal Sciences School of Life Sciences University of Hyderabad, 2006

人間の許容限界事典
中村整; 村田芳博; 山崎昌廣; 坂本和義; 関邦博 編
Japanese, Joint work, ５．嗅覚、６．味覚, 朝倉書店, Oct. 2005

アロマサイエンスシリーズ21、９、 香りの研究エッセイ
中村 整
Japanese, Joint work, 嗅繊毛にパッチクランプ, フレグナンスジャーナル社, Jun. 2005

Cilia, Mucus, and Mucociliary Interactions
Tadashi Nakamura; Tomo-Oki Satoh; Hyung-Hwan Lee; Hirokatsu Kobayashi; Satoru Noguchi
English, Joint work, Ionic mechanisms in olfactory reception : Perspective through ion channels in the vertebrate olfactory cilia, Marcel Dekker Inc., 1998

Experimental Cell Biology of Taste and Olfaction
Graeme Lowe; Tadashi Nakamura; Geoffrey H.Gold
English, Joint work, Patch clamping techniques for vertebrate olfactory recepfar cells, CRC Press,, 1995

Olfaction and Taste XI
Sio Miyamoto; Kazunobu Tsuru; Tadashi Nakamura
English, Joint work, Transmigration of Calcium Ions in the olfactory receptor cell, Springer-Verlag, 1994

Chemical senses I : Receptor events and transduction in taste and olfaction
G.H.Gold; G.Lowe; T.Nakamura
English, Joint work, A role for cyclic AMP in olfactory transduction, Marcel Dekker Inc., 1989

新臨床眼科全書，８A, 網膜疾患 １
吉澤透; 中村整
Japanese, Joint work, 視物質とその代謝, 金原出版, 1984

眼科Mook 16, 色覚異常
吉澤透; 中村整
Japanese, Joint work, ３．視物質と色覚, 金原出版, 1982

視覚から始めた嗅覚・味覚研究
中村整
Public discourse, Japanese, 講演会「味覚・嗅覚研究への提言」, Invited, 慶應義塾大学医学部生物学教室, 横浜市, 現在嗅覚の研究が世界的にも活発になっているが、そのきっかけとなった脊椎動物の嗅細胞CNGチャンネルの発見のストーリーを中心に演者の過去から現代までの研究について概説し、近年の大きな発見が異分野の衝突に発することが多く、より広範な異分野交流を提言した。, Domestic conference
22 Jan. 2016

昆虫の味覚および関連する神経機構
中村整
Invited oral presentation, Japanese, ミニシンポジウム「動物生理現象の分子論的研究」, Invited, 京都大学理学部生物物理学教室, 京都市, 昆虫の味覚受容に見られる異種味質間の抑制機構を中心に近年の昆虫の味覚受容機構を概説した。, Domestic conference
08 Nov. 2015

昆虫における苦味と甘味の対立的受容
中村整
Nominated symposium, Japanese, 日本動物学会第86回新潟大会・シンポジウムS11「ショウジョウバエと非モデル昆虫との相違点」, Invited, 日本動物学会, 新潟, 昆虫における苦味と甘味受容細胞の応答の相互作用現象やその現象におけるリポカリンの役割に関する研究について解説し、議論をおこなった。, Domestic conference
18 Sep. 2015

Sweet aspects of the bitterness for insects
Tadashi Nakamura
Invited oral presentation, English, Osaka University International Symposium on Sensory Signal Transduction and Information Processing, Invited, Graduate School of Frontier Biosciences, Osaka University International Symposium Office, http://saturn.bpe.es.osaka-u.ac.jp/OsakaSymposium2015/InternationalSymposiumJ.htm, Eleven researchers were invited to present and to discuss their recent researches in neuroscience on sensory transduction mechanisms and signal processing mechanisms., International conference
20 Mar. 2015

リポカリン、エレクトリックノーズの主要素材候補：その生理機能
中村 整
Others, Japanese, 生物規範工学 第二回全体会議, 文部科学省 科学研究費 新学術領域 「生物多様性を規範とする革新的材料技術」
Oct. 2013

Lipocalin family proteins found in the olfactory epithelium of Japanese common newt
Ken Sawada; Tadashi Nakamura; Tatsuo Iwasa
Public symposium, English, 8th International Congress of Comparative Physiology and Biochemistry, Symposium 28, Comparative Physiology and Biochemistry, Nagoya
Jun. 2011

The effect of food intake on expression level of AMPKβ in the brain of the blowfly, Phormia regina
Atsushi Nakamura; Tadashi Nakamura
Oral presentation, English, Comparative Physiology and Biochemistry/International Association of Comparative Physiology and Biochemistry
Jun. 2011

Pharmacological analysis of the AMP-activated protein kinase in the regulation of food intake in the blowfly, Phormia regina
Tomoyuki Suzuki; Atsushi Nakamura; Tadashi Nakamura
Oral presentation, English, Comparative Physiology and Biochemistry/International Association of Comparative Physiology and Biochemistry
Jun. 2011

クロキンバエ味覚器における苦味物質による糖応答抑制のメカニズム
瀬戸美星; 小川絵里; 中村 整
Oral presentation, Japanese, 日本動物学会関東支部第63回大会要旨集,日本動物学会関東支部第63回大会
Mar. 2011

クロキンバエの摂食におけるAMPKβの関与
仲村厚志; 中村整
Oral presentation, Japanese, 日本動物学会第81回大会予稿集,日本動物学会第81回大会
Sep. 2010

クロキンバエ摂食調節機能へのAMPキナーゼの関与
鈴木智之; 仲村厚志; 中村整
Oral presentation, Japanese, 日本動物学会第81回大会予稿集,日本動物学会第81回大会
Sep. 2010

クロキンバエ味覚毛における苦味物質による糖応答の抑制
瀬戸美星; 中村整
Oral presentation, Japanese, 日本動物学会第81回大会予稿集,日本動物学会第81回大会
Sep. 2010

クロキンバエＡＭＰＫの摂食調節機能への関与
鈴木智之; 仲村厚志; 中村整
Public symposium, Japanese, 日本比較生理生化学会, 日本比較生理生化学会第32回大会予稿集
Jul. 2010

クロキンバエＡＭＰＫβの摂食への関与
仲村厚志; 中村整
Oral presentation, Japanese, 日本比較生理生化学会第32回大会予稿集,日本比較生理生化学会
Jul. 2010

クロキンバエ中枢神経系におけるAMPKβの解析
仲村厚志; 中村 整
Oral presentation, Japanese, 日本比較生理生化学会、日本比較内分泌学会、,第34回日本比較内分泌学会大会日本比較生理生化学会第31回大会 合同大会 CompBiol2009
Oct. 2009

クロキンバエ中枢神経系における摂食調節機能へのＡＭＰＫの関与
鈴木智之; 仲村厚志; 中村整
Oral presentation, Japanese, 第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会 CompBiol2009,日本比較内分泌学会、日本比較生理生化学会
Oct. 2009

アカハライモリ嗅上皮におけるリポカリンによる匂い感度の修飾
野海芳博; 高橋司; 澤田研; 岩佐達郎; 中村整
Oral presentation, Japanese, 日本動物学会関東支部第61回大会およびシンポジウムプログラム・要旨,日本動物学会関東支部第61回大会
Mar. 2009

嗅細胞特異的Ｇ蛋白質Golfの細胞膜ラフトへの局在
仲村厚志; 竹田浩之; 中村整
Oral presentation, Japanese, 日本動物学会第79回大会予稿集,第79回大会
Sep. 2008

クロキンバエ中枢神経系における摂食調節機能へのAMPキナーゼの関与
鈴木智之; 仲村厚志; 中村整
Oral presentation, Japanese, 日本動物学会第79回大会予稿集,第79回大会
Sep. 2008

Bitter compound detection in the blowfly taste receptor cell: evidence for the inositol 1,4,5-trisphosphate-dependent transduction
Qin Ouyang; Hiroyasu Sato; Kiyoko Yonemoto; Yohei Ushijima; Yoshihiro Murata; Atsushi Nakamura; Tadashi Nakamura
Public symposium, English, International Seminar: Evolutionary Studies in Behavioral Neuroscience, 総合研究大学院大学・先導科学研究科・生命生体進化学専攻、および ニューロエソロジー談話会, 横須賀
Jun. 2008

クロキンバエにおけるリモネンガスとショ糖溶液を用いた条件付け方法の確立
鈴木智之; 谷口大揮; 松田惇; 戸部田学; 仲村厚志; 中村整
Oral presentation, Japanese, 日本動物学会第60回関東支部大会プログラム・要旨集,日本動物学会第60回関東支部大会
Mar. 2008

クロキンバエふ節感覚毛における苦味受容機構
欧陽琴; 佐藤博康; 勝沼祐介; 網谷拓郎; 村田芳博; 仲村厚志; 中村整
Oral presentation, Japanese, 日本動物学会第60回関東支部大会プログラム・要旨集,日本動物学会第60回関東支部大会
Mar. 2008

クロキンバエ唇弁における糖応答の苦味物質による抑制
米本聖夜子; 勝沼祐介; 中村整
Oral presentation, Japanese, 日本動物学会第60回関東支部大会プログラム・要旨集,日本動物学会第60回関東支部大会
Mar. 2008

Cp-PLBP: A possible ligand-binding protein found in the olfactory epithelium of Cynops pyrrhogaster
Hironobu Urita; Tadashi Nakamura; Keiko Okano; Tatsuo Iwasa
Oral presentation, English, 生物物理,日本生物物理学会第45回年会
Dec. 2007

クロキンバエPhormia regina の苦味受容細胞における情報変換機構の研究
欧陽琴; 佐藤博康; 網谷拓郎; 勝沼祐介; 村田芳博; 中村厚志; 中村整
Oral presentation, Japanese, 日本動物学会、第78回大会要旨集,日本動物学会第78回弘前大会
Sep. 2007

Roles of NO cascade and G proteins in transduction or adaptation of the sugar receptor cell in the blowfly
Mamiko Ozaki; Tadashi Nakamura
Oral presentation, English, Comparative Biochemistry and Physiology, Part A / Society for Experimental Biology
Apr. 2007

cDNA cloning and expression analysis of siganaling proteins in olfactory sensory system of Japanese common newt, Cynopus pyrrhogaster
Masataka Takashima; Keiko Okano; Ken Sawada; Tadashi Nakamura; Tatsuo Iwasa
Oral presentation, English, 生物物理
Nov. 2006

NO-cGMP signaling pathway in sugar receptor neurons in the blowfly
Tadashi Nakamura
Invited oral presentation, English, International Symposium on Frontiers in Molecular Endocrinology 2005, University of Hyderabad, India, Hyderabad, International conference
Dec. 2005

Contribution of tarsal taste receptors to learning of an association between smell and taste in the blowfly
Tadashi Nakamura
Others, English, Special lecture meeting at Center of Colgnitive Science, Center of Cognitive Science, University of Hyderabad, India
Dec. 2005

クロキンバエ培養味細胞におけるＮＯ産生
後藤信太郎; 村田芳博; 尾崎まみこ; 中村整
Oral presentation, English, 日本比較生理生化学会,第27回大会
Aug. 2005

クロキンバエ糖受容細胞の応答に対するl-cis ジルチアゼムの阻害効果
村田芳博; 尾崎まみこ; 中村整
Oral presentation, Japanese, 日本比較生理生化学会,代２７回大会
Aug. 2005

イモリ嗅上皮に発現する「リガンド」結合タンパク質
岩佐達郎; 満都拉; 高橋司; 澤田研; 岡野恵子; 中村整
Oral presentation, Japanese, 日本比較生理生化学会,第２７回大会
Aug. 2005

リモネンガス中で飼育したクロキンバエの食欲低下の行動学的解析
戸部田学; 仲村厚志; 尾崎まみこ; 中村整
Oral presentation, Japanese, 日本比較生理生化学会,第２７回大会
Aug. 2005

Lipocalins in the olfactory epithelium of the newt, Cynopus pyrrohogaster,
Iwasa T; Urano K; Sawada K; Okano K; Nakamura T
Oral presentation, English, Achems 2005 Annual Meeting, Sarasota
Apr. 2005

The nitric oxide – cyclic GMP cascade in sugar receptor cells of the blowfly, Phormia regina
Tadashi Nakamura; Yoshihiro Murata; Masashi Mashiko; Keiko Okano; Hiromasa Satoh; Mamiko Ozaki; Taisaku Amakawa
Invited oral presentation, English, Chemical Senses, kyoto, International conference
2005

Expression of nitric oxide synthase in the labellar chemosensory neurons of blowfly
Keiko Okano; Yoshihiro Murata; Tadashi Nakamura
Oral presentation, Comparative Biochemistry and Physiology, Part B
Dec. 2004

Possible involvement of guanylyl cyclase in the transduction mechanism of sugar receptor cells of the blowfly, Phormia regina
Yoshihiro Murata; Masashi Mashiko; Mamiko Ozaki; Tadashi Nakamura
Oral presentation, English, Comparative Biochemistry and Physiology, Part B
Dec. 2004

Proteome analysis in the labellar taste hair of blowfly, Phormia regina
Keiji Seno; Kazuyo Fujikawa; Chiyho Tada; Tadashi Nakamura; Mamiko Ozaki
Oral presentation, English, Comparative Biochemistry and Physiology, Part B
Dec. 2004

Morphological characteristics and physiological properties of cultured taste receptor cells in the blowfly, Phormia regian
Yoshihiro Murata; Mamiko Ozaki; Tadashi Nakamura
Oral presentation, English, International Symposium on Chemical Senses and Insect Behavior, Kyoto
Jul. 2004

Contribution of nitric oxide to the transduction pathway in the blowfly sugar receptor cells
Masashi Mashiko; Yoshihiro Murata; Mamiko Ozaki; Taisaku Amakawa; Tadashi Nakamura
Oral presentation, English, International Symposium on Chemical Senses and Insect Behavior, Kyoto
Jul. 2004

Primary culture and responsiveness of taste receptor cells from labella of developing blowfly, Phormia regina
Y.Murata; K.Seto; M. Ozaki; T.Nakamura
Oral presentation, English, Comparative Biochemistry and Physiology, Part B
Nov. 2003

Contribution of intriunsic nitric oxide to the taste response of the sugar receptor cell in the blowfly, Phormia regina
Masashi Mashiko; Yoshihiro Murata; Hiromasa Suzuki; Mamiko Ozaki; Taisaku Amakawa; Tadashi Nakamura
Oral presentation, English, Comparative Biochemistry and Physiology, Part B
Nov. 2003

脊椎動物嗅上皮粘液中のCl^-^濃度の再検討
高野 大; 中村 整
Oral presentation, Japanese, 日本比較生理生化学会第12回大会予稿集
Jul. 2001

イモリＥＯＧに対するCl^-^チャンネルブロッカーの影響
加藤 秀雄; 中村 整
Oral presentation, Japanese, 日本比較生理生化学会第１２回大会予稿集
Jul. 2001

蛍光Cl^-^プローブのラット嗅細胞への適用
中村 整; 金子 博; Be; Lindemann
Oral presentation, Japanese, 日本比較生理生化学会第12回大会予稿集
Jul. 2001

脊椎動物嗅上皮粘液中のCl^-^濃度の再検討
高野 大; 中村 整
Oral presentation, Japanese, 日本比較生理生化学会第12回大会予稿集
Jul. 2001

嗅覚情報変換機構の研究動向：ｃAMP経路を中心に
中村 整
Oral presentation, Japanese, 日本味と匂学会第34回大会，シンポジウムⅢ「21世紀を迎えた「匂」の受容から認識に至る研究の展望」，予稿集
Oct. 2000

両棲類嗅細胞の匂応答に対するCl-チャンネルブロッカーの影響
大石隆弘; 杉本康浩; 中村 整
Oral presentation, Japanese, 日本動物学会第71回大会，予稿集
Sep. 2000

両棲類嗅細胞の匂い応答に対するCl- チャンネルブロッカーの影響
大石隆弘; 杉本康浩; 中村整
Oral presentation, Japanese, Zoological Sci.
2000

嗅細胞内の塩化物イオン濃度勾配、日本生物物理学会第36回大会
金子博; 中村整
Oral presentation, Japanese, 生物物理
1998

吸引電極による単離イモリ嗅細胞の匂応答の記録
中村整
Oral presentation, Japanese, 比較生理生化学
1998

嗅細胞内の塩化物イオン濃度勾配
金子博; 中村整
Oral presentation, Japanese, 比較生理生化学
1998

イモリ嗅細胞におけるクロライドイオンの濃度分布
中村整; 金子博
Oral presentation, Japanese, Zoological Sci.
1998

蛍光色素を用いたイモリ嗅細胞における塩素イオン濃度測定
金子博; 中村整
Oral presentation, Japanese, Jap. J. Physiol.
1998

カエル嗅電図におけるCl- の成分
杉本康浩; 中村整
Oral presentation, Japanese, 生物物理
1997

ウシガエルの嗅電図におけるクロライド成分の研究
中村整; 杉本康浩; 若林良一郎
Oral presentation, Japanese, Zoological Sci.
1997

Ionic mechanisms of olfactory reception in vertebrate,
T.Nakamura
Invited oral presentation, English, Internatl Congress on Cilia, Mucus and Mucociliary Interactions, Jerusalem, International conference
1997

Ion channels contributing to the transduction in the olfactory receptor cell
T.Nakamura
Invited oral presentation, English, ASB94 Workshops, program, Harima, International conference
May 1994

臭い刺激の受容と変換、日本生物物理学会第31回年会、シンポジウム「感覚情報変換研究の新展開―細胞レベルの研究の現状と将来－」
中村整
Oral presentation, Japanese, 生物物理
1993

臭い刺激の受容と変換、日本生物物理学会第31回年会、シンポジウム「感覚情報変換研究の新展開―細胞レベルの研究の現状と将来－」
中村整
Invited oral presentation, Japanese, 生物物理
1993

Calcium ions in the transduction current of the olfactory receptor cell. Molecular mechanism of generation of electric signals in sensory cells
T.Nakamura; S.Hirota; Y.Kurimoto
Invited oral presentation, English, Proceedings of the 18th Taniguchi Intrntl. Sympo. Biophys. Division, ed. by F. Tokunaga, Kyoto, International conference
1992

Olfactory transduction, analogous mechanism to visual transduction
T.Nakamura; T.Satoh; S.Miyamoto
Invited oral presentation, English, Symposium on Molecular Mechanism of the Photo-reception and Transduction in the Bio-Information Systems. Abstracts, Chofu, International conference
1992

Calcium influx induced by intracellular cyclic AMP in the newt olfactory receptor cell
T.Nakamura; S.Hirota
Invited oral presentation, English, Proc. 2nd Japan-USSR Cooperative Symposium, Receptor : Structure and Function, Kyoto, International conference
1991

Study of cAMP and Ca++ in olfactory transduction
T.Nakamura
Invited oral presentation, English, 3rd Internatl. Congress of Comparative Physiology and Biochemistry, Abstracts, Tokyo, International conference
1991

嗅覚情報変換におけるサイクリックAMPとカルシウム・イオンの研究
中村整
Oral presentation, Japanese, 第25回味と匂のシンポジウム 中西賞受賞講演、論文集
1991

嗅覚情報変換におけるサイクリックAMPとカルシウム・イオンの研究
中村整
Invited oral presentation, Japanese, 第25回味と匂のシンポジウム 中西賞受賞講演、論文集
1991

Studies on the mechanism of olfactory transduction in vertebrates
G.H.Gold; G.Lowe; T.Nakamura
Invited oral presentation, English, Neurosci. Res, Katata, International conference
1990

Studies on the role of cyclic AMP in olfactory transduction
G.H.Gold; G.Lowe; T.Nakamura
Invited oral presentation, English, Proceedings of the tenth Internatl. Sympo. on Olfaction and Taste, Oslo, International conference
Jul. 1989

Studies on the role of cAMP in olfactory transduction.
T.Nakamura
Invited oral presentation, Proceedings of USSR-Japan Symposium. Receptors: Structure and Function, Moscow, International conference
1989

Ionic composition of toad olfactory mucus measured with ion selective microelectrodes, Xth Annual Meeting of the Association for Chemoreception Sciences
D.Chiu; T.Nakamura; G.H.Gold
Oral presentation, English, Chemical Senses, Sarasota
1988

EOG amplitude is correlated with odor-stimulated adenylate cyclase activity in the bullfrog olfactory epithelium. Xth Annual Meeting of the Association for Chemoreception Sciences
G.Lowe; T.Nakamura; G.H.Gold
Oral presentation, English, Chemical Senses, Sarasota
1988

Single channel properties of the ciliary cycle nucleotide-gated conductance, Xth Annual Meeting of the Association for Chemoreception Sciences
T.Nakamura; G.H.Gold
Oral presentation, English, Chemical Senses, Sarasota
1988

EOG amplitude is correlated with odor-stimulated adenylate cyclase activity in the bullfrog olfactory epithelium
G.Lowe; T.Nakamura; G.H.Gold
Oral presentation, English, Annual Meeting of Soc. Neurosci. Abstr.
1988

Monoclonal antibodies specific to chicken iodopsin and other cone pigments. in Molecular Physiology of Retinal Proteins
J.G.Chen; T.Nakamura; H.Matsumoto; T.G.Ebrey
Invited oral presentation, English, Kyoto, International conference
1988

Cyclic AMP: an intracellular messenger for olfactory transduction. ,
G.H.Gold; T.Nakamura
Invited oral presentation, English, Discussions in Neurosciences, IV Sensory Transduction, ed by A.J.Hudpeth et al., Geneva, International conference
1987

A cyclic nucleotide-gated conductance in olfactory cilia
T.Nakamura; G.H.Gold
Oral presentation, English, Bikophysical J., New Orleans
1987

Wavelength regulation in a cone pigment, chicken iodopsin
J.G.Chen; T.Nakamura; T.G.Ebrey; K.Odashima; K.Konno; F.Derguini; K.Nakanishi; B.Honig
Oral presentation, English, Biophysical J., New Orleans
1987

Light-regulation of intracellular calcium in the rod outer segment.
G.H.Gold; T.Nakamura
Invited oral presentation, English, Proceedings of the international society for eye research, Nagoya, International conference
Sep. 1986

Inhibition and enhancement of photoreceptor potential by some divalent cations. (29th Annual meeting of Biophysical Society)
T.Nakamura; T.Yoshizawa
Oral presentation, English, Biophysical J., Washington
1985

Characteristic inhibition of thrombin and plasmin by active ingredients of chinese herbs. (IX Internatl. Cong. Thrombosis and Haemostasis)
T.Nakamura; S.Okamoto; Y.Saito; T.Kuwaki; H.Matsumoto
Invited oral presentation, English, Thrombosis and Haemostasis, Stockholm, International conference
1983

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日本生理学会

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日本味と匂学会

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