YUKIO YAMADA
| Emeritus Professor etc. | Emeritus Professor |
| Center for Neuroscience and Biomedical Engineering | Visiting Professor |
- Profile:
1. High temperature heat exchanger
2. Radiation energy transport in participating media
3. Heat transfer in biological tissue
4. Light propagation in biological tissue
5. Diffuse optical tomography of biological tissue by near-infrared light
6. Noninvasive measurement of blood glucose level by near-infrared spectroscopy
7. Temperature measurement of fluid containing water using near-infrared spectroscopy
8. Measurement of biological information by use of near-infrared fluorescence spectroscopy
Researcher Information
Degree
Research Keyword
Field Of Study
Career
- 01 Apr. 2013 - 31 Mar. 2020
National Institute of Advanced Industrial Science and Technology, 健康工学研究部門, Visiting Researcher - 01 Sep. 2019
The University of Tokyo, Department of Human and Engineered Environment Studies, Graduate School of Frontier Sciences, Project Researcher - 01 Apr. 2019
University of Electro-Communications, Center for Neurosciences and Biomedical Engineering, Visiting Professor - 01 Jun. 2013 - 31 Mar. 2019
Nihon University, Faculty of Engineering, Visiting Professor - 01 Apr. 2013 - 31 Mar. 2019
University of Electro-Communications, Brain Science Inspired Life Support Research Center, Specially Assigned Professor - 01 Apr. 2013 - 31 Mar. 2014
University of Electro-Communications, 大学院情報理工学研究科、情報理工学部, Professor - 01 Apr. 2013
The University of Electro-Communications, Professor Emeritus - 01 Apr. 2013
Brain Science Inspired Life Support Research Center, Specially Assigned Professor - 01 Apr. 2001 - 31 Mar. 2013
University of Electro-Communications, 電気通信学部知能機械工学科, Professor - 01 May 1998 - 31 Mar. 2001
Mechanical Engineering Laboratory, MITI, 基礎技術部, Director, Dept. of Mat. Sci. & BioEng. - 01 Apr. 1993 - 30 Apr. 1998
Mechanical Engineering Laboratory, MITI, 基礎技術部バイオメカニクス研究室, Leader, Bioeng. Section - 01 Apr. 1991 - 31 Mar. 1993
Mechanical Engineering Laboratory, MITI, エネルギー部熱工学課, Leader, Thermal Eng. Section - 01 Apr. 1974 - 31 Mar. 1991
Mechanical Engineering Laboratory, MITI, エネルギー部熱工学課, Researcher, and Senior Researcher
Educational Background
Member History
- Aug. 2011 - Jul. 2012
大会長, 日本光脳機能イメージング研究会, Society - May 2009 - May 2010
副会長, 日本伝熱学会, Society - Jan. 2006 - Dec. 2009
Editorial Board Member for Physics in Medicine and Biology, Institute of Physics, Society - Jan. 2006 - Dec. 2009
学術雑誌「医学および生物学の物理」の編集委員, 英国物理学会, Society - May 2006 - May 2008
監事, 日本伝熱学会, Society - Jan. 2006 - Mar. 2008
Journal of Thermal Science and Technology編集委員会, 日本機械学会, Society - Oct. 2005 - Feb. 2008
110周年記念事業委員会式典小委員会, 日本機械学会, Society - Apr. 2005 - Mar. 2007
バイオエンジニアリング部門総務委員長, 日本機械学会, Society - Apr. 2005
Fellow, Japan Society of Mechanical Engineers, Society - Apr. 2005
フェロー, 日本機械学会, Society - Nov. 2004
fellow, Institute of Physics, Society - Nov. 2004
フェロー, 英国物理学会, Society - Apr. 2002 - Mar. 2004
熱工学部門運営委員, 日本機械学会, Society - Apr. 2002 - Mar. 2004
表彰部会, 日本機械学会, Society - Apr. 2001 - Mar. 2003
国際交流委員会, 日本機械学会, Society - Apr. 2002
世話人, 日本光脳機能イメージング研究会, Society - 1996 - 2002
Program Committee Member, Biomedical Topical Meeting, Optical Society of America, Society - 1996 - 2002
生体医用光学トピカルミーティング・プログラム委員, 米国光学会, Society - May 1997 - May 1999
「生体内輸送・伝播に関する研究会」幹事, 日本伝熱学会, Society - May 1996 - May 1998
理事, 日本伝熱学会, Society
Research Activity Information
Award
- Jan. 2015
日本機械学会 バイオエンジニアリング部門
功績賞（第19回 2014年度）, 山田幸生
Others, Japan - Jan. 2015
日本機械学会 バイオエンジニアリング部門
日本機械学会 バイオエンジニアリング部門 功績賞（第19回 2014年度）, 山田幸生
Others, Japan - May 2014
日本伝熱学会
名誉会員, 山田幸生
Others, Japan - May 2014
日本伝熱学会
日本伝熱学会 名誉会員, 山田幸生
Others, Japan - Nov. 2011
(社）日本伝熱学会
日本伝熱学会創立５０周年記念功労者表彰 - Jun. 2011
日本伝熱学会
近赤外分光法を応用した微量水溶液の温度イメージング
日本伝熱学会学術賞, 角田直人;近藤克哉;尾崎敦之;有本英伸;山田幸生
Official journal - Apr. 2005
日本機械学会賞（論文）"Anatomical and Functional Images for in vitro and in vivo Tissues by NIR Time-domain Diffuse Optical Tomography" - Apr. 2005
日本機械学会賞（論文）, 趙 会娟;高 峰;谷川ゆかり;本間一弘;小野寺陽一;山田幸生
Official journal - Jan. 2005
日本機械学会バイオエンジニアリング部門 第13回業績賞「光を用いた生体計測に関する基礎研究ほかの優れた業績」 - Jan. 2005
光を用いた生体計測に関する基礎研究ほかの優れた業績
日本機械学会バイオエンジニアリング部門 第13回業績賞
Others - Dec. 2002
Singapore
Outstanding Paper Award: "LIGHT PROPAGATION IN BIOLOGICAL TISSUES AND OPTICAL DIAGNOSTICS BY IMAGING AND SPECTROSCOPY," ICBME 2002 (International Congress on Biological and Medical Engineering 2002)
Singapore - Dec. 2002
Singapore
Outstanding Paper Award, ICBME 2002 (International Congress on Biological and Medical Engineering 2002)
International society - Apr. 2000
科学技術庁
生体の光学ファントム作製法
注目発明選定, 山田幸生;谷川ゆかり
Others - Apr. 1996
科学技術庁長官賞，研究功績者表彰:「光断層イメージングシステム」 - Apr. 1996
科学技術庁
光断層イメージングシステム
科学技術庁長官賞，研究功績者表彰
Others - Aug. 1994
工業技術院機械技術研究所
生体熱工学と光断層イメージングシステムに関する研究
機械技術研究所長賞 研究業績賞, 山田幸生
Others - Apr. 1993
科学技術庁長官
光CT装置
注目発明選定, 山田幸生
Others
Paper
- High-contrast and noise-robust image reconstruction with regularization minimizing entropy for diffuse optical tomography
Qaisar Shahzad; Yukio Yamada; Yoko Hoshi; Shinpei Okawa
Optics Continuum, Optica Publishing Group, 4, 2, 86-86, 16 Jan. 2025, The image reconstruction for diffuse optical tomography (DOT) employing a regularization method that minimizes entropy of the reconstructed optical property distribution was proposed to improve the contrast and noise robustness. We demonstrated the performance of the entropy regularization as compared to the l1-norm and l2-norm regularizations with numerical simulations and a phantom experiment. The entropy regularization provided the reconstructed images with improved contrast with artifacts caused by measurement noise suppressed. Our results indicate that entropy regularization has a potential to improve DOT imaging.
Scientific journal - Depth detection limit of a fluorescent object in tissue-like medium with background emission in continuous-wave measurements: a phantom study
Goro Nishimura; Takahiro Suzuki; Yukio Yamada; Haruki Niwa; Takuji Koike
Journal of Biomedical Optics, SPIE-Intl Soc Optical Eng, 29, 09, 097001-1-097001-17, 02 Sep. 2024, Peer-reviwed
Scientific journal, English - Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study
Xianyin Hu; Yuki Ban; Yukio Yamada; Shin’ichi Warisawa; Kaoru Sakatani
Oxygen Transport to Tissue XLIV, Advances in Experimental Medicine and Biology, Springer International Publishing, 1438, 21-26, 17 Oct. 2023, Peer-reviwed
In book, English - Determination of the absorption and reduced scattering coefficients by CW spatially resolved spectroscopy with long source-detector distances at high and low internal reflections
Yukio Yamada; Hiroshi Kawaguchi; Toru Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 12376, 2023
International conference proceedings - A comparative study of the delta-Eddington and Galerkin quadrature methods for highly forward scattering of photons in random media
H. Fujii; G. Chiba; Y. Yamada; Y. Hoshi; K. Kobayashi; M. Watanabe
Journal of Computational Physics, Elsevier, Vol. 423, Paper No. 109825, 1-14, Sep. 2020, Peer-reviwed
Scientific journal, English - Erratum: Near-infrared measurement of water temperature near a 1-mm-diameter magnetic sphere and its heat generation rate under induction heating (Journal of Applied Physics (2017) 122 (044901) DOI: 10.1063/1.4995284)
Naoto Kakuta; Keisuke Nishijima; Katsuya Kondo; Yukio Yamada
Journal of Applied Physics, American Institute of Physics Inc., 126, 23, 21 Dec. 2019
Scientific journal, English - Numerical treatment of highly forward scattering on radiative transfer using the delta-M approximation and Galerkin quadrature method
Hiroyuki Fujii; Go Chiba; Yukio Yamada; Yoko Hoshi; Kazumichi Kobayashi; Masao Watanabe
Proceedings of the 9th International Symposium on Radiative Transfer, RAD-19, SM05, 261-268, Sep. 2019, Peer-reviwed
International conference proceedings, English - Numerical errors of light propagation in the two-dimensional human neck model using the time-dependent radiative transfer equation with renormalized phase functions
Hiroyuki Fujii; Yamada Yukio; Hoshi Yoko; Kobayashi Kazumichi; Watanabe Masao
AIP Conference Proceedings (ICNAAM2018), 2116, 450037, 1-4, Jul. 2019, Peer-reviwed
International conference proceedings, English - Effects of Aging, Cognitive Dysfunction, Brain Atrophy on Hemoglobin Concentrations and Optical Pathlength at Rest in the Prefrontal Cortex: A Time-Resolved Spectroscopy Study
Kaoru Sakatani; Lizhen Hu; Katsunori Oyama; Yukio Yamada
Applied Sciences, MDPI, Vol. 9, Paper No. 2209, 1-11, May 2019, Peer-reviwed
Scientific journal, English - Light propagation models of the human neck for photoacoustic imaging of thyroid cancer
Kosuke Tabayashi; Hiroyuki Fujii; Shinpei Okawa; Kazumichi Kobayashi; Yukio Yamada; Yoko Hoshi; Masao Watanabe
CMBE Proceedings (6th International Conference on Computational & Mathematical Biomedical Engineering), A5, 161-164, May 2019, Peer-reviwed
International conference proceedings, English - Time-Domain Near-Infrared Spectroscopy and Imaging: A Review
Yukio Yamada; Hiroaki Suzuki; Yutaka Yamashita
Applied Sciences, MDPI, Vol. 9, Paper No. 1127, 1-53, Mar. 2019, Peer-reviwed, Invited
Scientific journal, English - Accurate and efficient computation of the 3D radiative transfer equation in highly forward-peaked scattering media using a renormalization approach
Hiroyuki Fujii; Yukio Yamada; Go Chiba; Yoko Hoshi; Kazumichi Kobayashi; Masao Watanabe
Journal of Computational Physics, 374, 591-604, Dec. 2018, Peer-reviwed
Scientific journal, English - Near-infrared temperature measurement technique for water surrounding an induction-heated small magnetic sphere
Naoto Kakuta; Keisuke Nishijima; van Cuong Han; Yuki Arakawa; Katsuya Kondo; Yukio Yamada
Journal of Visualized Experiments, Journal of Visualized Experiments, 2018, 134, 1-10, 30 Apr. 2018, Peer-reviwed
Scientific journal, English - Light propagation model of titanium dioxide suspensions in water using the radiative transfer equation
H. Fujii; Y. Yamada; Y. Hoshi; S. Okawa; K. Kobayashi; M. Watanabe
Reaction Kinetics, Mechanisms and Catalysis, 123, 2, 439-453, Apr. 2018, Peer-reviwed
Scientific journal, English - Measurement of temperature-dependent diffusion coefficients of aqueous solutions by near-infrared simultaneous imaging of temperature and concentration
Hiroki Yamashita; Naoto Kakuta; Daisuke Kawashima; Yukio Yamada
Biomedical Physics and Engineering Express, Institute of Physics, 4, 3, 1-12, Apr. 2018, Peer-reviwed
Scientific journal, English - Aspiration Risk Detection Using Oral Administration of Fluorescent Food --- Preliminary Experiments Using Meat Phantoms ---
Takahiro SUZUKI; Ryohei SAITO; Nobuo KITADA; Takuji KOIKE; Shojiro MAKI; Yukihiro MICHIWAKI; Goro NISHIMURA; Haruki NIWA; Yukio YAMADA
2017 IEEE International Conference on Cyborg and Bionic Systems (CBS 2017), IEEE, 1, 17 Oct. 2017, Peer-reviwed
International conference proceedings, English - Near-infrared measurement of water temperature near a 1-mm-diameter magnetic sphere and its heat generation rate under induction heating
Naoto Kakuta; Keisuke Nishijima; Katsuya Kondo; Yukio Yamada
JOURNAL OF APPLIED PHYSICS, 122, 4, Jul. 2017, Peer-reviwed
Scientific journal, English - Modeling of light propagation in the human neck for diagnoses of thyroid cancers by diffuse optical tomography
H. Fujii; Y. Yamada; K. Kobayashi; M. Watanabe; Y. Hoshi
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, 33, 5, May 2017, Peer-reviwed
Scientific journal, English - Normalization method of highly forward-peaked scattering phase function using the double exponential formula for radiative transfer
Hiroyuki Fujii; Shinpei Okawa; Yukio Yamada; Yoko Hoshi; Masao Watanabe
AIP Conference Proceedings (ICCMSE2016), 1790, 050002, 1-4, Dec. 2016, Peer-reviwed
International conference proceedings, English - Renormalization of the highly forward-peaked phase function using the double exponential formula for radiative transfer
Hiroyuki Fujii; Shinpei Okawa; Yukio Yamada; Yoko Hoshi; Masao Watanabe
JOURNAL OF MATHEMATICAL CHEMISTRY, 54, 10, 2048-2061, Nov. 2016, Peer-reviwed
Scientific journal, English - Simultaneous imaging of temperature and concentration of ethanol-water mixtures in microchannel using near-infrared dual-wavelength absorption technique
Naoto Kakuta; Hiroki Yamashita; Daisuke Kawashima; Katsuya Kondo; Hidenobu Arimoto; Yukio Yamada
MEASUREMENT SCIENCE AND TECHNOLOGY, 27, 11, 1-12, Nov. 2016, Peer-reviwed
Scientific journal, English - Overview of diffuse optical tomography and its clinical applications
Yoko Hoshi; Yukio Yamada
JOURNAL OF BIOMEDICAL OPTICS, 21, 9, 091312-1-091312-12, Sep. 2016, Peer-reviwed, Invited
Scientific journal, English - Visualization of Concentrations of Salts Produced during Neutralization Reactions by using Single Wavelength in the Near-infrared Region
Kawashima Daisuke; Kakuta Naoto; Arimoto Hidenobu; Kondo Katsuya; Yamada Yukio
Transactions of the Visualization Society of Japan, The Visualization Society of Japan, 36, 12, 62-70, 2016,This paper proposes a novel imaging method using near infrared light of single wavelength to visualize the concentration distribution of salt generated by neutralization reaction of aqueous solutions of acid and alkali in a microfluidic channel. This method is based on the absorption characteristics of the aqueous solutions at the wavelength of 1520 nm in the ν1+ν3 absorption band of water. The wavelength of 1520 nm is an isosbestic point for the aqueous solutions of the acid and alkali with respect to their concentrations while the absorbances of the salt solutions at 1520 nm vary with their salt concentrations. To verify the proposed single-wavelength imaging method, the concentration images of sodium chloride (NaCl) were obtained and analyzed in two cases of the combinations of two liquids flowing into a T-shaped microchannel: (i) water and aqueous solution of NaCl, and (ii) hydrochloric acid and sodium hydroxide. The measured concentrations of NaCl agreed well with the expected distributions of the concentrations and verified the proposed method.
English - Numerical modeling of photon migration in human neck based on the radiative transport equation
Hiroyuki Fujii; Shinpei Okawa; Ken Nadamoto; Eiji Okada; Yukio Yamada; Yoko Hoshi; Masao Watanabe
Journal of Applied Nonlinear Dynamics, L and H Scientific Publishing, LLC, 5, 1, 117-125, 2016, Peer-reviwed
Scientific journal, English - Numerical analysis of photon migration in three-dimensional turbid media using the delta-Eddington approximation
Hiroyuki Fujii; Shinpei Okawa; Ken Nadamoto; Eiji Okada; Yukio Yamada; Yoko Hoshi; Masao Watanabe
Proceedings of the 9th ICME International Conference on Complex Medical Engineering (CME 2015), ICME, 1, 1, 1-2, 19 Jun. 2015, Peer-reviwed, Invited
International conference proceedings, English - Near-infrared noninvasive blood glucose prediction without using multivariate analyses: introduction of imaginary spectra due to scattering change in the skin
Katsuhiko Maruo; Yukio Yamada
JOURNAL OF BIOMEDICAL OPTICS, 20, 4, No. 047003-No. 047003, Apr. 2015, Peer-reviwed
Scientific journal, English - Numerical modeling of photon migration in the cerebral cortex of the living rat using the radiative transport equation
Hiroyuki Fujii; Shinpei Okawa; Ken Nadamoto; Eiji Okada; Yukio Yamada; Yoko Hoshi; Masao Watanabe
Proceedings of SPIE, Biomedical Applications of Light Scattering IX, 9333, 933313, 1-6, Mar. 2015, Peer-reviwed
International conference proceedings, English - A coupling model of the radiative transport equation for calculating photon migration in biological tissue
Hiroyuki Fujii; Shinpei Okawa; Yukio Yamada; Yoko Hoshi; Masao Watanabe
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, SPIE, 9792, 2015, Peer-reviwed
International conference proceedings, English - A coupling model of the radiative transport equation for calculating photon migration in biological tissue
Hiroyuki Fujii; Shinpei Okawa; Yukio Yamada; Yoko Hoshi; Masao Watanabe
BIOPHOTONICS JAPAN 2015, 9792, Paper No. 979214, 1-5, 2015, Peer-reviwed
International conference proceedings, English - Hybrid model of light propagation in random media based on the time-dependent radiative transfer and diffusion equations
Hiroyuki Fujii; Shinpei Okawa; Yukio Yamada; Yoko Hoshi
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER, 147, 145-154, Nov. 2014, Peer-reviwed
Scientific journal, English - Reconstruction of cross-sectional temperature distributions of water around a thin heating wire by inverse Abel transform of near-infrared absorption images
Naoto Kakuta; Katsuya Kondo; Hidenobu Arimoto; Yukio Yamada
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 77, 852-859, Oct. 2014, Peer-reviwed
Scientific journal, English - A 3D-visualization of fluorescence target in deep human tissue by means of time-domain optical tomography
Goro Nishimura; Yukio Yamada; Hideo Saji; Yasuomi Ouchi
Transactions of Japanese Society for Medical and Biological Engineering, Japan Soc. of Med. Electronics and Biol. Engineering, 52, 62-SY-63, 17 Aug. 2014, Peer-reviwed
Scientific journal, English - Temperature Imaging of Water Around a Small Heated Sphere Using a Nera-Infrared Absorption Technique
Naoto Kakuta; Kenta Yamada; Ryota Fujioka; Katsuya Kondo; Hidenobu Armoto; Yukio Yamada
The 15th International Heat Transfer Conference, Proceedings, 10 Aug. 2014, Peer-reviwed
International conference proceedings, English - Reconstruction of localized fluorescent target from multi-view continuous-wave surface images of small animal with l(p) sparsity regularization
Shinpei Okawa; Tatsuya Ikehara; Ichiro Oda; Yukio Yamada
BIOMEDICAL OPTICS EXPRESS, 5, 6, 1839-1860, Jun. 2014, Peer-reviwed
Scientific journal, English - Diffuse Optical Tomography: Present Status and Its Future
Yukio Yamada; Shinpei Okawa
OPTICAL REVIEW, 21, 3, 185-205, May 2014, Peer-reviwed, Invited
Scientific journal, English - Understanding near infrared radiation propagation in pig skin reflectance measurements
Eduardo Zamora-Rojas; Ana Garrido-Varo; Ben Aernouts; Dolores Perez-Marin; Wouter Saeys; Yukio Yamada; Jose Emilio Guerrero-Ginel
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES, 22, 137-146, Apr. 2014, Peer-reviwed
Scientific journal, English - Image errors of time-resolved optical tomography based on the radiative transfer and diffusion equations
Hiroyuki Fujii; Shinpei Okawa; Tetsuya Yoshinaga; Yukio Yamada; Yoko Hoshi
ODF'14 Technical Digest (9th International Conference on Optics-photonics Design and Fabrication), 13PDb-20, 1-2, Feb. 2014, Peer-reviwed
International conference proceedings, English - cortex
Rei Murata; Yuki Takada; Hiroyuki Takuwa; Hiroshi Kawaguchi; Hiroshi Ito; Iwao Kanno; Naotomo Tottori; Yukio Yamada; Yutaka Tomita; Yoshiaki Itoh; Norihiro Suzuki; Katsuya Yamada; Kazuto Masamoto
Advances in Experimental Medicine and Biology, Springer New York LLC, 812, 241-246, 2014, Peer-reviwed
Scientific journal, English - Vessel Specific Imaging of Glucose Transfer with Fluorescent Glucose Analogue in Anesthetized Mouse Cortex
Rei Murata; Yuki Takada; Hiroyuki Takuwa; Hiroshi Kawaguchi; Hiroshi Ito; Iwao Kanno; Naotomo Tottori; Yukio Yamada; Yutaka Tomita; Yoshiaki Itoh; Norihiro Suzuki; Katsuya Yamada; Kazuto Masamoto
OXYGEN TRANSPORT TO TISSUE XXXVI, 812, 241-246, 2014, Peer-reviwed
Scientific journal, English - Automated Image Analysis for Diameters and Branching Points of Cerebral Penetrating Arteries and Veins Captured with Two-Photon Microscopy
Takuma Sugashi; Kouichi Yoshihara; Hiroshi Kawaguchi; Hiroyuki Takuwa; Hiroshi Ito; Iwao Kanno; Yukio Yamada; Kazuto Masamoto
OXYGEN TRANSPORT TO TISSUE XXXVI, 812, 209-215, 2014, Peer-reviwed
Scientific journal, English - Visualization and analysis of heat and mass transfer with chemical reactions in microchannels
D. Kawashima; N. Kakuta; K. Kondo; H. Arimoto; Y. Yamada
Proceedings of the 15th International Heat Transfer Conference, IHTC 2014, Proceedings, 2014, Peer-reviwed
International conference proceedings, English - Simulations of airflow and substance concentration around a human body
Shintaro Yokoyama; Naoto Kakuta; Yo Mizuta; Kunihiko Mabuchi
Journal of Physiological Anthropology and Applied Human Science, Japan Society of Physiological Anthropology, 57, 12, 493-498, Dec. 2013, Peer-reviwed, In order to predict airflow and suspended substance concentration around a human body, we developed a geometric model of the human form and generated grids around it for Computational Fluid Dynamics (CFD). According to a CFSV model proposed by us we made a domain that included a geometric human model and generated the grids within this domain. By using this model with the grids and the developed CFD program, it is possible to simulate the airflow and the transfer of a suspended substance around the body. The simulated airflow provided a different velocity profile for each region of the body due to the characteristics of the body shape. The simulated distribution of the suspended substance concentration demonstrates how usable the present model is for quantifying a substance in any exposed region of the body. J Physiol Anthropol 21 (5): 215-222, 2002 http://www.jstage.jst.go.jp/en/
Scientific journal, Japanese - Phantom and mouse experiments of time-domain fluorescence tomography using total light approach
Shinpei Okawa; Akira Yano; Kazuki Uchida; Yohei Mitsui; Masaki Yoshida; Masashi Takekoshi; Andhi Marjono; Feng Gao; Yoko Hoshi; Ikuhiro Kida; Kazuto Masamoto; Yukio Yamada
BIOMEDICAL OPTICS EXPRESS, 4, 4, 635-651, Apr. 2013, Peer-reviwed
Scientific journal, English - A coupling model of light propagation based on the radiative transfer and diffusion equations
Hiroyuki Fujii; Yoko Hoshi; Shinpei Okawa; Tetsuya Yoshinaga; Satoru Kohno; Yukio Yamada
AIP Conference Proceedings (ICNAAM 2013), 1558, 2528-2531, 2013, Peer-reviwed
International conference proceedings, English - In vivo Time-resolved DOT measurement and image reconstruction of human forearm under exercises
Y. Tanikawa; F. Gao; M. Miyakawa; T. Kiryu; T. Kizuka; S. Okawa; Y. Yamada
2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Proceedings, 1811-1814, 2013, Peer-reviwed
International conference proceedings, English - Influences of Blood Flow Changes in Cerebrospinal Fluid and Skin Layers on Optical Mapping
Shuping Wang; Yoko Hoshi; Yukio Yamada
2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Proceedings, 2632-2635, 2013, Peer-reviwed
International conference proceedings, English - 3D Analysis of Intracortical Microvasculature During Chronic Hypoxia in Mouse Brains
Kouichi Yoshihara; Hiroyuki Takuwa; Iwao Kanno; Shinpei Okawa; Yukio Yamada; Kazuto Masamoto
OXYGEN TRANSPORT TO TISSUE XXXIV, 765, 357-363, 2013, Peer-reviwed
Scientific journal, English - In vivo Time-resolved DOT images of human forearm under exercises
Yukari Tanikawa; Feng Gao; Michio Miyakawa; Toru Kiryu; Tomohiro Kizuka; Shinpei Okawa; Yukio Yamada
Functional Near Infrared Spectroscopy Conference, Abstract book, Abstract book, 177-177, 26 Oct. 2012, Peer-reviwed
International conference proceedings, English - Fluorescence diffuse optical tomography of small animals
Masaki Yoshida; Yohei Mitsui; Masashi Takekoshi; Shinpei Okawa; Yoko Hoshi; Ikuhiro Kida; Kazuto Masamoto; Yukio Yamada
NanoRad 2012 Abstract Book, NanoRad 2012 Abstract Book, 42-43, May 2012, Peer-reviwed
International conference proceedings, English - 拡散光トモグラフィーによるヒト前腕筋活動の評価
谷川 ゆかり; 高 峰; 宮川 道夫; 木竜 徹; 木塚 朝博; 遠藤 泰臣; 大川 晋平; 山田 幸生
電気学会論文誌C編, 132/Sec. C, 3, 374-383, Mar. 2012, Peer-reviwed
Scientific journal, Japanese - Evaluation of muscle activities in human forearms under exercises by diffuse optical tomography
Yukari Tanikawa; Feng Gao; Michio Miyakawa; Toru Kiryu; Tomohiro Kizuka; Yasuomi Endo; Shinpei Okawa; Yukio Yamada
IEEJ Transactions on Electronics, Information and Systems, Institute of Electrical Engineers of Japan, 132, 3, 6-383, 2012, Peer-reviwed
Scientific journal, English - 拡散光トモグラフィーによる生体内の光学特性値分布の再構成
大川晋平; 山田幸生
日本レーザー医学会誌, 32, 4, 402-410, 2012, Peer-reviwed - Improvement of Image Reconstruction for in vivo Fluorescence Molecular Imaging
大川晋平; 池原辰弥; 小田一郎; 山田幸生
光学, 応用物理学会分科会日本光学会, 8, 41, 424-429, 2012, Peer-reviwed
Japanese - 7D22 Quantitative analysis of micro vascular network structure in the cerebral cortex.
Takuma SUGASHI; Kouichi YOSHIHARA; Daiki YAMAGUCHI; Daigo SHIRAHATA; Hiroshi KAWAGUCHI; Iwao KANNO; Hiroshi ITO; Shinpei OKAWA; Kazuto MASAMOTO; Yukio YAMADA
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Japan Society of Mechanical Engineers, 2012.24, 0, \_}7D22, 2012, Peer-reviwed - Reduction of Poisson noise in measured time-resolved data for time-domain diffuse optical tomography
S. Okawa; Y. Endo; Y. Hoshi; Y. Yamada
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 50, 1, 69-78, Jan. 2012, Peer-reviwed
Scientific journal, English - Reduction of image artifacts induced by change in the optode coupling in time-resolved diffuse optical tomography
Ryo Fukuzawa; Shinpei Okawa; Shoko Matsuhashi; Takashi Kusaka; Yukari Tanikawa; Yoko Hoshi; Feng Gao; Yukio Yamada
JOURNAL OF BIOMEDICAL OPTICS, 16, 11, Paper No. 116022 (116022-1 , Nov. 2011, Peer-reviwed
Scientific journal, English - Dermal carbonyl modification is related to the yellowish color change of photo-aged Japanese facial skin
Yuki Ogura; Tomohiro Kuwahara; Minoru Akiyama; Shingo Tajima; Kazuhisa Hattori; Kouhei Okamoto; Shinpei Okawa; Yukio Yamada; Hchiro Tagami; Motoji Takahashi; Tetsuji Hirao
Journal of Dermatological Science, Vol. 64, pp. 45-52, Sep. 2011, Peer-reviwed
Scientific journal, English - Temperature imaging of water in a microchannel using thermal sensitivity of near-infrared absorption
Naoto Kakuta; Yuko Fukuhara; Katsuya Kondo; Hidenobu Arimoto; Yukio Yamada
Lab on a Chip, 11, 3479-3486, Sep. 2011, Peer-reviwed
Scientific journal, English - 3D analysis of intracortical microvasculature during chronic hypoxia in mouse brain
Kouichi Yoshihara; Hiroyuki Takuwa; Iwao Kanno; Shinpei Okawa; Yukio Yamada; Kazuto Masamoto
ISOTT 2011, ISOTT 2011, 1-8, Jul. 2011, Peer-reviwed
International conference proceedings, English - Development of image reconstruction algorithms for fluorescence diffuse optical tomography using total light approach
S. Okawa; H. Yamamoto; Y. Miwa; Y. Yamada
Optics InfoBase Conference Papers, 2011
International conference proceedings, English - Application of sparsity regularization to time-domain diffuse optical tomography
Shinpei Okawa; Yukio Yamada
Proceedings of the SICE Annual Conference, Society of Instrument and Control Engineers (SICE), 1505-1506, 2011
International conference proceedings, English - A regularization technique minimizing entropy for sparse reconstruction in diffuse optical tomography
Shinpei Okawa; Yukio Yamada
Proceedings of the SICE Annual Conference, Society of Instrument and Control Engineers (SICE), 2730-2731, 2011
International conference proceedings, English - Time-domain fluorescence diffuse optical tomography for living animals by total-light algorithm
Goro Nishimura; Kamlesh Awasthi; Kitsakorn Locharoenrat; Shinpei Okawa; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7896, 2011, Peer-reviwed
International conference proceedings, English - Time-domain fluorescence diffuse optical tomography for living animals by total-light algorithm
Goro Nishimura; Kamlesh Awasthi; Kitsakorn Locharoenrat; Shinpei Okawa; Yukio Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE IX, 7896, 78962Q-1-78962Q-7, 2011, Peer-reviwed
International conference proceedings, English - MEASUREMENT OF FLUORESCENCE PROPERTIES IN LIGHT SCATTERING MEDIUM
Shoji Maruoka; Yohei Mitsui; Shinpei Okawa; Yoko Hoshi; Yukio Yamada
PROCEEDINGS OF THE ASME/JSME 8TH THERMAL ENGINEERING JOINT CONFERENCE 2011, VOL 1 PTS A AND B, 33-+, 2011, Peer-reviwed
International conference proceedings, English - TIME-RESOLVED DIFFUSE OPTICAL TOMOGRAPHY OF HUMAN FOREARM UNDER EXERCISE
Yasuomi Endo; Yukari Tanikawa; Shinpei Okawa; Kazuto Masamoto; Hidetaka Okada; Tomohiro Kizuka; Michio Miyakawa; Yoko Hoshi; Yukio Yamada
PROCEEDINGS OF THE ASME/JSME 8TH THERMAL ENGINEERING JOINT CONFERENCE 2011, VOL 1 PTS A AND B, Paper No. AJTEC2011-44486, 71-+, 2011, Peer-reviwed
International conference proceedings, English - INFLUENCE OF BLOOD GLUCOSE LEVEL ON THE SCATTERING COEFFICIENT OF THE SKIN IN NEAR-INFRARED SPECTROSCOPY
Sachiko Kessoku; Katsuhiko Maruo; Shinpei Okawa; Kazuto Masamoto; Yukio Yamada
PROCEEDINGS OF THE ASME/JSME 8TH THERMAL ENGINEERING JOINT CONFERENCE 2011, VOL 1 PTS A AND B, Paper No. AJTEC2011-44471, 47-+, 2011, Peer-reviwed
International conference proceedings, English - EFFECT OF THE ARRANGEMENT OF OPTODES FOR 3D DIFFUSE OPTICAL TOMOGRAPHY
Kazuhiro Uchida; Shinpei Okawa; Kazuto Masamoto; Yoko Hoshi; Yukio Yamada
PROCEEDINGS OF THE ASME/JSME 8TH THERMAL ENGINEERING JOINT CONFERENCE 2011, VOL 1 PTS A AND B, Paper No. AJTEC2011-44480, 65-+, 2011, Peer-reviwed
International conference proceedings, English - MEASUREMENT OF OPTICAL PROPERTIES OF HUMAN SKIN
Kazuhisa Hattori; Tomohiro Kuwahara; Masato Ohmi; Masamitsu Haruna; Shinpei Okawa; Kazuto Masamoto; Yukio Yamada
PROCEEDINGS OF THE ASME/JSME 8TH THERMAL ENGINEERING JOINT CONFERENCE 2011, VOL 1 PTS A AND B, Paper No. AJTEC2011-44475, 55-63, 2011, Peer-reviwed
International conference proceedings, English - Development of image reconstruction algorithms for fluorescence diffuse optical tomography using total light approach
S. Okawa; H. Yamamoto; Y. Miwa; Y. Yamada
DIFFUSE OPTICAL IMAGING III, 8088, 1-6, 2011, Peer-reviwed
International conference proceedings, English - Improvement of image quality of time-domain diffuse optical tomography with l<inf>p</inf> sparsity regularization
Shinpei Okawa; Yoko Hoshi; Yukio Yamada
Biomedical Optics Express, OSA - The Optical Society, 2, 12, 3334-3348, 2011, Peer-reviwed
Scientific journal, English - Reconstruction of fluorescence/bioluminescence sources in biological medium with spatial filter
Shinpei Okawa; Yukio Yamada
Optics Express, 18, 12, 13151-13172, Dec. 2010, Peer-reviwed
Scientific journal, English - Effective optode configuration for the image reconstruction in diffuse optical tomography
Kazuhiro Uchida; Shinpei Okawa; Shoko Matsuhashi; Yoko Hoshi; Yukio Yamada
Medical Laser Application, 25, 3, 154-160, Aug. 2010, Peer-reviwed
Scientific journal, German - Reduction of Poisson Noise for Time-Resolved Diffuse Optical Measurement
S. Okawa; Y. Yamada
Proc. of SICE Annual Conference 2010 in Taiwan, 1, 1, Aug. 2010, Peer-reviwed
International conference proceedings, English - Source Reconstruction with Spatial Filter and Reduction of Artifacts in Fluorescence/Bioluminescence Diffuse Optical Tomography
S. Okawa; Y. Yamada
Proc. of SICE Annual Conference 2010 in Taiwan, 1, 2, Aug. 2010, Peer-reviwed
International conference proceedings, English - Reconstruction of fluorescence/bioluminescence sources in biological medium with spatial filter
Shinpei Okawa; Yukio Yamada
Optics Express, 18, 12, 13151-13172, Jul. 2010, Peer-reviwed
Scientific journal, English - Quantification of Fluorescence Target in Tissue Phantoms by Time‐Domain Diffuse Optical Tomography with Phantoms—Total‐Light Approach
Goro Nishimura; Kamlesh Awasthi; Kitsakorn Locharoenrat; Shinpei Okawa; Yukio Yamada
OSA Topical Meeting, Biomedical Optics (BIOMED), Abstract Book, BTuD11, Apr. 2010, Peer-reviwed
International conference proceedings, English - Simultaneous fluorescence yield and lifetime tomography from time-resolved transmittances of small-animal-sized phantom
Feng Gao; Jiao Li; Limin Zhang; Patrick Poulet; Huijuan Zhao; Yukio Yamada
Applied Optics, 49, 16, 3163-3172, Apr. 2010, Peer-reviwed
Scientific journal, English - Removal of a hydrogenated amorphous carbon film from the tip of a micropipette electrode using direct current corona discharge
Naoto Kakuta; Naoki Okuyama; Yukio Yamada
REVIEW OF SCIENTIFIC INSTRUMENTS, 81, 2, 1-6, Feb. 2010, Peer-reviwed
Scientific journal, English - Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities
Shuping Wang; Nanae Shibahara; Daishi Kuramashi; Shinpei Okawa; Naoto Kakuta; Eiji Okada; Atsushi Maki; Yukio Yamada
Optical Review, 17, 4, 410-420, 2010, Peer-reviwed
Scientific journal, English - Estimation of the absorption coefficients of two-layered media by a simple method using spatially and time-resolved reflectances
M. Shimada; C. Sato; Y. Hoshi; Y. Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 54, 16, 5057-5071, Aug. 2009, Peer-reviwed
Scientific journal, English - Temperature Imaging of Sub-Millimeter-Thick Water Using a Near-Infrared Camera
Naoto Kakuta; Katsuya Kondo; Atsushi Ozaki; Hidenobu Arimoto; Yukio Yamada
International Journal of Heat and Mass Transfer, 52, 4221-4228, Jul. 2009, Peer-reviwed
Scientific journal, English - Effects of Spatial Variation of Skull and Cerebrospinal Fluid Layers on Optical Mapping of Brain Activities
Shuping Wang; N. Shibahara; D. Kuramashi; S. Okawa; N. Kakuta; E. Okada; A. Maki; Y. Yamada
Proceedings of APBP2009, 114-115, May 2009, Peer-reviwed
International conference proceedings, English - Time-resolved DOT images of human forearm under excise
Y. Tanikawa; Feng Gao; M. Miyakawa; T. Kiryu; Y. Endo; S. Okawa; Y. Yamada
Proceedings of APBP2009, 120-121, May 2009, Peer-reviwed
International conference proceedings, English - Effects of the anatomy of the head on optical mapping of brain activities
M. Oki; N. Shibahara; R. Togashi; S. Okawa; Y. Hoshi; Y. Yamada
Proceedings of APBP2009, 129-130, May 2009, Peer-reviwed
International conference proceedings, English - Reduction of Poisson Noise from Time-Resolved Data for Diffuse Optical Tomography
S. Okawa; Y. Yamada
Proceedings of APBP2009, 131-132, May 2009, Peer-reviwed
International conference proceedings, English - Phantom experiments of fluorescence diffuse optical tomography
A. Yano; A. Marjono; K. Uchida; T. Abe; S. Okawa; G. Nishimura; Y. Hoshi; F. Gao; Y. Yamada
Proceedings of APBP2009, 137-138, May 2009
International conference proceedings, English - Effects of the movement of probes on the images of diffuse optical tomography
S. Matsuhashi; R. Fukuzawa; S. Okawa; Y. Hoshi; Y. Yamada
Proceedings of APBP2009, 139-140, May 2009, Peer-reviwed
International conference proceedings, English - 3D light source reconstruction with spatial filter for fluorescence/bioluminescence diffuse optical tomography
Shinpei Okawa; Yukio Yamada
Optics InfoBase Conference Papers, Optical Society of America, 2009
International conference proceedings, English - Simultaneously reconstructing fluorescent yield and lifetime from time-resolved transmittances of a small-animal-sized phantom
Feng Gao; Limin Zhang; Patrick Poulet; Jiao Li; Huijuan Zhao; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7369, 2009, Peer-reviwed
International conference proceedings, English - 3D light source reconstruction with spatial filter for fluorescence/ bioluminescence diffuse optical tomography
Shinpei Okawa; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7369, Article No. 736916, 2009, Peer-reviwed
International conference proceedings, English - 近赤外光を用いた非接触型微量流量計の研究
山下健作; 久保田壮一; 桃木秀幸; 角田直人; 大川晋平; 有本英伸; 落合洋; 山田幸生
日本機械学会論文集（B編）, The Japan Society of Mechanical Engineers, 74, 746, 2198-2204, Oct. 2008, Peer-reviwed, We have proposed a novel method of non-contact thermal type measurement for low flow rates using radiation heating and spectroscopy of water in the near-infrared wavelength range. We made a simulation for studying the performance of the flowmeter, and based on the simulation we conducted experiments using a prototype flowmeter. We obtained calibration curves between the estimated and true flow rates. From the experimental results, we can measure the flow rates from 0.3 to 9ml/min with the accuracy of about 10% of the flow rate. We also obtained agreement between the simulation and measurement results. Discussions are made to improve the measurement accuracy.
Scientific journal, Japanese - Total light approach of time-domain fluorescence diffuse optical tomography
Andhi Marjono; Akira Yano; Shinpei Okawa; Feng Gao; Yukio Yamada
OPTICS EXPRESS, 16, 19, 15268-15285, Sep. 2008, Peer-reviwed
Scientific journal, English - Three dimensional image reconstruction for time-resolved diffuse optical tomography
Hui-Juan Zhao; Zhao-Xia Wang; Ying-Ting Jiang; Feng Gao; Yukari Tanikawa; Yukio Yamada
Guangzi Xuebao/Acta Photonica Sinica, 37, 8, 1580-1584, Aug. 2008
Scientific journal, Chinese - Optical brain imaging in infants by use of near-infrared diffuse optical tomography
T. Kusaka; S. Okawa; M. Ueno; R. Fukuzawa; T. Nishida; K. Isobe; Y. Tanikawa; F. Gao; C. Sato; Y. Hoshi; Y. Yamada
Abstract Book of The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008), 18, Aug. 2008
International conference proceedings, English - A self-normalized, full time-resolved method for fluorescence diffuse optical tomography
Feng Gao; Huijuan Zhao; Limin Zhang; Yukari Tanikawa; Andhi Marjono; Yukio Yamada
Optics Express, 16, 17, 13104-13121, Jul. 2008, Peer-reviwed
Scientific journal, English - Temperature measurements of turbid aqueous solutions using near-infrared spectroscopy
Naoto Kakuta; Hidenobu Arimoto; Hideyuki Momoki; Fuguo Li; Yukio Yamada
Applied Optics, Vol. 47, Issue 13, pp. 2227-2233 (2008), 47, 13, 2227-2233, Apr. 2008
Scientific journal, English - Source estimation with spatial filter for fluorescence diffuse optical tomography
Shinpei Okawa; Yukio Yamada
2008 Biomedical Optics Topical Meeting, Poster No. BSuE41, Mar. 2008, Peer-reviwed
International conference proceedings, English - Full Time-Resolved Fluorescence Diffuse Optical Tomography using Total Light Approach
Andhi Marjono; Akira Yano; Shinpei Okawa; Yukio Yamada
2008 Biomedical Optics Topical Meeting, Poster No. BMD33, Mar. 2008, Peer-reviwed
International conference proceedings, English - Quantitative Imaging of Platelet Aggregation in a Microchannel Using an Interfacial Collision Reactor
Taisuke Hirono; Shinpei Okawa; Yukio Yamada
2008 Biomedical Optics Topical Meeting, Poster No. BTuF31, Mar. 2008, Peer-reviwed
International conference proceedings, English - 化学反応速度論的数理モデルを用いた血小板凝集の定量化
廣野泰亮; 大川晋平; 山田幸生
生体医工学, 46, 2, 177-188, Feb. 2008, Peer-reviwed
Scientific journal, Japanese - A self-normalized full time-resolved scheme for fluorescence diffuse optical tomography
Feng Gao; Limin Zhang; Huiyuan He; Huijuan Zhao; Jingying Jiang; Yukari Tanikawa; Andhi Marjono; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6850, 2008
International conference proceedings, English - Three-dimensional image reconstruction for time-domain fluorescence molecular tomography based on generalized pulse spectrum technique
Limin Zhang; Feng Gao; Huiyuan He; Yiwen Ma; Pingqiao Ruan; Huijuan Zhao
OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS III, 6826, U489-U496, 2008, Peer-reviwed
International conference proceedings, English - Microfluidic image cytometry for measuring number and sizes of biological cells flowing through a microchannel using the micro-PIV technique
T. Hirono; H. Arimoto; S. Okawa; Y. Yamada
Measurement Science and Technology, Institute of Physics Publishing, 19, 2, No. 025401 (13pp), 2008, Peer-reviwed
Scientific journal, English - Diffuse optical tomography maximizing localized variation in optical properties
Shinpei Okawa; Yukio Yamada
2008 PROCEEDINGS OF SICE ANNUAL CONFERENCE, VOLS 1-7, 1035-1038, 2008, Peer-reviwed
International conference proceedings, English - Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging
H. Zhao; F. Gao; Y. Tanikawa; Y. Yamada
J. Biomedical Optics, 12, 6, No. 062107(CID)-62107, Dec. 2007, Peer-reviwed
Scientific journal, English - Full Time-Resolved Data Scheme Using Total Light Approach in Time-Domain Fluorescence Diffuse Optical Tomography
A. Marjono; A. Yano; S. Okawa; F. Gao; Y. Yamada
Proceedings of 3rd Asian and Pacific Rim Symposium on Biophotonics, 47-48, Jul. 2007, Peer-reviwed
International conference proceedings, English - Microfluidic Image Cytometry for Measuring of Number and Sizes of Biological Particles
T. Hirono; S. Okawa; H. Arimoto; Y. Yamada
Proc. of 3rd Asian and Pacific Rim Symposium on Biophotonics, 65-66, Jul. 2007, Peer-reviwed
International conference proceedings, English - In vivo measurement of premature neonate head using diffuse optical tomography
M. Ueno; R. Fukuzawa; S. Okawa; Y. Yamada; T. Kusaka; T. Nishida; K. Isobe; Y. Tanikawa; F. Gao; C. Sato; Y. Hoshi
Proc. of 3rd Asian and Pacific Rim Symposium on Biophotonics, 43-44, Jul. 2007, Peer-reviwed
International conference proceedings, English - Effects of the CSF Layer on the Optical Mapping of Brain Activity
N. Shibahara; S. Okawa; Y. Yamada
Proc. of 3rd Asian and Pacific Rim Symposium on Biophotonics, 95-96, Jul. 2007, Peer-reviwed
International conference proceedings, English - Experimental study on near infrared diffuse optical tomography
Hui-Juan Zhao; Ying-Ting Jiang; Hui Miu; Feng Gao; Tanikawa Yukari; Yamada Yukio
Guangzi Xuebao/Acta Photonica Sinica, 36, 6, 1142-1146, Jun. 2007
Scientific journal, Chinese - Light propagation for time-domain fluorescence diffuse optical tomography by convolution using lifetime function
Andhi Marjono; Shinpei Okawa; Feng Gao; Yukio Yamada
OPTICAL REVIEW, 14, 3, 131-138, May 2007, Peer-reviwed
Scientific journal, English - 341 In vivo measurement of premature neonate head using diffuse optical tomography
UENO Masanori; SATO Chie; HOSHI Yoko; FUKUZAWA Ryo; OKAWA Shinpei; YAMADA Yukio; KUSAKA Takashi; NISHIDA Tomoko; ISOBE Kenichi; TANIKAWA Yukari; Gao Feng
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, The Japan Society of Mechanical Engineers, 2006, 0, 338-339, 2007, Peer-reviwed
Japanese - Full time-resolved scheme data in time-domain fluorescence diffuse optical tomography
Andhi Marjono; Akira Yano; Shinpei Okawa; Feng Gao; Yukio Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE VII, 6434, 2007, Peer-reviwed
International conference proceedings, English - Measurement of temperature differences between micro-regions in water using near-infrared spectroscopy
Naoto Kakuta; Atsushi Ozaki; Fuguo Li; Hidenobu Arimoto; Yukio Yamada
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 4564-4567, 2007, Peer-reviwed
International conference proceedings, English - A linear GPST-based scheme for time-domain fluorescence molecular tomography
Feng Gao; Yuan Xue; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6434, 2007, Peer-reviwed
International conference proceedings, English - Fluorescence diffuse optical tomography by full time-resolved scheme
Feng Gao; Hui Miao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6434, 2007, Peer-reviwed
International conference proceedings, English - A linear GPST-based scheme for time-domain fluorescence molecular tomography
Feng Gao; Yuan Xue; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE VII, 6434, 2007, Peer-reviwed
International conference proceedings, English - Fluorescence diffuse optical tomography by full time-resolved scheme
Feng Gao; Hui Miao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE VII, 6434, 2007, Peer-reviwed
International conference proceedings, English - Time-domain fluorescence diffuse optical tomography utilizing generalized pulse-spectrum technique
A. Marjono; S. Okawa; F. Gao; Y. Yamada
Proceedings of SPIE Vol. 6434, BiOS2007, 6434, Jan. 2007, Peer-reviwed
International conference proceedings, English - Measurement of temperature differences between micro-regions in water using near-infrared spectroscopy
Naoto Kakuta; Atsushi Ozaki; Fuguo Li; Hidenobu. Arimoto; Yuldo Yamada
2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16, 4564-+, 2007, Peer-reviwed
International conference proceedings, English - Noninvasive near-infrared blood glucose monitoring using a calibration model built by a numerical simulation method: Trial application to patients in an intensive care unit
Katsuhiko Maruo; Tomohiro Oota; Mitsuhiro Tsurugi; Takehiro Nakagawa; Hidenobu Arimoto; Mineji Hayakawa; Mamoru Tamura; Yukihiro Ozaki; Yukio Yamada
APPLIED SPECTROSCOPY, 60, 12, 1423-1431, Dec. 2006, Peer-reviwed
Scientific journal, English - A linear, featured-data scheme for image reconstruction in time-domain fluorescence molecular tomography
Feng Gao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
OPTICS EXPRESS, 14, 16, 7109-7124, Aug. 2006, Peer-reviwed
Scientific journal, English - New methodology to obtain a calibration model for noninvasive near-infrared blood glucose monitoring
K Maruo; T Oota; M Tsurugi; T Nakagawa; H Arimoto; M Tamura; Y Ozaki; Y Yamada
APPLIED SPECTROSCOPY, 60, 4, 441-449, Apr. 2006, Peer-reviwed
Scientific journal, English - Time-domain fluorescence molecular tomography: A FEM-diffusion based forward model
Wei Liu; Huijuan Zhao; Yukari Tanikawa; Andhi Marjono; Yukio Yamada
Optics InfoBase Conference Papers, Optical Society of America, 2006
International conference proceedings, English - Time-domain fluorescence molecular tomography based on generalized pulse spectrum technique
Wei Liu; Huijuan Zhao; Yukari Tanikawa; Andhi Marjono; Yukio Yamada
Optics InfoBase Conference Papers, Optical Society of America, 2006
International conference proceedings, English - Theoretical and experimental study on near infrared time-resolved optical diffuse tomography
Huijuan Zhao; Feng Gao; Yukari Tanikawa; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6163, 2006, Peer-reviwed
International conference proceedings, English - Influences of target size and contrast on near Infrared diffuse optical tomography: A comparison between featured-data and full time-resolved schemes
Feng Gao; Huijuan Zhao; Yukari Tanikawa; Kazuhiro Homma; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6047, 2006, Peer-reviwed
International conference proceedings, English - Theoretical and experimental study on near infrared time-resolved optical diffuse tomography - art. no. 61630G
Huijuan Zhao; Feng Gao; Yukari Tanikawa; Yukio Yamada
Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 6163, G1630-G1630, 2006, Peer-reviwed
International conference proceedings, English - Influences of target size and contrast on near infrared diffuse optical tomography: a comparison between featured-data and full time-resolved schemes
Feng Gao; Huijuan Zhao; Yukari Tanikawa; Kazuhiro Homma; Yukio Yamada
FOURTH INTERNATIONAL CONFERENCE ON PHOTONICS AND IMAGING IN BIOLOGY AND MEDICINE, PTS 1 AND 2, 6047, 2006, Peer-reviwed
International conference proceedings, English - Simple algorithm for the measurement of absorption coefficients of a two-layered medium by spatially resolved and time-resolved reflectance
M Shimada; Y Hoshi; Y Yamada
APPLIED OPTICS, 44, 35, 7554-7563, Dec. 2005, Peer-reviwed
Scientific journal, English - Influences of target size and contrast on near infrared diffuse optical tomography - a comparison between featured-data and full time-resolved schemes
F Gao; HJ Zhao; Y Tanikawa; K Homma; Y Yamada
OPTICAL AND QUANTUM ELECTRONICS, 37, 13-15, 1287-1304, Dec. 2005, Peer-reviwed
Scientific journal, English - Extraction of depth-dependent signals from time-resolved reflectance in layered turbid media
C Sato; M Shimada; Y Yamada; Y Hoshi
JOURNAL OF BIOMEDICAL OPTICS, 10, 6, 064008(CID) (pp. 1-11), Nov. 2005, Peer-reviwed
Scientific journal, English - Time-resolved Fluorescence Diffuse Optical Tomography Utilizing Generalized Pulse Spectrum Technique
Andhi Marjono; Feng Gao; Yukio Yamada
Proceedings of 4th World Congress on Industrial Process Tomography, Vol. 2, 619-624, Sep. 2005, Peer-reviwed
International conference proceedings, English - The development of leukocyte counter using fluorescence imaging analysis
T. Hirono; K. Yabusaki; Y. Yamada
Optical and Quantum Electronics, 37, 8, 735-753, Aug. 2005, Peer-reviwed
Scientific journal, English - Plasma-enhanced chemical vapor deposition method to coat micropipettes with diamond-like carbon
N Kakuta; M Watanabe; Y Yamada; N Okuyama; K Mabuchi
REVIEW OF SCIENTIFIC INSTRUMENTS, 76, 7, Paper No. 075109 (5 pages), Jul. 2005, Peer-reviwed
Scientific journal, English - Time-resolved diffuse optical tomographic imaging for the provision of both anatomical and functional information about biological tissue
HJ Zhao; F Gao; Y Tanikawa; K Homma; Y Yamada
APPLIED OPTICS, 44, 10, 1905-1916, Apr. 2005, Peer-reviwed
Scientific journal, English - マイクロポンプ用微量流量計の研究開発
西山 尚; 小西義昭; 村上元章; 藤原真人; 角田直人; 山田幸生
ライフサポート, 17, 1, 9-15, Apr. 2005, Peer-reviwed
Scientific journal, Japanese - Time-resolved fluorescence diffuse optical tomography
Andhi Marjono; Feng Gao; Yukio Yamada
6th Asian-Pacific Conference on Biomedical Engineering, PA-3-30, Apr. 2005, Peer-reviwed
International conference proceedings, English - Study of Flowmeter using Water Absorption Spectrum Change
H. Momoki; S. Kubota; H. Nishiyama; N. Kakuta; H. Ochiai; H. Arimoto; Y. Yamada
The 6th KSME-JSME Thermal and Fluids Engineering Conference, CE.03, Mar. 2005, Peer-reviwed
International conference proceedings, English - Depth profile of diffuse reflectance near-infrared spectroscopy for measurement of water content in skin.
Hidenobu Arimoto; Mariko Egawa; Yukio Yamada
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 11, 1, 27-35, Feb. 2005, True, BACKGROUND/PURPOSE: The penetration depth of light in diffuse reflectance near-infrared spectroscopy for measuring water content in skin is assessed both from theoretical and experimental points of view. METHODS: The Monte Carlo simulation was implemented to investigate the dependencies of the light penetration depth on a source-detector distance. To compare with the simulation results, an in vivo experiment for water contents of skin was performed introducing two different optical fiber probes. RESULTS: It is found that the minimum separation between a source and detector fibers influences largely the measurement depth. The larger separation leads to a deeper measurement depth at a particular wavelength. The measurement depth is also influenced fairly by the absorption coefficient of the tissue. The larger absorption coefficient results in a shallower measurement depth. CONCLUSION: The correlations between the water contents measured by the optical and capacitance techniques were discussed. The dependencies of the light penetration depth on the source-detector geometry and wavelength are presented.
Scientific journal, English - Micro-thermocouple probe for measurement of cellular thermal responses
M. S. Watanabe; N. Kakuta; K. Mabuchi; Y. Yamada
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Institute of Electrical and Electronics Engineers Inc., 7, 4858-4861, 2005
International conference proceedings, English - A method for measurement of water temperature in micro-region using near infrared light
N. Kakuta; F. Li; Y. Yamada
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Institute of Electrical and Electronics Engineers Inc., 7, 3145-3148, 2005
International conference proceedings, English - 828 Temperature Measurement Method of Micro-Region Using Near Infrared Light
LI Fuguo; KAKUTA Naoto; YAMADA Yukio
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2005, 59-60, 2005, We have proposed a method for non-invasively measuring the temperature changes of water in a micro-region using near infrared (NIR) light. The goal of this study is to measure the temperature changes of biological cells or tissues. This method is on the basis of the phenomenon that the NIR absorption spectrum of water depends on temperature. Absorbance spectra in the wavelength range of 1300-2000nm of water with a thickness of 100 and 500μm were measured by a micro-spectrometer. The measured spectra with temperature-dependence were calibrated using a regression analysis. The standard error of calibration was 0.30℃ for 100μm-thickness.
Japanese - 829 Optical measurement of water content in tissue with near infrared light
KITANO Masanori; NAKAMURA Yuichi; PILT Kristjan; ARIMOTO Hidenobu; KAKUTA Naoto; YAMADA Yukio
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2005, 61-62, 2005, Patients of kidney disease remove excess water by hemodialysis. In hemodialysis, blood pressure may fall and the patients may suffer from hypovolemic shock, because body fluid removal rate is normally larger than plasma refilling rate. The aim of our research is to measure water content in issue in order to prevent the hypovolemic shock and to know how much water has to be removed quantitatively. We employ a technique using near infrared spectroscopy for this purpose. It will have advantages of being real-time, noninvasive and continuous.
Japanese - 201 Micro-thermocouple probe for measurement of cellular thermal responses and its applications
WATANABE Mayu S; KAKUTA Naoto; TSUCHIYA Yu; MABUCHl Kunihiko; YAMADA Yukio
Proceedings of the JSME Bioengineering Conference and Seminar, The Japan Society of Mechanical Engineers, 2004, 39-40, 2005
Japanese - 412 Simulation of the optical mapping method using near-infrared light
KURAMASHI Daishi; MARJONO Andhi; KAKUTA Naoto; YAMADA Yukio
Proceedings of the JSME Bioengineering Conference and Seminar, The Japan Society of Mechanical Engineers, 2004, 155-156, 2005
Japanese - 433 Diamond-like carbon coating on micropipettes
KAKUTA Naoto; OKUYAMA Naoki; WATANABE Mayu; TSUCHIYA Yu; YAMADA Yukio
Proceedings of the JSME Bioengineering Conference and Seminar, The Japan Society of Mechanical Engineers, 2004, 365-366, 2005
Japanese - Influences from relative size and absorption contrast of an inhomogeneity on NIR diffuse optical image reconstruction
Huijuan Zhao; Feng Gao; Yukari Tanikawa; Kazuhiro Homma; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5693, 483-494, 2005, Peer-reviwed
International conference proceedings, English - Data optimization for enhancing robustness of time-resolved reflectance diffuse optical tomography to optode position uncertainty
Feng Gao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5693, 450-458, 2005, Peer-reviwed
International conference proceedings, English - Measurement of the anisotropy parameter of nails in the wavelength range from 900 nm to 1600 nm
M Ueno; Y Mashita; H Arimoto; N Kakuta; Y Yamada
2005 PACIFIC RIM CONFERENCE ON LASERS AND ELECTRO-OPTICS, 593-594, 2005, Peer-reviwed
International conference proceedings, English - Photon migration in biological tissues and diffuse optical imaging
Y Yamada
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, 5771, 15-27, 2005, Peer-reviwed
International conference proceedings, English - Influences from relative size and absorption contrast of an inhomogeneity on NIR diffuse optical image reconstruction
HJ Zhao; F Gao; Y Tanikawa; K Homma; Y Yamada
Optical Tomography and Spectroscopy of Tissue VI, 5693, 483-494, 2005, Peer-reviwed
International conference proceedings, English - Data optimization for enhancing robustness of time-resolved reflectance diffuse optical tomography to optode position uncertainty
F Gao; HJ Zhao; Y Tanikawa; Y Yamada
Optical Tomography and Spectroscopy of Tissue VI, 5693, 450-458, 2005, Peer-reviwed
International conference proceedings, English - In vivo NIR time-resolved measurements of human parietal region enhanced with indocyanine green as a contrast agent
Yukari Tanikawa; Huijuan Zhao; Feng Gao; Kaoru Sakatani; Yoko Hoshi; Chie Sato; Yukio Yamada
Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest, 2005, 989-990, 2005, Peer-reviwed
International conference proceedings, English - Measurement of the anisotropy parameter of nails in the wavelength range from 900 nm to 1600 nm
Masanori Ueno; Yukari Mashita; Hidenobu Arimoto; Naoto Kakuta; Yukio Yamada
Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest, 2005, 993-994, 2005, Peer-reviwed
International conference proceedings, English - A method for measurement of water temperature in micro-region using near infrared light
N. Kakuta; F. Li; Y. Yamada
2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7, 3145-3148, 2005, Peer-reviwed
International conference proceedings, English - Micro-thermocouple probe for measurement of cellular thermal responses
M. S. Watanabe; N. Kakuta; K. Mabuchi; Y. Yamada
2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7, 4858-4861, 2005, Peer-reviwed
International conference proceedings, English - 近赤外光を用いた無侵襲温度測定
桃木秀幸; 有本英伸; 角田直人; 山田幸生
電気学会論文誌, 124-C, 9, 1725-1730, Sep. 2004, Peer-reviwed
Scientific journal, Japanese - Non-invasive temperature measurement of biological tissues by NIR spectroscopy
Yukio Yamada; Hideyuki Momoki; Hidenobu Arimoto; Naoto Kakuta
Fourth Inter-Institute Workshop on Diagnostic Imaging from Bench to Bedside at The National Institutes of Health, Poster, Sep. 2004, Peer-reviwed
International conference proceedings, English - Photon migration in tissues, diffuse optical imaging and their applications to biomedicine
Y. Yamada; F. Gao; H. Zhao; Y. Tanikawa; K. Homma
ICO’04, 1-2, Jul. 2004, Peer-reviwed
International conference proceedings, English - in vivo measurements and image reconstruction of human lower legs using NIR diffuse optical tomography
Y. Tanikawa; H. Zhao; F. Gao; K. Homma; Y. Yamada
ICO’04, Poster 14D2-9, Jul. 2004, Peer-reviwed
International conference proceedings, English - Optimizing data-type for absolute diffuse optical tomographic imaging using time-domain reflectance
Feng Gao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
Biomedical Topical Meetings, Optical Society of America, Poster WF44, Apr. 2004, Peer-reviwed
International conference proceedings, English - Estimation of absorption coefficient of the lower layer in layered turbid media with time-resolved measurement
C. Sato; M. Shimada; Y. Yamada; Y. Hoshi
Biomedical Topical Meetings, Optical Society of America, Poster ThF4, Apr. 2004, Peer-reviwed
International conference proceedings, English - Optical tomographic mapping of cerebral haemodynamics by means of time-domain detection: methodology and phantom validation
F Gao; HJ Zhao; Y Tanikawa; Y Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 49, 6, 1055-1078, Mar. 2004, Peer-reviwed
Scientific journal, English - Diffuse optical tomography by use of time-resolved measurement
Feng Gao; Huijuan Zhao; Yukari Tanikawa; Kazuhiro Homma; Yukio Yamada
The 10th Conference of Peace through Mind / Brain Science, Poster P-14, Feb. 2004, Peer-reviwed
International conference proceedings, English - Diamond-like carbon coating on micropipettes
N Kakuta; N Okuyama; M Watanabe; Y Imai; K Mabuchi; Y Yamada
PROCEEDINGS OF THE 26TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, 26, 2454-2457, 2004, Peer-reviwed
International conference proceedings, English - Thermal behavior and floating simulation of inflatable Venus balloons
ICHIKAWA Kazuo; YAMADA Yukio; KAKUTA Naoto; IZUTSU Naoki
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2004, 439-440, 2004, Since Venus has the high-density atmosphere of carbon dioxide, a floating balloon is possible and it can perform various kinds of science observation. An inflatable balloon filled with water for buoyancy is heated by the high temperature atmosphere and ground. This paper reports the thermal and floating behaviors of the balloon predicted by heat transfer and motion analyses. It has found that the balloon can float steadily at the estimated altitude of about 35 km
Japanese - Present and future of thermal engineering in bioengineering
YAMADA Yukio
The Reference Collection of Annual Meeting, The Japan Society of Mechanical Engineers, 2004, 118-119, 2004, Thermal engineering plays important roles in bioengjneering covering from micro- to macro-scale heat and mass transfer including biochemistry. Current statuses of various fields in thermal engineering are reviewed and future prospects are discussed.
Japanese - Non-Invasive Measurements of Temperature Using near Infrared Light
Hideyuki Momoki; Naoto Kakuta; Hidenobu Arimoto; Yukio Yamada
IEEJ Transactions on Electronics, Information and Systems, 124, 9, 1725-1730, 2004, Peer-reviwed
Scientific journal, English - Simple algorithm to estimate the absorption coefficients of two-layered scattering media from the spatially- and time-resolved reflectance
M. Shimada; Y. Yamada; Y. Hoshi
SPIE Proc. Vol. 5321, 1-2, Jan. 2004, Peer-reviwed
International conference proceedings, English - Measurement of the optical properties of nails
Y Mashita; M Ueno; M Ohmi; H Arimoto; N Kakuta; M Haruna; Y Yamada
APBP 2004: SECOND ASIAN AND PACIFIC RIM SYMPOSIUM ON BIOPHOTONICS, PROCEEDINGS, 44-45, 2004, Peer-reviwed
International conference proceedings, English - Diffusely scattered polarized light in turbid media: Monte Carlo simulation
SP Wang; LQ Xu; H Li; Y Yamada
APBP 2004: SECOND ASIAN AND PACIFIC RIM SYMPOSIUM ON BIOPHOTONICS, PROCEEDINGS, 40-41, 2004, Peer-reviwed
International conference proceedings, English - Optical measurement of water content in tissue
Y Nakamura; K Pilt; N Kakuta; H Arimoto; Y Yamada
APBP 2004: SECOND ASIAN AND PACIFIC RIM SYMPOSIUM ON BIOPHOTONICS, PROCEEDINGS, 167-168, 2004, Peer-reviwed
International conference proceedings, English - The development of leukocyte counter using fluorescence imaging analysis
T Hirono; K Yabusaki; Y Yamada
APBP 2004: SECOND ASIAN AND PACIFIC RIM SYMPOSIUM ON BIOPHOTONICS, PROCEEDINGS, 213-214, 2004, Peer-reviwed
International conference proceedings, English - A comparative investigation of influences of target size and contrast on diffuse optical tomography by featured-data and full time-resolved reconstructions
F Gao; HJ Zhao; Y Tanikawa; K Homma; Y Yamada
APBP 2004: SECOND ASIAN AND PACIFIC RIM SYMPOSIUM ON BIOPHOTONICS, PROCEEDINGS, 144-145, 2004, Peer-reviwed
International conference proceedings, English - Study of non-invasive near-infrared blood glucose monitoring: estimation of weak absorbance change in skin tissue based on a Monte Carlo simulation
T. Ohta; K. Maruo; M. Tarumi; H. Arimoto; M. Shimada; Y. Yamada
A104, Nov. 2003, Peer-reviwed
International conference proceedings, English - Noninvasive Blood Glucose Assay Using a Newly Developed Near-Infrared System
K. Maruo; M. Tsurugi; J. Chin; T. Ohta; H. Arimoto; Y. Yamada; M. Tamura; M. Ishii; Y. Ozaki
IEEE J. Slected Topics in Quantum Electronics, 9, 2, 322-330, Aug. 2003, Peer-reviwed
Scientific journal, English - Simulation study of in vitro glucose measurement by NIR spectroscopy and a method of error reduction
M Tarumi; M Shimada; T Murakami; M Tamura; M Shimada; H Arimoto; Y Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 48, 15, 2373-2390, Aug. 2003, Peer-reviwed
Scientific journal, English - Image reconstruction for tomographic mapping of cerebral hemodynamics using time-domain detection
F. Gao; H. Zhao; Y. Tanikawa; Y. Yamada
SPIE Proceedings, 5138-25, Jun. 2003, Peer-reviwed
International conference proceedings, English - Spectroscopic blood component measurement by using reduced ranges of absorption spectra
H. Arimoto; Y. Yamada
SPIE Proceedings, 5138-46, Jun. 2003, Peer-reviwed
International conference proceedings, English - Optical transport process in turbid media and applications to optical imaging of tissues
Y. Yamada
ThW1-03, Jun. 2003, Peer-reviwed
International conference proceedings, English - 散乱の非等方性を考慮した反射型時間分解法による生体組織の光学特性測定に関する検討
田中健之; 谷川ゆかり; 荒木隆一郎; 山田幸生; 岡田英史
光学, 応用物理学会分科会日本光学会, 32, 5, 328-335, May 2003, Peer-reviwed
Scientific journal, Japanese - Instrumental requirements for non-invasive blood glucose measurement using NIR spectroscopy
H Arimoto; M Tarumi; Y Yamada
OPTICAL REVIEW, 10, 3, 161-165, May 2003, Peer-reviwed
Scientific journal, English - Solution of the time-dependent diffusion equation for layered diffusive media by the eigenfunction method
F Martelli; A Sassaroli; S Del Bianco; Y Yamada; G Zaccanti
PHYSICAL REVIEW E, 67, 5, 1-14, May 2003, Peer-reviwed
Scientific journal, English - Temperature-insensitive measurement of glucose concentration based on near infrared spectroscopy and partial least squares analysis
H Arimoto; M Tarumi; Y Yamada
OPTICAL REVIEW, 10, 2, 74-76, Mar. 2003, Peer-reviwed
Scientific journal, English - General programs for bio-heat and mass transfer analyses - Tissue element data generation based on the CFSV-model
N Kakuta; Y Mizuta; Y Yamada
PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4, 25, 2830-2833, 2003, Peer-reviwed
International conference proceedings, English - Optical measurement of water content in blood
NAKAMURA Yuichi; KAKUTA Naoto; YAMADA Yukio
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2003, 65-66, 2003, Water as well as wastes is removed from the blood of patients under dialysis treatment. If the quantity of the removed water exceeds the limit by some reasons the probability of dangerous accidents becomes high. Therefore, it is highly desired to monitor the blood status continuously during dialysis treatment. This paper presents some results of a fundamental research of measurement of water content in blood using near infrared spectroscopy and multivariate analysis for the purpose of continuous blood monitoring.
Japanese - Measurement of Cellular Thermal Response
IMAI Yuka; KAKUTA Naoto; MABUCHI Kunihiko; YAMADA Yukio
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2003, 7-8, 2003, We have developed a micro-thermocouple probe for measuring the cellular thermal responses. In addition to the metabolic heat generation, a cell generates heat by physical or chemical stimulus. If the measurement of such a heat generation becomes possible, it can contribute to the development of new medical technology in pharmaceutics and to the elucidation of physiology. The micro-thermocouple probe is fabricated by layering multiple metal thin films and electrical insulating films on a glass micropipette as a base, and it functions as a thermocouple and a microinjector simultaneously. The thermoelectric performance of the fabricated micro-thermocouple probe has been evaluated.
Japanese - Spectroscopic blood component measurement by using reduced ranges of absorption spectra
H Arimoto; Y Yamada
PHOTON MIGRATION AND DIFFUSE-LIGHT IMAGING, 5138, 323-330, 2003, Peer-reviwed
International conference proceedings, English - The ability of NIR diffuse optical tomography in providing both anatomical and functional images
HJ Zhao; F Gao; Y Tanikawa; K Homma; Y Yamada
PHOTON MIGRATION AND DIFFUSE-LIGHT IMAGING, 5138, 55-64, 2003, Peer-reviwed
International conference proceedings, English - Image reconstruction for tomographic mapping of cerebral hemodynamics using time-domain detection: simulation and phantom studies
F Gao; HJ Zhao; Y Tanikawa; Y Yamada
PHOTON MIGRATION AND DIFFUSE-LIGHT IMAGING, 5138, 148-159, 2003, Peer-reviwed
International conference proceedings, English - Instrumental requirements for blood glucose sensing based on diffuse reflectance NIR spectroscopy
H Arimoto; T Ota; M Tarumi; Y Yamada
OPTICAL DIAGNOSTICS AND SENSING IN BIOMEDICINE III, 4965, 17-24, 2003, Peer-reviwed
International conference proceedings, English - Optical property measurement of thin superficial tissue by using time-resolved spectroscopy
K Tanaka; Y Tanikawa; R Araki; Y Yamada; E Okada
DIAGNOSTIC OPTICAL SPECTROSCOPY IN BIOMEDICINE II, 5141, 315-324, 2003, Peer-reviwed
International conference proceedings, English - Development of a retractor for monitoring the oxygenation state of brain tissue
Y Onodera; Y Yamada; K Sakatani; T Hori
OXYGEN TRANSPORT TO TISSUE VOLUME XXIII, 510, 219-223, 2003, Peer-reviwed
Scientific journal, English - Treatment of nevus using medical tattooing
J Hata; M Shimada; Y Yamada; A Uchida; M Itoh; Y Nakayama; T Yatagai
JOURNAL OF BIOMEDICAL OPTICS, 8, 1, 93-101, Jan. 2003, Peer-reviwed
Scientific journal, English - Reflectance-type image reconstruction algorithm for time-resolved optical tomography of cerebral hemodynamics
F Gao; Y Tanikawa; HJ Zhao; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE V, 4955, 253-263, 2003, Peer-reviwed
International conference proceedings, English - NIR time domain diffuse optical tomographic experiments on human forearm
HJ Zhao; F Gao; Y Tanikawa; K Homma; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE V, 4955, 437-446, 2003, Peer-reviwed
International conference proceedings, English - Optical fiber arrangement of optical topography for spatial resolution improvement
T Yamamoto; E Okada; F Kawaguchi; A Maki; Y Yamada; H Koizumi
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE V, 4955, 487-496, 2003, Peer-reviwed
International conference proceedings, English - Instrumental requirements for blood glucose sensing based on diffuse reflectance NIR spectroscopy
H. Arimoto; T. Ota; M. Tarumi; Y. Yamada
SPIE Proceedings, Vol. 4965, 4965-03, Jan. 2003, Peer-reviwed
International conference proceedings, English - The ability of NIR diffuse optical tomography in providing both anatomical and functional images
H. Zhao; F. Gao; Y. Tanikawa; K.Homma; Y. Yamada
SPIE Proceedings, 5138-11, Jan. 2003, Peer-reviwed
International conference proceedings, English - Fundamental Study of Reflection Pulse Oximetry
Keisuke Matsushita; Kazuo Aoki; Naoto Kakuta; Yukio Yamada
Optical Review, Optical Society of Japan, 10, 5, 482-487, 2003, Peer-reviwed
International conference proceedings, English - Monte Carlo Simulation of Near Infrared Reflectance Spectroscopy in the Wavelength Range from 1000 nm to 1900 nm
Kenji Iino; Katsuhiko Maruo; Hidenobu Arimoto; Koji Hyodo; Tetsu Nakatani; Yukio Yamada
Optical Review, Optical Society of Japan, 10, 6, 600-606, 2003, Peer-reviwed
International conference proceedings, English - Photon migration in biological tissue and application to diffuse optical tomography
Yukio Yamada; Feng Gao; Huijuan Zhao; Yukari Tanikawa; Kazuhiro Homma
Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest, Institute of Electrical and Electronics Engineers Inc., 2, 463, 2003, Peer-reviwed
International conference proceedings, English - Anatomical and functional images of in vitro and in vivo tissues by NIR time-domain diffuse optical tomography
HJ Zhao; F Gao; Y Tanikawa; K Homma; Y Onodera; Y Yamada
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, 45, 4, 1033-1039, Dec. 2002, Peer-reviwed
Scientific journal, English - LIGHT PROPAGATION IN BIOLOGICAL TISSUES AND OPTICAL DIAGNOSTICS BY IMAGING AND SPECTROSCOPY
Yukio Yamada
1-2, Dec. 2002, Peer-reviwed
International conference proceedings, English - Semi-three-dimensional algorithm for time-resolved diffuse optical tomography by use of the generalized pulse spectrum technique
F. Gao; Y. Tanikawa; H. Zhao; Y. Yamada
Applied Optics, 41, 34, 7346-7358, Nov. 2002, Peer-reviwed
Scientific journal, English - 透過型時間分解法による生体組織の光学特性測定
田中健之; 谷川ゆかり; 荒木隆一郎; 山田幸生; 岡田英史
光学, 31, 12, 886-892, Nov. 2002, Peer-reviwed
Scientific journal, Japanese - Monte Carlo simulation of NIR reflectance spectroscopy in the wavelength range from 1000nm to 1900nm
Kenji IINO; Katsuhiko MARUO; Yukio YAMADA
Asian Symposium of Biomedical Optics and Photomedicine (BOPM 2002), 232-233, Oct. 2002, Peer-reviwed
Research society, English - Analysis of light propagation in strongly scattering media, and its application to optical topography
Takeshi SUZUKI; Tsuyoshi YAMAMOTO; Yukio YAMADA
Asian Symposium of Biomedical Optics and Photomedicine (BOPM 2002),, 102-103, Oct. 2002, Peer-reviwed
International conference proceedings, English - Fundamental study of reflection pulse oximetry
Keisuke MATSUSHITA; Kazuo AOKI; Yukio YAMADA
Asian Symposium of Biomedical Optics and Photomedicine (BOPM 2002),, 188-189, Oct. 2002, Peer-reviwed
International conference proceedings, English - Arranging optical fibres for the spatial resolution improvement of topographical images
T Yamamoto; A Maki; T Kadoya; Y Tanikawa; Y Yamada; E Okada; H Koizumi
PHYSICS IN MEDICINE AND BIOLOGY, 47, 18, 3429-3440, Sep. 2002, Peer-reviwed
Scientific journal, English - 組織酸素飽和度計測用光プローブ付き脳へらの開発
小野寺陽一; 山田幸生; 酒谷 薫; 堀 智勝
医用電子と生体工学, 40, 3, 157-164, Jul. 2002, Peer-reviwed
Scientific journal, Japanese - Optical imaging using time-resolved measurements
Y. Yamada; F. Gao; H. Zhao; Y. Tanikawa; Y. Onodera; A. Sassaroli
PIERS (Progress In Electromagnetics Research Symposium) 2002, Jul. 2002
International conference proceedings, English - Optical Topography --- Visualization of Brain Activation by Near-Infrared Spectroscopy
T. Yamamoto; A. Maki; Y. Tanikawa; M. Kiguchi; E. Okada; Y. Yamada; H. Koizumi
PIERS (Progress In Electromagnetics Research Symposium) 2002, Jul. 2002
International conference proceedings, English - Imaging of in vitro chicken leg using time-resolved near-infrared optical tomography
HJ Zhao; F Gao; Y Tanikawa; Y Onodera; M Ohmi; M Haruna; Y Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 47, 11, 1979-1993, Jun. 2002, Peer-reviwed
Scientific journal, English - Maps of optical differential pathlength factor of human adult forehead, somatosensory motor and occipital regions at multi-wavelengths in NIR
HJ Zhao; Y Tanikawa; F Gao; Y Onodera; A Sassaroli; K Tanaka; Y Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 47, 12, 2075-2093, Jun. 2002, Peer-reviwed
Scientific journal, English - Photochemical and photothermal model for pulsed-laser ablation
M Sadoqi; S Kumar; Y Yamada
JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER, 16, 2, 193-199, Apr. 2002, Peer-reviwed
Scientific journal, English - Analysis of multi-spectral reflectance of exposed brain tissue
K. Yokoyama; K. Honjo; M. Watanabe; E. Okada; A. Maki; Y. Yamada; H. Iseki
Advances in Optical Imaging and Photon Migration (AOIPM), Opt. Soc. Am., Apr. 2002
International conference proceedings, English - Improvement of image quality in diffuse optical tomography by use of full time-resolved data
Feng Gao; Huijuan Zhao; Yukio Yamada
Applied Optics, Optical Society of America (OSA), 41, 4, 778-791, 01 Feb. 2002, Peer-reviwed
Scientific journal, English - Improvement of image quality in diffuse optical tomography by use of full time-resolved data
F Gao; HJ Zhao; Y Yamada
APPLIED OPTICS, 41, 4, 778-791, Feb. 2002, Peer-reviwed
Scientific journal, English - Anatomical and physiological images of tissues by time-resolved optical tomography
ZHAO Hui juan; GAO Feng; TANIKAWA Yukari; HOMMA Kazuhiro; ONODERA Yoichi; YAMADA Yukio
Proceedings of thermal engineering conference, The Japan Society of Mechanical Engineers, 2002, 381-382, 2002, Near infra-red (NIR) diffuse optical tomography (DOT) has gained much attention for recent years because it is noninvasive and deeply penetrating to biologic tissue. Here we report our reconstruction results of an in vitro chicken leg and an in vivo exercising human forearm using a multi-channel time-resolved NIR system and a two-dimensional image reconstruction algorithm based on a modified generalized pulse spectrum technique for simultaneous reconstruction of the absorption and scattering coefficients. The images revealed the anatomies of a chicken leg and a human forearm, and the bones were clearly distinguished from the muscle. The absorption images showed the blood volume changes during the forearm exercise, proving that the system and the algorithm could potentially be used for imaging not only the anatomy but also the hemodynamics in living tissues.
Japanese - Fundamental study of ultra low meter for insulin pump
NISHIYAMA Hisashi; KONISHI Yoshiaki; FUJIWARA Masato; NAONO Yoshiaki; KAKUTA Naoto; YAMADA Yukio
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2002, 17-18, 2002, The flow rate of insulin from insulin pumps for diabetic patients is less than 3.0 μl/min, and the average flow velocity in a tube with a diameter of 0.4 mm becomes less than 0.4 mm/s resulting in the maximum Reynolds number of about 0.2. A thermo-trace type flow meter is employed for a low meter in this very small range of flow rate and velocity. A theoretical analysis and preliminary experiment were conducted for the flow meter. It was found that the influence of heat conduction in the direction of the tube axis must be included which is usually ignored in the boundary flow analyses.
Japanese - Analytical approximate solutions of the time-domain diffusion equation in layered slabs
F Martelli; A Sassaroli; Y Yamada; G Zaccanti
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 19, 1, 71-80, Jan. 2002, Peer-reviwed
Scientific journal, English - Time-resolved diffuse optical tomography using a modified generalized pulse spectrum technique
F Gao; HJ Zhao; Y Tanikawa; Y Yamada
IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS, E85D, 1, 133-142, Jan. 2002, Peer-reviwed
Scientific journal, English - Experimental and numerical study of the colour appearance of tattoo models
M. Shimada; J. Hata; Y. Yamada; M. Itoh; A. Uchida; T. Yatagai
Medical and Biological Engineering and Computing, Peter Peregrinus Ltd, 40, 2, 218-224, 2002, Peer-reviwed
Scientific journal, English - Melanin and blood concentration in human skin studied by multiple regression analysis: experiments
M Shimada; Y Yamada; M Itoh; T Yatagai
PHYSICS IN MEDICINE AND BIOLOGY, 46, 9, 2385-2395, Sep. 2001, Peer-reviwed
Scientific journal, English - Melanin and blood concentration in a human skin model studied by multiple regression analysis: assessment by Monte Carlo simulation
M Shimada; Y Yamada; M Itoh; T Yatagai
PHYSICS IN MEDICINE AND BIOLOGY, 46, 9, 2397-2406, Sep. 2001, Peer-reviwed
Scientific journal, English - Biomedical optical imaging by a time-resolved multichannel system
Y. Yamada
Joint Symposium on Bio-Sensing and Bio-Imaging, Yamagata, Japan, August 2-4, 2001, Aug. 2001
International conference proceedings, English - 計測用プローブの高密度配置によるトポグラフィック画像の画質改善
山本剛; 牧敦; 角谷卓磨; 谷川ゆかり; 岡田英史; 山田幸生
日本光学会 第2回生体医用光学研究会講演論文集, Jul. 2001
Symposium, Japanese - Development of a retractor with the capability of oxygenation monitoring
Y. Onodera; Y. Yamada; K. Sakatani; T. Hori
PIERS (Progress in Electromagnetic Research Symposium) 2000, Osaka, Japan, July 18-22, 2001, Jul. 2001, Peer-reviwed
International conference proceedings, English - 反射型時間分解法による小体積試料の光学特性測定
田中健之; 荒木隆一郎; Angelo Sassaroli; 山田幸生; 岡田英史
第40回日本ME学会大会 医用電子と生体工学, May 2001
Symposium, Japanese - Performance of fitting procedures in curved geometry for retrieval of the optical properties of tissue from time-resolved measurements
A Sassaroli; F Martelli; G Zaccanti; Y Yamada
APPLIED OPTICS, 40, 1, 185-197, Jan. 2001, Peer-reviwed
Scientific journal, English - Image reconstruction from experimental measurements of an multichannel time-resolved optical tomographic imaging system
F Gao; H Zhao; Y Onodera; A Sassaroli; Y Tanikawa; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE IV, 4250, 351-361, 2001, Peer-reviwed
International conference proceedings, English - 3D simultaneous reconstruction of absorption and scattering coefficients in time-resolved optical tomography
F Gao; P Poulet; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE IV, 4250, 514-521, 2001, Peer-reviwed
International conference proceedings, English - Method to measure the diffusion coefficient of a layered medium
F Martelli; A Sassaroli; Y Yamada; G Zaccanti
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE IV, 4250, 101-108, 2001, Peer-reviwed
International conference proceedings, English - Measuring of optical properties of small volume samples using time-resolved reflectance spectroscopy.
K Tanaka; R Araki; Y Yamada; E Okada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE IV, 4250, 282-289, 2001, Peer-reviwed
International conference proceedings, English - Noninvasive brain-function measurement system: Optical topography
T Yamamoto; A Maki; Y Yamashita; Y Tanikawa; Y Yamada; H Koizumi
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE IV, 4250, 339-350, 2001, Peer-reviwed
International conference proceedings, English - Light propagation in adult heads obtained from a time-resolved NIR optical imaging system
H Zhao; Y Onodera; Y Tanikawa; F Gao; A Sassaroli; K Tanaka; Y Yamada
CLEO(R)/PACIFIC RIM 2001, VOL I, TECHNICAL DIGEST, 362-363, 2001, Peer-reviwed
International conference proceedings, English - Photon migration in biological tissues, their optical properties and imaging
Y Yamada; A Sassaroli; F Martelli; F Gao; HJ Zhao; Y Onodera; Y Tanikawa; K Tanaka; R Araki
CLEO(R)/PACIFIC RIM 2001, VOL I, TECHNICAL DIGEST, 368-369, 2001
International conference proceedings, English - Measurement of optical properties of brain in vivo
Y. Yamada; A. Sassaroli; Y. Tanikawa; F. Martelli; R. Arakai; K. Tanaka
Pacifichem 2000, Symposium No. 75, Frontiers of Spectroscopic Analysis of the Brain, Honolulu, USA, (Dec. 14-15, 2000), Dec. 2000
International conference proceedings, English - Simultaneous mapping of absorption and scattering coefficients from a three-dimensional model of time-resolved optical tomography
F Gao; P Poulet; Y Yamada
APPLIED OPTICS, 39, 31, 5898-5910, Nov. 2000, Peer-reviwed
Scientific journal, English - Method for measuring the diffusion coefficient of homogeneous and layered media
F Martelli; A Sassaroli; Y Yamada; G Zaccanti
OPTICS LETTERS, 25, 20, 1508-1510, Oct. 2000, Peer-reviwed
Scientific journal, English - 皮膚下における色素の見え方の変化
島田美帆; 畑寿太郎; 山田幸生; 伊藤雅英; 内田彰子; 谷田貝豊彦
光学, 29, 6, 392-398, Jun. 2000, Peer-reviwed
Scientific journal, Japanese - Fabrication of dynamic human head phantom and time-resolved measurement
Y. Tanikawa; D. Imai; K. Tanaka; H. Kawamura; Y. Yamada
Proceedings of the 8th International Conference on Rapid Prototyping, Tokyo (June 12-13, 2000), 296-301, Jun. 2000
International conference proceedings, English - Measurement of optical properties of a pig head
SASSAROLI Angelo; TANIKAWA Yukari; MARTELLI Fabrizio; ARAKI Ryuichiro; TANAKA Kenji; YAMADA Yukio
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2000, 335-336, 2000
English - Explanation of human skin color by multiple linear regression analysis based on the modified Lambert-Beer law
Miho Shimada; Yuji Masuda; Yukio Yamada; Masahide Itoh; Motoji Takahashi; Toyohiko Yatagai
Optical Review, Optical Society of Japan, 7, 4, 348-352, 2000, Peer-reviwed
Scientific journal, English - Development and application of noninvasive optical topography
T Yamamoto; A Maki; Y Yamashita; H Yoshizawa; M Iwata; E Watanabe; Y Tanikawa; Y Yamada; H Koizumi
OPTICAL SENSING, IMAGING, AND MANIPULATION FOR BIOLOGICAL AND BIOMEDICAL APPLICATIONS, 4082, 24-33, 2000, Peer-reviwed
International conference proceedings, English - Time-resolved measurements of in vivo optical properties of piglet brain
Angelo Sassaroli; Fabrizio Martelli; Yukari Tanikawa; Kenji Tanaka; Ryuichiro Araki; Yoichi Onodera; Yukio Yamada
Optical Review, Optical Society of Japan, 7, 5, 420-425, 2000, Peer-reviwed
Scientific journal, English - Performance of a multi-channel time-resolved optical tomographic imaging system and tomographic images
Y Yamada; M Tamura; H Eda; Oda, I; Y Ito; Y Wada; Y Oikawa; Y Tsunazawa; M Takada; Y Tsuchiya; Y Yamashita; M Oda; A Sassaroli
PROCEEDINGS OF INTER-INSTITUTE WORKSHOP ON IN VIVO OPTICAL IMAGING AT THE NIH, 200-204, 2000, Peer-reviwed
International conference proceedings, English - Study on the propagation of ultra-short pulse light in cylindrical optical phantoms
A Sassaroli; F Martelli; D Imai; Y Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 44, 11, 2747-2763, Nov. 1999, Peer-reviwed
Scientific journal, English - Light Propagation in biological Tissue and，Medical ImagingProceedings of Technology for the Next Century---In Celebration of 100 years of Mechanical Engineering at Polytechnic University
Y. Yamada
Polytechnic University, (Nov. 4-5, 1999), Nov. 1999
International conference proceedings, English - Multichannel time-resolved optical tomographic imaging system
H Eda; Oda, I; Y Ito; Y Wada; Y Oikawa; Y Tsunazawa; M Takada; Y Tsuchiya; Y Yamashita; M Oda; A Sassaroli; Y Yamada; M Tamura
REVIEW OF SCIENTIFIC INSTRUMENTS, 70, 9, 3595-3602, Sep. 1999, Peer-reviwed
Scientific journal, English - Measurements of Optical Properties of Biological Tissues Using an Integrating Sphere and Time-resolved Spectroscopy,Advances in Optical Imaging, Photon Migration, and Tissue Optics
K. Tanaka; R. Araki; Y. Tanikawa; D. Imai; H. Kawamura; Y. Yamada
Conference on Biomedical Optics, CLEO/Europe and Optical Society of America, Munchen, 247-249, Jun. 1999, Peer-reviwed
International conference proceedings, English - Properties of the light emerging from a diffusive medium: angular dependence and flux at the external boundary
F Martelli; A Sassaroli; G Zaccanti; Y Yamada
PHYSICS IN MEDICINE AND BIOLOGY, 44, 5, 1257-1275, May 1999, Peer-reviwed
Scientific journal, English - 零空間補正と最大帰納確率法を用いた光CTの画像再構成
I. W. Kwee; S. G. Proskurin; 谷川ゆかり; 山田幸生
日本機械学会論文集，A編, 65, 633, 982-988, May 1999, Peer-reviwed
Scientific journal, Japanese - Characteristics of the light transmitted through diffusing media: angular distribution and photon flux at the external boundary
F Martelli; A Sassaroli; G Zaccanti; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF, 3597, 164-174, 1999, Peer-reviwed
International conference proceedings, English - Ultra-short pulse light propagation in cylindrical optical phantoms
A Sassaroli; F Martelli; Y Yamada; Y Tzunazawa
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF, 3597, 146-154, 1999, Peer-reviwed
International conference proceedings, English - Analytical solution of the time-dependent photon diffusion equation for a layered medium
F Martelli; A Sassaroli; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF, 3597, 79-89, 1999, Peer-reviwed
International conference proceedings, English - Realistic dynamic brain phantom and time-resolved measurement
D Imai; K Tanaka; Y Tanikawa-Takahashi; Y Tsunazawa; H Kawamura; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF, 3597, 108-117, 1999, Peer-reviwed
International conference proceedings, English - Fabrication of realistic and dynamic human head phantoms
Yukari Tanikawa; Daigo Imai; Kenji Tanaka; Yukio Yamada
JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing, Japan Society of Mechanical Engineers, 42, 3, 487-491, 1999, Peer-reviwed
Scientific journal, English - Simulation of 3D light propagation in a layered head model including a clear CSF layer, OSA TOPS
S. Takahashi; Y. Yamada
Advances in Optical Imaging and Photon Migration, 21, 2-6, Nov. 1998, Peer-reviwed
International conference proceedings, English - Propagation-loss prediction using ray tracing with a random-phase technique
S Takahashi; Y Yamada
IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES, E81A, 7, 1445-1451, Jul. 1998, Peer-reviwed
Scientific journal, English - Determination of the asymmetry parameter and scattering coefficient of turbid media from spatially resolved reflectance measurements
Matthew R. Jones; Yukio Yamada
Optical Review, Optical Society of Japan, 5, 2, 72-76, 1998, Peer-reviwed
Scientific journal, English - A new method of bone tissue measurement based upon light scattering
A Takeuchi; R Araki; SG Proskurin; Y Takahashi; Y Yamada; J Ishii; S Katayama; A Itabashi
JOURNAL OF BONE AND MINERAL RESEARCH, 12, 2, 261-266-266, Feb. 1997, Peer-reviwed
Scientific journal, English - Fundamental 3D FEM analysis of light propagation in head model toward 3D optical tomography
S Takahashi; D Imai; Y TanikawaTakahashi; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE: THEORY, INSTRUMENTATION, MODEL, AND HUMAN STUDIES II, PROCEEDINGS OF, 2979, 250-260, 1997, Peer-reviwed
International conference proceedings, English - Measurements of time-resolved transmittances through cylindrical solid phantoms. Comparison with 2D and 3D FEM simulations
SG Proskurin; S Takahashi; Kwee, I; Y Tanikawa; Y Yamada
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE: THEORY, INSTRUMENTATION, MODEL, AND HUMAN STUDIES II, PROCEEDINGS OF, 2979, 261-271, 1997, Peer-reviwed
International conference proceedings, English - Simulation of Optical Computed Tomography by an Inversion Method
JONES Matthew R.; YAMADA Yukio; TEZUKA Akira
Transactions of the Japan Society of Mechanical Engineers Series B, The Japan Society of Mechanical Engineers, 62, 595, 842-846, 25 Mar. 1996, Optical computed tomography is a medical imaging modality in which red and near infrared light are used to probe biological tissues. Images are obtained by mapping the absorption coefficient of the tissue. Realization of clinically viable optical computed tomography depends on the development of reliable and fast methods of obtaining inverse solutions of the photon diffusion equation which describes the photon migration in biological tissues. In this paper we use a linearization and regularization technique and a finite element method to invert the diffusion approximation, and we propose the use of a zooming method as a way to improve the resolution of the images. We compare the performance of three regularization methods, i. e., the truncated singular value decomposition, Tikhonov regularization, and Phillips-Twomey regularization, The usefulness of the zooming method is demonstrated.
Japanese - Optical tomography by the temporally extrapolated absorbance method
Ichiro Oda; Hideo Eda; Yoshio Tsunazawa; Michinosuke Takada; Yukio Yamada; Goro Nishimura; Mamoru Tamura
Applied Optics, 35, 1, 169-175, 01 Jan. 1996, Peer-reviwed
Scientific journal, English - Optical tomography by the temporally extrapolated absorbance method
Oda, I; H Eda; Y Tsunazawa; M Takada; Y Yamada; G Nishimura; M Tamura
APPLIED OPTICS, 35, 1, 169-175, Jan. 1996, Peer-reviwed
Scientific journal, English - Pico-Second Time-Resolved Measurement of Photon Migration in Tissue
TAKAHASHI Yukari; YAMADA Yukio; HASEGAWA Yasuo
Transactions of the Society of Instrument and Control Engineers, The Society of Instrument and Control Engineers, 29, 8, 883-887, 31 Aug. 1993, Near-infrared light is considered to be able to diagnose the oxygenation state of living bodies, and time-resolved spectroscopy is expected to be promising for sophisticated optical tomographic measurement. However, because light is strongly scattered by living tissues, fundamental understanding of scattering characteristics of light through living tissues is needed. In this paper, fundamental experiment using homogeneous samples was carried out for understanding of light propagation and for estimation of scattering and absorption coefficients by time-resolved measurements. The experimental results were compared with numerical results which were obtained by the Monte-Carlo method and the Finite-Element method solving the time-dependent proton diffusion equation. Good agreement between them are obtained.
Japanese - Medical Diagnosis Using Near-Infrared Light.
Yamada Yukio
Jpn. J. Thermophys. Prop., JAPAN SOCIETY OF THERMOPHYSICAL PROPERTIES, 7, 2, 115-120, 1993, Images of oxygenation state of living body can be obtained by use of time-resolved near-infrared spectroscopy based on the change in the absorption spectra of hemoglobin or myoglobin. The photon-tissue interaction is analyzed by the Monte Carlo method and the Finite Element method to solve the photon diffusion equation. The absorbance extrapolated temporally to the shortest time of flight are shown to provide a set of projection data for the reconstruction by the filtered back projection. FEM (Finite Element Method) analyses are shown to be flexible to the complex change in the distribution of the optical properties. More sophisticated procedures of the inverse problems are expected to be developed for optical-CT (computed tomography) in the near future.
Japanese - Monte Carlo simulation of light scattering and absorption by living bodies.
HASEGAWA Yasuo; YAMADA Yukio; NOMURA Yasutomo; TAMURA Mamoru
Transactions of the Japan Society of Mechanical Engineers Series C, The Japan Society of Mechanical Engineers, 56, 524, 1173-1177, 1990, The Monte Carlo method was used to analyze characteristics of light scattering and absorption by living bodies. The intensity of transmitted light through a slab of emulsion which simulates living bodies was calculated. The emulsion contained two types of particles ; small particles with isotropic scattering and large particles with strong forward scattering. Time-resolved analysis clarified the profile of transmitted light intensity, and the optical density, which is calculated from light attenuation caused by absorbing particles, was found to be in proportion to the absorption coefficient of particles and the optical path length. From spatial analysis of transmitted light intensity, the mean optical pathlengths have been found to be four to ten times the geometrical pathlength.
Japanese - Study of fluidized bed heat exchangers for stirling engines.
YAMADA Yukio
Transactions of the Japan Society of Mechanical Engineers Series C, The Japan Society of Mechanical Engineers, 54, 507, 3284-3289, 1988, The present study proposes to use fluidized bed heat exchangers to improve thermal performances of high temperature heat exchangers for Stirling engines. Seven pot-type heat exchangers consisting of U-tubes with 6 mm outer diameter were inserted in a hot fluidized bed to measure heat transfer coefficients at the outer tube surfaces in the bed temperature range up to 400°C. Three different sizes of alumina particles were used as the bed material. The effects of particle size, tube number, fin size, superficial velocity, bed temperature, etc., were investigated. Also, the uniformity in temperature in the fluidized bed was found to be food enough to be used for heat exchangers of Stirling engines.
Japanese
MISC
- Numerical study of light scattering in the human neck for diagnosis of thyroid cancers by optical tomography
Fujii Hiroyuki; Yamada Yukio; Hoshi Yoko; Kobayashi Kazumichi; Watanabe Masao
2018, Extended abstract of the 12th CME International Conference, OS12, 2, English, Summary international conference - Concentration Imaging of Reactants and Products during Neutralization Reaction in Microfluidic Channel
大畑俊哉; 角田直人; 川嶋大介; 山田幸生
2017, 可視化情報学会誌, 37, Suppl.1(CD-ROM), 0916-4731, 201802210939045065 - Concentration Imaging and Quantitative Analysis of Neutralization Reaction in Microfluidic Channel
角田直人; 大畑俊哉; 川嶋大介; 山田幸生
2017, 可視化情報学会誌, 37, Suppl.2(CD-ROM), 0916-4731, 201802213917853613 - 近赤外吸収イメージング法を用いた中和反応の可視定量分析
角田直人; 大畑俊哉; 川嶋大介; 山田幸生
2017, 近赤外フォーラム講演要旨集, 33rd, 201702265544949100 - 温度・濃度同時イメージング法を利用した各種水溶液における拡散係数の温度依存性の定量化
山下大樹; 角田直人; 川嶋大介; 山田幸生
2017, 日本伝熱シンポジウム講演論文集(CD-ROM), 54th, 1346-1532, 201702286598000537 - Numerical Calculation Of Time-resolved Light Reflectance From Biological Tissue Using The Radiative Transfer Equation
Hiroyuki Fujii; Yukio Yamada; Yoko Hoshi; Kazumichi Kobayashi; Masao Watanabe
2017, Extended abstract of The International Conference on Mathematics in (bio)Chemical Kinetics and Engineering (MaCKiE) 2017, English, Summary international conference - 拡散光による甲状腺腫瘍診断のためのヒト頸部内における光伝播の数値解析
藤井 宏之; 山田 幸生; 星 詳子; 小林 一道; 渡部 正夫
2017, 第３３回近赤外フォーラム 講演論文集, I, 07, Japanese, Summary national conference - Visualization of Thermal Diffusion and Mass Diffusion of Aqueous Solutions in Microfluidic Channel
山下大樹; 角田直人; 川嶋大介; 近藤克哉; 有本英伸; 山田幸生
2016, 可視化情報学会誌, 36, Suppl.1(CD-ROM), 0916-4731, 201702213116025384 - Visualization and analysis of unstable interface between two aqueous solutions having different densities
川嶋大介; 角田直人; 有本英伸; 近藤克哉; 山田幸生
2016, 可視化情報学会誌, 36, Suppl.1(CD-ROM), 0916-4731, 201702276568607342 - 水溶液の不安定な反応拡散現象における近赤外吸収イメージング
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
2016, 日本伝熱シンポジウム講演論文集(CD-ROM), 53rd, 1346-1532, 201602292450395608 - 近赤外吸収イメージング法を利用した水溶液の拡散係数の温度依存性に関する研究
山下大樹; 角田直人; 川嶋大介; 近藤克哉; 有本英伸; 山田幸生
2016, 日本伝熱シンポジウム講演論文集(CD-ROM), 53rd, 1346-1532, 201602294017592203 - GS0610 Experimental Study on Temperature Dependence of Diffusion Coefficient of Ethanol Aqueous Solution
Yamashita Hiroki; Kakuta Naoto; Kawashima Daisuke; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
Temperature dependence of diffusion coefficient of ethanol in dilute ethanol aqueous solutions is investigated by using a simultaneous imaging method of temperature and concentration. The simultaneous imaging is achieved by absorption imaging with two wavelengths of 1905 nm and 1935 nm in the ν_2+ν_3 absorption band of water. The absorbance at 1905 nm is the most sensitive to the temperature in the band but that at 1935 nm is insensitive. Whereas, the absorbances at both wavelength are highly sensitive to the water molar fraction, which is inversely proportional to the ethanol concentration. When a 2 wt% ethanol aqueous solution and pure water flowed in parallel through a microfluidic channel, the concentration changes by diffusion mixing were measured at different temperatures, and the diffusion coefficients were determined by fitting the analytical solution of one-dimensional diffusion equation to the measured concentration data., The Japan Society of Mechanical Engineers, 2016, The Proceedings of Conference of Kanto Branch, 2016, 0, _GS0610-1_-_GS0610-2_, Japanese, 110010050007, AA11902161 - Visualization of Diffusion Phenomena in a Microchannel by using Near-infrared Light
KAKUTA Naoto; YAMASHITA Hiroki; KAWASHIMA Daisuke; KONDO Katsuya; ARIMOTO Hidenobu; YAMADA YukioIt is important and required for chemical analysis/synthesis using microfluidic channels to visualize diffusion phenomena and chemical reactions. We have thus developed a near-infrared (NIR) absorption imaging method to simultaneously measure the temperature and concentration distributions of aqueous solutions. This method is based on the fact that the ν2 + ν3 absorption band of water in an NIR region shifts to shorter wavelength as the temperature increases and that the band is very sensitive to the mole fraction of water. This paper shows the temperature and concentration images of aqueous solutions of methanol, ethanol, and glucose flowing in a Y-shaped microchannel. From the concentration images, the diffusion coefficient of each solute in water is determined by using a fitting function based on a one-dimensional diffusion equation, and its temperature dependence is quantitatively discussed.
, The Japan Society of Mechanical Engineers, 2016, The Proceedings of Mechanical Engineering Congress, Japan, 2016, 0, G0600703, Japanese, 130007063694 - B122 Temperature distribution estimation around heated micro-particles in liquids
Fujioka Ryota; Kakuta Naoto; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
Free convection generated in the fluid temperature difference by local heating, influences that can`t be ignored in heat transfer characteristics. Therefore, it is required to measure the amount of heat generated up to the free convection occurs. In previous studies, we've been estimated for the temperature distribution and the free convection around the micro heating magnetic sphere of mm size in the water. In this study, the micro particles under the alternating magnetic field over time imaging the absorbance at a wavelength of 1150 nm or 1412 nm, to estimate the temperature distribution by obtaining the absorbance of images. This time, we set up micro particles in the syrup, to estimate the temperature distribution from the absorbance image., The Japan Society of Mechanical Engineers, 23 Oct. 2015, Procee[d]ings of Thermal Engineering Conference, 2015, "B122-1"-"B122-2", Japanese, 110010045392, AA11901963 - H215 Estimation of three-dimensional temperature distributions in free convection field around a small heated sphere in water
Miyake Tomohiro; Kakuta Naoto; Fujioka Ryota; Kondo Katsuya; Aritomo Hidenobu; Yamada Yukio
We propose a novel method for estimating three-dimensional temperature distributions of water in a free convection field around a small heated sphere. This method consists of a near-infrared absorption imaging with a wavelength of 1150 nm and inverse Abel transform. Since temperature distributions formed by free convection above a heated sphere can be assumed to be axisymmetric ones, where the axis is in the opposite direction of gravity, the three-dimensional temperature distributions are reconstructed by applying the inverse Abel transform to every absorbance line profile perpendicular to the axis. The reconstructed temperature distributions show the transient process of free convection, indicating the validity of this method., The Japan Society of Mechanical Engineers, 23 Oct. 2015, Procee[d]ings of Thermal Engineering Conference, 2015, "H215-1"-"H215-2", Japanese, 110010045581, AA11901963 - J0510204 Visualization of temperature field in aqueous solution with a small heated region using near-infrared light
KAKUTA Naoto; YAMADA Kenta; FUJIOKA Ryota; KONDO Katsuya; ARIMOTO Hidenobu; YAMADA Yukio
This paper introduces a novel method for imaging the temperature fields in water with a small heated sphere. This method is based on the temperature dependence of the absorption coefficient of water at the wavelength of 1150 nm. When a 1 mm diameter steel sphere in water contained in a rectangular glass cell with a light path length of 10 mm was heated inductively by a 760 kHz magnetic field, the absorbance images at this wavelength were acquired by using a near-infrared imaging system. The images showed that the absorbances around the sphere increased, corresponding to the heating power levels, and that a circularly symmetric distribution was formed by thermal conduction in a certain initial period and subsequently upward flow occurred by free convection. To the circularly symmetric distributions, inverse Abel transform was applied, and radial temperature distributions were reconstructed., The Japan Society of Mechanical Engineers, 13 Sep. 2015, Mechanical Engineering Congress, Japan, 2015, "J0510204-1"-"J0510204-3", Japanese, 110010048887, AA12588255 - 近赤外域の多波長を用いた酸・アルカリ水溶液の中和熱と生成塩濃度の可視化
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
2015, 日本伝熱シンポジウム講演論文集(CD-ROM), 52nd, 1346-1532, 201502210965141922 - Visualization of Neutralization Reaction Product by using Near-infrared Absorption Spectroscopy Technique
川嶋大介; 角田直人; 有本英伸; 近藤克哉; 山田幸生
2015, 可視化情報学会誌, 35, Suppl.1, 0916-4731, 201702231728665925 - G221 Concentration Measurement in Vicinity of Neutralization Reaction Interface using Near-infrared Absorption Imaging Technique
Kawashima Daisuke; Kakuta Naoto; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
This paper focuses on the mixing phenomena at the neutralization reaction interface in a microchannel. Visualization of diffusion and chemical reaction of the aqueous solutions of hydrochloric acid and sodium hydroxide in microchannel is performed by using a novel imaging technique based on the near-infrared absorption spectroscopy of aqueous solutions. We observe the salt generation and diffusion by the reaction when the flow of the two reagents and gravitational directions are changed. The results show that salt diffusion phenomena are greatly influenced by gravitational direction., The Japan Society of Mechanical Engineers, 2015, The Proceedings of the Thermal Engineering Conference, 2015, 0, _G221-1_-_G221-2_, Japanese, 110010045555, AA11901963 - H214 Observation of Diffusion Phenomena in Ethanol Aqueous Solutions using Near-infrared Absorption Characteristics
Yamashita Hiroki; Kakuta Naoto; Kawashima Daisuke; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
This paper presents a simultaneous imaging method of the temperature and concentration of ethanol aqueous solutions in a microchannel. Absorbance images at the two wavelengths in the ν_2 + ν_3 absorption band of water: 1905 nm and 1935 nm, are simultaneously acquired and converted to the temperature and concentration images. The absorbance at 1905 nm is the most sensitive to the temperature in the band, but that at 1935 nm is insensitive, i.e., an isosbestic point. Whereas, the absorbances at both wavelength are highly sensitive to the water molar fraction, which is inversely proportional to the ethanol concentration. When a 2 wt% ethanol aqueous solution and pure water meet and diffuse to each other, changes in the concentration are observed, and the temperature dependence of the diffusion coefficient is discussed., The Japan Society of Mechanical Engineers, 2015, The Proceedings of the Thermal Engineering Conference, 2015, 0, _H214-1_-_H214-2_, Japanese, 110010045580, AA11901963 - 生体光イメージングのためのヒト頸部内光伝播モデルの構築
藤井 宏之; 大川 晋平; 灘本 健; 岡田 英史; 山田 幸生; 星 詳子; 渡部 正夫
Jan. 2015, バイオエンジニアリング講演会講演論文集, 2015.27, 1G21, Japanese, Summary national conference - D211 Prediction of Heat Generation Rates of a Small Magnetic Sphere under High Frequency Magnetic Field using Near-Infrared Absorption Imaging Method
YAMADA Kenta; KAKUTA Naoto; FUJIIOKA Ryota; KONDO Katsuya; ARIMOTO Hidenobu; YAMADA Yukio
This paper presents a novel method for reconstructing the temperature distributions of water around a small heated sphere and predicting the heat generation rates of the sphere. This method is based on the temperature dependence of the absorbance of water at the wavelength of 1150 nm. Absorbance images at 1150 nm were obtained when a 1 mm diameter steel sphere located in water contained in a glass cell with a light path length of 10 mm was heated by a 760 kHz alternating magnetic field. Inverse Abel transform is applied to the line profiles of the absorbance, and radial temperature distributions are reconstructed. The heat generation rates calculated from these temperature distributions well agree with induction heating power levels., The Japan Society of Mechanical Engineers, 08 Nov. 2014, Procee[d]ings of Thermal Engineering Conference, 2014, "D211-1"-"D211-2", Japanese, 110009939013, AA11901963 - H215 Onset of free convection around a small heated sphere in water
Fujioka Ryota; Kakuta Naoto; Yamada Kenta; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
This paper describes the onset of free convection around a 1 mm diameter steel sphere heated inductively in water using a light absorption imaging method with a wavelength of 1150 nm. Since the concentric absorbance distributions formed by pure thermal conduction are distorted by free convection, the onsets of free convection are determined by measuring the position of a centroid of a region with a certain absorbance and compared to Rayleigh number., The Japan Society of Mechanical Engineers, 08 Nov. 2014, Procee[d]ings of Thermal Engineering Conference, 2014, "H215-1"-"H215-2", Japanese, 110009939105, AA11901963 - 1B13 3D imaging of fluorescence diffuse optical tomography using generalized pulse spectrum technique
TAKEKOSHI Masashi; OKAWA Shinpei; MASAMOTO Kazuto; NISHIMURA Goro; YAMADA Yukio
The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014, 26, 47-48, Japanese, 110009955987, AA11903175 - 近赤外域の2波長を用いたマイクロ流路内の酸・アルカリ水溶液混合場の濃度イメージング
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
2014, 日本伝熱シンポジウム講演論文集(CD-ROM), 51st, 1346-1532, 201402204060826354 - 近赤外吸収イメージング法を応用したマイクロ流路内の酸塩基中和反応の可視化
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
2014, 近赤外フォーラム講演要旨集, 30th, 201502282223275448 - 近赤外吸収イメージング法を用いた微量水溶液の温度と濃度の可視化
角田直人; 川嶋大介; 近藤克哉; 有本英伸; 山田幸生
2014, 東京都立産業技術研究センター研究成果発表会要旨集, 2014, June, 201502215955623849 - 近赤外光を用いたマイクロ流路内のアルコール水溶液の温度・濃度同時イメージング
角田直人; 川嶋大介; 乙黒奈津希; 近藤克哉; 有本英伸; 山田幸生
2014, 応用物理学会秋季学術講演会講演予稿集(CD-ROM), 75th, 2758-4704, 201402236711282934 - D142 Visualization of Exothermic Chemical Reactions in Microchannels using the Near-Infrared Two-Wavelength Imaging Method : Analysis of Neutralization Reaction of Acid and Base with Absorption Images
Kawashima Daisuke; Kakuta Naoto; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
This paper presents the visualization of neutralization reactions of an acid (HCl) and a base (NaOH) in a microchannel. Increases in temperature and concentration of the products, caused by the neutralization reactions, are visualized by using the absorbance images at two wavelengths in a near-infrared region: 1412 nm and 1442 nm. Absorbance images at 1412 nm reflect the temperature increases because the absorbance increases with the elevation of temperature. Absorbance images at 1442 nm reflect the concentrations of the products because the absorbance is insensitive to the temperature but sensitive to the concentrations. The absorbance increment caused by heat generation is observed at 1412 nm and that increment caused by products, salt and water, is observed at 1442 nm, respectively., The Japan Society of Mechanical Engineers, 2014, The Proceedings of the Thermal Engineering Conference, 2014, 0, _D142-1_-_D142-2_, Japanese, 110009939010, AA11901963 - 22am2-F8 Observation of Acid-Base Mixture Region in Microchannel by using Near-Infrared Absorption Imaging Method
KAWASHIMA Daisuke; KAKUTA Naoto; KONDO Katsuya; ARIMOTO Hidenobu; YAMADA Yukio
This study aims to visualize the mixing and chemical reactions of aqueous solutions in microchannels by using a near-infrared absorption imaging technique based on the spectral characteristics of water and solutes. This paper focuses on the effect of the salt generated from neutralization reaction of HCl and NaOH aqueous solutions on the spectra, and tries to construct the concentration images of the salt by using absorbance difference images at the wavelength of 1412 nm and 1442 nm., The Japan Society of Mechanical Engineers, 2014, The Proceedings of the Symposium on Micro-Nano Science and Technology, 2014, 0, _22am2-F8--_22am2-F8-, Japanese, 110009950736, AA12456946 - F113 Prediction of Temperature Distributions of Water around a Small Heated Sphere using a Near-Infrared Absorption Imaging Method
YAMADA Kenta; KAKUTA Naoto; ARIMOTO Hidenobu; KONDO Katsuya; YAMADA Yukio
This paper presents a method of reconstructing the temperature distributions of water around a small heated sphere. This method is based on the temperature dependence of the absorbance of water at the wavelength of 975 nm. Absorbance images at this wavelength were obtained when an iron sphere with a diameter of 1 mm located in water contained in a glass cell with a light path length of 10 mm was heated by a high-frequency magnetic field. Inverse Abel transform was applied to the line profiles of the absorbance, and cross-sectional temperature distributions around the sphere were reconstructed. The temperature distributions vary with the magnitudes of the magnetic field, which indicates the possibility of quantitative evaluation of induction heating systems., The Japan Society of Mechanical Engineers, 18 Oct. 2013, Procee[d]ings of Thermal Engineering Conference, 2013, 167-168, Japanese, 110009955675, AA11901963 - 3F08 Intravital imaging of glucose transportation with two-photon microscopy in mouse cerebral cortex
TAKADA Yuki; MURATA Rei; TAKUWA Hiroyuki; KANNO Iwao; ITO Hiroshi; YAMADA Yukio; MASAMOTO Kazuto
The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013, 25, 633-634, Japanese, 110009920196, AA11903175 - 3F09 Reconstruction of the Distribution of the Optical Properties in Layered Human Skin
KOSUGE Tomoya; OKAWA Shinpei; MASAMOTO Kazuto; YAMADA Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013, 25, 635-636, Japanese, 110009920197, AA11903175 - 1F03 A method for predicting temperature distributions around a heating particle for in vitro magnetic hyperthermia
KAKUTA Naoto; YAMADA Kenta; KONDO Katsuya; NAKATA Satoshi; ARIMOTO Hidenobu; YAMADA Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013, 25, 183-184, Japanese, 110009919969, AA11903175 - 水の近赤外吸収特性を利用した水溶液の温度と水体積分率の同時測定
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
2013, 日本伝熱シンポジウム講演論文集(CD-ROM), 50th, 1346-1532, 201302217583278757 - Remote Temperature Imaging Using Near-infrared Absorption Characteristics of Water
KAKUTA Naoto; KONDO Katsuya; ARIMOTO Hidenobu; YAMADA Yukio
Institute of Systems, Control and Information Engineers, 2013, Systems, control and information, 57, 12, 493-498, Japanese, 0916-1600, 110009685989, AN10062329 - F112 Visualization of exothermic chemical reactions in microchannels using a near-infrared two-wavelength imaging method : Absorption spectra and two-wavelength images of aqueous solutions of HCl and NaOH
Kawashima Daisuke; Kakuta Naoto; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
This paper presents the visualization of heat and mass transfer of aqueous solutions in microchannels by using the simultaneous imaging method of the temperature and solute concentration. This method is based on the absorption characteristics of water in a near-infrared region: absorbance at a wavelength of 1412 nm is dependent on the temperature whereas that at 1442 nm is independent. This visualization method is applied to experimental researches on chemical reactions between hydrochloric acid and sodium hydroxide aqueous solutions. These two reagents are supplied into two inlets of a Y-shaped rectangular microchannel at several different flow rates. Absorbance difference images in the merging region of the two flows are obtained at the two wavelengths simultaneously, which demonstrate that the magnitude and distribution of the absorbance difference vary with the concentrations and flow rates., The Japan Society of Mechanical Engineers, 2013, The Proceedings of the Thermal Engineering Conference, 2013, 0, 165-166, Japanese, 110009955674, AA11901963 - P-G1-2 Simultaneous Imaging of Temperature and Water Volume Fraction of Aqueous Solutions Based on the Near-infrared Absorption Characteristics of Water
Kakuta Naoto; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
A remote and marker-free method for simultaneously imaging the temperature and the volume fraction of water (VFW) of aqueous solutions in mini/microchannels is presented. The principle of this method is based on the temperature dependence of the near-infrared absorption band (ν_1+ν_3 band) of water. An absorbance image at the wavelength of 1412 nm, the most sensitive to temperature in the band, and that at 1445 nm, isosbestic point, were alternately obtained, each at 10 frames/s, by using an alternate narrow-bandpass filtering system and a near-infrared camera. The 1412 nm-images demonstrated a change in temperature distribution caused by the inflow of heated water. A change in VFW appeared in the images at the both wavelengths and it was confirmed that the VFW was nearly proportional to the concentration of ethanol as a solute., The Japan Society of Mechanical Engineers, 21 Oct. 2012, マイクロ・ナノ工学シンポジウム, 2012, 4, 193-194, Japanese, 110009953458, AA12456946 - G060065 Prediction of Temperature Distribution of Water around a Thin Heating Wire using Near-Infrared Absorption Images
KAKUTA Naoto; KONDO Katsuya; NAKATA Satoshi; ARIMOTO Hidenobu; YAMADA Yukio
A prediction method of internal temperatures distributed axisymmetrically in an aqueous solution with a thickness from sub-mm to a few mm is presented. This method consists of a near-infrared (NIR) absorption imaging and an inverse Abel transform. In the NIR absorption imaging, absorbance images at the wavelength of 1412 nm, the most temperature-sensitive wavelength in the v_1 + v_3 absorption band of water, are obtained by using a narrow-bandpass filter and an NIR camera. In the case that the internal temperature possesses an axisymmetric distribution, it can be predicted by Abel inversion of the measured absorbance profile. In this study the absorbance profiles are approximated by multi-Gaussian functions because their inverse transform can be calculated analytically. Cross-sectional temperature distributions around a thin hot wire in 1.5 mm thick water are shown., The Japan Society of Mechanical Engineers, 09 Sep. 2012, Mechanical Engineering Congress, Japan, 2012, "G060065-1"-"G060065-3", Japanese, 110009994294, AA12588255 - 7D24 Dynamics of glucose transportation from blood to cells in the cerebral cortex
TAKADA Yuki; YOSHIHARA Kouichi; TAKUWA Hiroyuki; KANNO Iwao; ITO Hiroshi; OKAWA Shinpei; YAMADA Yukio; MASAMOTO Kazuto
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012, 24, "7D24-1"-"7D24-2", Japanese, 110009688978, AA11903175 - 7D21 Pseudo-3D imaging of fluorescence diffuse optical tomography using a phantom
YOSHIDA Masaki; MITSUI Yohei; TAKEKOSHI Masashi; HOSHI Yoko; KIDA Ikuhiro; OKAWA Shimpei; MASAMOTO Kazuto; YAMADA Yukio
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012, 24, "7D21-1"-"7D21-2", Japanese, 110009688975, AA11903175 - 蛍光イメージングによる脳微小血管血流速の計測
山口大貴; 吉原光一; 須貸拓馬; 白畑大悟; 田桑弘之; 川口拓之; 伊藤浩; 大川晋平; 正本和人; 菅野巖; 山田幸生
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 24th (CD-ROM), 24, ROMBUNNO.7D47-1"-"7D47-2", Japanese, 1348-2920, 201202287731761811, 110009688993, AA11903175 - 脳微小血管ネットワーク構造の定量解析法
須貸拓馬; 吉原光一; 山口大貴; 白畑大悟; 川口拓之; 菅野巖; 伊藤浩; 大川晋平; 正本和人; 山田幸生
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 24th (CD-ROM), 24, ROMBUNNO.7D22-1"-"7D22-2", Japanese, 1348-2920, 201202237345816000, 110009688976, AA11903175 - 生体組織の散乱が二光子顕微鏡イメージングの空間分解能に与える影響
白畑大悟; 吉原光一; 須貸拓馬; 山口大貴; 川口拓之; 菅野巖; 伊藤浩; 大川晋平; 正本和人; 山田幸生
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 24th (CD-ROM), 24, ROMBUNNO.7D42-1"-"7D42-2", Japanese, 1348-2920, 201202298711776083, 110009688988, AA11903175 - ダイナミック・マルチレベル生体光イメージング : 拡散光・蛍光トモグラフィ (特集 分子イメージングの最先端(後編))
星 詳子; 山田 幸生
寺田国際事務所先端医療技術研究所, 2012, PET journal, 20, 9-12, Japanese, 2186-022X, 40019550375 - 6-5 Temperature Imaging of Aqueous Solutions in Microchannels Using the Near-Infrared Absorption Characteristics of Water
Kakuta Naoto; Fukuhara Yuko; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
This paper presents a remote and preparation-free method of temperature imaging of aqueous solutions in microchannels of micro-fluidic chips. The principle of this method is based on the temperature dependency of the near-infrared absorption band (v_2+v_3 band) of water. Temperature images were constructed from absorbances at the wavelength of 1908nm, the most sensitive to temperature in the band, measured by using a near-infrared camera and optical narrow-bandpass filter. Calculation and calibration results demonstrated a temperature coefficient of 1.5×10^<-2>K^<-1>mm^<-1>. Temperature images of 0.05mm thick water in a Y-shaped PDMS microchannel locally heated by a neighboring hot wire were obtained, in which thermal diffusion processes in the microchip were visualized., The Japan Society of Mechanical Engineers, 25 Sep. 2011, マイクロ・ナノ工学シンポジウム, 2011, 3, 67-68, Japanese, 110009664142, AA12456946 - Scientific Contribution Award of the Heat Transfer Society of Japan
KAKUTA Naoto; KONDO Katsuya; OZAKI Atsushi; ARIMOTO Hidenobu; YAMADA Yukio
01 Jul. 2011, 伝熱 : journal of the Heat Transfer Society of Japan, 50, 212, 5-5, Japanese, 1344-8692, 10029327153, AA11315621 - G34 Effect of thickness of thin-film aqueous solution on near-infrared temperature imaging
FUKUHARA Yuko; KAKUTA Naoto; KONDO Katsuya; ARIMOTO Hidenobu; YAMADA Yukio
The Japan Society of Mechanical Engineers, 17 Mar. 2011, 日本機械学会九州支部講演論文集, 2011, 64, 263-264, Japanese, 110009666768, AN0036066X - 8I-17 Measurement of optical properties of human skin
Hattori Kazuhisa; Kuwahara Tomohiro; Okawa Shinpei; Masamoto Kazuto; Ogura Yuki; Tajima Shingo; Ohmi Masato; Haruna Masamitsu; Yamada Yukio
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 293-294, Japanese, 110008744138, AA11903175 - 8I-16 Quantitative analysis of microvessels exposed hypoxia and hyperoxia in mouse cerebral cortex
SAKAMOTO Ryota; YOSHIHARA Kouichi; ASAGA Ryutaro; OKAWA Shinpei; MASAMOTO Kazuto; KANNO Iwao; YAMADA Yukio
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 291-292, Japanese, 110008744137, AA11903175 - 8I-15 Spatiotemporal analysis of fluorescence glucose in brain
ASAGA Ryutaro; YOSHIHARA Kouichi; SAKAMOTO Ryota; OKAWA Shinpei; MASAMOTO Kazuto; KANNO Iwao; YAMADA Yukio
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 289-290, Japanese, 110008744136, AA11903175 - 生物発光・蛍光と生体イメージング
山田幸生; 大川晋平; 正本和人
日本伝熱学会, Jan. 2011, 伝熱, 50, 210, 25-30, Japanese, Introduction other, 1344-8692, 10027724559, AA11315621 - タイムラプス二光子顕微鏡で取得したマウス大脳皮質における脳微小血管構造の4次元解析
吉原光一; 川口拓之; 田桑弘之; 小畠隆行; 大川晋平; 正本和人; 菅野巖; 山田幸生
08 Nov. 2010, Optics & Photonics Japan講演予稿集, 2010, 380-381, Japanese, 201102286102470800 - B122 Temperature Measurement of Aqueous Solution in MicroChannel Using Near-Infrared Spectroscopy
Kakuta Naoto; Fukuhara Yuko; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
Temperature measurement of aqueous solution in a micro-fluidic chip by using near-infrared spectroscopy is presented. The principle is based on the temperature dependence of the v_2 + v_3 absorption band of water. Absorbance spectra for two areas in 50-μm thick water in a temperature controlled Y-channel were measured simultaneously by two photospectrometers. The spectra indicated the temperature difference between the two areas. The images of absorbance at 1905 nm corresponding to temperature images were obtained by using a near-infrared camera and narrow bandpass filter. Calibration measurements on water in the Y-channel from 24.0℃ to 46.0℃ demonstrated a temperature coefficient of 4.5 x 10^<-4>℃^<-1>. Finally, temperature distributions caused by a heating wire were visualized., The Japan Society of Mechanical Engineers, 29 Oct. 2010, Procee[d]ings of Thermal Engineering Conference, 2010, 41-42, Japanese, 110008742655, AA11901963 - Involvement of dermal carbonyl modification in yellowish change of skin color with photo-aging in Japanese
Yuki Ogura; Tomohiro Kuwahara; Tetsuji Hirao; Minoru Akiyama; Shingo Tajima; Kazuhisa Hattori; Kouhei Okamoto; Shinpei Okawa; Yukio Yamada; Hachiro Tagami; Motoji Takahashi
Sep. 2010, JOURNAL OF DERMATOLOGY, 37, 73-73, English, Summary international conference, 0385-2407, WOS:000281733400277 - 0825 Measurement of the Optical Properties of Human Stratum Corneum
Hattori Kazuhisa; Okamoto Kohei; Hatakeyama Shuya; Kuwahara Tomohiro; Ohmi Masato; Haruna Masamitsu; Okawa Shinpei; Yamada Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 320-320, Japanese, 110008064698, AA11903175 - 1033 Simulation of 3D Diffuse Optical Tomography
UCHIDA Kazuhiro; MATSUHASHI Shoko; HOSHI Yoko; OKAWA Shinpei; YAMADA Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 366-366, Japanese, 110008064743, AA11903175 - 1034 Two-photon imaging of in vivo cerebral microvasculature with considering wavelength-dependent optical properties.
YOSHIHARA Kouichi; YONEYA Kazuhiro; MASAMOTO Kazuto; OKAWA Shinpei; KANNO Iwao; TANISHITA Kazuo; YAMADA Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 367-367, Japanese, 110008064744, AA11903175 - 1111 Noninvasvie blood glucose measurement using near-infrared spectroscopy based on simulation of light propagation.
KESSOKU Sachiko; MARUO Katsuhiko; OKAWA Shinpei; YAMADA Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 197-197, Japanese, 110008064576, AA11903175 - 1113 Measurement of fluorescence characteristics in light scattering medium
MARUOKA Shoji; UCHIDA Kazuki; MITSUI Yohei; OKAWA Shinpei; HOSHI Yoko; YAMADA Yukio
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 199-199, Japanese, 110008064578, AA11903175 - 二光子励起イメージングにおける生体組織の散乱の影響
吉原光一; 正本和人; 川口拓之; 大川晋平; 菅野巖; 山田幸生
2010, 酸素ダイナミクス研究会プログラム・抄録集, 14th, 51, Japanese, 201102219893617606 - In vivo Measurement of Optical Properties in Pig Heads
TANIKAWA Yukari; SASSAROLI Angelo; MARTELLI Fabrizio; IMAI Daigo; TANAKA Kenji; ARAKI Ryuichiro; YAMADA Yukio
12 Nov. 2009, 電気学会研究会資料. LAV, 光応用・視覚研究会, 1999, 18, 7-11, Japanese, 10024607986, AN00346658 - Measurements of optical properties of biological tissues using an integrating sphere and time-resolved spectroscopy
TANAKA Kenji; TANIKAWA Yukari; ARAKI Ryichiro; KAWAMURA Hiroshi; YAMADA Yukio
12 Nov. 2009, 電気学会研究会資料. LAV, 光応用・視覚研究会, 1999, 18, 1-5, Japanese, 10024607979, AN00346658 - 生体光伝播シミュレーションの近赤外線分光法への応用
岡田英史; 川口拓之; 坂口浩一郎; 山田幸生
Jul. 2009, 脈管学, 49, 2, 113-119, Japanese, Introduction other - 樹脂材料のレーザー溶着技術---光散乱材料の光学特性値測定と溶着性能の評価
山田幸生; 黒﨑晏夫; 又吉智也
大成社, Mar. 2009, Polyfile, 46, 541, 14-19, Japanese, Introduction other, 0910-2175, 40016575933, AN10153107 - 111 Effects of thickness of the cerebrospinal fluid and skull layers on optical mapping
WANG Shuping; SHIBAHARA Nanae; KURAMASHI Daishi; OKAWA Shinpei; KAKUTA Naoto; OKADA Eiji; MAKI Atsushi; YAMADA Yukio
The Japan Society of Mechanical Engineers, 22 Jan. 2009, バイオエンジニアリング講演会講演論文集, 2008, 21, 21-22, English, 110007706272, AA11903175 - B219 In vivo Time-resolved Diffuse Optical Tomography of Human Forearm under the Handgrip Exercise
TANIKAWA Yukari; Gao Feng; MIYAZAKI Yasuaki; IWATA Naoyuki; NAKAMURA Yasuo; OKAWA Shinpei; YAMADA Yukio; KIRYU Toru; MIYAKAWA Michio
時間分解法を応用した拡散光トモグラフィ装置は、光減衰量のみならず、パルスの到達時間から光路長を推定することができるため、定量的な評価が可能な装置と言われている。本研究では、この拡散光トモグラフィ装置の運動効果の定量評価への適用可能性を調べるため、ヒト前腕に放射状にファイバを設置し、ハンドグリップ圧縮運動を対象にin vivoで測定を行った。さらにこの結果を画像再構成アルゴリズムで解析し、運動時および安静時の計測からヒト前腕の酸素飽和度変化の断層画像再構成を行った。, The Japan Society of Mechanical Engineers, 22 Sep. 2008, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2008, 19, 75-76, Japanese, 1348-2939, 110007705764, AA11902434 - B217 Effects of the anatomy of the head on the optical mapping of brain activities
OOKI Mariko; SHIBAHARA Nanae; TOGASHI Ryo; WANG Shuping; OOKAWA Shinpei; HOSHI Youko; YAMADA Yukio
The Japan Society of Mechanical Engineers, 22 Sep. 2008, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2008, 19, 71-72, Japanese, 1348-2939, 110007705762, AA11902434 - マイクロナノバイオエンジニアリングにおける輸送現象
谷下一夫; 山田幸生
Jul. 2008, 日本機械学会誌, 111, 1076, 573, Japanese, Introduction other - WS(4) 近赤外分光法を利用した培養細胞の熱測定(WS バイオトランスポートの新展開,ワークショップ)
角田 直人; 尾崎 敦之; 近藤 克哉; 有本 英伸; 山田 幸生
一般社団法人日本機械学会, 13 Mar. 2008, 日本機械学会関東支部総会講演会講演論文集, 2008, 14, 19-22, Japanese, 110007705074, AA11902161 - 近赤外光による生体内血液状態分布測定技術
山田幸生
Feb. 2008, 冷凍, 83, 965, 167-172, Japanese, Introduction other - 205 Quantification of platelet aggregation by solving a linear inverse problem of chemical kinetic model
Hirono Taisuke; Okawa Shinpei; Yamada Yukio
The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007, 20, 49-50, Japanese, 110007085283, AA11903175 - Imaging hemodynamic changes in preterm infant brains with two-dimensional diffuse optical tomography
Feng Gao; Yiwen Ma; Fang Yang; Huijuan Zhao; Jingying Jiang; Takashi Kusaka; Masanori Ueno; Yukio Yamada
2008, ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VI, 6848, English, 0277-786X, 42149136347, WOS:000255549900021 - Temperature measurement of bio-micro-aqueous solutions using near-infrared spectroscopy
N. Kakuta; A. Ozaki; H. Arimoto; Y. Yamada
2008, BIORHEOLOGY, 45, 1-2, 100-101, English, Summary international conference, 0006-355X, WOS:000258929100134 - 近赤外分光法による脳機能計測の基礎，歴史と最近の動向
山田幸生
Dec. 2007, 光学, 36, 12, 676-685, Japanese, Introduction other - F243 Temperature Measurement of Brown Adipose Cells Using Near-Infrared Spectroscopy
Ozaki Atsushi; Kakuta Naoto; Arimoto Hidenobu; Yamada Yukio
This paper introduces a method of temperature measurement of brown adipose cells using near-infrared spectroscopy. The measurement principle is based on the fact that the peak wavelength of the water absorption band with its center near 1910nm shifts with changes in temperature. We developed a measurement system for temperature changes of brown adipose cells cultured on a 60-mm-dish. To induce the heat production of the brown adipose cells, norepinephrine was added to the culture solution during measurement. Irregular changes of absorption coefficient at 1908nm were observed after the norepinephrine administration. However, the relationship between these changes and temperature has not been clear., The Japan Society of Mechanical Engineers, 23 Nov. 2007, Procee[d]ings of Thermal Engineering Conference, 2007, 393-394, Japanese, 110007082930, AA11901963 - C115 Temperature Imaging of Sub-Millimeter-Thick Water using a Near-Infrared Camera
Kakuta Naoto; Ozaki Atsushi; Kondo Katsuya; Arimoto Hidenobu; Yamada Yukio
We report a method using near-infrared camera and optical filter to obtain the temperature image of sub-millimeter-thick water. The measurement principle is based on the fact that the peak wavelength of the water absorption band with its center near 1440nm shifts with changes in temperature. Temperature images can be constructed by calculating absorbances near 1412nm, which most strongly depend on temperature, for all pixels. We first calibrated the temperatures of 0.5-mm-thick water over the temperature range from 26.0℃ to 40.0℃. The average of temperature coefficients obtained was 1.46×10^<-3> absorbance/℃. Finally, we formed the temperature distribution in this water film by heating an immersed nichrome wire and obtained sequential temperature images demonstrating the distribution., The Japan Society of Mechanical Engineers, 23 Nov. 2007, Procee[d]ings of Thermal Engineering Conference, 2007, 105-106, Japanese, 110007083109, AA11901963 - Two-dimensional optical tomography of hemo-dynamic changes in a preterm infant brain
Feng Gao; Yuan Xue; Huijuan Zhao; Takashi Kusaka; Masanori Ueno; Yukio Yamada
Aug. 2007, CHINESE OPTICS LETTERS, 5, 8, 472-474, English, 1671-7694, 34648846844, WOS:000255024100013 - 3.多重散乱系での光伝播に関する光学特性値と基礎方程式
山田幸生
NTS出版, 2007, 非侵襲・可視化技術ハンドブック., 272-275, 20001638112 - 616 Effect of sulci and elevations of skin surface on the light propagation in the skin
MASHITA Yukari; ARIMOTO Hidenobu; KAKUTA Naoto; YAMADA Yukio; Ohta Tomohiro; Maruo Katsuhiko
The Japan Society of Mechanical Engineers, 12 Jan. 2006, バイオエンジニアリング講演会講演論文集, 2005, 18, 409-410, Japanese, 110006205625, AA11903175 - 540 Fundamental Study for the Temperature Measurement of Micro-Biological Sample Using Near Infrared Light
LI Fuguo; KAKUTA Naoto; ARIMOTO Hidenobu; YAMADA Yukio
We have proposed a method for non-invasively measuring the temperature changes of water in a micro-region using near infrared (NIR) light. The goal of this study is to measure the temperature changes of biological cells or tissues. This method is on the basis of the phenomenon that the NIR absorption spectrum of water depends on temperature. Absorbance spectra in the wavelength range of 1300-2000nm of water with a thickness of 100 and 500μm were measured by a micro-spectrometer. Also, glucose solution was measured. The measured spectra with temperature-dependence were calibrated using a regression analysis. The standard error of calibration was 0.1-0.3℃., The Japan Society of Mechanical Engineers, 12 Jan. 2006, バイオエンジニアリング講演会講演論文集, 2005, 18, 379-380, Japanese, 110006205610, AA11903175 - 539 Study of integrating sphere type reflection pulse oximeter
TAKIGAWA Ryusuke; Yin Na; KAKUTA Naoto; YAMADA Yukio; KIMURA Toshihisa; AOKI Kazuo
The Japan Society of Mechanical Engineers, 12 Jan. 2006, バイオエンジニアリング講演会講演論文集, 2005, 18, 377-378, Japanese, 110006205609, AA11903175 - 分子イメージングにおける光学技術への期待
山田幸生
2006, 光学, 35, 2, 65, Japanese, Introduction other - A154 Fluorescence Image Analysis for Leukocyte Counting in Blood Products
Hirono Taisuke; Yabusaki Katsumi; Yamada Yukio
Fluorescence image was investigated for development of a leukocyte counter for quality assurance tests of transfusion blood products. The standard leukocyte fluorescence image profile was established by averaging the actual fluorescence image of leukocytes. It was used for development of an optimum image analysis algorithm to avoid miss-counting of the dust contaminated from the environment. The centrifugal concentration process was investigated by a computer simulation, and it was found that this process caused leukocyte overlapping and limited the measurement range. We succeed in developing the leukocyte counter, with improving the accuracy and the measurement range up to 25 [WBC/μl]., The Japan Society of Mechanical Engineers, 02 Nov. 2005, Procee[d]ings of Thermal Engineering Conference, 2005, 35-36, Japanese, 110006206637, AA11901963 - A141 Biomedical Measurement and Imaging Using Near Infrared Light
YAMADA Yukio
This review introduces the recent developments in the field of biomedical measurement and imaging using near infra-red light, including pulse oximeter, oxygen monitor, optical mapping (topography), diffuse optical tomography, retinal imaging, and fluorescence tomography., The Japan Society of Mechanical Engineers, 02 Nov. 2005, Procee[d]ings of Thermal Engineering Conference, 2005, 23-24, Japanese, 110006206631, AA11901963 - (1)Anatomical and Functional Images of in vitro and in vivo Tissues by NIR Time-domain Diffuse Optical Tomography
趙 会娟; 高 峰; 谷川 ゆかり; 本間 一弘; 小野寺 陽一; 山田 幸生
The Japan Society of Mechanical Engineers, 05 May 2005, Journal of the Japan Society of Mechanical Engineers, 108, 1038, 345-345, Japanese, 0021-4728, 110006218925, AN00187394 - Time-resolved diffuse optical tomographic imaging for providing both anatomical and functional information of biological tissue
ZHAO Huijuan; ZHAO Huijuan; GAO Feng; GAO Feng; TANIKAWA Yukari; HOMMA Kazuhiro; YAMADA Yukio
2005, APPLIED OPTICS, 44, 10, 1905-1916, 0003-6935, 80017827745, 15813527 - 光伝播の時間分解計測に基づく拡散光トモグラフィの開発
山田幸生
2005, 熱物性, 19, 6, 103-108, Japanese, Introduction other - 光学的血糖値測定手法開発の現状と実現へのとりくみ
垂水正敏; 島田光功; 有本英伸; 丸尾勝彦; 山田幸生
2005, ライフサポート, 17, 1, 3-8, Japanese, Introduction other - 時間分解計測法による拡散光トモグラフィ
山田幸生
2005, 日本レーザー医学会誌, 26, 3, 214-221, Japanese, Introduction other - Determination of absorption coefficient of the lower layer in layered turbid media with the time-resolved spectroscopy
SATO Chie; SHIMADA Miho; YAMADA Yukio; HOSHI Yoko
We propose a new method to determ ine the absorption coefficient (μ_a) of the lower layer in a two-layered medium using time-resolved spectroscopy (TRS). To estimate the variation of μ_a with the depth, the difference in the temporal profiles of light attenuation between a two-layered medium and a homogeneous one was divided into time segments, and a slope of each segment was calculated to get the time-segmented μ_a of the layered medium. Its validity was examined both by a Monte Carlo simulation and phantom experiments. The results suggest the possi bility that μ_a of hum an cerebral tissue can be selectively determined by TRS., The Japan Society of Mechanical Engineers, 10 Nov. 2004, Procee[d]ings of Thermal Engineering Conference, 2004, 393-394, Japanese, 110004058065, AA11901963 - Simple algorithm to estimate the absorption coefficients of two-layered scattering media from the spatially- and time-resolved reflectance
Miho Shimada; Yukio Yamada; Yoko Hoshi
27 Oct. 2004, Proceedings of SPIE - The International Society for Optical Engineering, 5321, 138-148, 0277-786X, 5644265080 - 体表温の正規化への試み : 異なる温熱環境下における体表温の比較評価のための正規化された体表温指標作成の試み
角田 直人; 山田 幸生; 横山 真太郎; 満渕 邦彦
07 Jun. 2004, Biomedical thermology : the journal of the Japanese Society of Thermorogy = 医学・生物学サーモロジー, 24, 1, 11-11, Japanese, 0916-6238, 10013438573, AN10339852 - 2003年光学界の進展 17.医学・生物応用光学
山田幸生
Apr. 2004, 光学, 33, 227-228, Japanese, Introduction other - 拡散光イメージングによる脳機能計測
山田幸生
Feb. 2004, 光学, 33, 103-109, Japanese, Introduction other - Fundamental study of ultra-low flow meters for artificial pancreas
NISHIYAMA Hisashi; KONISHI Yoshiaki; MURAKAMI Motoaki; FUJIWARA Masato; KAKUTA Naoto; YAMADA Yukio
The Japan Society of Mechanical Engineers, 2004, 日本機械学会第16回バイオエンジニアリング講演会講演論文集2004, 207-208, Japanese, 110002484165, AA11903175 - 拡散光を用いた生体組織のイメージング：最近の成果と動向
山田幸生
日本オプトメカトロニクス協会, 2004, 光技術コンタクト, 42, 7, 359-369, Japanese, Introduction other, 0913-7289, 40006353509, AN10075091 - Optics for biology and medicine
YAMADA Yukio
This paper reviews the current status and future prospects of optical technologies using near-infrared light for biology and medicine. Light in the near-infrared wavelength range has higher transmittance through biological tissues, and is frequently used for measuring physiological information such as tissue oxygenation, hemodynamics, and concentrations of tissue fluids. However, light in the near-infrared wavelength range is subject not only to the absorption but also to the strong scattering by tissues. Due to this strong scattering of light by tissue light propagates diffusely in tissues. This paper focuses on the technologies of diffuse optical imaging and noninvasive measurement of blood glucose level., The Japan Society of Mechanical Engineers, 10 Nov. 2003, Procee[d]ings of Thermal Engineering Conference, 2003, 329-330, Japanese, 110002489708, AA11901963 - Development of less-invasive brain tumor resection using 3D-optical CT
SAKATANI Kaoru; YAMADA Yukio; KATAYAMA Yoichi
28 Sep. 2003, 日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine, 24, 3, 201-201, Japanese, 0288-6200, 10012435520, AN0035795X - Measurements of Optical Properties of Tissues
OKADA Kenji; MASHITA Yukari; IINO Kenji; MOMOKI Hideyuki; KAKUTA Naoto; YAMADA Yukio
The Japan Society of Mechanical Engineers, 17 Sep. 2003, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2003, 14, 135-136, Japanese, 1348-2939, 110002479253, AA11902434 - 光学的血糖値測定の数値シミュレーションと誤差低減法
山田幸生; 垂水正敏
Japanese Society of Medical Instrumentation, Aug. 2003, 医科器械学, 73, 8, 415-421, Japanese, Introduction other, 0385-440X, 110002514935, AN00013123 - 光学的血糖値測定システムの開発状況
丸尾勝彦; 鶴来充啓; 清崎若正; 太田智浩; 有本英伸; 山田幸生; 田村 守; 石井正孝; 尾崎幸洋
(一社)日本医療機器学会, Aug. 2003, 医科器械学, 73, 8, 406-414, Japanese, Introduction other, 0385-440X, 2004016859 - 拡散光トモグラフィ（光CT）の研究開発
山田幸生
Aug. 2003, BME（日本エム・イー学会雑誌）, 17, 4, 35-43, Japanese, Introduction other - Noninvasive blood glucose monitoring using near-infrared dermis tissue spectra
K Maruo; M Tsurugi; J Chin; T Ota; H Arimoto; Y Yamada; M Tamura; M Ishii; Y Ozaki
Jun. 2003, DIABETES, 52, A435-A435, English, Summary international conference, 0012-1797, WOS:000183173801871 - Micro-Thermocouple Probe for Measuring Cellular Thermal Responses
KAKUTA Naoto; SUZUKI Takafumi; SAITO Takashi; MABUCHI Kunihiko; YAMADA Yukio
The Japan Society of Mechanical Engineers, 20 Jan. 2003, バイオエンジニアリング講演会講演論文集, 2003, 15, 239-240, Japanese, 110002483968, AA11903175 - Measurement of Optical Properties for Light Propagation Simulation on Skin Tissue
Ota Tomohiro; Tarumi Masatoshi; Arimoto Hidenobu; Shimada Miho; Yamada Yukio
The Japan Society of Mechanical Engineers, 20 Jan. 2003, バイオエンジニアリング講演会講演論文集, 2003, 15, 123-124, Japanese, 110002483910, AA11903175 - 逆問題解法による拡散光断層イメージング
山田幸生; 高 峰
Nov. 2002, レーザー研究, 30, 11, 625-629, Japanese, Introduction other - 脳機能の光計測
山田幸生
レ-ザ-学会, Nov. 2002, レーザー研究, 30, 11, 623-624, Japanese, Introduction other, 0387-0200, 40005496807, AN00255326 - A Monte Carlo simulation of NIR spectrum changes induced by variations of glucose concentration
Masatoshi Tarumi; Mitsunori Shimada; Tomoya Murakami; Mamoru Tamura; Miho Shimada; Yukio Yamada
24 May 2002, Proceedings of SPIE - The International Society for Optical Engineering, 4624, 28-35, 0277-786X, 10012675552, 0036057207 - Measurement of DPF in human head using optical imaging system
TANIKAWA Yukari; ZHAO Hui juan; SASSAROLI Angelo; GAO Feng; ONODERA Yoichi; YAMADA Yukio
The Japan Society of Mechanical Engineers, 01 Mar. 2002, バイオエンジニアリング講演会講演論文集, 2002, 14, 335-336, Japanese, 110002483841, AA11903175 - 脳組織モデルを用いたマルチスペクトル画像の重回帰分析
横山健太郎; 本庄一史; 渡辺基志; 牧敦; 山田幸生; 伊関洋; 岡田英史
2002, 応用物理学関係連合講演会講演予稿集, 49th, 3, 200902163922755041 - バイオエンジニアリングにおける伝熱研究の進展
山田幸生
日本伝熱学会, Jan. 2002, 伝熱, 41, 166, 3-8, Japanese, Introduction other, 1344-8692, 10010165832, AA11315621 - 光CTの原理と現状・将来
山田幸生
Apr. 2001, 精密工学会誌, 67, 4, 541-545, Japanese, Introduction other - Cooperation between Industry, Academia and Government
YAMADA Yukio
01 Mar. 2001, 伝熱研究 = News of HTSJ, 40, 161, 13-14, Japanese, 0910-7851, 10017034832, AN0015409X - A method to measure the diffusion coefficient of homogeneous and layered media
Martelli Fabrizio; Angelo Sassaroli; Giovanni Zaccanti
The Japan Society of Mechanical Engineers, 15 Jan. 2001, バイオエンジニアリング講演会講演論文集, 2001, 13, 256-257, English, 110002483654, AA11903175 - 光と生体
山田幸生
共立出版, 2001, 光による医学診断, 19-36, 20001543260 - Optical probe for monitoring the oxygenation state of brain tissue
ONODERA Yoichi; YAMADA Yukio; SAKATANI Kaoru; HORI Tomokatu
30 Dec. 2000, Journal of Japan Society of Computer Aided Surgery : J.JSCAS, 2, 3, 145-146, Japanese, 1344-9486, 10024482515, AA11908088 - Optical Mapping Image Reconstruction for Brain Activity
ODA Ichiro; TSUNAZAWA Yoshio; YAMADA Yukio
The Japan Society of Mechanical Engineers, 27 Nov. 2000, The Computational Mechanics Conference, 2000, 13, 411-412, Japanese, 1348-026X, 110002487088, AA1190257X - 近赤外光による生体機能計測と光CT
山田幸生; 田村守; 綱澤義夫; 土屋裕
Apr. 2000, 計測と制御（自動制御学会誌）, 39, 4, 239-245, Japanese, Introduction other - Fundamental studies of photon migration in biological tissues and their application to optical tomography
Yukio Yamada
Optical Society of Japan, 2000, Optical Review, 7, 5, 366-374, English, Peer-reviwed, Introduction other, 1340-6000, 0034346609 - 生体熱工学の現状と展望
山田幸生
一般社団法人日本機械学会, Nov. 1999, 日本機械学会熱工学部門ニュースレター，日本機械学会誌, 102, 972, 701-709, Japanese, Introduction other, 0021-4728, 110002439198, AN00187394 - 光断層イメージングシステム---ナショナルプロジェクトの成果---
山田幸生
Nov. 1999, 日本機械学会誌，トピックス欄, 102, 972, 692, Japanese, Introduction other - ダイナミック部分を持つヒト頭部光学ファントムの作製
今井 大吾; 谷川 ゆかり; 山田 幸生
工業技術院機械技術研究所, May 1999, 機械技術研究所所報, 53, 3, 72-81, Japanese, 0388-4252, 40000578879, AN00048977 - 低温やけどについて
山田幸生
Mar. 1999, 製品と安全, 72, 2-8, Japanese, Introduction other - 光トポグラフィの画像作成アルゴリズム評価
山本剛; 牧敦; 谷川ゆかり; 山下優一; 山田幸生; 小泉英明
1999, 応用物理学会学術講演会講演予稿集, 60th, 3, 200902187801685557 - 酸素状態の断層像を描き出す光ＣＴ
山田幸生
医歯薬出版, Aug. 1998, 医学のあゆみ, 186, 5, 335-340, Japanese, Introduction other, 0039-2359, 40000112772, AN10289798 - Observe Inside Body by Light - Biological Diagnosis by Optical Tomography -
YAMADA Yukio
The Japan Society of Mechanical Engineers, 05 Jul. 1998, Journal of the Japan Society of Mechanical Engineers, 101, 956, 529-533, Japanese, 0021-4728, 110002438586, AN00187394 - 光で体の中を視る 光ＣＴによる生体診断
山田幸生
Jul. 1998, 日本機械学会誌, 101, 956, 29-33, Japanese, Introduction other - Radiation Propagation in Scattering Media and Its Application to Biomedical Optics
YAMADA Yukio; TAKAHASHI Shuichi; TANIKAWA Yukari
応用物理学会分科会日本光学会, 10 Dec. 1997, Japanese journal of optics, 26, 12, 649-656, Japanese, 0389-6625, 10016237046, AN00080324 - Modeling of Ultrashort Light Pulse Propagation in Light Scattering Media
KUMAR Sunil; MITRA Kunal; VEDAVARZ Ali; YAMADA Yukio
Light pulses have found increasing use in medicine and biology. Biological tissues, however, scatter light very strongly, and the modeling of light pulse propagation in biological tissues has not been established because of scattering. We compare the results of three modeling methods, the photon diffusion approximation, the diffusive wave approximation, and the two-flux method with those of the discrete ordinate method which provides the exact solution of the transient equation of radiative transfer for the case of 1 picosecond pulse incidence on scattering and absorbing slab or semi-infinite media simulating biological tissues. The early behavior of the light pulses predicted by the photon diffusion approximation is quite different from that by the diffusive wave approximation. In the later period both the photon diffusion and diffusive wave approximations are able to give reasonable results, but the two-flux method is not. Because of much shorter computation time, the diffusive wave approximation is advantageous to the photon diffusion approximation., The Japan Society of Mechanical Engineers, 25 Mar. 1997, Transactions of the Japan Society of Mechanical Engineers. Series C., 63, 607, 895-900, Japanese, 0387-5024, 110002385017, AN00187463 - Manufacturing of Optical Phantoms and Measurement of Their Optical Properties Using an Integrating Sphere
MIZUNO Sho; TANIKAWA Yukari; YAMADA Yukio; MAKI Hiroshi
Noninvasive diagnosis by near-infrared light is widely used because it can provide physiological information about biological tissues. For quantitative measurement, however, estimation of the optical properties of biological tissues is necessary with respect to understanding of photon migration in media which scatter light strongly. The purpose of this study is to fabricate stable, solid phantoms which optically simulate biological tissues, and to measure their optical properties using an integrating sphere and a Monte Carlo simulation. The solid phantoms were fabricated using either polyester or epoxy resin as the base material, and small titanium oxide particles were mixed to provide appropriate scattering of light. Their optical properties were measured by means of spectroscopy using an integrating sphere and numerical simulation using a Monte Carlo method. The reduced scattering coefficients were measured within an uncertainty of approximately 4% and ranged from 0.3 to 1.5 mm^<-1>, which are typical values of biological tissues in the near-infrared wavelength range. The measured absorption coefficients of the phantoms were below 0.0034 mm^<-1>, which are satisfactorily small values., The Japan Society of Mechanical Engineers, 25 Mar. 1997, Transactions of the Japan Society of Mechanical Engineers. Series C., 63, 607, 889-894, Japanese, 0387-5024, 110002385016, AN00187463 - Optical Tomography by Using the Zooming Method in the Inversion Process
JONES Matthew R.; PROSKURIN Sergei G.; TANIKAWA Yukari; YAMADA Yukio
日本エム・イー学会, 10 Mar. 1997, Japanese journal of medical electronics and biological engineering, 35, 1, 55-63, Japanese, 0021-3292, 10009790925, AN00016981 - Simulation of Optical-CT Imaging for a Highly Scattering Body : 2nd Report, Fan-Beam Type
Yamada Yukio; Hasegawa Yasuo
Optical-CT (Computed Tomography) imaging of living bodies poses the difficulty caused by strong scattering of light by tissues. In our previous paper, time-resolved spectroscopy was shown to have potential for realization of optical-CT imaging. In this second paper, it is shown that utilization of the characteristics of strong scattering makes fan-beam-type optical-CT imaging possible. The Monte Carlo method is employed to simulate the strongly scattering and weakly absorbing media. Hybrid scattering calculation is proposed to simulate the highly forward-directed scattering to avoid unrealistic sharp peaks at the shortest time of flight observed when only isotropic scattering approximation is employed. The temporally extrapolated absorbance method is employed for the object and reference cylinder, as in the previous paper. Fan-beam-type optical-CT imaging is numerically shown to be capable of reconstructing an image of the difference in the absorption coefficient with satisfactory accuracy and spatial resolution., The Japan Society of Mechanical Engineers, May 1993, Transactions of the Japan Society of Mechanical Engineers. Series B., 59, 561, p1766-1769, Japanese, 0387-5016, 110002392032, AN00187441 - Simulation of Optical Tomography
YAMADA Yukio
工業技術院機械技術研究所, Sep. 1991, Journal of Mechanical Engineering Laboratory, 45, 5, p219-224, Japanese, 0388-4252, 40000578766, AN00048977 - Simulation of Optical-CT Imaging for a Highly Scattering Body
YAMADA Yukio; HASEGAWA Yasuo
Computed tomography (CT) essentially assumes that rays such as X-rays propagate straight within the body ; therefore, it is difficult to apply this assumption to bodies which scatter the incident rays. Since the living tissues are very strong light-scattering media, realization of optical-CT scanners is not considered easy, although it is highly desired because of its possible ability to measure the oxygenation states in the body with a noninvasive method. This report shows how optical-CT imaging is possible by the use of time-resolved spectroscopy. The object is a cylindrical scattering medium containing a coaxial small cylinder with both scattering and absorption, while the reference is only the scattering cylinder. The light transmission data are generated by the Monte Carlo method. The temporal variations of the difference in the optical density between the object and reference provide the projection data necessary for the CT reconstruction procedure. The obtained image reflects the profile of the difference in the absorption coefficient between the object and the reference with satisfactory accuracy and spacial resolution., The Japan Society of Mechanical Engineers, Aug. 1991, Transactions of the Japan Society of Mechanical Engineers. Series B., 57, 540, p2822-2825, Japanese, 0387-5016, 110002402429, AN00187441 - Research and Development of Ceramic Gas Turbines
YAMADA Yukio
The Japan Society of Mechanical Engineers, Feb. 1990, Journal of the Japan Society of Mechanical Engineers, 93, 855, p129-135, Japanese, 0021-4728, 110002436754, AN00187394
Books and other publications
- “Oxygen Transport to Tissue XLV,” Advances in Experimental Medicine and Biology, Volume 1463
Editors; Kaoru Sakatani; Kazuto Masamoto; Yukio Yamada; Felix Scholkmann; Joseph C. LaManna
Springer, Oct. 2024, 9783031674570 - For Making More Accurate Measurements in fNIRS (functional Near-Infrared Spectroscopy)
Yukio Yamada
Others, Japanese, Joint work, Japan Optical functional Brain Imaging Society, Mar. 2017, Booklet for beginners in functional near-infrared spectroscopy to investigate brain functions. - 医用画像解析ハンドブック
山田幸生
Scholarly book, Japanese, Contributor, 4.6.1 近赤外光, オーム社, Nov. 2012 - 医用画像工学ハンドブック
山田幸生
Scholarly book, Japanese, Contributor, Part I 第２章 ６．４拡散光イメージング, 日本医用画像工学会, Sep. 2012 - シミュレーション辞典
山田幸生; 大川晋平
Japanese, Joint work, 蛍光トモグラフィー, コロナ社, Feb. 2012 - NIRS---基礎と臨床
山田幸生
Japanese, Joint work, 第I章A-5 拡散光トモグラフィー, 新興医学出版社, Jan. 2012 - 伝熱工学資料 改訂第５版
山田幸生
Japanese, Joint work, ６・５・５ 生体のふく射, 日本機械学会, May 2009 - 機械工学便覧
山田幸生
Japanese, Joint work, 応用システム編 γ9 医療・福祉・バイオ機器，「4・11 その他の映像検査装置 4・11・1 CT」, 日本機械学会, Aug. 2008 - Noninvasive and Visualizing Technologies
Yukio Yamada
Japanese, Joint work, 第３章第１節３．多重散乱系での光伝播に関する光学特性値と基礎方程式，第３章第３節３.２光拡散方程式に基づく拡散光トモグラフィ，第３章第４節３．小動物の蛍光イメージングおよび生物発光イメージング, （株）エヌ・ティー・エス, Jun. 2007 - 糖尿病学の進歩（第41集）
M. Tamura; K. Maruo; Y. Yamada
Japanese, Joint work, 非観血的血糖計測装置, （株）診断と治療社, Mar. 2007 - エレクトロニクス分野における熱制御，放熱・冷却技術
石塚勝; 渡辺聡志監修
Japanese, Joint work, 第4章第5節［１］低温やけどのメカニズム, 技術情報協会, Oct. 2006 - レーザーハンドブック第２版
山田幸生
Japanese, Joint work, IX編バイオフォトニクス，38章臨床診断，３８・２ 拡散光トモグラフィ, オーム社, Apr. 2005 - 表面・界面工学大系
Naoto Kakuta; Yukio Yamada
Japanese, Joint work, 上巻基礎編 第20章第6節「温度の測定」, フジテクノシステム, Mar. 2005 - 大森豊明監修，「生体物理刺激と生体反応」の分担執筆：第１編第11章「熱」，pp. 158-166，第２編第11章「熱による生体への影響」，pp. 323-330，第３編第13章「熱の医療応用」pp. 547-555
山田幸生
Japanese, Joint work, 第１編第11章「熱」，第２編第11章「熱による生体への影響」，第３編第13章「熱の医療応用」, フジテクノシステム, Jan. 2004 - 先端放射医療技術と計測（電気学会放射波の医療応用と計測技術調査専門委員会編）中，7.1節「近赤外光による計測とイメージング」
山田幸生
Japanese, Joint work, コロナ社，2001年11月15日, Nov. 2001 - 光による医学診断（田村 守編著）中，1-1節「光と生体---生体分光学への招待」）
山田幸生
Japanese, Joint work, 共立出版，平成13年3月30日, Mar. 2001 - 田村 守編著，「光による医学診断」，山田幸生分担執筆：１-１節「光と生体---生体分光学への招待」
山田幸生
Japanese, Joint work, 共立出版, Mar. 2001 - メディカルエンジニアリング（立石哲也編著）中，2-3節「光による生体診断」，3-2節「レーザ治療」
山田幸生
Japanese, Joint work, 米田出版，2000年4月５日, Apr. 2000 - からだと熱と流れの科学（山田幸生編著）中，「はじめに」，3章「身体の中の良い熱・悪い熱」，6章「レーザの光と熱を用いる診断・医療技術」
山田幸生
Japanese, Editor, オーム社，1998年10月30日, Oct. 1998
Lectures, oral presentations, etc.
- 近赤外光による生体センシング--パルスオキシメータから拡散光トモグラフィまで--
山田幸生
Invited oral presentation, Japanese, 第24回 酸素ダイナミクス研究会, Invited, Domestic conference
10 Oct. 2020 - 分光学的視点から見た非侵襲血糖測定技術
丸尾勝彦; 山田幸生
Others, Japanese, 日本学術振興会第185委員会2019年度第1回研究会, 日本学術振興会第185委員会, 東京都千代田区, Domestic conference
17 Jun. 2019 - Numerical treatment of highly forward-directed scattering on radiative transfer using the delta-m approximation and galerkin quadrature method
Hiroyuki Fujii; Go Chiba; Yukio Yamada; Yoko Hoshi; Kazumichi Kobayashi; Masao Watanabe
Oral presentation, English, The 9th International Symposium on Radiative Transfer (RAD-19), ICHMT, Athens, Greece, International conference
03 Jun. 2019 - 近赤外分光による非侵襲血糖測定‐分光学的視点から見た非侵襲血糖測定技術‐
丸尾勝彦; 山田幸生
Invited oral presentation, Japanese, 2019年度日本分光学会年次講演会, Invited, 日本分光学会, 京都府宇治市, Domestic conference
14 May 2019 - 蛍光食品を利用した誤嚥検査法および水の近赤外光吸収スペクトルを利用した温度・濃度変化のイメージング
山田幸生
Others, Japanese, 日本学術振興会第185委員会2018年度第3回研究会, Invited, 日本学術振興会第185委員会, 東京都千代田区, Domestic conference
28 Feb. 2019 - Near-infrared spectroscopic method for noninvasive blood glucose prediction without using multivariate analyses
K. Maruo; Y. Yamada
Poster presentation, English, 78th Scientific Sessions of American Diabetes Association, American Diabetes Association, Orlando, Florida, USA, International conference
22 Jun. 2018 - Aspiration Risk Detection Using Oral Administration of Fluorescent Food --- Preliminary Experiments Using Meat Phantoms ---
Takahiro SUZUKI; Ryohei SAITO; Nobuo KITADA; Takuji KOIKE; Shojiro MAKI; Yukihiro MICHIWAKI; Goro NISHIMURA; Haruki NIWA; Yukio YAMADA
Oral presentation, English, 2017 IEEE International Conference on Cyborg and Bionic Systems (CBS 2017), IEEE, Beijing, China, International conference
17 Oct. 2017 - Recent Progresses of DOT and Blood Glucose Measurement
Yukio Yamada
Public discourse, English, Special talk at College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Invited, College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, China, International conference
30 May 2017 - Non-invasive near-infrared blood glucose measurement: two new approaches
Yukio Yamada
Nominated symposium, English, Samsung Future Tech Forum, Invited, Samsung Future Technology Research Center, Suwan, Korea, International conference
25 Oct. 2016 - 生体内光伝播と生体内熱移動 ― 光温熱療法に向けて ―
山田幸生
Public discourse, Japanese, 第47回BASIC（分野横断型医工学研究プラットフォーム）講演会, Invited, ASIC（分野横断型医工学研究プラットフォーム）, 東京, Domestic conference
24 Aug. 2016 - Numerical modeling of photon migration in the cerebral cortex of the living rat using the radiative transport equation
Hiroyuki Fujii; Shinpei Okawa; Ken Nadamoto; Eiji Okada; Yukio Yamada; Yoko Hoshi; Masao Watanabe
Oral presentation, English, SPIE BiOS 2015, SPIE, San Francisco, USA, International conference
07 Feb. 2015 - 生体光イメージングのためのヒト頸部内光伝播モデルの構築
藤井宏之; 大川晋平; 灘本健; 岡田英史; 山田幸生; 星詳子; 渡部正夫
Oral presentation, Japanese, 日本機械学会第27回バイオエンジニアリング講演会, 日本機械学会, 新潟市, Domestic conference
09 Jan. 2015 - 近赤外吸収イメージング法を応用したマイクロ流路内の酸塩基中和反応の可視化
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
Oral presentation, Japanese, 第30回近赤外フォーラム, 近赤外分光研究会, つくば市, Domestic conference
27 Nov. 2014 - Numerical modeling of photon migration in human thyroid based on the radiative transport equation
H. Fujii; S. Okawa; K. Nadamoto; E. Okada; Y. Yamada; Y. Hoshi; M. Watanabe
Public symposium, English, The 3rd International Conference on Complex Dynamical Systems & Their Applications, Ankara, Turkey, International conference
24 Nov. 2014 - 生体医用光学の発展と産学連携および将来
山田幸生
Public discourse, Japanese, 第６回 BioOpto Japanカンファレンス, Invited, BioOpto Japan, 横浜市, Domestic conference
15 Oct. 2014 - 時間分解スペクトロスコピー（TRS）の基礎
山田幸生
Public discourse, Japanese, 次世代NIRS「時間分解スペクトロスコピー（TRS）」セミナー, Invited, 日本大学工学部 次世代工学技術研究センター, 福島県郡山市, Domestic conference
28 Sep. 2014 - 近赤外吸収イメージング法を応用した高周波磁場下における磁性微小球周りの水の温度分布推定
山田健太; 角田直人; 藤岡良太; 近藤克哉; 有本英伸; 山田幸生
Oral presentation, Japanese, 第５1回日本伝熱シンポジウム, 日本伝熱学会, 浜松市, Domestic conference
21 May 2014 - 近赤外域の２波長を用いたマイクロ流路内の酸・アルカリ水溶液混合場の濃度イメージング
川嶋大介; 角田直人; 近藤克哉; 有本英伸; 山田幸生
Oral presentation, Japanese, 第５1回日本伝熱シンポジウム, 日本伝熱学会, 浜松市, Domestic conference
21 May 2014 - 近赤外分光法と拡散光トモグラフィー・蛍光トモグラフィー
山田幸生
Nominated symposium, Japanese, 京都大学数理解析研究所研究集会「偏微分方程式に対する逆問題の数学解析と数値解析」, Invited, 京都大学数理解析研究所, 京都市, Domestic conference
16 Jul. 2013 - 近赤外光法と拡散光トモグラフィー・蛍光トモグラフィー
山田幸生
Nominated symposium, Japanese, 自然科学研究機構 画像逆問題の数理解析研究会 第二回研究会, Invited, 自然科学研究機構, 東京都千代田区, Domestic conference
21 Dec. 2012 - 近赤外分光法による生体計測とイメージング・医学応用
山田幸生
Nominated symposium, Japanese, 放射線医学総合研究所セミナー, Invited, 放射線医学総合研究所, 千葉市, Domestic conference
18 Sep. 2012 - 近赤外光を用いた生体計測技術の新展開
山田幸生
Public symposium, Japanese, 東北大学GCOEプログラム「流動ダイナミクスと医療の融合」ワークショップ, 東北大学
Feb. 2011 - 生体熱工学と低温熱傷について
山田幸生
Invited oral presentation, Japanese, 病院環境設備研究会講演会, 病院環境設備研究会
Dec. 2010 - 拡散光トモグラフィーとその展開について
山田幸生; 大川晋平
Invited oral presentation, Japanese, 日本光学会 光設計研究グループ第45回研究会「生体イメージングの新しい展開」, 日本光学会
Nov. 2010 - 拡散光トモグラフィーおよび蛍光トモグラフィーによる生体情報の断層画像化について
山田幸生
Invited oral presentation, Japanese, 第14回酸素ダイナミクス研究会, 酸素ダイナミクス研究会
Sep. 2010 - 時間分解計測と拡散方程式を用いた拡散光トモグラフィーの現状
山田幸生
Invited oral presentation, Japanese, 研究集会「偏微分方程式の逆問題解析とその周辺分野に関する研究」, 京都大学数理解析研究所
Jun. 2010 - 大学が育成を目指す伝熱人材像
山田幸生
Others, Japanese, 第47回日本伝熱シンポジウム 産学連携フォーラム, 社）日本伝熱学会
May 2010 - Some topics in biomedical optics --- Toward collaboration between China and Japan
Y. Yamada
Others, English, Seminar at College of Precision Instrument and Optoelectronics Engineering, Tianjin University
Apr. 2010 - 拡散光を用いた生体医用光学
山田幸生
Others, Japanese, 第10回連携創造本部先端研究推進部門『ナノ・フォトニクス技術セミナー』, 神戸大学
Jan. 2010 - 蛍光トモグラフィーにおける画像化技術
山田幸生
Others, Japanese, 大学知財群活用セミナー, 経済産業省 関東経済産業局
Jan. 2010 - Diffuse Light Spectroscopy and Imaging for Biomedical Engineering
Y. Yamada
Invited oral presentation, English, Workshop on Information, Nano and Photonics Technology 2009, Kobe University, Kobe, Japan, International conference
Dec. 2009 - Optical brain imaging in infants by use of near-infrared diffuse optical tomography
T. Kusaka; S. Okawa; M. Ueno; R. Fukuzawa; T. Nishida; K. Isobe; Y. Tanikawa; F. Gao; C. Sato; Y. Hoshi; Y. Yamada
Oral presentation, English, Abstract Book of The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008)
Aug. 2008 - Physical fundamentals of optical mapping and diffuse optical tomography using NIRS
Yukio Yamada
Invited oral presentation, English, The 36th Annual Conference of International Society of Oxygen Transport to Tissue (ISOTT2008), International Society of Oxygen Transport to Tissue, Sapporo, Japan, International conference
Aug. 2008 - 光脳機能イメージングの原理
山田幸生
Invited oral presentation, Japanese, 第９回日本光脳機能イメージング研究会, 日本光脳機能イメージング研究会
Jul. 2008 - “医療及び健康・福祉分野を支える光技術と将来展望に関する調査研究報告書”，「第II章 第５節 拡散光トモグラフィー」，「第IV章 第１節 血糖値センサー（１）」
山田幸生
Others, Japanese, 医療及び健康・福祉分野を支える光技術と将来展望に関する調査研究委員会，（社）日本オプトメカトロニクス協会,医療及び健康・福祉分野を支える光技術と将来展望に関する調査研究委員会報告
Mar. 2008 - New methodology of optical blood glucose monitoring based on simulation of light propagation in the skin
Yukio Yamada; Katsuhiko Maruo; Hidenobu Arimoto; Mamoru Tamura; Yukihiro Ozaki
Invited oral presentation, English, Optical Imaging 2006 at NIH --- Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at the National Institutes of Health ---, NIH (National Institute of Health), Bethesda, Maryland, USA, International conference
Sep. 2007 - 文部科学省科学技術・学術審議会資源調査分科会報告“光資源を活用し，創造する科学技術の振興～持続可能な「光の世紀」に向けて～，「第３章３．光を用いた非侵襲生体診断」
山田幸生
Others, Japanese, 文部科学省科学技術・学術審議会資源調査分科会,文部科学省科学技術・学術審議会資源調査分科会報告書
Sep. 2007 - 皮膚などの光散乱体中の光伝搬シミュレーション
山田幸生
Invited oral presentation, Japanese, 第22回近赤外フォーラム, 近赤外研究会
Nov. 2006 - New methodology of optical blood glucose monitoring based on simulation of light propagation in the skin
Yukio Yamada; Katsuhiko Maruo; Hidenobu Arimoto; Mamoru Tamura; Yukihiro Ozaki
Invited oral presentation, English, Optical Imaging 2006 at NIH --- Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside, National Institutes of Health, USA, Bethesda, USA, International conference
Sep. 2006 - 近赤外光を用いた生体計測とイメージング
山田幸生
Oral presentation, Japanese, 日本機械学会,熱工学コンファレンス2005
Nov. 2005 - 近赤外光を用いた生体計測とイメージング
山田幸生
Oral presentation, Japanese, 日本機械学会,熱工学コンファレンス2005, 日本機械学会, Domestic conference
Nov. 2005 - 分光技術による眼底の機能情報イメージングと課題
山田幸生
Oral presentation, Japanese, NEDOワークショップ「人体の“窓”，眼底から体内を見る（診る）」
Apr. 2005 - バイオエンジニアリングにおける熱工学の現状と将来
山田幸生
Oral presentation, Japanese, 日本機械学会,2004日本機械学会年次大会
Sep. 2004 - PHOTON MIGRATION IN BIOLOGICAL TISSUES AND DIFFUSE OPTICAL IMAGING
Yukio Yamada
Invited oral presentation, English, Saratov Fall Meeting SFM’04, Saratov, Russia, International conference
Sep. 2004 - 生体医用光学の最近の動向
山田幸生
Oral presentation, Japanese, 社）日本オプトメカトロニクス協会,光センシング技術部会
Jul. 2004 - Photon migration in tissues, diffuse optical imaging and their applications to biomedicine
Y. Yamada; F. Gao; H. Zhao; Y. Tanikawa; K. Homma
Invited oral presentation, English, ICO’04 (2004 ICO International Conference Optics & Photonics in Technology Frontier, Chiba, Japan, International conference
Jul. 2004 - 時間分解法による拡散光断層イメージングの現状と展望
山田幸生
Oral presentation, Japanese, 第１回光脳機能イメージング研究会
Mar. 2004 - 拡散光トモグラフィとその可能性
山田幸生; 高 峰; 趙 会娟; 谷川ゆかり; 本間一弘
Oral presentation, Japanese, レーザー学会,レーザー学会学術講演会第24回年次大会
Jan. 2004 - 拡散光トモグラフィとその可能性
山田幸生; 高 峰; 趙 会娟; 谷川ゆかり; 本間一弘
Invited oral presentation, Japanese, レーザー学会学術講演会第24回年次大会, レーザー学会
Jan. 2004 - Photon migration in biological tissue and application to diffuse optical tomography
Y. Yamada
Invited oral presentation, English, The 5th Pacific Rim Conference on Lasers and Electro-Optics, Taipei, Taiwan, International conference
Dec. 2003 - 生体内熱輸送および光伝播とイメージング
山田幸生
Oral presentation, Japanese, 日本機械学会,日本機械学会熱工学部門特別企画「熱工学の新領域に関するセミナー」
Nov. 2003 - Optical transport process in turbid media and applications to optical imaging of tissues
Y. Yamada
Invited oral presentation, English, XI Conference on Laser Optics, Pertersburg, Russia, International conference
Jun. 2003 - NIRSイメージング：トモグラフィによる定量化の実現
山田幸生; 高 峰; 趙 会娟; 谷川ゆかり
Oral presentation, Japanese, ヒト脳機能マッピング学会,第５回ヒト脳機能マッピング学会大会, 第５回ヒト脳機能マッピング学会大会
Mar. 2003 - NIRSイメージング：トモグラフィによる定量化の実現
山田幸生; 高 峰; 趙 会娟; 谷川ゆかり
Oral presentation, Japanese, ヒト脳機能マッピング学会,第５回ヒト脳機能マッピング学会大会
Mar. 2003 - LIGHT PROPAGATION IN BIOLOGICAL TISSUES AND OPTICAL DIAGNOSTICS BY IMAGING AND SPECTROSCOPY
Yukio Yamada
Invited oral presentation, English, ICBME 2002 (International Congress on Biological and Medical Engineering 2002), Invited, ICBME 2002 (International Congress on Biological and Medical Engineering 2002), International conference
Dec. 2002 - LIGHT PROPAGATION IN BIOLOGICAL TISSUES AND OPTICAL DIAGNOSTICS BY IMAGING AND SPECTROSCOPY
Yukio Yamada
Invited oral presentation, English, ICBME 2002 (International Congress on Biological and Medical Engineering 2002), International conference
Dec. 2002 - Optical imaging using time-resolved measurements
Y. Yamada; F. Gao; H. Zhao; Y. Tanikawa; Y. Onodera; A. Sassaroli
Invited oral presentation, English, PIERS (Progress In Electromagnetics Research Symposium) 2002, PIERS (Progress In Electromagnetics Research Symposium), International conference
Jul. 2002 - Optical Topography --- Visualization of Brain Activation by Near-Infrared Spectroscopy
T. Yamamoto; A. Maki; Y. Tanikawa; M. Kiguchi; E. Okada; Y. Yamada; H. Koizumi
Invited oral presentation, English, PIERS (Progress In Electromagnetics Research Symposium) 2002, PIERS (Progress In Electromagnetics Research Symposium), International conference
Jul. 2002 - Biomedical optical imaging by a time-resolved multichannel system
Y. Yamada
Invited oral presentation, English, Joint Symposium on Bio-Sensing and Bio-Imaging, Joint Symposium on Bio-Sensing and Bio-Imaging, Yamagata, Japan, International conference
02 Aug. 2001 - Photon migration in biological tissues, their optical properties and imaging
Y. Yamada; A. Sassaroli; F. Martelli; F. Gao; H. Zhao; Y. Onodera; Y. Tanikawa; K. Tanaka; R. Araki
Invited oral presentation, English, CLEO/Pacific Rim 2001, Special Session: Spectroscopy and Imaging for Brain and Characterization of Tissues, CLEO/Pacific Rim 2001, Chiba, Japan, International conference
15 Jul. 2001 - Photon migration in biological tissues, their optical properties and imaging
Y. Yamada; A. Sassaroli; F. Martelli; F. Gao; H. Zhao; Y. Onodera; Y. Tanikawa; K. Tanaka; R. Araki
Invited oral presentation, English, Technical Digest of CLEO/Pacific Rim 2001, Special Session: Spectroscopy and Imaging for Brain and Characterization of Tissues, Chiba, Japan, 15-19 July, 2001, International conference
Jul. 2001 - Measurement of optical properties of brain in vivo
Y. Yamada; A. Sassaroli; Y. Tanikawa; F. Martelli; R. Arakai; K. Tanaka
Invited oral presentation, English, Pacifichem 2000, Symposium No. 75, Frontiers of Spectroscopic Analysis of the Brain, Pacifichem 2000, Honolulu, USA, International conference
14 Dec. 2000 - Performance of a Multi-Channel Time-Resolved Optical Tomographic Imaging System and Tomographic Images
Y. Yamada; M Tamura; H. Eda; I. Oda; Y. Ito; Y. Wada; Y. Oikawa; Y. Tsunazawa; M. Takada; Y. Tsuchiya; Y. Yamashita; M. Oda; A. Sassaroli
Invited oral presentation, English, Proceedings of Inter-Institute Workshop on In Vivo Optical Imaging at the NIH (National Institutes of Health), Ed. A. H. Gandjbakhche, OSA, International conference
2000 - Performance of a Multi-Channel Time-Resolved Optical Tomographic Imaging System and Tomographic Images
Y. Yamada; M Tamura; H. Eda; I. Oda; Y. Ito; Y. Wada; Y. Oikawa; Y. Tsunazawa; M. Takada; Y. Tsuchiya; Y. Yamashita; M. Oda; A. Sassaroli
Invited oral presentation, English, Inter-Institute Workshop on In Vivo Optical Imaging at the NIH, National Institutes of Health, Bethesda, Maryland, USA, International conference
16 Sep. 1999 - Performance of a Multi-Channel Time-Resolved Optical Tomographic Imaging System and Tomographic Images
Y. Yamada
Oral presentation, English, Inter-Institute Workshop on In Vivo Optical Imaging at the NIH (National Institutes of Health), Bethesda, Maryland, USA, (Sep. 16-17, 1999)
Sep. 1999
Affiliated academic society
Research Themes
- 蛍光食品を用いた非侵襲誤嚥検査法の研究開発
山田幸生
01 Jul. 2018 - 31 Mar. 2021 - Quantitative evaluation of reaction-diffusion front by near-infrared-based simultaneous imaging of temperature and concentration
Kakuta Naoto; YAMADA Yukio
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Tokyo Metropolitan University, Grant-in-Aid for Scientific Research (B), Reaction-diffusion phenomena of aqueous solutions in microfluidic channels were visualized by using a near-infrared-based technique for simultaneous imaging of temperature and concentration. Variations in concentration distributions at the interface between two aqueous solutions were used to determine the diffusion coefficient and its temperature dependence of each solution. Regarding aqueous solutions of acid and alkali, the concentration distributions of reactive substances and salt generated by neutralization were simultaneously obtained. Furthermore, the effects of chemical reaction and diffusion on the instability of the interface, especially on the onset time of convection, were investigated. The results obtained in this study indicate the utility of the imaging technique and the feasibility of quantitative analysis of reaction-diffusion fronts., 26289049
01 Apr. 2014 - 31 Mar. 2017 - 数値解析・応用数学的アプローチによる高解像光トモグラフィ実現のための基礎研究
磯 祐介
01 Apr. 2013 - 31 Mar. 2016 - Measurement of exothermic reactions in micro-chemical chips by the near-infrared temperature imaging method
KAKUTA Naoto; ARIMOTO Hidenobu; KONDO Katsuya; YAMADA Yukio
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), A simultaneous imaging system of the temperature and concentration of aqueous solutions in microchannels was developed. The principle of this method is based on the temperature dependence of near-infrared absorption spectrum of water. The system acquires absorbance images at the temperature sensitive wavelength (1412 nm or 1905 nm) and at the isosbestic point (1442 nm or 1935 nm) alternately with 100 frames/s for each wavelength. The absorbance images of ethanol aqueous solutions with several conditions of temperature and concentration in the microchannels were obtained, and using these images at the two wavelengths, temperature and concentration images were constructed, which indicated the validity of the method. In the neutralization experiments, the concentration changes of the acid and base solutions by the reaction were successfully shown., 23360102
01 Apr. 2011 - 31 Mar. 2014 - Breast Cancer Diagnosis by Optical Imaging with Inverse Problem of Source Estimation
OKAWA Shinpei; YAMADA Yukio
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, The University of Electro-Communications, Grant-in-Aid for Young Scientists (B), The algorithms to solve the inverse problems in the optical imaging using near-infrared light for diagnoses of breast cancer were studied. The technique for reconstructing fluorescent light sources in biological media by use of spatial filter was proposed. The method to reduce noise in the time-resolved measurement data using maximum a priori estimation was also developed. The proposed methods were validated with the numerical simulations and the phantom experiments. Efficient arrangement of the light sources and detectors for diffuse optical tomography was also investigated., 21760312
2009 - 2010 - 針型マイクロプローブへのDLCコーティング技術の開発とその応用
奥山 直樹; 角田 直人; 山田 幸生
日本学術振興会, 科学研究費助成事業, 電気通信大学, 萌芽研究, 高周波プラズマCVD装置をベースとした、針型マイクロプローブへのDLC成膜装置の改良と、高電圧パルス成膜法の有効性を検討した。昨年度までに開発した成膜装置は、成膜対象の針型プローブ(先鋭部径1μm、直径1mm、高さ50mm)自体をカソード電極とし、このカソード電極を中心に、ステンレスメッシュ製の円筒形電極(直径40mm、高さ50mm)をアノード電極(グランド)とした電極構造を有する。アノード内のプローブ周囲に比較的均一なプラズマの発生が可能であったが、特に先端部のDLC膜が変質する場合が観察されたため、印加電圧の制御方法について改良を実施した。具体的には、先端部は過度なイオン衝突による温度上昇が発生しやすいため、放電・冷却サイクルのパラメータを変更し、膜質との関係を検証した。絶縁破壊電圧が-400V、放電維持電圧が-120V、放電時間が5s以下、冷却時間が45s以上で膜の剥離や変性がほとんど起きないことを確かめた。本年度後半からは、さらなる膜厚化と多数プローブの同時成膜を目的として、3極構造とした高電圧パルス成膜を実施した。平行平板間でプラズマを発生させ(バイアス電圧-350V)、プラズマ中に第3の電極となるプローブを挿入し、これに高電圧パルス(-800V;10μs,100Hz)を付加した。安定した成膜が可能であり、1hの成膜時間で1μm以上の膜厚がプローブ全体で得られた。堆積した膜は水素を多く含有する重合膜に近いものであったが、高電圧パルスのパラメータを変更することで膜質の変更が可能であり、用途に応じた成膜を多数本のプローブに対して行える基盤技術を提供できたといえる。, 16651078
2004 - 2005 - Development of Micro Robot for Nano Operation into Bio Cell
AOYAMA Hisayuki; YAMADA Yukio; IWATA Futoshi
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, The University of Eelctro-Communications, Grant-in-Aid for Scientific Research (B), In this research, it is the final goal to develop the micro robot with nano positioning resolution for injecting such micro glass pipette into the bio cell in order to operate the material. In the next step, it will be considered that the micro flow of such protein in the bio cell can be monitored and the micro robot with micro probe can make the nano manipulation for micro chemical reaction. In this project, the results as mentioned below were achieved ; (1)Micro robot with nano manipulation : The newly developed micro robot is composed of the piezo and electro magnet for providing nano stepping motion. And the micro tool also can be controlled to the specified potision with the accuracy of nano level. And the bio cell can be converyed and rotated around the vibrated pipette alon the micro flow. (2)Micro thermal sensng by the micro pipette coated the metal. In order to measure the temperature at the local area of bio cell, the micro pipette that is coated by the special metal such Ni and Cu to generate the micro voltage. (3)Nano machining by SPM It was succeeded that the special thin SPM probe was developed for making femt level of machining with the help of electrical field effect between the tip and the sample. As the results of experiment, it succeeded in providing nano metal on the small target tip., 15360134
2003 - 2005 - 生命系のホメオスタシスを構築するトランスファロームのシステム生物学
谷下 一夫; 山田 幸生; 石黒 博; 高松 洋; 白樫 了; 小林 弘祐
日本学術振興会, 科学研究費助成事業, 慶應義塾大学, 基盤研究(C), 生命システムは、呼吸循環系と代謝系を中心に、熱と物質の移動を極めて精密かつ緻密に制御し、深部温度を一定に保つことができ、さらに広範囲な分子量にわたる物質の移動を制御することによって、エネルギ代謝を行い、生命活動の原動力になっている。従って、生命システムは熱と物質移動の宝庫とも言うべきものであるが、従来は局所的な熱と物質移動の取り扱いがされているだけで、生命システム全体で、熱と物質移動現象が、生命システムの動的恒常性であるホメオスタシスを実現しているかが不明であった。生命システムの熱と物質移動現象は、生命活動に直接関わっているため、生命システム全体の熱と物質移動が明らかになることによって、医学における診断・治療や薬物輸送の薬理効果が明らかになり、革新的な医学が出現する可能性がある。生命システムにおける熱と物質移動の総体を、ここでトランスファロームと名づけ、これまでのシステム生物学では重点的に取り上げられていなかった熱と物質移動のダイナミクスをトランスファロームで明らかにすることを目標としている。そこで、まず本企画調査では、生命システムにおける熱と物質移動現象に関して、移動現象論、医学生物学および薬理学の立場から調査・討論を行い、トランスファロームのシステム生物学を確立するための研究計画をたてた。具体的には、5回の研究会(シンポジウムを2回)、幹事会を2回開催し、研究計画の独自性、ニーズ、特徴、社会への波及効果などを中心に議論を行った。その結果、十分に特定研究のテーマとして相応しいという結論に達し、今後特定研究の具体的な申請の手続きを行うこととした。, 16636004
2004 - 2004
Industrial Property Rights
- 検出装置、検出方法、及び検出器
Patent right, 山田幸生, 西村吾朗, 丹羽治樹, 牧昌次郎, 道脇幸博, 小池卓二, 鈴木祟弘, 田代剛大, 特願2019-132298, Date applied: 17 Jul. 2019, The University of Electro-Communications - 光断層像の生成法
Patent right, 山田幸生, 大川晋平, 山本拓明, 2009-020330, Date applied: 30 Nov. 2009, （株）富士フィルム, 特開2010-1754, Date announced: 30 Jan. 2010, 第5283525号, Date issued: 07 Jun. 2013 - 計測対象保持具，生体保持具及び光計測装置
Patent right, 山田幸生, 清水仁, 木村壮士, 特願2009-020331, Date applied: 30 Nov. 2009, （株）富士フィルム, 特開2010-197381, Date announced: 09 Sep. 2010, 第5274492号, Date issued: 24 May 2013 - マイクロ化学チップ装置
Patent right, 山田幸生, 角田直人, 廣野泰亮, 2006-142214, Date applied: 23 May 2006, 特開2007-315753, Date announced: 06 Dec. 2007, 第4915690号, Date issued: 03 Feb. 2012 - 光学的成分測定方法および装置
Patent right, 垂水正敏, 山田幸生, 特願2001-167339号, 特願2001-228507号, Date applied: 27 Jul. 2001, （株）日機装，（独）産業技術総合研究所, 特開2003-50200号, Date announced: 21 Feb. 2003, 第4633302号, Date issued: 26 Nov. 2010 - 流量測定方法およびそれに用いる測定装置
Patent right, 山田幸生, 桃木秀幸, 角田直人, 2003-042619, 2004-043386, Date applied: 19 Feb. 2004, （株）キャンパスクリエイト, 2004-271523, Date announced: 30 Sep. 2004, 第4565233号, Date issued: 13 Aug. 2010 - 光プローブ，これを用いた計測システム，および，これを用いた反射光検出方法
Patent right, 山田幸生, 角田直人, 青木一男, 木村利久, 2003-118301, 2004-128918, Date applied: 23 Apr. 2004, （株）オータックス，（株）キャンパスクリエイト, 2004-337605, Date announced: 02 Dec. 2004, 第4551998号, Date issued: 23 Jul. 2010 - 粒子計測装置、及び粒径計測装置
Patent right, 山田幸生, 大川晋平, 廣野泰亮, 12/595,348, The University of Electro-Communications, US2010/0110177A1, Date announced: 06 May 2010 - 流量測定装置及び流量測定方法
Patent right, 濱崎英司, 山田幸生, 大川晋平, 正本和人, 白石 和, 2010-81438, Date applied: 31 Mar. 2010, The University of Electro-Communications - マイクロ化学チップ装置
Patent right, 廣野泰亮, 山田幸生, 大川晋平, 2008-197679, Date applied: 31 Jul. 2008, The University of Electro-Communications, 2010-32472, Date announced: 12 Feb. 2010 - 計測対象保持具
Patent right, 山田幸生, 清水仁, 2009-020331, Date applied: 30 Nov. 2009, 電気通信大学，（株）富士フィルム - 光学的血糖値測定用ピックアップ
Patent right, 丸尾勝彦, 鶴来充啓, 中川武大, 山田幸生, 2003-313164, Date applied: 04 Sep. 2003, （株）パナソニック電工, 第4363130号, Date issued: 28 Aug. 2009 - MICRO CHIP DEVICE
Patent right, Yukio Yamada, Naoto Kakuta, Taisuke Hirono, 11/751,793, Date applied: 22 May 2007, US 2008/0056953 A1, Date announced: 06 Mar. 2008, US 7,553,454 B2, Date issued: 30 Jun. 2009 - 血小板凝集反応評価方法，及び血小板凝集反応評価装置
Patent right, 山田幸生, 大川晋平, 廣野泰亮, 2008-090211, Date applied: 31 Mar. 2008, The University of Electro-Communications, 2009-244053 - 光学的散乱特性推定装置およびその作動方法
Patent right, 垂水正敏, 山田幸生, 有本英伸, 2002-302287, Date applied: 16 Oct. 2002, 日機装，産業技術総合研究所, 2004-138454, Date announced: 13 May 2004, 第3902999号, Date issued: 12 Jan. 2007 - 樹脂製マイクロ流体チップの溶着方法
Patent right, 黒﨑晏夫, 山田幸生, 大川晋平, 清水直紀, 2006-312841, Date applied: 20 Nov. 2006 - 目的物質の塗布方法，及びマイクロ化学チップ
Patent right, 山田幸生, 角田直人, 廣野泰亮, 2006-142215, Date applied: 23 May 2006 - 非接触温度測定装置
Patent right, 山田幸生, 角田直人, 李 富国, 2005-243214, Date applied: 24 Aug. 2005 - マイクロプローブ並びにその製造装置及び方法
Patent right, 角田直人, 奥山直樹, 渡邊まゆ, 山田幸生, 2005-041142, Date applied: 17 Feb. 2005 - 温度測定方法およびそれに用いる測定装置
Patent right, 山田幸生, 桃木秀幸, 角田直人, 2003-042620, Date applied: 20 Feb. 2003, 2004-251766, Date announced: 09 Sep. 2004 - Optical phantom of Living Body and Method for Producing It（生体の光学ファントム及びその製造法（日本の特許を米国でも取得））
Patent right, Yukio Yamada, Yukari Tanikawa, Shuichi Takhashi, Daigo Imai, 09/145227, Date applied: 01 Sep. 1998, 6083008, Date issued: 04 Jul. 2004 - 生体組織モニタリング用プローブ付きへら
Patent right, 山田幸生, 小野寺陽一, 酒谷 薫, 堀 智勝, 特願2000-71711, Date applied: 15 Mar. 2000, 3502902, Date issued: 19 Dec. 2003 - 散乱物体の光学定数決定法
Patent right, 山田幸生, 荒木隆一郎, 山下 豊, 平7-300464, Date applied: 26 Oct. 1995, 3401376, Date issued: 21 Feb. 2003 - 生体の光学ファントム作製法(注目発明選定：科学技術庁長官(2000年４月18日))
Patent right, 山田幸生, 谷川ゆかり, 鎮西清行, 高橋修一, 今井大吾, 平9-38513, Date applied: 06 Feb. 1997, 2857753, Date issued: 04 Dec. 1998 - 光ＣＴ装置(注目発明選定：科学技術庁長官(1993年４月12日))．
Patent right, 山田幸生, 長谷川裕夫, 平2-279942, Date applied: 18 Oct. 1991, 1841512, Date issued: 12 May 1994
