NIWA HARUKI

Emeritus Professor etc.Emeritus Professor
Center for Neuroscience and Biomedical EngineeringVisiting Professor
  • Profile:
    1970-1973：Isolation, structure determination, and bionsynthesis of daphniphyllum alkaloids of the plant Daphniphyllaseae.
    1973-1980：Synthesis and structure/activity relationship of prostaglandin analogs and leukotriene analogs.
    1980-1994：Isolation, structure determination, total synthesis, and mode of action of putaquiloside, the active principle for carcinigenicity and cattle Bracken posoning caused by edible plant "Bracken Fern (Warabi in Japanese)"
    1980-1994：Total Synthesis of neneurotoxic sesquiterpenoids (anisatin, neoanisatin, picrotoxinin, tutin, and coriamyrtin) of plant origin.
    1980-1994：Total Synthesis of pyrrolizidine alkaloids (senecionine, integgerimine, monocrotaline, yamataimine, retronecine, and otonecine) of the plant origin.
    1994-2013 ：Bioorganic stydies on the molecular bases and molecular mechanism of the bioluminescence of various organisms such as firefly, the limpet-like snail Latia neritoides, the jellyfish Aequorea aequorea (OWANKURAGE in Japanese), the sea firefly Vargula (Cypridina) hilgendorfii (UMIBOTARU in Japanese), the fungi Mycea chlorophos (YAKOUTAKE in Japanese), the sea fireworm Odontosyllis undecimdonta and O. phosphrea, and the seahare Plocamopherus imperials.
    2013-2014 :Appprication of Bioluminescence-based Bioimaging system for Brain Science inspired Life Support.
Researcher Information

Degree

  • 理学博士, 名古屋大学, Mar. 1979
  • Ph. D, Nagoya University

Research Keyword

  • Bioluminescence
  • Natural Products
  • Biological Organic Chemistry
  • 生物発光
  • 天然有機化合物
  • 生物有機化学

Field Of Study

  • Life sciences, Bioorganic chemistry
  • Nanotechnology/Materials, Biochemistry
  • Nanotechnology/Materials, Molecular biochemistry

Career

  • Apr. 2019 - Present
    The University of Electro-communications, Center of Neuroscinece and Biomedical Engineering, Visiting Professor
  • Apr. 2013 - Present
    The University of Electro-Communications, 名誉教授
  • Apr. 2013 - Mar. 2019
    The University of Electro-communications, Brain Science Inspired Life Support Research Center, Designated Professor of Bio-Organic Chemistry
  • Apr. 2010 - Mar. 2013
    The University of Electro-communications, Graduate School of Informatics and Engineering, Professor
  • Apr. 1994 - Mar. 2010
    The University of Electro-communications, Faculty of Electro-communications, Professor
  • Mar. 1984 - Mar. 1994
    Nagoya University, Faculty of Science, Associate Professor
  • Jun. 1980 - Mar. 1984
    Nagoya University, Faculty of Science, Assistant Professor
  • Apr. 1973 - Jun. 1980
    Ono Pharmaceutical Co. Ltd., Central Reasearch Lab, Researcher

Educational Background

  • Apr. 1971 - Mar. 1973
    Nagoya University, Graduate School, Division of Natural Science, Department of Chemistry
  • Apr. 1966 - Mar. 1971
    Nagoya University, Faculty of Science, Department of Chemistry

Member History

  • 2001 - 2003
    Assocate editor of Bull. Chem. Soc. Jpn., The Chemical Society of Japan, Society
  • 2001 - 2003
    欧文誌編集委員, 日本化学会, Society
  • 1988 - 1988
    Assocate editor of Bull. Chem. Soc. Jpn., The Chemical Society of Japan, Society
  • 1988 - 1988
    欧文誌編集委員, 日本化学会, Society
Research Activity Information

Award

  • Feb. 1987
    Incentive Award in Synthetic Organic Chemistry, Japan (The Society of Synthetic Organic Chemistry, Japan)

Paper

  • Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution
    Nobuo Kitada; Tsuyoshi Saitoh; Yuma Ikeda; Satoshi Iwano; Rika Obata; Haruki Niwa; Takashi Hirano; Atsushi Miyawaki; Koji Suzuki; Shigeru Nishiyama; Shojiro A. Maki
    Tetrahedron Letters, Elsevier Ltd, 59, 12, 1087-1090, 21 Mar. 2018, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Aspiration Risk Detection Using Oral Administration of Fluorescent Food --- Preliminary Experiments Using Meat Phantoms ---
    Takahiro SUZUKI; Ryohei SAITO; Nobuo KITADA; Takuji KOIKE; Shojiro MAKI; Yukihiro MICHIWAKI; Goro NISHIMURA; Haruki NIWA; Yukio YAMADA
    2017 IEEE International Conference on Cyborg and Bionic Systems (CBS 2017), IEEE, 1, 17 Oct. 2017, Peer-reviwed
    International conference proceedings, English
  • A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.
    Takahiro Kuchimaru; Satoshi Iwano; Masahiro Kiyama; Shun Mitsumata; Tetsuya Kadonosono; Haruki Niwa; Shojiro Maki; Shinae Kizaka-Kondoh
    Nature communications, 7, 11856-11856, 14 Jun. 2016, Peer-reviwed, True, In preclinical cancer research, bioluminescence imaging with firefly luciferase and D-luciferin has become a standard to monitor biological processes both in vitro and in vivo. However, the emission maximum (λmax) of bioluminescence produced by D-luciferin is 562 nm where light is not highly penetrable in biological tissues. This emphasizes a need for developing a red-shifted bioluminescence imaging system to improve detection sensitivity of targets in deep tissue. Here we characterize the bioluminescent properties of the newly synthesized luciferin analogue, AkaLumine-HCl. The bioluminescence produced by AkaLumine-HCl in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677 nm), and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations, as compared with D-luciferin and emerging synthetic luciferin CycLuc1. These characteristics offer a more sensitive and accurate method for non-invasive bioluminescence imaging with native firefly luciferase in various animal models.
    Scientific journal, English
    DOI URL
  • Synthesis and evaluation of new firefly luciferin analogues for luminescent materials
    Ioka, Shuji; Saitoh, Tsuyoshi; Iwano, Satoshi; Suzuki, Koji; Maki, Shojiro; Niwa, Haruki; Miyawaki, Atsushi; Imoto, Masaya; Nishiyama, Shigeru
    Chemistry, A European Journal, Chemistry, A European Journal, 22, 1-9, 2016, Peer-reviwed, ホタル生物発光基質のチアゾリン環（右環部）の硫黄原子を炭素原子に変換した新規化合物の合成と発光活性およびその活性についてまとめた．
    Scientific journal, English
  • "Synthesis and evaluation of the luminescent properties of firefly luciferin analogues "
    Ioka, Shuji; Saitoh, Tsuyoshi; Iwano, Satoshi; Suzuki, Koji; Maki, Shojiro; Niwa, Haruki; Miyawaki, Atsushi; Imoto, Masaya; Nishiyama, Shigeru
    Chemistry, A European Journal, 22, 1-9, 2016, Peer-reviwed, ホタル生物発光基質のチアゾリン環（右環部）の硫黄原子を炭素原子に変換した新規化合物の合成と発光活性およびその活性についてまとめた．
    Scientific journal, English
  • Spectroscopic properties of BF2 complexes of N-(5-phenyl-2- pyrazinyl)pivalamides exhibiting fluorescence in solution and solid state (http://dx.doi.org/10.1016/j.jphotochem.2015.10.014)
    Sojiro Hachiya; Daisuke Hashizume; Hiroshi Ikeda; Minoru Yamaji; Shojiro Maki; Haruki Niwa; Takashi Hirano
    Journal of Photochemistry and Photobiology A: Chemistry, 331, 206-214, 2016, Peer-reviwed, Boron difluoride (BF2) complexes of N-(5-phenyl-2-pyrazinyl)pivalamide and its derivatives having a substituent on the phenyl group were prepared and their spectroscopic properties were investigated. It was found that the BF2 complexes show fluorescence in solution and the solid state. The origins of the fluorescence properties are discussed on the basis of the fluorescence yields and lifetimes, crystal structures and DFT calculations. The present work would provide a guide to design BF2 complexes of amidopyrazines exhibiting solid state fluorescence.
    Scientific journal, English
  • Multicolor Bioluminescence Obtained Using Firefly Luciferin
    Masahiro Kiyama; Ryohei Saito; Satoshi Iwano; Rika Obata; Haruki Niwa; Shojiro A. Maki
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 16, 24, 2648-2655, 2016, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Fluorescence Properties of Diphenylthiazolo[4,5-b]pyrazines Tuned by Donor-Acceptor Substituent Effects
    Tatsuki Nakagawa; Minoru Yamaji; Shojiro Maki; Haruki Niwa; Takashi Hirano
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 91, 4, 807-813, Jul. 2015, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Synthesis and chemiluminescent properties of 6,8-diaryl-2-methylimidazo[1,2-alpha]pyrazin-3(7H)-ones: Systematic investigation of substituent effect at para-position of phenyl group at 8-position
    Ryota Saito; Takashi Hirano; Shojiro Maki; Haruki Niwa
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 293, 12-25, Nov. 2014, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Substituent effects on fluorescence properties of thiazolo[4,5-b]pyrazine derivatives
    Tatsuki Nakagawa; Minoru Yamaji; Shojiro Maki; Haruki Niwa; Takashi Hirano
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 13, 12, 1765-1772, 2014, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Synthesis and luminescence properties of biphenyl-type firefly luciferin analogs with a new, near-infrared light-emitting bioluminophore
    Chihiro Miura; Masahiro Kiyama; Satoshi Iwano; Kazuto Ito; Rika Obata; Takashi Hirano; Shojiro Maki; Haruki Niwa
    TETRAHEDRON, 69, 46, 9726-9734, Nov. 2013, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light
    Satoshi Iwano; Rika Obata; Chihiro Miura; Masahiro Kiyama; Kazutoshi Hama; Mitsuhiro Nakamura; Yoshiharu Amano; Satoshi Kojima; Takashi Hirano; Shojiro Maki; Haruki Niwa
    Tetrahedron, 69, 19, 3847-3856, 13 May 2013, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Evaluation of Bioluminescence Activity of Firefly Luciferin Nucleotide Derivatives
    Satoshi IWANO; Satoshi KOJIMA; Takashi HIRANO; Shojiro MAKI; Haruki NIWA
    ECS Transactions, The Electrochemical society, 50, 1-3, 2013, Peer-reviwed, 天然ホタル生物発光では，発光酵素はAMP化と酸素化反応の２つの反応に関わっている，AMPの核酸と糖の部位をいくつか変えて，発光活性を測定した．その結果，

    糖部位をデオキシリボースに変換すると活性が大きく減衰すること，単環性の核酸でも活性は減衰するが，発光活性さほど失われないことがわかった．
    Scientific journal, English
  • 5-[4-(Dimethylamino)phenyl]-2-benzamidopyrazines: fluorescent dyes based on Cypridina oxyluciferin
    Takashi Hirano; Tatsuki Nakagawa; Ai Kodaka; Shojiro Maki; Haruki Niwa; Minoru Yamaji
    RESEARCH ON CHEMICAL INTERMEDIATES, 39, 1, 233-245, Jan. 2013, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Anoikis Induction and Inhibition of Peritoneal Metastasis of Pancreatic Cancer Cells by a Nuclear Factor-kappa B Inhibitor, (-)-DHMEQ
    Masanori Sato; Kazuaki Nakanishi; Sanae Haga; Masato Fujiyoshi; Motoi Baba; Kazuhiro Mino; Yimin; Haruki Niwa; Hideki Yokoo; Kazuo Umezawa; Yoshihiro Ohmiya; Toshiya Kamiyama; Satoru Todo; Akinobu Taketomi; Michitaka Ozaki
    ONCOLOGY RESEARCH, 21, 6, 333-343, 2013, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Spectroscopic studies of the color modulation mechanism of firefly (beetle) bioluminescence with amino-analogs of luciferin and oxyluciferin
    Hirano, T; Nagai, H; Matsuhashi, T; Hasumi, Y; Iwano, S; Ito, K; Maki, S; Niwa, H; Viviani, V. R
    Photochem. Photobiol. Sci., 11, 8, 1281-1284, Aug. 2012, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Studies on (-)ESI-MS/MS of a glycosaminoglycan disaccharide N-acetyllactosamine-6,6 '-disulfate disodium salt-Charge-localization isomers
    Yoko Ohashi; Masayuki Kubota; Hiroshi Hatase; Takashi Hirano; Shojiro Maki; Haruki Niwa
    INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 312, 179-184, Feb. 2012, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Spectroscopic studies of the color modulation mechanism of firefly (beetle) bioluminescence with amino-analogs of luciferin and oxyluciferin
    Takashi Hirano; Hiroyuki Nagai; Takuto Matsuhashi; Yosuke Hasumi; Satoshi Iwano; Kazuto Ito; Shojiro Maki; Haruki Niwa; Vadim R. Viviani
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 11, 8, 1281-1284, 2012, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Bioluminescence characteristics of the fruiting body of Mycena chlorophos
    Kenichi Mori; Satoshi Kojima; Shojiro Maki; Takashi Hirano; Haruki Niwa
    LUMINESCENCE, 26, 6, 604-610, Nov. 2011, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Influence of Electron-Donating and Electron-Withdrawing Substituents on the Chemiluminescence Behavior of Coelenterazine Analogs
    Saito, R; Hirano, T; Maki, S; Niwa, H; M. Ohashi, M
    Bull. Chem. Soc. Jpn., The Chemical Society of Japan, 84, 1, 90-99, Jan. 2011, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Influence of Electron-Donating and Electron-Withdrawing Substituents on the Chemiluminescence Behavior of Coelenterazine Analogs
    Ryota Saito; Takashi Hirano; Shojiro Maki; Haruki Niwa; Mamoru Ohashi
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 84, 1, 90-99, Jan. 2011, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Colorimetric and fluorometric sensing of the Lewis acidity of a metal ion by metal-ion complexation of imidazo[1,2-a]pyrazin-3(7H)-ones
    Takashi Hirano; Takashi Sekiguchi; Daisuke Hashizume; Hiroshi Ikeda; Shojiro Maki; Haruki Niwa
    TETRAHEDRON, 66, 21, 3842-3848, May 2010, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Synthesis and properties of bis(pyrazino[2 ',3 ':4,5]imidazole)-fused 1,2,5,6-tetrahydro-1,4,5,8,9,10-hexaazaanthracenes: a new fluorescent nitrogen-rich heterocycle
    Sojiro Hachiya; Daisuke Hashizume; Shojiro Maki; Haruki Niwa; Takashi Hirano
    TETRAHEDRON LETTERS, 51, 10, 1401-1403, Mar. 2010, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Synthesis and fluorescence properties of difluoro[amidopyrazinato-O,N]boron derivatives: a new boron-containing fluorophore
    Sojiro Hachiya; Takayuki Inagaki; Daisuke Hashizume; Shojiro Maki; Haruki Niwa; Takashi Hirano
    TETRAHEDRON LETTERS, 51, 12, 1613-1615, Mar. 2010, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Distinction of Sialyl Anomers on ESI- and FAB-MS/MS: Stereo-Specific Fragmentations
    Yoko Ohashi; Masayuki Kubota; Hiroshi Hatase; Mitsuhiro Nakamura; Takashi Hirano; Haruki Niwa; Yoshitaka Nagai
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20, 3, 394-397, Mar. 2009, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Spectroscopic Studies of the Light-Color Modulation Mechanism of Firefly (Beetle) Bioluminescence
    Takashi Hirano; Yosuke Hasumi; Kazuhiro Ohtsuka; Shojiro Maki; Haruki Niwa; Minoru Yamaji; Daisuke Hashizume
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 6, 2385-2396, Feb. 2009, Peer-reviwed
    Scientific journal, English
    DOI URL
  • CHEMIEXCITATION MECHANISM FOR CYPRIDINA (VARGULA) AND AEQUOREA BIOLUMINESCENCE
    T. Hirano; H. Ohba; Y. Takahashi; S. Maki; S. Kojima; H. Ikeda; H. Niwa
    BIOLUMINESCENCE AND CHEMILUMINESCENCE, 19-22, 2009, Peer-reviwed
    International conference proceedings, English
  • The reaction mechanism for the high quantum yield of Cypridina (Vargula) bioluminescence supported by the chemiluminescence of 6-aryl-2-methylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues)
    Takashi Hirano; Yuto Takahashi; Hiroyuki Kondo; Shojiro Maki; Satoshi Kojima; Hiroshi Ikeda; Haruki Niwa
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 7, 2, 197-207, 2008, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Electrolysis and its hybrid methods applied to decomposition of endocrine disrupting chemicals
    Naomi Takagami; Kazuhiro Ohtsuki; Shojiro Maki; Haruki Niwa; Shin-ichi Hatanaka; Shigeo Hayashi
    ELECTROCHEMISTRY, 74, 8, 599-602, Aug. 2006, Peer-reviwed
    Scientific journal, English
  • Chemiluminescence of 6-aryl-2-methylimidazo[1,2-a]pyrazin-3(7H)-ones in DMSO/TMG and in diglyme/acetate buffer: support for the chemiexcitation process to generate the singlet-excited state of neutral oxyluciferin in a high quantum yield in the Cypridina (Vargula) bioluminescence mechanism
    Yuto Takahashi; Hiroyuki Kondo; Shojiro Maki; Haruki Niwa; Hiroshi Ikeda; Takashi Hirano
    TETRAHEDRON LETTERS, 47, 34, 6057-6061, Aug. 2006, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Real light emitter in the bioluminescence of the calcium-activated photoproteins aequorin and obelin: light emission from the singlet-excited state of coelenteramide phenolate anion in a contact ion pair
    Kotaro Mori; Shojiro Maki; Haruki Niwa; Hiroshi Ikeda; Takashi Hirano
    TETRAHEDRON, 62, 26, 6272-6288, Jun. 2006, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Construction of a New Firefly Bioluminescence System using L-luciferin
    Mitsuhiro Nakamura; Kazuki Niwa; Shojiro Maki; Takashi Hirano; Yoshihiro Ohmiya; Haruki Niwa
    Tetrahedron Letters, 47, 7, pp. 1197-1200, 2006, Peer-reviwed
    Scientific journal, English
  • Substituent effects on the kinetics for the chemiluminescence reaction of 6-arylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues): support for the single electron transfer (SET)-oxygenation mechanism with triplet molecular oxygen
    H Kondo; T Igarashi; S Maki; H Niwa; H Ikeda; T Hirano
    TETRAHEDRON LETTERS, 46, 45, 7701-7704, Nov. 2005, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Substituent effects on the spectroscopic properties of solvatochromic 2-phenylimidazo[1,2-a]pyrazin-3(7H)-ones: an effective control for the colorimetric sensor properties
    Y Takamuki; S Maki; H Niwa; H Ikeda; T Hirano
    TETRAHEDRON, 61, 42, 10073-10080, Oct. 2005, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Bioluminescence in the limpet-like snail Latia neritoides.
    Yoshihiro Ohmiya; Satoshi Kojima; Mitsuhiro Nakamura; Haruki Niwa
    Bull. Chem. Soc. Jpn., 78, 7, pp. 1197-1205, Jul. 2005, Peer-reviwed
    Scientific journal, English
  • Firefly luciferase exhibits bimodal action depending on the luciferin chirality
    M Nakamura; S Maki; Y Amano; Y Ohkita; K Niwa; T Hirano; Y Ohmiya; H Niwa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331, 2, 471-475, Jun. 2005, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Electron-transfer oxygenation mechanism in the chemiluminescence reaction of imidazo[1,2-a]pyrazin-3(7H)-one with triplet dioxygen
    Hiroyuki Kondo; Takayuki Igarashi; Shojiro Maki; Haruki Niwa; Hiroshi Ikeda; Takashi Hirano
    Tetrahedron Letters, 46, 7701-7704, 2005, Peer-reviwed, ウミホタル生物発光反応を確立するため，６位のフェニル基上に種々置換基を導入した誘導体を用いて，詳細な化学発光反応の速度論を解析した．この結果，反応機構中，酸素化過程が電子移動によって支配されていることを明らかにした．
    Scientific journal, English
  • Characterization of [1-13C]-Specifically Labeled Amino Acids Using ESIMS/MS in the Selected Reaction Monitoring Mode
    Yoko Ohashi; Hiroshi Hatase; Mitsuhiro Nakamura; Takashi Hirano; Shojiro Maki; Haruki Niwa
    Journal of the Mass Spectrometry Society of Japan, the Mass Spectrometry Society of Japan, 53, 309-314, 2005, Peer-reviwed
    Scientific journal, English
  • 6,8-diarylimbazo[1, 2-a]pyrazin-3(7H) - Ones as potential chemiluminescent pH/superoxide double sensors
    R Saito; N Suga; A Katoh; S Maki; T Hirano; H Niwa
    Bioluminescence & Chemiluminescence: Progress and Perspectives, 335-338, 2005, Peer-reviwed
    International conference proceedings, English
  • Development of the chemistry of the imidazopyrazionone-bioluminescence system: From the bio- and chemiluminescence mechanism to a design of sensor molecules
    T Hirano; S Nakai; S Sekiguchi; S Fujio; S Maki; H Niwa
    Bioluminescence & Chemiluminescence: Progress and Perspectives, 117-120, 2005, Peer-reviwed
    International conference proceedings, English
  • Bioluminescence activity of Latia luciferin analogues: replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups
    M Nakamura; M Mamino; M Masaki; S Maki; R Matsui; S Kojima; T Hirano; Y Ohmiya; H Niwa
    TETRAHEDRON LETTERS, 46, 1, 53-56, Jan. 2005, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Characterization of Regio-specific 13CO-Labeling of Amino Acids Using ESIMS/MS in the SRM Mode.
    Yoko OHASHI; Hiroshi HATASE; Mitsuhiro NAKAMURA; Takashi HIRANO; Shojiro MAKI; Haruki NIWA
    J. Mass Spectrom. Soc. jpn, 53, 6, pp. 309-314, 2005, Peer-reviwed
    Scientific journal, English
  • Substituent effects on the solvatochromism of 2-phenylimidazopyrazinones: Effective control of the color variation range and sensitivity toward an indication of the proton-donor ability of solvents by an electron-withdrawing group substitution
    Y Takamuki; S Maki; H Niwa; H Ikeda; T Hirano
    CHEMISTRY LETTERS, 33, 11, 1484-1485, Nov. 2004, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Regioselective phenyl-substitution effects on the solvatochromism of 2-phenylimidazo[1,2-a]pyrazin-3(7H)-one derivatives: Expansion of the color variation range of a visible indicator for the proton donor ability of solvents.
    Shunsuke Fujio; Daisuke Hashizume; Yoshiharu Takamuki; Masanori Yasui; Fujiko Iwasaki; Shojiro Maki; Haruki Niwa; Hiroshi Ikeda; Takashi Hirano
    Tetrahedron Letters, 45, 46, pp. 8531-8534, Oct. 2004, Peer-reviwed
    Scientific journal, English
  • Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS
    N Koda; Y Tsutsui; H Niwa; S Ito; DF Woodward; K Watanabe
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 424, 2, 128-136, Apr. 2004, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Synthesis of Latia Luciferin Benzoate Analogues and those Bioluminescent Activity.
    Mitsuhiro Nakamura; Mizuki Masaki; Shojiro Maki; Ryo Matsui; Minako Hieda; Masashi Mamino; Takashi Hirano; Yoshihiro Ohmiya; Haruki Niwa
    Tetrahedron Letters, 45, 10, pp. 2203-2205, Feb. 2004, Peer-reviwed
    Scientific journal, English
  • Analysis of sugar epimers using mass spectrometry: N-acetyllactosamine-6,6 '-disulfate and the 2 '-epimer
    Y Ohashi; Y Itoh; M Kubota; K Hamada; M Ohashi; T Hirano; H Niwa
    EUROPEAN JOURNAL OF MASS SPECTROMETRY, 10, 2, 269-278, 2004, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Metal-ion complexation of imidazo[1,2-a]pyrazin-3(7H)-ones: continuous changes in absorption spectra of complexes depending on the Lewis acidity of the metal ion
    T Sekiguchi; S Maki; H Niwa; H Ikeda; T Hirano
    TETRAHEDRON LETTERS, 45, 5, 1065-1069, Jan. 2004, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Fundamental studies on the structures and spectroscopic properties of imidazo[1,2-a]pyrazin-3(7H)-one derivatives
    S Nakai; M Yasui; M Nakazato; F Iwasaki; S Maki; H Niwa; M Ohashi; T Hirano
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 76, 12, 2361-2387, Dec. 2003, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Essential (110)Cys in active site of membrane-associated prostaglandin E synthase-2
    K Watanabe; H Ohkubo; H Niwa; N Tanikawa; N Koda; S Ito; Y Ohmiya
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 306, 2, 577-581, Jun. 2003, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Pd black deposited on polypropylene sheet as a highly selective catalyst for hydrogenation of alkenes
    S Maki; M Okawa; T Makii; T Hirano; H Niwa
    TETRAHEDRON LETTERS, 44, 18, 3717-3721, Apr. 2003, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Hydrogenolysis-free Hydrogenation Using Pd Black Catalyst Deposited on Pd Sheet.
    Shojiro Maki; Makiko Okawa; Toshimichi Makii; Takashi Hirano; Haruki Niwa
    ITE Letters on Batteries, New Technologies and Medicine, 4, 1, pp. 49-54, 2003, Peer-reviwed
    Scientific journal, English
  • Viscosity-dependent fluorescence decay of the GFP chromophore in solution due to fast internal conversion
    AD Kummer; C Kompa; H Niwa; T Hirano; S Kojima; ME Michel-Beyerle
    JOURNAL OF PHYSICAL CHEMISTRY B, 106, 30, 7554-7559, Aug. 2002, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Preparation of deoxygenated derivatives of neoanisatin, a neurotoxic sesquiterpenoid having a beta-lactone
    K Obitsu; S Maki; T Hirano; H Niwa
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 75, 2, 347-354, Feb. 2002, Peer-reviwed
    Scientific journal, English
  • Reduction in Desorption Mass Spectrometry: Multiple Protonation on Flavins without Charge Increment.
    Yoshiyuki Itoh; Yoko Ohashi; Toshimichi Shibue; Akio Hayashi; Shojiro Maki; Takashi Hirano; Haruki Niwa
    J. Mass Spectrom. Jpn., 50, 2, pp. 52-57, 2002, Peer-reviwed
    Scientific journal, English
  • Preparation and Toxic Property of Carbapicrotoxinin, a Cyclopropane-containing Analog of a GABA-antagonistic Sesquiterpenoid Picrotoxinin.
    Kazuyoshi Obitsu; Shojiro Maki; Takashi Hirano; Haruki Niwa
    ITE Letters on Batteries, New Technologies and Medicine, 3, 3, pp. 358-361, 2002, Peer-reviwed
    Scientific journal, English
  • Fluorescence properties of phenolate anions of coelenteramide analogues: the light-emitter structure in aequorin bioluminescence
    Y Imai; T Shibata; S Maki; H Niwa; M Ohashi; T Hirano
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 146, 1-2, 95-107, Dec. 2001, Peer-reviwed
    Scientific journal, English
  • Effect of solvent and hydrogen during selective hydrogenation
    S Maki; Y Harada; R Matsui; M Okawa; T Hirano; H Niwa; M Koizumi; Y Nishiki; T Furuta; H Inoue; C Iwakura
    TETRAHEDRON LETTERS, 42, 47, 8323-8327, Nov. 2001, Peer-reviwed
    Scientific journal, English
  • Hydrogenolysis-free hydrogenation by Pd black powder catalyst
    S Maki; M Okawa; R Matsui; T Hirano; H Niwa
    SYNLETT, 10, 1590-1592, Oct. 2001, Peer-reviwed
    Scientific journal, English
  • Purification and Properties of the Luciferase from the Marine Ostracod Vargula hilgendorfii.
    Koji Kobayashi; Yoshihiro Ohmiya; Daisaku Shinohala; Takuji Nabetani; Haruki Niwa
    "Bioluminescence and Chemiluminescence," ed by J. F. Case, P. J. Herring, B. H. Robinson, S. H. D. Haddock, L. J. Kricka, and P. E. Stanley: World Scientific, Singapore, World Scientific, Singapore, 87-90, 2001, Peer-reviwed
    International conference proceedings, English
  • Improved Syntheses of Watasenia Preluciferin (Coelenterazine) and Watasenia Luciferin (Coelenterazine Disulfate), and Site Specific Syntheses of the Coelenterazine Monosulfates.
    Satoshi Kojima; Shojiro Maki; Takashi Hirano; Haruki Niwa; Mamoru Ohashi; Frederick I. Tsuji
    ITE Letters on Batteries, New Technologies and Medicine, 2, 3, pp. C1-C5, 2001, Peer-reviwed
    Scientific journal, English
  • Intramolecular electron-transfer-induced cleavage of dioxetanes observed in fast-atom bombardment tandem mass spectrometry
    M Ohashi; M Takanashi; N Watanabe; M Matsumoto; T Saisu; H Niwa
    EUROPEAN JOURNAL OF MASS SPECTROMETRY, 7, 6, 441-445, 2001, Peer-reviwed
    Scientific journal, English
  • Isoquinoline formation by a novel photochemical intermolecular cycloaddition of 1,1-diphenylethene derivatives to 1,4-dicyanobenzene
    H Ishii; Y Imai; T Hirano; S Maki; H Niwa; M Ohashi
    TETRAHEDRON LETTERS, 41, 33, 6467-6471, Aug. 2000, Peer-reviwed
    Scientific journal, English
  • 2,3,3a,4,9,9a-Hexahydro-9-phenyl-benzo[f]indene derivatives
    D Hashizume; N Takashima; T Oikawa; H Ishii; H Niwa; F Iwasaki
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 56, 827-829, Jul. 2000, Peer-reviwed
    Scientific journal, English
  • Bioluminescence activity of Latia luciferin analogs
    S Kojima; S Maki; T Hirano; Y Ohmiya; H Niwa
    TETRAHEDRON LETTERS, 41, 22, 4409-4413, Jun. 2000, Peer-reviwed
    Scientific journal, English
  • Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an inorganic particle matrix for small molecule analysis
    T Kinumi; T Saisu; M Takayama; H Niwa
    JOURNAL OF MASS SPECTROMETRY, 35, 3, 417-422, Mar. 2000, Peer-reviwed
    Scientific journal, English
  • Synthesis, chemi- and bioluminescence properties, and photolysis of a coelenterazine analogue having a photoreactive azido group
    Jing Ling Zheng; Feng Qi Chen; Takashi Hirano; Yoshihiro Ohmiya; Shojiro Maki; Haruki Niwa; Mamoru Ohashi
    Bulletin of the Chemical Society of Japan, 73, 2, 465-469, Feb. 2000, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Synthesis and Chemi-and Bio-luminescence Properties of a Photolabile Coelenterazine Analogue Bearing an Azido Group.
    Zheng, J. L; Chen, F. Q; Hirano, T; Ohmiya, Y; Maki, S; Niwa, H; Ohashi, M
    Bull. Chem. Soc. Jpn., 73, 2, pp. 465-469, 2000, Peer-reviwed
    Scientific journal, English
  • Differentiation Between N-Acetylchondrosine and N-Acetyldermosin by Matrix-assisted Laser Desorption Ionization Time-of-flight Post Source Decay Mass Spectrometry.
    Mamoru Ohashi; Masami Araki; Takumi Saisu; Takuji Nabetani; Haruki Niwa
    J. Mass Spectrom. Jpn., 48, 1, pp. 26-31, 2000, Peer-reviwed
    Scientific journal, English
  • Phosphopeptide sequencing by in-source decay spectrum in delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    T Kinumi; H Niwa; H Matsumoto
    ANALYTICAL BIOCHEMISTRY, 277, 2, 177-186, Jan. 2000, Peer-reviwed
    Scientific journal, English
  • Selective alkene hydrogenation with atomic hydrogen permeating through a Pd sheet electrode
    S Maki; Y Harada; T Hirano; H Niwa; Y Yoshida; S Ogata; S Nakamatsu; H Inoue; C Iwakura
    SYNTHETIC COMMUNICATIONS, 30, 19, 3575-3583, 2000, Peer-reviwed
    Scientific journal, English
  • Purification and Chracteristic Properties of the Luciferase from the Marine Ostracod Vargula hilgendorfii.
    Koji Kobayashi; Daisaku Shinohara; Takuji Nabetani; Haruki Niwa; Yoshihiro Ohmiya
    ITE Letters on Batteries, New Technologies & Medicine, 1, 3, pp. 422-426, 2000, Peer-reviwed
    Scientific journal, English
  • Reactivity and pi-facial selectivity of nucleophile addition to the radical cations of 7-benzhydrylidenenorbornene derivatives
    H Ishii; S Shiina; T Hirano; H Niwa; M Ohashi
    TETRAHEDRON LETTERS, 40, 3, 523-526, Jan. 1999, Peer-reviwed
    Scientific journal, English
  • Regiocontrolled construction of functionalized spiro[4,4]nonanones through mercury(II) salt-assisted and acid-induced spiroannulation reactions
    Y Hashizume; S Maki; M Ohashi; H Niwa
    SYNTHETIC COMMUNICATIONS, 29, 7, 1223-1233, 1999, Peer-reviwed
    Scientific journal, English
  • Stereoselective tandem cyclization of 1,1-diphenyl-1,n-alkadienes via photoinduced electron transfer reaction
    H Ishii; R Yamaoka; Y Imai; T Hirano; S Maki; H Niwa; D Hashizume; F Iwasaki; M Ohashi
    TETRAHEDRON LETTERS, 39, 51, 9501-9504, Dec. 1998, Peer-reviwed
    Scientific journal, English
  • Synthesis of (+/-)-isoitalicene by electrolysis under irradiation as a key step
    Y Harada; S Maki; H Niwa; T Hirano; S Yamamura
    SYNLETT, 12, 1313-1314, Dec. 1998, Peer-reviwed
    Scientific journal, English
  • Synthesis of dimethyl gloiosiphone A
    Y Hashizume; S Maki; M Ohashi; H Niwa
    SYNLETT, 12, 1357-1358, Dec. 1998, Peer-reviwed
    Scientific journal, English
  • Bioluminescent properties of fluorinated semi-synthetic aequorins
    Takashi Hirano; Yoshihiro Ohmiya; Shojiro Maki; Haruki Niwa; Mamoru Ohashi
    Tetrahedron Letters, 39, 31, 5541-5544, 30 Jul. 1998, Peer-reviwed
    Scientific journal, English
    DOI URL
  • A novel, stereoselective photo-Ritter reaction of 1,1-diphenyl-1,6-heptadiene via photoindnced electron transfer reaction
    H Ishii; T Hirano; S Maki; H Niwa; M Ohashi
    TETRAHEDRON LETTERS, 39, 18, 2791-2792, Apr. 1998, Peer-reviwed
    Scientific journal, English
  • "Fluorescent Properties of Model Chromophores of Tyrosine-66 Substituted Mutants of Aequorea Green Fluorescent Protein(GFP)"
    Satoshi Kojima; Hiroko Ohkawa; Takashi Hirono; Haruki Niwa; Mamoru Ohashi; satoshi Inouye; Frederick I. Tsuji
    Tetrahedron Letters, Elsevier Ltd., 39, 29, 5239-5242, 1998, Peer-reviwed, GFPの発色団は６５−６７番目のSer-Tyr-Glyの間で形成する．近年，異なる蛍光性を示すGFP変異体GFP Y66F，GFP Y66Hなどが作製されているがその発色団構造に関する知見はない．本報告では各変異体に対応する発色団のモデル化合物を合成しその蛍光挙動を検討した．また，各変異体タンパクを発現させその蛍光スペクトルよりモデル化合物の構造の妥当性を明らかとした．
    Scientific journal, English
  • Substituent effects on the chemiluminescent properties of coelenterazine analogues
    R Saito; T Hirano; H Niwa; M Ohashi
    CHEMISTRY LETTERS, 27, 1, 95-96, 1998, Peer-reviwed
    Scientific journal, English
  • FAB-CID Mass Spectrometry of Imizdazplone DErivatives Related to the Chromophore of Green Fluorescent Potein in Jellyfish Bioluminescence.
    Toshikazu Hiraki; Masayasu Kubota; Takashi Hirano; Haruki Niwa; Mamoru Ohashi
    J. Mass Spectrom. Jpn., 46, 1, pp. 37-43, 1998, Peer-reviwed
    Scientific journal, English
  • Fluorescent Properties of Model Chromophores for the Mutant Proteins of Aequorea Green Fluorescent Protein(GFP).
    Satoshi Kojima; Hiroko Ohkawa; Takashi Hirono; Haruki Niwa; Mamoru Ohashi; satoshi Inouye; Frederick I. Tsuji
    Tetrahedron Lett., 39, 29, pp. 5239-5243, 1998, Peer-reviwed
    Scientific journal, English
  • Bioluminescent Properties of Fluorinated Semi-synthetic Aequorins : Structure Elucidation of the Light-emitter in Aequorin Bioluminescence.
    Takashi Hirano; Yoshihiro Ohmiya; Shojiro Maki; Haruki Niwa; Mamoru Ohashi
    Tetrahedron Lett., 39, 31, pp. 5541-5545, 1998, Peer-reviwed
    Scientific journal, English
  • FAB CID-MS/MS of In-source Fragment Ions as a Means to Differenciate Linkage Isomers of Branched Sugars : Le＾a＾ and Le＾x ＾Type Glycoconjugates.
    Yoko Ohashi; Tadashi Ii; Masayasu Kubota; Shigeki Nunomura; Haruki Niwa; Mamoru Ohashi; Tomoyo Ogawa; Yoshitaka Nagai
    J. Mass Spectrom. Jpn., The Mass Spectrometry Society of Japan, 46, 1, pp. 45-52, 1998, Peer-reviwed, Here we report that FAB CID-MS/MS, choosing an ion originating from the in-source degradation prior to the full acceleration of the molecule-related ion as the precursor, is an excellent means to differentiate linkage isomers. FAB CID-MS/MS performed in this way results in a product ion spectrum, which is enriched with the fragmentation information, and which may thus indicate the position of the newly formed OH group already produced in the ion source. Linkage knowledge may be classified into one of three categories as described later. This method was applied to acidic Lewis-type glycoconjugates —putative ligands for selectins [L. L. W. Cooling, D.-S. Zhang, and T. A. W. Koerner, Trends in Glycosci. Glycotech., 9, 191 (1997)]— and their neutral analogs to differentiate linkage isomers by mass spectrometry. With these glycoconjugates FAB CID-MS/MS having [M+H]+s as the precursor ions is a good means to distinguish the linkage isomers only in simple cases, but not in general cases. By using ions originating from in-source degradation prior to the full acceleration of the molecule-related ion as the precursor, we were able to differentiate between Lea and Lex.
    Scientific journal, English
    URL
    URL 2
    DOI URL
  • Novel dehydration reaction of neoanisatin and transformation of neoanisatin into anisatin
    J Yoshizawa; K Obitsu; S Maki; H Niwa; T Hirano; M Ohashi
    SYNLETT, 12, 1387-1388, Dec. 1997, Peer-reviwed
    Scientific journal, English
  • Facile cleavage reactions of styrylic olefins using electrochemical methods
    S Maki; H Niwa; T Hirano
    SYNLETT, 12, 1385-1386, Dec. 1997, Peer-reviwed
    Scientific journal, English
  • An efficient synthesis of racemic necine bases from a common intermediate
    H Niwa; A Kuroda; T Sakata; K Yamada
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 70, 10, 2541-2543, Oct. 1997, Peer-reviwed
    Scientific journal, English
  • Solvent and substituent effects on the fluorescent properties of coelenteramide analogues
    R Saito; T Hirano; H Niwa; M Ohashi
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 9, 1711-1716, Sep. 1997, Peer-reviwed
    Scientific journal, English
  • Abnormal reactivity of anisatin and neoanisatin to samarium iodide hexamethylphosphorictriamide
    K Obitsu; S Maki; H Niwa; T Hirano; M Ohashi
    TETRAHEDRON LETTERS, 38, 23, 4111-4112, Jun. 1997, Peer-reviwed
    Scientific journal, English
  • Mechanism of the redox reaction of the Aequorea green fluorescent protein (GFP)
    S Kojima; T Hirano; H Niwa; M Ohashi; S Inouye; FL Tsuji
    TETRAHEDRON LETTERS, 38, 16, 2875-2878, Apr. 1997, Peer-reviwed
    Scientific journal, English
  • Aequorea green fluorescent protein: Structural elucidation of the chromophore
    H Niwa; T Matsuno; S Kojima; M Kubota; T Hirano; M Ohashi; S Inouye; Y Ohmiya; FI Tsuji
    BIOLUMINESCENCE AND CHEMILUMINESCENCE, 395-398, 1997, Peer-reviwed
    International conference proceedings, English
  • Chemical nature of the light emitter of the Aequorea green fluorescent protein
    H Niwa; S Inouye; T Hirano; T Matsuno; S Kojima; M Kubota; M Ohashi; FI Tsuji
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93, 24, 13617-13622, Nov. 1996, Peer-reviwed
    Scientific journal, English
  • Unusual reactions of C-60 with aldehydes in the presence of aqueous ammonia
    A Komori; M Kubota; T Ishida; H Niwa; T Nogami
    TETRAHEDRON LETTERS, 37, 23, 4031-4034, Jun. 1996, Peer-reviwed
    Scientific journal, English
  • A POTENTIAL PHOTOAFFINITY PROBE FOR LABELING THE ACTIVE-SITE OF AEQUORIN - A PHOTOLABILE COELENTERAZINE ANALOG WITH A TRIFLUOROMETHYLDIAZIRINE GROUP
    FQ CHEN; JL ZHENG; T HIRANO; H NIWA; Y OHMIYA; M OHASHI
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 17, 2129-2134, Sep. 1995, Peer-reviwed
    Scientific journal, English
  • ENANTIOSELECTIVE SYNTHESIS OF THE MACROCYCLIC PYRROLIZIDINE ALKALOID YAMATAIMINE
    H NIWA; K KUNITANI; T NAGOYA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 67, 11, 3094-3099, Nov. 1994, Peer-reviwed
    Scientific journal, English
  • AN IMPROVED SYNTHESIS OF (+/-)-OTONECINE AND A SYNTHESIS OF A 12-MEMBERED OTONECINE DIESTER
    H NIWA; T SAKATA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 67, 8, 2345-2347, Aug. 1994, Peer-reviwed
    Scientific journal, English
  • A SYNTHESIS OF SENECIONINE, A REPRESENTATIVE OF HEPATOTOXIC, MACROCYCLIC PYRROLIZIDINE ALKALOIDS OF RETRONECINE TYPE
    H NIWA; T SAKATA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 67, 7, 1990-1993, Jul. 1994, Peer-reviwed
    Scientific journal, English
  • DIDEMNILACTONE-A AND DIDEMNILACTONE-B AND NEODIDEMNILACTONE, 3 NEW FATTY-ACID METABOLITES ISOLATED FROM THE TUNICATE DIDEMNUM MOSELEYI (HERDMAN)
    H NIWA; M WATANABE; H INAGAKI; K YAMADA
    TETRAHEDRON, 50, 25, 7385-7400, Jun. 1994, Peer-reviwed
    Scientific journal, English
  • Structures of monodontamides A, B, C, D, E, and F, six new alkaloids isolated from the marine gastropod mollusc Monodonta labio (Linné)
    Haruki Niwa; Masaru Watanabe; Atsushi Sano; Kiyoyuki Yamada
    Tetrahedron, 50, 23, 6805-6818, 1994, Peer-reviwed
    Scientific journal, English
    DOI URL
  • Monodontamides A, B, and C, three new putrescine alkaloids from the marine gastropod mollusc Monodonta labio (Linné)
    Haruki Niwa; Masaru Watanabe; Kiyoyuki Yamada
    Tetrahedron Letters, 34, 46, 7441-7444, 12 Nov. 1993, Peer-reviwed
    Scientific journal, English
    DOI URL
  • TOTAL SYNTHESIS OF NATURAL (-)-PTAQUILOSIN, THE AGLYCON OF A POTENT BRACKEN CARCINOGEN PTAQUILOSIDE, AND THE (+)-ENANTIOMER AND THEIR DNA CLEAVING ACTIVITIES
    H KIGOSHI; Y IMAMURA; K MIZUTA; H NIWA; K YAMADA
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 115, 8, 3056-3065, Apr. 1993, Peer-reviwed
    Scientific journal, English
  • AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF INDICINE N-OXIDE, AN ANTITUMOR PYRROLIZIDINE ALKALOID
    T OGAWA; H NIWA; K YAMADA
    TETRAHEDRON, 49, 8, 1571-1578, Feb. 1993, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF OPTICALLY-ACTIVE MONOCROTALINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID POSSESSING AN 11-MEMBERED RETRONECINE DILACTONE
    H NIWA; T OGAWA; O OKAMOTO; K YAMADA
    TETRAHEDRON, 48, 48, 10531-10548, Nov. 1992, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE
    H NIWA; Y MIYACHI; O OKAMOTO; Y UOSAKI; A KURODA; H ISHIWATA; K YAMADA
    TETRAHEDRON, 48, 3, 393-412, Jan. 1992, Peer-reviwed
    Scientific journal, English
  • NOVEL TRANSFORMATION OF FORMYL GROUPS INTO HYDROXYL-GROUPS UTILIZING DEFORMYLATIVE AUTOXIDATION OF ALDEHYDES
    H KIGOSHI; Y IMAMURA; A SAWADA; H NIWA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 64, 12, 3735-3737, Dec. 1991, Peer-reviwed
    Scientific journal, English
  • FURTHER CHEMICAL STUDIES ON ANISATIN, A NEUROTOXIC SESQUITERPENOID HAVING A BETA-LACTONE
    H NIWA; TSUKADA, I; M NISIWAKI; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 64, 9, 2860-2862, Sep. 1991, Peer-reviwed
    Scientific journal, English
  • DIDEMNILACTONE AND NEODIDEMNILACTONE, 2 NEW FATTY-ACID METABOLITES POSSESSING A 10-MEMBERED LACTONE FROM THE TUNICATE DIDEMNUM-MOSELEYI (HERDMAN)
    H NIWA; H INAGAKI; K YAMADA
    TETRAHEDRON LETTERS, 32, 38, 5127-5128, Sep. 1991, Peer-reviwed
    Scientific journal, English
  • FACTORS THAT CAUSE CONTRASTERIC ALKYLATION OF A CYCLOPENTANE-1,2-DICARBOXYLIC ACID MONOESTER
    H KIGOSHI; Y IMAMURA; K YOSHIKAWA; H NIWA; K YAMADA
    TETRAHEDRON LETTERS, 32, 35, 4541-4544, Aug. 1991, Peer-reviwed
    Scientific journal, English
  • THE 3-DIMENSIONAL STRUCTURE OF NEOHALICHOLACTONE, AN UNUSUAL FATTY-ACID METABOLITE FROM THE MARINE SPONGE HALICHONDRIA-OKADAI KADOTA
    H KIGOSHI; H NIWA; K YAMADA; TJ STOUT; J CLARDY
    TETRAHEDRON LETTERS, 32, 22, 2427-2428, May 1991, Peer-reviwed
    Scientific journal, English
  • SYNTHESIS OF (-)-NEOANISATIN, A NEUROTOXIC SESQUITERPENOID HAVING A NOVEL SPIRO BETA-LACTONE
    H NIWA; K YAMADA
    CHEMISTRY LETTERS, 20, 4, 639-640, Apr. 1991, Peer-reviwed
    Scientific journal, English
  • SYNTHESIS OF (-)-NORANISATIN, AN OXIDATION-PRODUCT OF A NEUROTOXIC SESQUITERPENOID ANISATIN HAVING A NOVEL SPIRO BETA-LACTONE
    H NIWA; S ITO; T HASEGAWA; K WAKAMATSU; T MORI; K YAMADA
    TETRAHEDRON LETTERS, 32, 10, 1329-1330, Mar. 1991, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF (+/-)-(Z)-9-(BROMOMETHYLENE)-1,5,5-TRIMETHYLSPIRO[5.5]UNDECA-1,7-DIEN-3-ONE, A BROMINATED SESQUITERPENE OF THE CHAMIGRANE TYPE
    H NIWA; Y YOSHIDA; T HASEGAWA; K YAMADA
    TETRAHEDRON, 47, 12-13, 2155-2162, Mar. 1991, Peer-reviwed
    Scientific journal, English
  • ALKYLATION OF NUCLEOSIDES BY DEHYDROMONOCROTALINE, THE PUTATIVE TOXIC METABOLITE OF THE CARCINOGENIC PYRROLIZIDINE ALKALOID MONOCROTALINE
    H NIWA; T OGAWA; O OKAMOTO; K YAMADA
    TETRAHEDRON LETTERS, 32, 7, 927-930, Feb. 1991, Peer-reviwed
    Scientific journal, English
  • ON THE MECHANISM OF THE CLEAVAGE REACTION OF (METHYLTHIO)METHYL ETHER WITH TRIPHENYLMETHYL CATION
    H NIWA; Y MIYACHI
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 64, 2, 716-718, Feb. 1991, Peer-reviwed
    Scientific journal, English
  • STEREOSELECTIVE SYNTHESIS OF (-)-TRACHELANTHIC ACID AND (+)-VIRIDIFLORIC ACID, NECIC ACID COMPONENTS OF PYRROLIZIDINE ALKALOIDS FROM A COMMON INTERMEDIATE
    H NIWA; T OGAWA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 63, 12, 3707-3709, Dec. 1990, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (-)-ANISATIN - A NEUROTOXIC SESQUITERPENOID POSSESSING A NOVEL SPIRO BETA-LACTONE
    H NIWA; M NISIWAKI; TSUKADA, I; T ISHIGAKI; S ITO; K WAKAMATSU; T MORI; M IKAGAWA; K YAMADA
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 112, 24, 9001-9003, Nov. 1990, Peer-reviwed
    Scientific journal, English
  • A BIOGENETIC-TYPE SYNTHESIS OF (+/-)-APLYSIADIOL, A BROMINATED DITERPENE ISOLATED FROM THE MARINE MOLLUSK APLYSIA-KURODAI
    H NIWA; S IEDA; H INAGAKI; K YAMADA
    TETRAHEDRON LETTERS, 31, 49, 7157-7158, 1990, Peer-reviwed
    Scientific journal, English
  • ACUTE MICROCIRCULATORY CHANGES INDUCED BY INTRAVENOUS ADMINISTRATION TO RABBITS OF PTAQUILOSIDE, A BRACKEN CARCINOGEN
    M ASANO; C OHKUBO; A SASAKI; HIRONO, I; K YAMADA; H NIWA; M OJIKA
    JOURNAL OF ETHNOPHARMACOLOGY, 27, 1-2, 213-220, Nov. 1989, Peer-reviwed
    Scientific journal, English
  • SYNTHESIS OF A FUNCTIONALIZED CARBOCYCLIC SKELETON OF PTAQUILOSIN, THE AGLYCONE OF A BRACKEN CARCINOGEN PTAQUILOSIDE BASED ON AN INTRAMOLECULAR DIELS-ALDER REACTION
    H KIGOSHI; A SAWADA; H NIWA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 62, 5, 1639-1642, May 1989, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF PTAQUILOSIN - THE AGLYCON OF PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN
    H KIGOSHI; Y IMAMURA; H NIWA; K YAMADA
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 111, 6, 2302-2303, Mar. 1989, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (+/-)-PTAQUILOSIN - THE AGLYCONE OF PTAQUILOSIDE - A BRACKEN CARCINOGEN
    H KIGOSHI; A SAWADA; Y NAKAYAMA; H NIWA; K YAMADA
    TETRAHEDRON LETTERS, 30, 15, 1983-1986, 1989, Peer-reviwed
    Scientific journal, English
  • PTAQUILOSIN, THE AGLYCONE OF A BRACKEN CARCINOGEN PTAQUILOSIDE - CHEMICAL DERIVATION FROM PTAQUILOSIDE AND THE REACTIVITY
    H KIGOSHI; A SAWADA; Y IMAMURA; H NIWA; K YAMADA
    TETRAHEDRON, 45, 9, 2551-2556, 1989, Peer-reviwed
    Scientific journal, English
  • HALICHOLACTONE AND NEOHALICHOLACTONE, 2 NOVEL FATTY-ACID METABOLITES FROM THE MARINE SPONGE HALICHONDRIA-OKADAI KADOTA
    H NIWA; K WAKAMATSU; K YAMADA
    TETRAHEDRON LETTERS, 30, 34, 4543-4546, 1989, Peer-reviwed
    Scientific journal, English
  • AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF (+)-INDICINE N-OXIDE, AN ANTITUMOR PYRROLIZIDINE ALKALOID
    H NIWA; T OGAWA; K YAMADA
    TETRAHEDRON LETTERS, 30, 37, 4985-4986, 1989, Peer-reviwed
    Scientific journal, English
  • A TIN-MEDIATED ONE-STEP SYNTHESIS OF (+)-DICROTALINE, AN 11-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID
    H NIWA; O OKAMOTO; H ISHIWATA; A KURODA; Y UOSAKI; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 61, 8, 3017-3019, Aug. 1988, Peer-reviwed
    Scientific journal, English
  • A BROMINATED QUINAZOLINEDIONE FROM THE MARINE TUNICATE PYURA-SACCIFORMIS
    H NIWA; Y YOSHIDA; K YAMADA
    JOURNAL OF NATURAL PRODUCTS, 51, 2, 343-344, Mar. 1988, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF OPTICALLY-ACTIVE MONOCROTALINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID HAVING AN 11-MEMBERED DILACTONE
    H NIWA; O OKAMOTO; K YAMADA
    TETRAHEDRON LETTERS, 29, 40, 5139-5142, 1988, Peer-reviwed
    Scientific journal, English
  • AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF THE (-)-N-(ETHOXYCARBONYL)METHYL GEISSMAN-WAISS LACTONE - A PRACTICAL SYNTHETIC ROUTE TO (+)-RETRONECINE
    H NIWA; O OKAMOTO; Y MIYACHI; Y UOSAKI; K YAMADA
    JOURNAL OF ORGANIC CHEMISTRY, 52, 13, 2941-2943, Jun. 1987, Peer-reviwed
    Scientific journal, English
  • ISOLATION OF THE STRAINED BRIDGEHEAD ENOL ETHER OF A BICYCLO[3.3.1]NONAN-2-ONE SYSTEM
    K WAKAMATSU; H TAN; N BAN; N UCHIYAMA; H NIWA; K YAMADA
    CHEMISTRY LETTERS, 16, 1, 121-122, 1987, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (+/-)-NORPATCHOULENOL AND 2 METABOLITES OF PATCHOULI ALCOHOL, (+/-)-HYDROXY PATCHOULI ALCOHOL AND THE CORRESPONDING (+/-)-CARBOXYLIC ACID
    H NIWA; T HASEGAWA; N BAN; K YAMADA
    TETRAHEDRON, 43, 5, 825-834, 1987, Peer-reviwed
    Scientific journal, English
  • PTAQUILOSIDE, A POTENT CARCINOGEN ISOLATED FROM BRACKEN FERN PTERIDIUM-AQUILINUM VAR LATIUSCULUM - STRUCTURE ELUCIDATION BASED ON CHEMICAL AND SPECTRAL EVIDENCE, AND REACTIONS WITH AMINO-ACIDS, NUCLEOSIDES, AND NUCLEOTIDES
    M OJIKA; K WAKAMATSU; H NIWA; K YAMADA
    TETRAHEDRON, 43, 22, 5261-5274, 1987, Peer-reviwed
    Scientific journal, English
  • STRUCTURES OF NEW P-HYDROXYSTYRENE GLYCOSIDES, PTELATOSIDE-A AND PTELATOSIDE-B ISOLATED FROM BRACKEN FERN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM, AND SYNTHESIS OF PTELATOSIDE-A
    M OJIKA; K WAKAMATSU; H NIWA; K YAMADA
    TETRAHEDRON, 43, 22, 5275-5280, 1987, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED SYNTHESIS OF POLYFUNCTIONALIZED TRANS-HYDRINDAN SYSTEMS - A MODEL STUDY TOWARD ANISATIN
    H NIWA; T MORI; T HASEGAWA; K YAMADA
    JOURNAL OF ORGANIC CHEMISTRY, 51, 7, 1015-1018, Apr. 1986, Peer-reviwed
    Scientific journal, English
  • 4 NEW C-15 ACETYLENIC POLYENES OF BIOGENETIC SIGNIFICANCE FROM THE RED ALGA LAURENCIA-OKAMURAI - STRUCTURES AND SYNTHESIS
    H KIGOSHI; Y SHIZURI; H NIWA; K YAMADA
    TETRAHEDRON, 42, 14, 3781-3787, 1986, Peer-reviwed
    Scientific journal, English
  • ISOLATION OF (10R,11R)-(+)-SQUALENE-10,11-EPOXIDE FROM THE RED ALGA LAURENCIA-OKAMURAI AND ITS ENANTIOSELECTIVE SYNTHESIS
    H KIGOSHI; M OJIKA; Y SHIZURI; H NIWA; K YAMADA
    TETRAHEDRON, 42, 14, 3789-3792, 1986, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIME, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE .1. ENANTIOSELECTIVE SYNTHESIS OF THE PROTECTED (+/-)-INTEGERRINECIC ACID
    H NIWA; Y MIYACHI; Y UOSAKI; K YAMADA
    TETRAHEDRON LETTERS, 27, 38, 4601-4604, 1986, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE .2. ENANTIOSELECTIVE SYNTHESIS OF (+)-RETRONECINE
    H NIWA; Y MIYACHI; O OKAMOTO; Y UOSAKI; K YAMADA
    TETRAHEDRON LETTERS, 27, 38, 4605-4608, 1986, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE .3. REGIOSELECTIVE ELABORATION OF THE UNSYMMETRICAL 12-MEMBERED DILACTONE AND TOTAL SYNTHESIS OF (-)-INTEGERRIMINE
    H NIWA; Y MIYACHI; Y UOSAKI; A KURODA; H ISHIWATA; K YAMADA
    TETRAHEDRON LETTERS, 27, 38, 4609-4610, 1986, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-TUTIN AND (+)-ASTEROMURIN-A, TOXIC PICROTOXANE SESQUITERPENES
    K WAKAMATSU; H KIGOSHI; K NIIYAMA; H NIWA; K YAMADA
    TETRAHEDRON, 42, 20, 5551-5558, 1986, Peer-reviwed
    Scientific journal, English
  • ISOLATION OF PETASITENINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID FROM FARFUGIUM-JAPONICUM
    H NIWA; H ISHIWATA; K YAMADA
    JOURNAL OF NATURAL PRODUCTS, 48, 6, 1003-1004, Nov. 1985, Peer-reviwed
    Scientific journal, English
  • GENOTOXICITY OF PTAQUILOSIDE, A BRACKEN CARCINOGEN, IN THE HEPATOCYTE PRIMARY CULTURE DNA-REPAIR TEST
    H MORI; S SUGIE; HIRONO, I; K YAMADA; H NIWA; M OJIKA
    MUTATION RESEARCH, 143, 1-2, 75-78, 1985, Peer-reviwed
    Scientific journal, English
  • A NEW METHOD FOR DIRECT OXIDATION OF THE METHYLENE GROUP ADJACENT TO A CYCLOPROPANE RING TO THE KETO GROUP
    T HASEGAWA; H NIWA; K YAMADA
    CHEMISTRY LETTERS, 14, 9, 1385-1386, 1985, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF (+/-)-(Z)-9-(BROMOMETHYLENE)-1,5,5-TRIMETHYLSPIRO[5.5]UNDECA-1,7-DIEN-3-ONE, A BROMINATED SESQUITERPENE OF CHAMIGRANE TYPE
    H NIWA; Y YOSHIDA; T HASEGAWA; K YAMADA
    CHEMISTRY LETTERS, 14, 11, 1687-1688, 1985, Peer-reviwed
    Scientific journal, English
  • STUDIES ON PTERIDIUM-AQUILINUM VAR LATIUSCULUM .4. ISOLATION OF 3 PARA-HYDROXYSTYRENE GLYCOSIDES AND AN EFFICIENT METHOD FOR THE ISOLATION OF PTAQUILOSIDE, AN UNSTABLE BRACKEN CARCINOGEN
    M OJIKA; H KIGOSHI; H KUYAMA; H NIWA; K YAMADA
    JOURNAL OF NATURAL PRODUCTS, 48, 4, 634-637, 1985, Peer-reviwed
    Scientific journal, English
  • ACTIONS OF PICROTOXININ AND RELATED-COMPOUNDS ON THE FROG SPINAL-CORD - THE ROLE OF A HYDROXYL-GROUP AT THE 6-POSITION IN ANTAGONIZING THE ACTIONS OF AMINO-ACIDS AND PRESYNAPTIC INHIBITION
    Y KUDO; H NIWA; A TANAKA; K YAMADA
    BRITISH JOURNAL OF PHARMACOLOGY, 81, 2, 373-380, 1984, Peer-reviwed
    Scientific journal, English
  • SEPARATION OF CARCINOGENIC FRACTION OF BRACKEN FERN
    HIRONO, I; K YAMADA; H NIWA; Y SHIZURI; M OJIKA; S HOSAKA; T YAMAJI; K WAKAMATSU; H KIGOSHI; K NIIYAMA; Y UOSAKI
    CANCER LETTERS, 21, 3, 239-246, 1984, Peer-reviwed
    Scientific journal, English
  • ISOLATION AND STRUCTURES OF 2 NEW PARA-HYDROXYSTYRENE GLYCOSIDES, PTELATOSIDE-A AND PTELATOSIDE-B FROM BRACKEN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM, AND SYNTHESIS OF PTELATOSIDE-A
    M OJIKA; K WAKAMATSU; H NIWA; K YAMADA; HIRONO, I
    CHEMISTRY LETTERS, 13, 3, 397-400, 1984, Peer-reviwed
    Scientific journal, English
  • HYPERPLASTIC NODULES OF THE LIVER INDUCED IN RATS FED BRACKEN DIET
    HIRONO, I; S AISO; T YAMAJI; H NIWA; M OJIKA; K WAKAMATSU; K YAMADA
    CANCER LETTERS, 22, 2, 151-155, 1984, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (+/-)-HYDROXY PATCHOULI ALCOHOL AND THE CORRESPONDING (+/-)-CARBOXYLIC ACID, METABOLITES OF PATCHOULI ALCOHOL, AND (+/-)-NORPATCHOULENOL
    H NIWA; T HASEGAWA; N BAN; K YAMADA
    TETRAHEDRON LETTERS, 25, 26, 2797-2800, 1984, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (-)-PICROTOXININ AND (+)-CORIAMYRTIN VIA A COMMON ISOTWISTANE INTERMEDIATE
    H NIWA; K WAKAMATSU; T HIDA; K NIIYAMA; H KIGOSHI; M YAMADA; H NAGASE; M SUZUKI; K YAMADA
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 106, 16, 4547-4552, 1984, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-TUTIN, A TOXIC SESQUITERPENE OF PICROTOXANE TYPE
    K WAKAMATSU; H KIGOSHI; K NIIYAMA; H NIWA; K YAMADA
    TETRAHEDRON LETTERS, 25, 35, 3873-3874, 1984, Peer-reviwed
    Scientific journal, English
  • STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-ASTEROMURIN-A, A PICROTOXANE SESQUITERPENE ISOLATED FROM THE SCALE INSECT ASTEROCOCCUS-MURATAE KUWANA
    K WAKAMATSU; K NIIYAMA; H NIWA; K YAMADA
    CHEMISTRY LETTERS, 13, 10, 1763-1764, 1984, Peer-reviwed
    Scientific journal, English
  • REPRODUCTION OF ACUTE BRACKEN POISONING IN A CALF WITH PTAQUILOSIDE, A BRACKEN CONSTITUENT
    HIRONO, I; Y KONO; K TAKAHASHI; K YAMADA; H NIWA; M OJIKA; H KIGOSHI; K NIIYAMA; Y UOSAKI
    VETERINARY RECORD, 115, 15, 375-378, 1984, Peer-reviwed
    Scientific journal, English
  • STRUCTURE AND SYNTHESIS OF MIYAGININ, A PARA-ALLYLPHENYL GLYCOSIDE FROM LESPEDEZA-THUNBERGII FORMA MACRANTHA
    M OJIKA; H KUYAMA; H NIWA; K YAMADA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 57, 10, 2893-2896, 1984, Peer-reviwed
    Scientific journal, English
  • CARCINOGENICITY IN RATS OF PTAQUILOSIDE ISOLATED FROM BRACKEN
    HIRONO, I; S AISO; T YAMAJI; H MORI; K YAMADA; H NIWA; M OJIKA; K WAKAMATSU; H KIGOSHI; K NIIYAMA; Y UOSAKI
    GANN, 75, 10, 833-836, 1984, Peer-reviwed
    Scientific journal, English
  • STRUCTURE OF PTAQUILOSIDE TETRAACETATE, C28H38O12
    S OHBA; Y SAITO; HIRONO, I; H NIWA; M OJIKA; K WAKAMATSU; K YAMADA
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 40, NOV, 1877-1879, 1984, Peer-reviwed
    Scientific journal, English
  • A CONVENIENT SYNTHESIS OF (+/-)-RETRONECINE
    H NIWA; A KURODA; K YAMADA
    CHEMISTRY LETTERS, 12, 1, 125-126, 1983, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF (+/-)-CYCLOSEYCHELLENE, A NOVEL TETRACYCLIC SESQUITERPENE
    H NIWA; N BAN; K YAMADA
    TETRAHEDRON LETTERS, 24, 9, 937-938, 1983, Peer-reviwed
    Scientific journal, English
  • SEPARATION AND DETERMINATION OF MACROCYCLIC PYRROLIZIDINE ALKALOIDS OF THE OTONECINE TYPE PRESENT IN THE EDIBLE PLANT PETASITES-JAPONICUS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    H NIWA; H ISHIWATA; K YAMADA
    JOURNAL OF CHROMATOGRAPHY, 257, 1, 146-150, 1983, Peer-reviwed
    Scientific journal, English
  • FARFUGINE, A NEW PYRROLIZIDINE ALKALOID ISOLATED FROM FARFUGIUM-JAPONICUM KITAM
    H NIWA; H ISHIWATA; A KURODA; K YAMADA
    CHEMISTRY LETTERS, 12, 5, 789-790, 1983, Peer-reviwed
    Scientific journal, English
  • PTAQUILOSIDE, A NOVEL NORSESQUITERPENE GLUCOSIDE FROM BRACKEN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM
    H NIWA; M OJIKA; K WAKAMATSU; K YAMADA; HIRONO, I; K MATSUSHITA
    TETRAHEDRON LETTERS, 24, 38, 4117-4120, 1983, Peer-reviwed
    Scientific journal, English
  • STEREOCHEMISTRY OF PTAQUILOSIDE, A NOVEL NORSESQUITERPENE GLUCOSIDE FROM BRACKEN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM
    H NIWA; M OJIKA; K WAKAMATSU; K YAMADA; S OHBA; Y SAITO; HIRONO, I; K MATSUSHITA
    TETRAHEDRON LETTERS, 24, 48, 5371-5372, 1983, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF (+/-)-OTONECINE, A NECINE BASE OF PYRROLIZIDINE ALKALOIDS
    H NIWA; Y UOSAKI; K YAMADA
    TETRAHEDRON LETTERS, 24, 51, 5731-5732, 1983, Peer-reviwed
    Scientific journal, English
  • SYNTHESIS OF (+1)-CARBA-ANALOGS OF 5-HPETE AND LEUKOTRIENE A4, UNSTABLE INTERMEDIATES OF SLOW-REACTING SUBSTANCE (SRS)
    Y ARAI; M KONNO; K SHIMOJI; Y KONISHI; H NIWA; M TODA; M HAYASHI
    CHEMICAL & PHARMACEUTICAL BULLETIN, 30, 1, 379-382, 1982, Peer-reviwed
    Scientific journal, English
  • STRUCTURAL ANALOGS OF LEUKOTRIENE-C AND LEUKOTRIENE-D AND THEIR CONTRACTILE ACTIVITIES
    S OKUYAMA; S MIYAMOTO; K SHIMOJI; Y KONISHI; D FUKUSHIMA; H NIWA; Y ARAI; M TODA; M HAYASHI
    CHEMICAL & PHARMACEUTICAL BULLETIN, 30, 7, 2453-2462, 1982, Peer-reviwed
    Scientific journal, English
  • ISOLATION AND STRUCTURES OF TRANS-LAURENCENYNE, A POSSIBLE PRECURSOR OF THE C-15 HALOGENATED CYCLIC ETHERS, AND TRANS-NEOLAURENCENYNE FROM LAURENCIA-OKAMURAI
    H KIGOSHI; Y SHIZURI; H NIWA; K YAMADA
    TETRAHEDRON LETTERS, 23, 14, 1475-1476, 1982, Peer-reviwed
    Scientific journal, English
  • TOTAL SYNTHESIS OF AN ANTI-TUMOR ANTIBIOTIC, (+/-)-REDUCTIOMYCIN
    M OJIKA; H NIWA; Y SHIZURI; K YAMADA
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 11, 628-629, 1982, Peer-reviwed
    Scientific journal, English
  • STRUCTURE AND SYNTHESIS OF REDUCTILINE, A NOVEL METABOLITE FROM A VARIANT OF STREPTOMYCES-ORIENTALIS
    M OJIKA; Y SHIZURI; H NIWA; K YAMADA; S IWADARE
    TETRAHEDRON LETTERS, 23, 47, 4977-4980, 1982, Peer-reviwed
    Scientific journal, English
  • (10R, 11R)-(+)-SQUALENE-10, 11-EPOXIDE - ISOLATION FROM LAURENCIA-OKAMURAI AND THE ASYMMETRIC-SYNTHESIS
    H KIGOSHI; M OJIKA; Y SHIZURI; H NIWA; K YAMADA
    TETRAHEDRON LETTERS, 23, 51, 5413-5414, 1982, Peer-reviwed
    Scientific journal, English
  • A CONVENIENT PREPARATION OF N-ACYLPYROGLUTAMIC ACID
    K IMAKI; H NIWA; S SAKUYAMA; T OKADA; M TODA; M HAYASHI
    CHEMICAL & PHARMACEUTICAL BULLETIN, 29, 9, 2699-2701, 1981, Peer-reviwed
    Scientific journal, English
  • A NEW METHOD FOR CLEAVAGE OF ALIPHATIC METHYL ETHERS
    H NIWA; T HIDA; K YAMADA
    TETRAHEDRON LETTERS, 22, 42, 4239-4240, 1981, Peer-reviwed
    Scientific journal, English
  • LAURENCENYNE, A PLAUSIBLE PRECURSOR OF VARIOUS NON-TERPENOID C-15-COMPOUNDS, AND NEOLAURENCENYNE FROM THE RED ALGA LAURENCIA-OKAMURAI
    H KIGOSHI; Y SHIZURI; H NIWA; K YAMADA
    TETRAHEDRON LETTERS, 22, 47, 4729-4732, 1981, Peer-reviwed
    Scientific journal, English
  • Recent Studies on the Chemical Synthesis of Eicosanoids.
    E. J. Corey; H. Niwa; J. R. Falck; C. Mioskowski; Y. Arai; A. Marfat
    "Advances in Prostaglandin and Thromboxane Research" ed. by B. Samuelsson, P. W. Ramwell, and R. Paoletti, Raven Press, New York, 6, 19-25, 1980, Peer-reviwed
    Scientific journal, English
  • Synthesis of 15,17-Methylene-prostaglandins.
    Haruki Niwa; Masayasu Kurono
    Chemistry Letters, 8, 1, 23-26, 1979, Peer-reviwed
    Scientific journal, English
  • Synthesis of a New Prostaglandin Endoperoxide (PG H2) Analog and Its Function as an Inhibitor of the Biosynthesis of Thromboxane A2 (TX A2).
    E. J. Corey; Haruki Niwa; Miriam Bloom; Peter W. Ramwell
    Tetrachedron Letters, 8, 671-674, 1979, Peer-reviwed
    Scientific journal, English
  • Selective Epoxidation of Eicosa-cis-5,8,11,14-tetraenoic(Arachidonic)Acid and Eicosa-cis-8,11,14-trienoic Acid.
    E. J. Corey; Haruki Niwa; J. R. Falck
    J. Am. Chem. Soc., 101, 6, 1586-1587, 1979, Peer-reviwed
    Scientific journal, English
  • Total Synthesis of (S)-12 Hydroxy-5,8,14-cis-10-trans-eicosatetraenoic Acid(Samuelsson's HETE).
    E. J. Corey; Haruki Niwa; Jochen Knolle
    J. Am. Chem. Soc., 100, 6, 1942-1943, 1978, Peer-reviwed
    Scientific journal, English
  • Synthesis of 15,19-Methano-ω-nor-prostaglandins.
    Haruki Niwa; Masayasu Kurono
    Chemistry Letters, 6, 10, 1211-1214, 1977, Peer-reviwed
    Scientific journal, English
  • The Alkaloids from the Fruits of the Plant Daphniphyllaceae.
    Masaaki Toda; Haruki Niwa; Hajime Irikawa; Yoshimasa Hirata; Shosuke Yamamura
    Tetrahedron, 30, 16, 2683-2688, 1974, Peer-reviwed
    Scientific journal, English
  • Chemical Studies on Nitrogen Heterocylic Skeleton of the Daphniphyllum Alkaloids.
    Haruki Niwa; Masaaki Toda; Sueaki Ishimaru; Yoshimasa Hirata; Shosuke Yamamura
    Tetrahedron, 30, 17, 3031-3036, 1974, Peer-reviwed
    Scientific journal, English
  • The Structure of Daphniphyllidine.
    Masaaki Toda; Haruki Niwa; Yoshimasa Hirata; Shosuke Yamamura
    Tetrachedron Letters, 14, 11, 797-798, 1973, Peer-reviwed
    Scientific journal, English
  • Biosynthesis of Daphniphyllum Alkaloids.
    Kazuo T. Suzuki; Shigenobu Okuda; Haruki Niwa; Masaaki Toda; Yoshimasa Hirata; Shosuke Yamamura
    Tetrachedron Letters, 14, 11, 799-802, 1973, Peer-reviwed
    Scientific journal, English
  • Biosynthesis of Daphnilactone-B.
    Haruki Niwa; Yoshimasa Hirata; Kazuo T. Suzuki; Shosuke Yamamura
    Tetrachedron Letters, 14, 23, 2129-2132, 1973, Peer-reviwed
    Scientific journal, English
  • 2-Azabicyclo[3.3.1]non-1-ene Systems as Reaction Intermediates.
    Masaaki Toda; Haruki Niwa; Kazuharu Ienaga; Yoshimasa Hirata; Shosuke Yamamura
    Tetrachedron Letters, 13, 5, 335-338, 1972, Peer-reviwed
    Scientific journal, English
  • Daphnilactone-B, a Major Alkaloid, from the Fruits of Daphniphyllaceae.
    Haruki Niwa; Masaaki Toda; Yoshimasa Hirata; Shosuke Yamamura
    Tetrachedron Letters, 13, 26, 2697-2700, 1972, Peer-reviwed
    Scientific journal, English

MISC

  • 生物発光の原理と応用
    丹羽治樹
    Jul. 2012, 自動車技術会 関東支部報「高翔」, 58, xx, Japanese, Introduction other
  • 生物発光の原理と応用
    丹羽治樹
    Apr. 2012, 日本大気電気学会誌, 6, 1, 31-34, Japanese, Introduction other
  • オワンクラゲの生物発光機構
    丹羽治樹
    Apr. 2009, 岩波書店「科学」, 79, 4, 96-97, Japanese, Introduction other
  • 生物はなぜ光るのか－生物発光とその応用－
    丹羽治樹
    Oct. 2005, ２００５第１９回「大学と科学」公開シンポジウム講演収録集 『不思議な生物現象の化学』, pp. 171-182, Japanese, Introduction other
  • Study on the bioluminescent mechanism of luminous snail Latia neritoides: the Km value of luciferase and the product analyses of bioluminescent reactions of the Latia luciferin analogs
    MASAKI MIZUKI; MAMINO MASASHI; NAGAIE SATOSHI; NAKAMURA MITSUHIRO; KOJIMA SATOSHI; OMIYA YOSHIHIRO; MAKI SHOJIRO; HIRANO TAKASHI; NIWA HARUKI
    11 Mar. 2005, 日本化学会講演予稿集, 85th, 2, 862, Japanese, 0285-7626, 200902221179445784
  • 生物発光のメカニズムとその応用
    丹羽治樹
    2002, 現代化学, 379, 29-36, Japanese, Introduction other
  • The application of electroorganic chemical reaction
    S Maki; H Niwa
    Sep. 1998, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 56, 9, 725-735, Japanese, Peer-reviwed, Introduction other, 0037-9980, WOS:000076044300003
  • Baiotec Illustrated : Mechanism of Sensitized Bioluminescence of Aequorea victoria
    Haruki Niwa
    1998, Bioscience and Industry, 56, 7, 443, Japanese, Introduction other
  • Topics : Mechanism of Sensitized Bioluminescence of Aequorea victoria
    Haruki niwa
    1998, Bioscience and Industry, 56, 7, 471-472, Japanese, Introduction other
  • Luminous Reactions(Topics : Luminous Organisms)
    haruki Niwa
    裳華房, 1996, Idenn, 50, 11, 35-42, Japanese, Introduction other, 0387-0022, 40000132708, AN00015468
    URL
  • 植物神経毒アニサチンの合成
    丹羽治樹; 山田靜之
    1991, ファルマシア(日本薬学会), 27, 7, 924-927, Japanese, Introduction other
  • 植物起源の発がん物質の合成
    山田靜之; 丹羽治樹; 木越英夫
    1990, 化学増刊118「生体機能解明のための化学合成」 化学同人(京都), 191-201, Japanese, Introduction other
  • TOTAL SYNTHESIS OF POLYFUNCTIONALIZED, BIOLOGICALLY-ACTIVE NATURAL-PRODUCTS - SYNTHESIS OF MACROCYCLIC PYRROLIZIDINE ALKALOIDS
    H NIWA
    Jul. 1988, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 46, 7, 693-703, Japanese, Introduction other, 0037-9980, WOS:A1988P301900006
  • Total Synthesis of Sesquiterpenoids of Picrotoxane Type.
    Haruki Niwa; Kiyoyuki Yamada
    1986, J. Synth. Org. Chem., Jpn., 44, 3, 180-190, Japanese, Introduction other

Books and other publications

  • 医学のための細胞生物学：コラム「ＧＦＰと下村脩先生」
    丹羽治樹; コラム執筆分担; 監修 永田和宏; 田浩平
    Japanese, Joint work, 南山堂, Aug. 2009
  • 岩波：科学 Vol. 71, No. 4 (2009).特集「クラゲ」-オワンクラゲの生物発光機構-
    丹羽治樹
    Japanese, Joint work, クラゲの生物発光, 岩波書店, Apr. 2009
  • 天然物化学ー 海洋生物編： 1.2.7「海洋生物の発光現象」
    丹羽治樹; 執筆分担; 監修 山村庄助; 長谷川宏司
    Japanese, Joint work, 1.2.7「海洋生物の発光現象, アイピーシー, Jun. 2008
  • 生物物理学ハンドブック： 7.6 生物発光
    丹羽治樹
    Japanese, Joint work, 7.6 生物発光, 朝倉書店, Apr. 2007
  • 別冊『化学：分子イメージング最前線』 1.4 入門「自然界に光る生き物とその原理」
    丹羽治樹
    Japanese, Joint work, 1.4：入門「自然会の”光る生物”とその原理」, 化学同人, Apr. 2007
  • 天然物化学ー植物編
    丹羽治樹; 執筆分担; 監修 山村庄助; 長谷川宏司
    Japanese, Joint work, 第３章 植物由来の生理活性天然有機化合物の合成 3.1.2 プタキロシン、アニサチン, アイピーシー, Feb. 2007
  • バイオサイエンス化学－生命から学ぶ化学－ 第４章 生命の物質－炭素化合物
    新井孝夫; 大森大二郎; 立屋敷哲; 丹羽治樹
    Japanese, Joint work, 第４章 生命の物質－炭素化合物, 東京化学同人, Mar. 2003
  • 有機化学実験のてびき-3
    丹羽治樹; 執筆分担; 監修 後藤俊夫; 芝 哲夫; 浦輝夫
    Japanese, Joint work, 化学同人, 1990
  • 有機化学実験のてびき-4
    丹羽治樹; 執筆分担; 監修 後藤俊夫; 芝 哲夫; 浦輝夫
    Japanese, Joint work, 化学同人, 1990
  • 有機化学実験のてびき-1
    丹羽治樹; 執筆分担; 監修 後藤俊夫; 芝 哲夫; 浦輝夫
    Japanese, Joint work, 化学同人, 1988

Lectures, oral presentations, etc.

  • 生物発光、温故知新
    丹羽治樹
    Invited oral presentation, Japanese, 生物発光化学発光研究会第30学術講演会（東工大大岡山キャンパス, 目黒区）、抄録集PLxx（2013.11.02), 生物発光化学発光研究会第30学術講演会（東工大大岡山キャンパス, 目黒区）、抄録集PLxx（2013.11.02)
    Nov. 2013
  • ホタル生物発光系をモデルとした人工発光系の創製と実用化
    岩野 智; 伊藤 和人; 北田 昇雄; 牧 昌次郎; 丹羽 治樹
    Others, Japanese, 第8回産学官連携DAY in 電通大 電気通信大学 産学官連携センター産学連携支援部門第１７回共同研究成果発表会(電気通信大学、調布）（2012.6.6), 第8回産学官連携DAY in 電通大 電気通信大学 産学官連携センター産学連携支援部門第１７回共同研究成果発表会(電気通信大学、調布）（2012.6.6)
    Jun. 2012
  • 生物発光の化学とその イメージングへの応用
    丹羽治樹
    Keynote oral presentation, Japanese, 平成19年度日本バイオイメージング学会公開講座 「理学と工学が拓くバイオイメージング」 (2007.10.31、東京理科大学野田キャンパス）, 平成19年度日本バイオイメージング学会公開講座 「理学と工学が拓くバイオイメージング」 (2007.10.31、東京理科大学野田キャンパス）, Domestic conference
    Oct. 2007
  • 生物発光研究の新展開：ラチア、ホタル、発光ゴカイ
    丹羽治樹
    Invited oral presentation, Japanese, 第八回神奈川ハイテク・リサーチ・センター研究発表会 (神奈川大学、2006.6.10), 第八回神奈川ハイテク・リサーチ・センター研究発表会 (神奈川大学、2006.6.10)
    Jun. 2006
  • ホタルの光～生物の光通信～
    丹羽治樹
    Keynote oral presentation, Japanese, 『夏休み子供のための公開シンポジウム：生物の情報通信を探る』（平成１７年度文部科学省「科学研究補助金研究成果公開促進費」補助事業）補助資料(2005.8.9), Domestic conference
    Aug. 2005
  • 生物はなぜ光るのか－生物発光とその応用－
    丹羽治樹
    Keynote oral presentation, Japanese, 第１９回「大学と科学」公開シンポジウム 『不思議な生物現象の化学』, 第１９回「大学と科学」公開シンポジウム 『不思議な生物現象の化学』(2005.1.29), Domestic conference
    Jan. 2005
  • Targetted Pursuit of Challenging Bioactive Molecules [Summary Report of Research Projekt (1999~2002)]
    Haruki Niwa
    Others, English, The Grant-in-Aid for Scientific Research on Priority Areas; The Ministry of Education, Culture, Sports, Scinece and Technology
    Apr. 2004
  • 巻き貝ラチア生物発光の分子機構
    丹羽治樹
    Invited oral presentation, Japanese, 日本化学会第80秋季年会（千葉,千葉）,講演予稿集，(2001.9.21)，（招待）
    Sep. 2001
  • 生物と光―生物発光の分子基盤研究とその応用
    丹羽治樹
    Invited oral presentation, Japanese, 第38回茅コンファランス「光科学の新しい展開とその応用」（福島，裏磐梯）
    Nov. 2000
  • 発光クラゲの緑色蛍光蛋白質（ＧＦＰ）の化学
    丹羽治樹
    Invited oral presentation, Japanese, 第１１回海洋生物活性 談話会（厚岸）（１９９７．５．２５）
    May 1997

Courses

  • 有機化学2
    東邦大学大学院理学研究科
  • 有機化学2
    東邦大学大学院理学研究科
  • 有機化学2
    東邦大学大学院理学研究科

Affiliated academic society

  • The Chemical Society of Japan
  • 生物発光・化学発光研究会

Industrial Property Rights

  • 検出装置、検出方法、及び検出器
    Patent right, 山田幸夫, 西村吾朗, 丹羽治樹, 牧昌次郎, 道脇幸博, 小池卓二, 鈴木崇弘, 田代剛大, 特願2020-123183(優先権主張番号:特願2019-132298 出願日2019.7.17), Date applied: 17 Jul. 2020, 電気通信大学、北海道大学、昭和大学, 特開2021-16798, Date announced: 15 Feb. 2021, Domestic
  • 特願2014-189314 新規複素環式化合物及びその塩、並びに、発光基質組成物(原特願2013-198998; 2013/9/25)
    Patent right, 牧 昌次郎, 丹羽治樹, 特願2014-189314(原特願2013-198998; 2013/9/25), Date applied: 17 Sep. 2014, The University of Electro-Communications, 特開2015-193584, Date announced: 05 Nov. 2015, 特許第6353751, Date issued: 15 Jun. 2018
  • 特願2013-530040：ルシフェラーゼの発光基質
    Patent right, 西山 繁, 齋藤 毅, 牧 昌次郎, 丹羽治樹, 特願2013-530040, Date applied: 22 Aug. 2012, 国立大学法人 電気通信大学, WO/2013/027770 A1, Date announced: 28 Feb. 2013, 特許第6049019, Date issued: 02 Dec. 2016
  • 特願2013-097755 新規ハロゲン化水素塩
    Patent right, 牧 昌次郎, 丹羽治樹, 特願2013-097755, Date applied: 07 May 2013, 国立大学法人電気通信大学, 特開2014-218456, Date announced: 20 Nov. 2014, 特許第6011974号, Date issued: 30 Sep. 2016
  • PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit
    Patent right, Nishiyama, Shigeru, Saito, Tsuyoshi, Maki, Shojiro, Niwa, Haruk, PCT/JP2012/071207, Date applied: 22 Aug. 2012,  The University of Electro-Communications, Japan, CN103796999A, Date announced: 14 May 2014, ZL201280041269.3, Date issued: 22 Jul. 2015
  • 特願2010-137031 遷移元素触媒およびその製造方法、並びに選択的水素添加方法
    Patent right, 牧昌次郎, 丹羽治樹, 特願2010-137031, Date applied: 16 Jun. 2010, 国立大学法人電気通信大学, 特開2011-020116, Date announced: 03 Feb. 2011, 特許第5605619, Date issued: 05 Sep. 2014
  • PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit
    Patent right, Nishiyama, Shigeru, Saito, Tsuyoshi, Maki, Shojiro, Niwa, Haruk, PCT/JP2012/071207, Date applied: 22 Aug. 2012,  The University of Electro-Communications, Japan, US2014-0221665A1, Date announced: 07 Aug. 2014
  • PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit
    Patent right, Nishiyama, Shigeru, Saito, Tsuyoshi, Maki, Shojiro, Niwa, Haruk, PCT/JP2012/071207, Date applied: 22 Aug. 2012,  The University of Electro-Communications, Japan, EP2754657A1, Date announced: 16 Jul. 2014
  • 特願2012-265382 環化化合物の製造方法、及び、環化化合物を含有する溶液の発光方法
    Patent right, 斎藤 毅, 西山 繁, 井岡秀二, 牧 昌次郎, 丹羽治樹, 特願2012-265382, Date applied: 04 Dec. 2012, 学校法人慶応義塾、国立大学法人電気通信大学, 特開2014-108957, Date announced: 12 Jun. 2014
  • 特願2009-064595：波長が制御されたルシフェラーゼの発光基質および製造方法
    Patent right, 牧 昌次郎, 小島 哲, 丹羽治樹, 特願2009-064595, Date applied: 17 Mar. 2009, The University of Electro-Communications, 特開2010-215795, Date announced: 30 Sep. 2010, 特許第5550035号, Date issued: 30 May 2014
  • 特願2008-023396:「ルシフェラーゼの発光基質」
    Patent right, 牧 昌次郎, 小島 哲, 丹羽 治樹, 特願2008-023396, Date applied: 02 Feb. 2008, 国立大学法人電気通信大学, 特開2009-184932, Date announced: 20 Aug. 2009, 特許第5464311, Date issued: 31 Jan. 2014
  • 特願2012-049619：ルシフェラーゼの発光基質
    Patent right, 牧 昌次郎, 丹羽 治樹, 特願2012-49619, Date applied: 06 Mar. 2012, 国立大学法人 電気通信大学, 特開2013-184909, Date announced: 19 Sep. 2013
  • PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit
    Patent right, Nishiyama, Shigeru, Saito, Tsuyoshi, Maki, Shojiro, Niwa, Haruk, PCT/JP2012/071207, Date applied: 22 Aug. 2012,  The University of Electro-Communications, Japan, WO/2013/027770 A1, Date announced: 28 Feb. 2013
  • HETEROCYCLIC COMPOUND AND LUMINESCENCE METHOD
    Patent right, 牧 昌次郎, 小島 哲, 丹羽治樹, 平野 誉, PCT/JP2007/056227, Date applied: 26 Mar. 2007, The University of Electro-Communications, WO2007/116687, Date announced: 18 Oct. 2007, 特許第5194258号, Date issued: 15 Feb. 2013
  • 特願2011-108654 蛍光色素
    Patent right, 平野 誉, 中川 達規, 牧 昌次郎, 丹羽治樹, 特願2011-108654, Date applied: 13 May 2011, 国立大学法人 電気通信大学, 特開2012-241014, Date announced: 10 Dec. 2012
  • （取下げ擬制）特願2011-182224：ルシフェラーゼの発光基質
    Patent right, 西山 繁, 齋藤 毅, 牧 昌次郎, 丹羽治樹, (取下げ擬制)特願2011-182224, Date applied: 24 Aug. 2011, 国立大学法人 電気通信大学
  • 特願2009-187979：抗体－ルシフェリルペプチド複合体、これを用いた被検物質の測定方法及び被検物質の測定試薬並びに測定試薬の調製方法
    Patent right, 志賀 一樹, 河口 成, 牧 昌次郎, 丹羽 治樹, 特願2009-187979, Date applied: 14 Aug. 2009, キッコーマン株式会社、国立大学法人電気通信大学、株式会社キャンパスクリエイト, 特開2011-037791, Date announced: 24 Feb. 2011
  • 特願2004-379971：天然型L-システインまたはその誘導体を用いたホタル発光基質の生合成システム及び本システムを含んだ発光基質溶液
    Patent right, 近江谷克裕, 丹羽一樹, 丹羽治樹, 中村光裕, 龍福正行, 特願2004-379971, Date applied: 28 Dec. 2004, 産業技術総合研究所、電気通信大学、東洋ビーネット, 特開2006-180825, Date announced: 13 Jul. 2006, 特許4682310, Date issued: 18 Feb. 2011
  • PCT/JP2009/000376：ルシフェラーゼの発光基質
    Patent right, 牧 昌次郎, 小島 哲, 丹羽治樹, PCT/JP2009/000376, Date applied: 02 Feb. 2009, The University of Electro-Communications, US2011/033878A1, Date announced: 10 Feb. 2011
  • PCT/JP2010/053177波長が制御されたルシフェラーゼの発光基質および製造方法
    Patent right, 牧,小島,丹羽, PCT/JP2010/053177, Date applied: 28 Feb. 2010, The University of Electro-Communications, WO/2010/106896 A1, Date announced: 23 Sep. 2010
  • 特願2009-027654 ルシフェラーゼの発光基質
    Patent right, 牧 昌次郎, 小島 哲, 丹羽治樹, 特願2009-027654, Date applied: 09 Feb. 2009, The University of Electro-Communications, 特開2010-180191, Date announced: 19 Aug. 2010
  • 特願2004-067098: イミダゾピラジノン誘導体及びビスアミノピラジノン誘導体並びに化学発光物質
    Patent right, 特願2004-067098, Date applied: 10 Mar. 2004, 三菱科学(株), 特開2005-255579, Date announced: 22 Sep. 2005, 特許4561132, Date issued: 06 Aug. 2010
  • 特願2008-244890［アシルアミノピラジナート-O,N］ーボロン誘導体および蛍光色素
    Patent right, 平野 誉, 牧 昌次郎, 丹羽治樹, 特願2008-244890, Date applied: 24 Sep. 2008, The University of Electro-Communications, 特開2010-077040, Date announced: 08 Apr. 2010
  • 特願2008-192596: ε-N-ルシフェリルリシン化合物、これを用いたペプチド標識剤及びペプチド標識方法
    Patent right, 牧 昌次郎, 小島 哲, 丹羽 治樹, 河口 成, 特願2008-192596, Date applied: 25 Jul. 2008, 電気通信大学、キッコーマン株式会社、株式会社キャンパスクリエイト, 特開2010-30918, Date announced: 12 Feb. 2010
  • 特願2003-195905: ビスイミダゾピラジノン系新規蛍光性・化学発光生物質
    Patent right, 平野 誉, 丹羽治樹, 牧 昌次郎, 特願2003-195905:, Date applied: 11 Jul. 2003, 三菱化学, 特開2005-29500, Date announced: 03 Feb. 2005, 特許4363098, Date issued: 28 Aug. 2009
  • 特願2003-026134: 還元触媒及びその製造方法、並びに選択的水素添加方法
    Patent right, 牧 昌次郎, 丹羽治樹, 特願2003-026134, Date applied: 02 Feb. 2003, Japan Science and Technology Agency, 特開2004-23714, Date announced: 26 Aug. 2004, 特許4116891, Date issued: 25 Apr. 2008
  • 特願2006-086175:複素環化合物及び発光方法
    Patent right, 牧 昌次郎, 小島 哲, 丹羽治樹, 平野 誉, 特願2006-086175, Date applied: 27 Mar. 2006, The University of Electro-Communications, 特開2007-194258, Date announced: 02 Aug. 2007
  • 特願2002-33258: パラジウム触媒を用いた選択的水素添加反応方法
    Patent right, 牧 昌次郎, 丹羽治樹, 佐野淳典, 特願2002-33258, Date applied: 08 Feb. 2002, 和光純薬工業 (株), 特開2003-238482, Date announced: 27 Aug. 2003, 特許第3976579, Date issued: 29 Jun. 2007
  • 特願2005-031574:複素環化合物及び発光甲虫ルシフェラーゼ発光系用発光物質
    Patent right, 丹羽治樹, 牧昌次郎, 平野 誉, 特願2005-031574, Date applied: 08 Feb. 2005, The University of Electro-Communications, 特開2006-219381, Date announced: 24 Aug. 2006
  • SYSTEM FOR BIOSYNTHESIS OF FIREFLY LUMINESCENCE SUBSTRATES WITH NATURAL L-CYSTEINE OR DERIVATIVES THEREOF AND LUMINESCENCE SUBSTRATE SOLUTIONS CONTAINING THE SYSTEM
    Patent right, 近江谷克裕, 丹羽一樹, 丹羽治樹, 中村光裕, 龍福正行, PCT/JP2005/023847, Date applied: 27 Dec. 2005, 産業技術総合研究所、電気通信大学、東洋ビーネット, WO/2006/070775, Date announced: 06 Jul. 2006
  • 特願2003-292606: 発光キノコヤコウタケの簡便栽培法
    Patent right, 杉本正志, 丹羽治樹, 特願2003-292606, Date applied: 09 Jul. 2003, 杉本正志, 特開2005-27634, Date announced: 03 Feb. 2005
  • 特願2003-116616: 芳香族有機化合物の分解方法
    Patent right, 牧昌次郎, 丹羽治樹, 平野 誉, 特願2003-116616, Date applied: 22 Apr. 2003, Japan Science and Technology Agency, 特開2004-321275, Date announced: 18 Nov. 2004
  • 特願2002-80931: 新規なパラジウム触媒
    Patent right, 牧昌次郎, 丹羽治樹, 佐野淳典, 大野桂二, 特願2002-80931, Date applied: 22 Mar. 2002, 和光純薬工業 (株)., 特開2003-275593, Date announced: 30 Sep. 2003
  • 特願2002-80930: パラジウムブラックの新規な製造方法
    Patent right, 牧 昌次郎, 丹羽 治樹, 佐野 淳典, 大野 桂二, 特願2002-80930, Date applied: 22 Mar. 2002, 和光純薬工業 (株), 特開2003-275586, Date announced: 30 Sep. 2003
  • 特願2002-80929: 担持型パラジウム触媒
    Patent right, 牧昌次郎, 丹羽治樹, 佐野淳典, 大野桂二, 特願2002-80929, Date applied: 22 Mar. 2002, 和光純薬工業 (株)., 特開2003-275585, Date announced: 30 Sep. 2003
  • 特願2000-340644: アルケン類の選択的水素添加反応並びにこれに用いる触媒及び触媒構造体
    Patent right, 小泉 恵, 錦 善則, 古田 常人, 丹羽 治樹, 牧 昌次郎, 特願2000-340644, Date applied: 08 Nov. 2000, ペルメレック電極 (株)., 特開2002-145818, Date announced: 22 May 2002
  • 特願2000-133584: アルケン類の選択的水素添加方法
    Patent right, 小泉 恵, 尾形節郎, 錦 善則, 井上博史, 岩倉千秋, 丹羽治樹, 牧昌次郎, 特願2000-133584, Date applied: 02 May 2000, ペルメレック電極 (株), 特開2001-316315, Date announced: 13 Nov. 2001
  • 特願平11-137401: アルケンの選択的水素添加方法
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