Dr. Eng., Tohoku University

numerical analysis

vibration

diagnostic apparatus

hearing aid

auditory system

聴覚器 補聴 診断装置 振動 数値解

Informatics, Mechanics and mechatronics

Life sciences, Biomaterials

Life sciences, Biomedical engineering

01 Apr. 2010
The University of Electro-Communications, Professor

01 Apr. 2007 - 31 Mar. 2010
The University of Electro-Communications, Associate Prof.

Sep. 2002 - 31 Mar. 2007
The University of Electro-Communications, Associate Prof.

Dec. 1998 - Aug. 2002
Tohoku University, Assistant Prof.

Apr. 1996 - Nov. 1998
Tohoku University, Research Assistant

Mar. 1996
Tohoku University, Graduate School, Division of Engineering, Mechanical Engineering

Mar. 1993
Tohoku University, Graduate School, Division of Engineering, Mechanical Engineering

Mar. 1991
Tohoku University, Faculty of Engineering, Mechanical Engineering

Apr. 2020 - Mar. 2022
バイオエンジニアリング部門幹事, 日本機械学会, Society

Apr. 2013 - Mar. 2018
バイオエンジニアリング部門英文ジャーナル編集委員, 日本機械学会, Society

Apr. 2013 - Apr. 2015
バイオエンジニアリング部門総務委委員長, 日本機械学会, Society

May 2024
日本機械学会, バイオエンジニアリング部門業績賞は前年度末までに発表されたバイオエンジニアリング関連の研究及び技術の中で優秀と認められる業績を挙げた個人に贈られる賞で、小池教授は、耳鼻咽喉科領域の医工連携研究において優れた業績を挙げたことが評価されました。
2023年度第31回業績賞, 小池卓二
Japan society, Japan

Feb. 2017
日本機械学会
フェロー称号授与

Oct. 2008
日本耳科学会
日本耳科学会奨励賞基礎部門

Jan. 2004
The Seguchi Prize (12th)

Apr. 2001
日本機械学会奨励賞（研究）

Oct. 1998
日本耳科学会奨励賞臨床部門

Classification of ossicular fixation based on a computational simulation of ossicular mobility
Sinyoung Lee; Hyeonsik You; Yoji Morita; Sho Kanzaki; Fei Zhao; Takuji Koike
Scientific Reports, 14, Sep. 2024, Peer-reviwed
Scientific journal, English

Effectiveness of active middle ear implant placement methods in pathological conditions: basilar membrane vibration simulation
Sinyoung Lee; Masaomi Motegi; Takuji Koike
Frontiers in Neurology, Frontiers Media SA, 15, 08 Aug. 2024, Active middle ear implants (AMEI) amplify mechanical vibrations in the middle ear and transmit them to the cochlea. The AMEI includes a floating mass transducer (FMT) that can be placed using two different surgical approaches: “oval window (OW) vibroplasty” and “round window (RW) vibroplasty.” The OW and RW are windows located on the cochlea. Normally, sound stimulus is transmitted from the middle ear to cochlea via the OW. RW vibroplasty has been suggested as an alternative method due to the difficulty of applying OW vibroplasty in patients with ossicle dysfunction. Several reports compare the advantages of each approach through pre and postoperative hearing tests. However, quantitatively assessing the treatment effect is challenging due to individual differences in pathologies. This study investigates the vibration transmission efficiency of each surgical approach using a finite-element model of the human cochlea. Vibration of the basilar membrane (BM) of the cochlea is simulated by applying the stimulus through the OW or RW. Pathological conditions, such as impaired stapes mobility, are simulated by increasing the stiffness of the stapedial annular ligament. RW closure due to chronic middle ear diseases is a common clinical occurrence and is simulated by increasing the stiffness of the RW membrane in the model. The results show that the vibration amplitude of the BM is larger when the stimulus is applied to the RW compared to the OW, except for cases of RW membrane ossification. The difference in these amplitudes is particularly significant when stapedial mobility is limited. These results suggest that RW vibroplasty would be advantageous, especially in cases of accompanying stapedial mobility impairment. Additionally, it is suggested that transitioning to OW vibroplasty could still ensure a sufficient level of vibratory transmission efficiency when placing the FMT on the RW membrane is difficult due to anatomical problems in the tympanic cavity or confirmed severe pathological conditions around the RW.
Scientific journal, English

Vibrations as a new tool for pest management – a review
Ryuhei Yanagisawa; Haruki Tatsuta; Takayuki Sekine; Takaho Oe; Hiromi Mukai; Nami Uechi; Takuji Koike; Ryuichi Onodera; Ryuichi Suwa; Takuma Takanashi
Entomologia Experimentalis et Applicata, 10 May 2024, Peer-reviwed
Scientific journal, English

Relationship between DPOAE and pure tone hearing levels: Numerical analysis with human cochlear finite element model
Takuji Koike; Sinyoung Lee
Lead, AIP Conference Proceedings, AIP Publishing, 3062, 1, 040003-040003, Feb. 2024, Peer-reviwed
International conference proceedings, English

Numerical analysis of nonlinearity of outer hair cells based on comparison with measurements of DPOAEs
Sinyoung Lee; Takuji Koike
AIP Conference Proceedings, AIP Publishing, 3062, 030009-030009, Feb. 2024, Peer-reviwed
International conference proceedings, English

Diagnosing Middle Ear Malformation by Pure-Tone Audiometry Using a Three-Dimensional Finite Element Model: A Case-Control Study
Shin-ichiro Kita; Toru Miwa; Rie Kanai; Yoji Morita; Sinyoung Lee; Takuji Koike; Shin-ichi Kanemaru
Journal of Clinical Medicine, MDPI AG, 12, 23, 7493-7493, 04 Dec. 2023, Background: Hearing loss caused by middle ear malformations is treated by tympanoplasty to reconstruct the acoustic conduction system. The mobility of the ossicles plays a crucial role in postoperative success. However, identifying the location of ossicular malformation based solely on preoperative audiograms is challenging due to the complex relationship between fixation location, deformity levels, and ossicular mobility. Methods: Middle ear finite element models for simulating ossicular malformations were created, and the results were compared with the actual preoperative audiograms. Results: This approach objectively diagnosed ossicular fixation and disarticulation, bypassing traditional criteria reliant on physician examination or imaging. Conclusion: This study suggests that future research should focus on developing a diagnostic framework utilizing large-scale data.
Scientific journal, English

A Systematic Review of the Audiological Efficacy of Cartilage Conduction Hearing Aids and the Factors Influencing Their Clinical Application
Bei Li; Sinyoung Lee; Zuwei Cao; Takuji Koike; Robin Joseph; Tamsin Holland Brown; Fei Zhao
Audiology Research, MDPI AG, 13, 4, 636-650, 10 Aug. 2023, This systematic review evaluates the efficacy and benefit of cartilage conduction hearing aids (CC-HAs) and that factors that influence purchasing decisions. The hearing thresholds and functional gain following CC-HA wear were synthesised. A one-way analysis of variance compared the differences in the hearing thresholds and functional gain at individual frequencies and in patients with a variety of pathological changes. The synchronised aided hearing threshold and functional gain at 2.0 kHz were significantly better than at 0.5, 1.0, and 4.0 kHz. There was no significant difference in the synchronised unaided hearing thresholds across individual frequencies between 0.5 and 4.0 kHz. The synchronised functional gain in patients with atresia was significantly greater than in patients with aural atresia or stenosis and middle ear pathologies with normal ear canals. The acceptability of CC-HAs in terms of purchase decision is influenced by the condition of the external auditory meatus and severity of hearing loss, with the highest purchase rate seen in patients with aural atresia or stenosis. CC-HAs’ fitting procedure advantages and cosmetic considerations make these devices a viable and preferred choice for individuals with microtia and aural atresia. Additional research to evaluate the benefits towards emotional well-being is crucial to gain insights into the psychological impact of CC-HA use.
Scientific journal, English

内リンパ圧上昇時の基底板振動変化：ヒト蝸牛有限要素モデルを用いた数値解析
李 信英; 小池卓二
Otology Japan, 32, 2, Nov. 2022, Peer-reviwed
Scientific journal, Japanese

Potential of substrate‑borne vibration to control greenhouse whitefly Trialeurodes vaporariorum and increase pollination efficiencies in tomato Solanum lycopersicum
Takayuki Sekine; Takuma Takanashi; Ryuichi Onodera; Takaho Oe; Yasuyuki Komagata; Shota Abe; Takuji Koike
Journal of Pest Science, SPRINGER HEIDELBERG, Online, Oct. 2022, Peer-reviwed, The effects of substrate-borne vibration with frequencies of 30 and 300 Hz on the number of the greenhouse whitefly Trialeurodes vaporariorum and the number of fruit sets in greenhouse tomatoes were investigated. When tomatoes were intermittently subjected to 300-Hz vibration generated from vibrational exciters installed in a greenhouse, the number of adult and larval T. vaporariorum was significantly reduced compared with non-vibration plots. The substrate-borne 30-Hz vibration generated from different vibrational exciters did not affect the number of T. vaporariorum when smaller acceleration was applied to tomato plants; however, it showed a suppressive effect when greater acceleration was applied. Regarding pollination, the number of fruit sets in tomatoes subjected to 300-Hz vibration was the same as that in non-vibration plots, which was lower than that in plant growth regulation treatment plots. The number of fruit sets in tomatoes subjected to 30-Hz vibration significantly increased compared with that in non-vibration plots, which was comparable to that in plant growth regulation treatment plots. Our findings suggest that applying substrate vibration to tomatoes is effective in suppressing the plant infestation by T. vaporariorum and promoting tomato pollination. Vibrations could disrupt various behaviors associated with infestation and cause repellency in T. vaporariorum. This study focused on the effectiveness of vibrational conditions, including frequency, acceleration, and temporal characteristics, in detail, aiming to incorporate them into integrated pest management programs in greenhouse tomato cultivation.
Scientific journal, English

Exploring Mechanisms Underlying Unexplained Air-Bone Gaps Post-Myringoplasty: Temporal Bone model and Finite Element Analysis
Jie Wang; Xingmei Wei; Ying Zhang; Takuji Koike; Sinyoung Lee; Fei Zhao
Ear, Nose & Throat Journal, SAGE PUBLICATIONS INC, Online, Aug. 2022, Peer-reviwed
Scientific journal, English

Effects of an Active Noise Control Technology Applied to Earphones on Preferred Listening Levels in Noisy Environments
Takunari Hoshina; Daiki Fujiyama; Takuji Koike; Katsuhisa Ikeda
J Audiol Otol, Online Mar 24, Mar. 2022, Peer-reviwed
Scientific journal, English

外有毛細胞の部分的機能低下によるDPOAE および純音聴力変化：ヒト蝸牛有限要素モデルによる数値解析
李 信英; 小池 卓二
Audiology Japan, 64, 642, 170-177, 01 Feb. 2021, Peer-reviwed
Scientific journal, Japanese

Effects of endoscopic sinus surgery on nasal spray deposition using dye-based methods for humans and a human silicone sinonasal cavity model
Katsuhisa Ikeda; Tatsunari Harashima; Takuji Koike
Am J Otolaryngol, 42, 6, 2021, Peer-reviwed
Scientific journal, English

Development of a Musculoskeletal Model of Hyolaryngeal Elements for Understanding Pharyngeal Swallowing Mechanics
Takuya Hashimoto; Mariko Urabe; Foo Chee-Sheng; Atsuko Murakoshi; Takahiro Kikuchi; Yukihiro Michiwaki; Takuji Koike
Applied Sciences, 10, 8, 6276-6291, 2020, Peer-reviwed
Scientific journal, English

Use of sound-elicited fetal heart rate accelerations to assess fetal hearing in the second and third trimester
Remi Hibiya-Motegi; Marina Nakayama; Rina Matsuoka; Jun Takeda; Shuko Nojiri; Atsuo Itakura; Takuji Koike; Katsuhisa Ikeda
International Journal of Pediatric Otorhinolaryngology, Elsevier, 133, -, in press-110001, 2020, Peer-reviwed, True, OBJECTIVES: We previously reported that fetal heart rate (FHR) accelerations could be obtained after fetal sound stimulation. We examined FHR accelerations during 20-37 weeks gestational age (GA) in order to assess the optimal time for the test. METHODS: The fetus was stimulated from the maternal abdomen with pure tone 2000 Hz, 90 dB, 5 s. Changes in the FHR before and after the sound stimulation were measured by a cardiotocometer. RESULTS: Compared with the positive rate of FHR accelerations at 20-21 weeks GA, significant increases were recognized in 26-27, 28 to 29, 30 to 31, and 34-35 weeks GA. Comparing the positive rate of FHR accelerations between the minimal and moderate variability of FHR baseline, no significant differences were observed at 20-27 weeks GA. On the other hand, at 28-37 weeks GA, the positive rate to detect FHR accelerations due to sound stimulation was 100% in moderate FHR baseline variability. CONCLUSION: Considering development of human fetal hearing, the method should be performed between 28 and 37 weeks GA and during moderate FHR variability corresponding to active sleep conditions. The method developed in the present study may provide a promising tool for evaluating the fetal hearing.
Scientific journal, English

Development of Intra-operative Assessment System for Ossicular Mobility and Middle Ear Transfer Function
Takuji Koike; Yuuka Irie; Ryo Ebine; Takaaki Fujishiro; Sho Kanzaki; Chee Sze Keat; Takenobu Higo; Kenji Ohoyama; Masaaki Hayashi; Hajime Ikegami
Hearing Research, *, 139-148, 2019, Peer-reviwed, True, Objective measurements of the ossicular mobility have not been commonly performed during the surgery, and the assessment of ossicular mobility is made by palpation in most cases. Palpation is inherently subjective and may not always be reliable, especially in milder degrees of ossicular fixation and in the case of multiple fixation. Although several devices have been developed to quantitatively measure the ossicular mobility during surgery, they have not been widely used. In this study, a new system with a hand-held probe which enables intraoperative quantitative measurements of ossicular mobility has been developed. This system not only measures the ossicular mobility, but also investigates "local" transmission characteristics of the middle ear by directly applying vibration to the ossicles and measuring cochlear microphonic. The basic performance of this system was confirmed by measuring the mobility of artificial ossicles and cochlear microphonics in an animal experiment. Our system may contribute to selection of a better surgical method and reducing the risks of revision surgery.
Scientific journal, English

数値解析に基づいた耳小骨固着部位判定法の検討
李 信英; 神崎 晶; 小池 卓二
Otology Japan, 29, 2, 2019, Peer-reviwed
Scientific journal, Japanese

Visualization of cochlear vibration by computer simulation:Analysis of distortion product otoacoustic emissions generated on the basilar membrane
Takuji Koike; Sinyoung Lee
AUDIOLOGY JAPAN, Japan Audiological Society, 61, 6, 525-530, 28 Dec. 2018
Scientific journal

Simulation of mechano-electrical transduction in the cochlea considering basilar membrane vibration and the ionic current of the inner hair cells
Sinyoung Lee; Takuji Koike
AIP Conference Proceedings, American Institute of Physics Inc., 1965, 1, 31 May 2018, Peer-reviwed, The inner hair cells (IHCs) in the cochlea transduce mechanical vibration of the basilar membrane (BM), caused by sound pressure, to electrical signals that are transported along the acoustic nerve to the brain. The mechanical vibration of the BM and the ionic behaviors of the IHCs have been investigated. However, consideration of the ionic behavior of the IHCs related to mechanical vibration is necessary to investigate the mechano-electrical transduction of the cochlea. In this study, a finite-element model of the BM, which takes into account the non-linear activities of the outer hair cells (OHCs), and an ionic current model of IHC were combined. The amplitudes and phases of the vibration at several points on the BM were obtained from the finite-element model by applying sound pressure. These values were fed into the ionic current model, and changes in membrane potential and calcium ion concentration of the IHCs were calculated. The membrane potential of the IHC at the maximum amplitude point (CF point) was higher than that at the non-CF points. The calcium ion concentration at the CF point was also higher than that at the non-CF points. These results suggest that the cochlea achieves its good frequency discrimination ability through mechano-electrical transduction.
International conference proceedings, English

Relationship between the levels of DP components and non-Active portions of the basilar membrane: Simulation using human cochlear finite-element model
Takuji Koike; Sinyoung Lee
AIP Conference Proceedings, American Institute of Physics Inc., 1965, 1, 31 May 2018, Peer-reviwed, In this study, a three-dimensional finite-element model of the human cochlea was created considering the non-linear activity of the outer hair cells (OHCs) to investigate the mechanism of the development of distortion product otoacoustic emissions (DPOAEs). Two tones with frequencies of f1 and f2 were simultaneously applied to the stapes head of the model, and distortion components generated on the basilar membrane (BM) and at the stapes were calculated. The results suggested that the activity of the OHCs at the more basal part of the BM compared to the characteristic frequency position of f2 has critical roles to generate DPOAEs.
International conference proceedings, English

Measurement of pollination process for efficient vibration pollination
SHIBATA Kengo; TAKANASHI Takuma; KOIKE Takuji
The Proceedings of the JSME Conference on Frontiers in Bioengineering, The Japan Society of Mechanical Engineers, 2018.29, 1B32, 2018
Japanese

コンピュータシミュレーションによる蝸牛振動の可視化－基底板上における歪成分耳音響放射の解析－
小池卓二; 李 信英
Audiology Japan, 6, 1-6, 2018, Peer-reviwed
Scientific journal, Japanese

Piezoelectric vibrator-stimulated potential and heart rate accelerations detected from the fetus
Rina Matsuoka; Sinyoung Lee; Miho Sato; Remi Hibiya; Yota Shimanuki; Misato Kasai; Kazusaku Kamiya; Atsuo Itakura; Takuji Koike; Katsuhisa Ikeda
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, ELSEVIER IRELAND LTD, 101, *, 204-210, Oct. 2017, Peer-reviwed, Objectives: The fetus is well known to have a substantial capacity for sound recognition in the uterine environment. The aim of this study was to develop a sound stimulus system equipped with a piezoelectric vibrator (PV), record the PV-stimulated potential (PVSP) of the fetus and monitor changes of the fetal heart rate (FHR) under PV stimulation.
Methods: The relationship between the input voltage applied to a piezoelectric vibrator and the sound pressure generated in the uterus was calibrated based on a model of the maternal abdomen. Fourteen fetuses for the measurement of the PVSP and 22 fetuses for the measurement of the heart rate changes from low-risk pregnant women were recruited.
Results: The PVSP responses were obtained in 9 out of 14 fetuses. All the tested fetuses accelerated the FHR after the 2 kHz tone stimulation at 70 dB intensity generated by PV from 32 to 37 weeks gestational age.
Conclusions: Using a newly developed sound stimulus system equipped with PV, the electric responses of a fetus recorded from electrodes placed on the mother's abdomen may be closely related to the auditory evoked response. Significant accelerations of FHR were objectively, accurately and readily obtained after the sound stimulation. (C) 2017 Elsevier B.V. All rights reserved.
Scientific journal, English

Vibration sensitivity in longicorn beetles and biomimetic potential for insect pest control
TAKANASHI Takuma; SAKAMOTO Hironori; SKALS Niels; FUKUI Shuji; MATSUI Yasuhiro; KOIKE Takuji; NISHINO Hiroshi
International Symposium on Engineering Neo-Biomimeteics VII, *, *, *-*, 17 Feb. 2017, Peer-reviwed, Invited
International conference proceedings, English

Simulation of the Basilar Membrane Vibration of Endolymphatic hydrops
Sinyoung Lee; Takuji Koike
IUTAM SYMPOSIUM ON ADVANCES IN BIOMECHANICS OF HEARING, ELSEVIER SCIENCE BV, 24, 64-71, 2017, Peer-reviwed, Endolymphatic hydrops (EH) causes fluctuating hearing loss especially at low frequencies. In this paper, we analyze EH with the human cochlear finite element model which includes activity of the outer hair cells (OHC). EH was simulated by loading static pressure on the surface of the basilar membrane (BM) of the cochlear model. The vibrations of the BM in the EH model were calculated by applying sound pressure to the stapes, and the results were compared with those in the normal cochlea model. As a result, the distribution of characteristic frequency (CF) was changed and the displacement of the BM was decreased by loading static pressure to the BM. This suggests that the mechanism of hearing loss was caused by EH. (c) 2017 Published by Elsevier B.V.
International conference proceedings, English

Simulation of the Basilar Membrane Vibration of Endolymphatic hydrops
Sinyoung Lee; Takuji Koike
IUTAM SYMPOSIUM ON ADVANCES IN BIOMECHANICS OF HEARING, ELSEVIER SCIENCE BV, 24, 64-71, 2017, Peer-reviwed, Endolymphatic hydrops (EH) causes fluctuating hearing loss especially at low frequencies. In this paper, we analyze EH with the human cochlear finite element model which includes activity of the outer hair cells (OHC). EH was simulated by loading static pressure on the surface of the basilar membrane (BM) of the cochlear model. The vibrations of the BM in the EH model were calculated by applying sound pressure to the stapes, and the results were compared with those in the normal cochlea model. As a result, the distribution of characteristic frequency (CF) was changed and the displacement of the BM was decreased by loading static pressure to the BM. This suggests that the mechanism of hearing loss was caused by EH. (c) 2017 Published by Elsevier B.V.
International conference proceedings, English

Development of a new method for behavioral control of an agricultural insect pest by vibration
Yuta Yoshimura; Takuji Koike; Takuma Takanashi
The 4th Annual Meeting of the Society for Bioacoustics, *, 2017, Peer-reviwed
International conference proceedings, English

Finite-element model of human active cochlea: Short-time variation of DP components on the BM
Sinyoung Lee; Takuji Koike
The 3rd Annual Meeting of the Society for Bioacoustics, *, *, *-*, 10 Dec. 2016, Peer-reviwed
International conference proceedings, English

Measurement and evaluation of vibration characteristics of mushroom logs aimed at insect pest control
Yuta Yoshimura; Yuncong Ma; Takuji Koike
The 3rd Annual Meeting of the Society for Bioacoustics, *, *, *-*, 10 Dec. 2016, Peer-reviwed
International conference proceedings, English

Vibration sensitivity in cerambycid beetles and its potential for insect pest control
TAKANASHI Takuma; SAKAMOTO Hironori; SKALS Niels; FUKUI Shuji; MATSUI Yasuhiro; KOIKE Takuji; NISHINO Hiroshi
The 22nd International Congress of Zoology，The 87th meeting of Zoological Society of Japan，Joint events, *, *, *-*, 14 Nov. 2016, Peer-reviwed
International conference proceedings, English

Nonlinear Time-Domain Cochlear Model Using Finite-Element Method: Simulation of DPOAEs
Takuji Koike; Hideyuki Mochizuki; Sinyoung Lee
IUTAM Symposium on Advances in Biomechanics of Hearing, *, *, *-*, 17 May 2016, Peer-reviwed
International conference proceedings, English

Simulation of the Basilar Membrane Vibration of the Endolymphatic Hydrops
Sinyoung Lee; Takuya Hashimoto; Takuji Koike
IUTAM Symposium on Advances in Biomechanics of Hearing, *, *, *-*, 17 May 2016, Peer-reviwed
International conference proceedings, English

Development of musculoskeletal model for the hyoid bone during swallowing
Takuya Hashimoto; Atsuko Murakoshi; Takahiro Kikuchi; Yukihiro Michiwaki; Takuji Koike
3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Institute of Electrical and Electronics Engineers Inc., 457-460, 18 Apr. 2016, Swallowing, or deglutition, is simple and smooth process to transport food and drink from the mouth to the stomach, whereas it is difficult to understand its physiological mechanism because it consists of complex neuromuscular coordination. Movements of the hyoid are important to describe swallowing in pharyngeal phase. We therefore develop a musculoskeletal model of the hyoid based on anatomical knowledge to verify activities of muscles around the hyoid in swallowing. Individual muscle force is estimated by the inverse dynamics computation and optimization. The estimation results of muscle force are compared to the results found in a previous study. The results of this study contributes to provide greater insight into swallowing and to improve treatments for dysphagia.
International conference proceedings, English

Simulation of distortion-product optoacoustic emissions (DPOAEs) using finite-element model of human cochlea
Takuji Koike; Hideyuki Mochizuki; Sinyoung Lee
The 2nd Annual Meeting of the Society for Bioacoustics, *, *, *-*, 12 Dec. 2015, Peer-reviwed
International conference proceedings, English

Vibration analysis of standing trees using finite element models for insect pest control
Yuncong Ma; Takuji Koike
The 2nd Annual Meeting of the Society for Bioacoustics, *, *, *-*, 12 Dec. 2015, Peer-reviwed
International conference proceedings, English

Modeling of Human Active Cochlea Using Finite-Element Method: Simulation of DPOAEs
Koike T; Mochizuki H; Sakashita T
Inner Ear Biology Workshop, *, *, *-*, 01 Nov. 2014, Peer-reviwed
International conference proceedings, English

Development of semi-implantable bone-conduction hearing aid using giant magnetostrictive material
Takuji Koike; Eri Tanaka; Naoki Hayashi; Takuya Hashimoto; Sho Kanzaki; Naohito Hato
The 4th Japan-Switzerland Workshop on Biomechanics, *, *, *-*, 01 Sep. 2014, Invited
International conference proceedings, English

Safety of Ultrasonic Bone Curette in Ear Surgery by Measuring Skull Bone Vibrations
Tsukasa Ito; Hideyuki Mochizuki; Tomoo Watanabe; Toshinori Kubota; Takatoshi Furukawa; Takuji Koike; Seiji Kakehata
OTOLOGY & NEUROTOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 35, 4, E135-E139, Apr. 2014, Peer-reviwed, Hypothesis
Mastoidectomy using an ultrasonic bone curette (UBC) is as safe for the inner ear as a mastoidectomy using a high-speed drill.
Background
Transcanal endoscopic ear surgery (TEES) is a minimally invasive, secure, and functional technique, which has been performed using high-speed drills. We have started to use a UBC instead of the high-speed drill because a UBC allows for simultaneous bone cutting, irrigation, and aspiration. These features of the UBC make it an excellent candidate for use in one-handed TEES, but the safety of the UBC still needs to be confirmed. We thus measured skull vibrations caused by the UBC to estimate the effects of UBC on the inner ear.
Methods
Eight patients with cholesteatoma underwent mastoidectomy using a Sonopet UST-2001 UBC (Stryker, MI, USA) and 2 high-speed drills (drills A and B). Skull vibrations were measured using polyvinylidene difluoride film taped to the forehead as a piezoelectric vibration sensor. The recorded data were transformed to the power spectrum in the frequency domain by fast Fourier transform. The mean and peak values of vibrations were analyzed in four frequency bands: 200 to 500 Hz, 500 to 2,000 Hz, 2,000 to 8,000 Hz, and 8,000 Hz to 20 kHz.
Results
Both the mean values and the peak values of skull vibrations caused by the UBC were significantly smaller than those values obtained for drill B between 500 and 8,000 Hz, (p < 0.05). No significant differences were found among the 3 instruments below 500 Hz or above 8,000 Hz.
Conclusion
Skull vibration levels generated by the UBC were found to be comparable or even lower than those levels associated with conventional high-speed drills. These findings indicated that the UBC can be safely applied to TEES without the risk of harmful effects on the inner ear.
Scientific journal, English

Transfer functions of normal and pathologic middle ears - theoretical analysis -
Takuji Koike
International Symposium on Middle-Ear Mechanics in Research and Minimally Invasive Otology, Beijing, China, *, *, *-*, 20 Apr. 2013, Invited
International conference proceedings, English

Intraoperative Measurement of Skull Bone Vibration during Mastoidectomy Using an Ultrasonic Bone Curette
Tsukasa Ito; Hideyuki Mochizuki; Tomoo Watanabe; Toshinori Kubota; Takatoshi Furukawa; Takuji Koike; Seiji Kakehata
146th Annual Meeting AMERICAN OTOLOGICAL SOCIETY, *, *, *-*, 12 Apr. 2013, Peer-reviwed
International conference proceedings, English

蝸牛のモデル化とその臨床応用
小池卓二; 望月秀行; 坂下輔
日本音響学会聴覚研究会, 日本音響学会聴覚研究会, 43, 3, 207-211, 2013
Japanese

哺乳類末梢聴覚器の振動挙動シミュレーション
小池卓二
生物科学, 生物科学学会, 43, 3, 75-81, 2013, Peer-reviwed, Invited
Scientific journal, Japanese

Development of a bone-conduction artificial middle ear using giant magnetostrictive material
Takuji Koike; Ryosuke Tachi; Naohito Hato; Sho Kanzaki
The 6th International Symposium on Middle-Ear Mechnanics in Research and Otology, *, *, 164-165, Jun. 2012
International conference proceedings, English

Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane
Takuji Koike; Chiaki Sakamoto; Tasuku Sakashita; Ken Hayashi; Sho Kanzaki; Kaoru Ogawa
Hearing Research, 283, 117-125, 2012, Peer-reviwed
Scientific journal, English

有限要素法による蝸牛基底板振動シミュレーション：人工内耳電極挿入時の基底板振動挙動変化
小池卓二; 坂下 輔; 塙慎太郎; 熊川孝三
耳鼻臨床, 補132, 24-31, 2012, Peer-reviwed
Scientific journal, Japanese

超磁歪素子を用いた埋め込み型骨導補聴器の開発
小池卓二; 羽藤直人; 神崎晶
Otology Japan, 22, 5, 918-922, 2012
Scientific journal, Japanese

超磁歪素子を用いた埋め込み型骨導補聴器の開発
小池卓二; 羽藤直人; 神崎晶
Otology Japan, THE JAPAN OTOLOGICAL SOCIETY, 22, 5, 918-922, 2012, To circumvent some of the disadvantages of conventional hearing aids such as sound distortion, feedback, and cosmetic factors, implantable hearing devices have been developed. However, these hearing devices also have problems such as insufficient output at high frequencies and inflammation.
In this study, a new subcutaneously implanted bone-conduction hearing aid with an external unit and an internal unit is proposed. The external unit consists of a microphone, a speech processor, and a transmitting coil, which send the sound signals and energy to the internal unit by generating a magnetic field. The internal unit consists of a receiving coil, a driving coil, and a vibrator made of giant magnetostrictive material (GMM), which deforms its body by changing the magnetic field. The internal unit is surgically embedded in the temporal bone under the skin and vibrates the skull when the magnetic flux is applied by the external unit. For the first stage in the development of the new bone-conduction hearing aid, a prototype was made and its fundamental properties were examined.
The GMM vibrator has a good linear response and high output especially at high frequencies. In contrast, the output at low frequencies is relatively lower than that at high frequencies. To enhance the output of the implanted bone-conduction hearing aid at low frequencies is an issue in the future.
Scientific journal, Japanese

超磁歪素子を用いた埋め込み型骨導補聴器の開発
小池卓二; 羽藤直人; 神崎晶
Otology Japan, THE JAPAN OTOLOGICAL SOCIETY, 22, 5, 918-922, 2012, To circumvent some of the disadvantages of conventional hearing aids such as sound distortion, feedback, and cosmetic factors, implantable hearing devices have been developed. However, these hearing devices also have problems such as insufficient output at high frequencies and inflammation.
In this study, a new subcutaneously implanted bone-conduction hearing aid with an external unit and an internal unit is proposed. The external unit consists of a microphone, a speech processor, and a transmitting coil, which send the sound signals and energy to the internal unit by generating a magnetic field. The internal unit consists of a receiving coil, a driving coil, and a vibrator made of giant magnetostrictive material (GMM), which deforms its body by changing the magnetic field. The internal unit is surgically embedded in the temporal bone under the skin and vibrates the skull when the magnetic flux is applied by the external unit. For the first stage in the development of the new bone-conduction hearing aid, a prototype was made and its fundamental properties were examined.
The GMM vibrator has a good linear response and high output especially at high frequencies. In contrast, the output at low frequencies is relatively lower than that at high frequencies. To enhance the output of the implanted bone-conduction hearing aid at low frequencies is an issue in the future.
Scientific journal, Japanese

Simulation of the Inner Ear Vibration: Optimization of Electric Acoustic Stimulation Using a Cochlear Implant
Takuji Koike
New Trends in Hearing Implant Science, *, 2011
International conference proceedings, English

G0200-1-2 Development of implantable hearing aid using giant magnetostrictive material : Investigation of the frequency response of a vibrator installed in human cadavers
HARASHIMA Tatsunari; KOIKE Takuji; HOMMA Kyoji; AOKI Michihito; HATO Naoto; KANZAKI Syo
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2010, 3-4, 2010, In this study, a new subcutaneously implanted bone-conduction hearing aid with an external unit and an internal unit is proposed. A prototype transducer was made and installed in a cadaver head, and the performance of the transducer was investigated when the method of installation (number of fixed point) of the transducer was changed. The frequency response of the amplitude of the cadaver generated by the transducer depended on the number of the fixed point. The ear-canal sound pressure generated by the transducer with single point fixation was higher than that with two point fixation. These results suggest that single point fixation method is suitable for installing the transducer to the cadaver.
Japanese

J0206-4-4 Finite element modeling of human ear by coupling the ear canal and the middle ear
FUJIWARA Yasuhiro; KOIKE Takuji; HOMMA Kyoji; AOKI Michihito
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2010, 115-116, 2010, In this study, a three-dimensional finite-element (FE) model of the human ear was established, including the ear canal, middle ear, loading of the cochlea. The acoustic-structure interaction analysis was performed using this coupling model. The impulse-responses of the pressure in the ear canal and the displacement of the stapes were calculated step by step, and the time domain responses were transformed into frequency domain responses by FFT. The general tendency in the frequency response of the each results obtained using the FE model was nearly same as the measurement results. In this way, the measurement of "Otorefrectance" which is a new hearing test was simulated by the analysis using the FE model.
Japanese

ASSESSMENT OF AN IMPLANTED BONE-CONDUCTION HEARING AID PERFORMANCE BY EXPERIMENTS USING HUMAN CADAVERS
Tatsunari Harashima; Makiko Fujii; Takuji Koike; Michihito Aoki; Kyoji Homma; Naohito Hato; Sho Kanzaki
PROCEEDINGS OF THE 17TH INTERNATIONAL CONGRESS ON SOUND AND VIBRATION, INT INST ACOUSTICS & VIBRATION, CD-ROM, 2010, In this study, a new subcutaneously implanted bone-conduction hearing aid is proposed. A vibrator unit of the hearing aid consists of two coils and an element made of giant magnetostrictive material (GMM). For the first stage in the development of the new bone-conduction hearing aid, fundamental properties of the GMM vibrator were examined. In addition, a prototype transducer was made and installed in cadaver heads, and the performance of the prototype transducer was investigated. The output of the prototype transducer was linearly increased with increasing the input current. The frequency response varied depends on the cadavers. These results suggest that the gain of our hearing aid can be controlled by changing the input current, but individual differences of patients should be considered.
International conference proceedings, English

Comparison of round window and cochleostomy approaches for hearing preservation: Analysis using computational structures technology
Kozo Kumakawa; Chiaki Sakamoto; Takuji Koike
Joint Meeting - IV Consensus in Auditory Implants & VEAONO Instructional Workshop, *, 2010
International conference proceedings, English

ASSESSMENT OF AN IMPLANTED BONE-CONDUCTION HEARING AID PERFORMANCE BY EXPERIMENTS USING HUMAN CADAVERS
Tatsunari Harashima; Makiko Fujii; Takuji Koike; Michihito Aoki; Kyoji Homma; Naohito Hato; Sho Kanzaki
PROCEEDINGS OF THE 17TH INTERNATIONAL CONGRESS ON SOUND AND VIBRATION, INT INST ACOUSTICS & VIBRATION, *, 2010, Peer-reviwed, In this study, a new subcutaneously implanted bone-conduction hearing aid is proposed. A vibrator unit of the hearing aid consists of two coils and an element made of giant magnetostrictive material (GMM). For the first stage in the development of the new bone-conduction hearing aid, fundamental properties of the GMM vibrator were examined. In addition, a prototype transducer was made and installed in cadaver heads, and the performance of the prototype transducer was investigated. The output of the prototype transducer was linearly increased with increasing the input current. The frequency response varied depends on the cadavers. These results suggest that the gain of our hearing aid can be controlled by changing the input current, but individual differences of patients should be considered.
International conference proceedings, English

Effects of a perilymphatic fistula on the vibration of the basilar membrane
Ken Hayashi; Takuji Koike; Sho Kanzaki; Kaoru Ogawa
Sixth International Symposium on Meniere’s Disease and Inner Ear Disorders, *, 2010, Peer-reviwed
International conference proceedings, English

Effects of a cochlear fistula on the vibration of the basilar membrane: Theoretical analysis
Tasuku Sakashita; Chiaki Sakamoto; Takuji Koike
The 15th Auditory Research Forum, *, 2010
International conference proceedings, English

COCHLEAR OUTER HAIR CELLS IN A DOMINANT-NEGATIVE CONNEXIN26 MUTANT MOUSE PRESERVE NON-LINEAR CAPACITANCE IN SPITE OF IMPAIRED DISTORTION PRODUCT OTOACOUSTIC EMISSION
A. Minekawa; T. Abe; A. Inoshita; T. Iizuka; S. Kakehata; Y. Narui; T. Koike; K. Kamiya; H. -O. Okamura; H. Shinkawa; K. Ikeda
NEUROSCIENCE, PERGAMON-ELSEVIER SCIENCE LTD, 164, 3, 1312-1319, Dec. 2009, Peer-reviwed, Mutations in the connexin26 gene (GJB2) are the most common genetic cause of congenital bilateral non-syndromic sensorineural hearing loss. Transgenic mice were established carrying human Cx26 with the R75W mutation that was identified in a deaf family with autosomal dominant negative inheritance [Kudo T et al. (2003) Hum Mol Genet 12:9951004]. A dominant-negative Gjb2 R75W transgenic mouse model shows incomplete development of the cochlear supporting cells, resulting in profound deafness from birth [Inoshita A et al. (2008) Neuroscience 156:1039-1047]. The Cx26 defect in the Gjb2 R75W transgenic mouse is restricted to the supporting cells; it is unclear why the auditory response is severely disturbed in spite of the presence of outer hair cells (OHCs). The present study was designed to evaluate developmental changes in the in vivo and in vitro function of the OHC, and the fine structure of the OHC and adjacent supporting cells in the R75W transgenic mouse. No detectable distortion product oto-acoustic emissions were observed at any frequencies in R75W transgenic mice throughout development. A characteristic phenotype observed in these mice was the absence of the tunnel of Corti, Nuel's space, and spaces surrounding the OHC; the OHC were compressed and squeezed by the surrounding supporting cells. On the other hand, the OHC developed normally. Structural features of the lateral wall, such as the membrane-bound subsurface cisterna beneath the plasma membrane, were intact. Prestin, the voltage-dependent motor protein, was observed by immunohistochemistry in the OHC basolateral membranes of both transgenic and non-transgenic mice. No significant differences in electromotility of isolated OHCs during development was observed between transgenic and control mice. The present study indicates that normal development of the supporting cells is indispensable for proper cellular function of the OHC. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
Scientific journal, English

Finite element analysis of the middle ear transfer functions and related pathologies
Fei Zhao; Takuji Koike; Jie Wang; Hans Sienz; Rhys Meredith
MEDICAL ENGINEERING & PHYSICS, ELSEVIER SCI LTD, 31, 8, 907-916, Oct. 2009, Peer-reviwed, With developments in software and micro-measurement technology, a three-dimensional middle ear finite element (FE) model can now be more easily constructed to study sound transfer function Many FE models of the middle ear have been constructed to date. and each has its own particular advantages and disadvantages In this article, we review the latest developments and technologies in the field of the FE models of the middle ear. and the use of FE in the study of middle ear pathology. Proposals are made for future developments in the field of finite element analysis of middle ear transfer function. Crown Copyright (C) 2009. Published by Elsevier Ltd on behalf of IPEM. All rights reserved
Scientific journal, English

J0202-4-4 Long-Term Time Variation of Adhesive Strength of Marine Mussel Plaque
AOKI Michihito; HAYATA Mariko; KOIKE Takuji; HOMMA Kyoji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2009, 165-166, 2009, Mussel adhesive protein (MAP) is expected to be used as a new artificial adhesive material for bonding under wet conditions such as surgical incisions. The adhesive strength of MAP, however, has not been accurately measured until now for practical use. The study aims to clarify the time variation of adhesive strength from an engineering perspective. Adhesive strengths have been measured during the range from ready to one month after adhesion setup, using prototype peel test procedure. The results show that the adhesive strength depends on time and repeated seesawing strength with the elapse of days.
Japanese

J0204-2-4 Evaluation of the vibration force generated by a bone-conduction implantable hearing aid using giant magnetostrictive material
KOIKE Takuji; YAMAMOTO Kensei; HARASHIMA Tatsunari; AOKI Michito; HOMMA Kyoji; HATO Naoto; KANZAKI Sho
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2009, 217-218, 2009, In this study, a new subcutaneously implanted bone-conduction hearing aid with an external unit and an internal unit is proposed. The internal unit consists of a receiving coil, a driving coil, and a vibrator made of giant magnetostrictive material (GMM). AM signals were applied to the internal unit through mutual induction between a transmitting coil and the receiving coil, and the force generated by the GMM vibrator was measured with a piezoelectric force sensor. The high-frequency carrier signal was efficiently transmitted from the transmitting coil to the receiving coil, and the force with a component of audible frequency corresponding to the modulating frequency was generated with high intensity. This result suggests that the GMM vibrator had a function of self-demodulation, and a simple structured implanted bone-conduction hearing aid can be developed using GMM.
Japanese

Adhesive Strength of Marine Mussel Plaques to Soda-Lime Glass
Michihito AOKI; Kyoji HOMMA; Sayuri MURAKAMI; Takuji KOIKE
Journal of Environment and Engineering, Japan Society of Mechanical Engineers, 4, 1, 135-144, 2009, Peer-reviwed
Scientific journal, English

AE信号の処理方法の違いが屋外石油タンクのAE源位置標定精度に及ぼす影響
村上小百合; 小島渉; 小池卓二; 山田實; 湯山茂徳; 本間恭二
非破壊検査, 58, 9, 403-407, 2009, Peer-reviwed
Scientific journal, Japanese

Development of distortion product otoacoustic emissions in C57BL/6J mice
Yuya Narui; Akira Minekawa; Takashi Iizuka; Masayuki Furukawa; Takeshi Kusunoki; Takuji Koike; Katsuhisa Ikeda
INTERNATIONAL JOURNAL OF AUDIOLOGY, TAYLOR & FRANCIS LTD, 48, 8, 576-581, 2009, Peer-reviwed, Distortion product otoacoustic emissions (DPOAEs) have been used to examine the development of hearing in the rat and gerbil. However, no reports of DPOAE measurement from the onset of hearing in mice are available. Commercially-available components were assembled and adapted to provide a suitable probe microphone and sound delivery system for measuring DPOAE in developing C57BL/6J mice. Furthermore, DPOAE data were compared with the findings of the auditory brainstem response (ABR). DPOAEs were obtained at 8 kHz from 11 days after birth, 20 kHz from 12 days, and 30 kHz from 13 days. Adult-like patterns of DPOAE were obtained 21 days at 8 and 20 kHz, and 28 days at 30 kHz. On the other hand, the ABR thresholds at 12 to 36 kHz appeared between 11 and 12 days and were saturated at 14 days. Based on these data, the onset of measureable DPOAEs in the mouse were earlier than in the rat and gerbil. The maturation of DPOAE in the mouse begins at a lower frequency in the high frequency range. In addition, the ABR threshold reached maturation earlier than DPOAE.
Scientific journal, English

Development of an Implanted Bone-conduction Hearing Aid using Giant Magnetostrictive Material
Takuji Koike; Kensei Yamamoto; Michihito Aoki; Kyoji Homma; Naohito Hato; Sho Kanzaki
Proceedings of the 5th Symposium on Middle Ear Mechanics, web, 2009, Peer-reviwed
International conference proceedings, English

3D Finite Element Model for Perilymphatic Fistula
Ken Hayashi; Takuji Koike; Syo Kanzaki; Kaoru Ogawa
The 2008 Annual Meeting & OTO EXPO in Chicago, *, *, *, Oct. 2008
International conference proceedings, English

Moths produce extremely quiet ultrasonic courtship songs by rubbing specialized scales
Ryo Nakano; Niels Skals; Takuma Takanashi; Annemarie Surlykke; Takuji Koike; Keisuke Yoshida; Hirotaka Maruyama; Sadahiro Tatsuki; Yukio Ishikawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 105, 33, 11812-11817, Aug. 2008, Peer-reviwed, insects have evolved a marked diversity of mechanisms to produce loud conspicuous sounds for efficient communication. However, the risk of eavesdropping by competitors and predators is high. Here, we describe a mechanism for producing extremely low-intensity ultrasonic songs (46 dB sound pressure level at 1 cm) adapted for private sexual communication in the Asian corn borer moth, Ostrinia furnacalis. During courtship, the male rubs specialized scales on the wing against those on the thorax to produce the songs, with the wing membrane underlying the scales possibly acting as a sound resonator. The male's song suppresses the escape behavior of the female, thereby increasing his mating success. Our discovery of extremely low-intensity ultrasonic communication may point to a whole undiscovered world of private communication, using "quiet" ultrasound.
Scientific journal, English

養生温度がムラサキイガイ付着盤の接着強度に及ぼす影響
青木路人; 小池卓二; 村上小百合; 本間恭二
Sessile Organisms, 25, 2, 85-90, Feb. 2008, Peer-reviwed
Japanese

Measurement of distortion product otoacoustic emissions (DPOAEs) in neonatal GJB2 transgenic mice
Akira Minekawa; Yuya Narui; Ayako Inoshita; Takashi Iizuka; Gota Higashiki; Takuji Koike; Katsuhisa Ikeda
Association for Research in Otolaryngology Midwinter Meeting, Abstract, *, *, *, Feb. 2008, Peer-reviwed
International conference proceedings, English

ヒト蝸牛モデルによる基底板および内耳液振動解析：外リンパ瘻のシミュレーション
小池 卓二
Otology Japan, THE JAPAN OTOLOGICAL SOCIETY, 18, 1, 33-38, Jan. 2008, Peer-reviwed, In this study, dynamic behavior of the basilar membrane and cochlear fluid caused by the vibration of the stapes was analyzed using a three-dimensional finite element model of the human cochlea. Numerical results and the measurement results were compared, and the validity of the model was verified. In addition, an influence of perilymphatic fistula on the vibration of the basilar membrane was analyzed. The leakage of the lymph from a perforation opened near the round window did not have the great influence on the vibration of the basilar membrane. In contrast, the amplitude of the basilar membrane decreased when the lymph flowed out through the perforation near the oval window. This result suggests that oval window perilymphatic fistula causes an increase of hearing threshold from the viewpoint of dynamics.
Scientific journal, Japanese

Speech Signal Captured by PVDF Sensor
Rajkishore Prasad; Takuji Koike; Fumitoshi Matsuno
2008 PROCEEDINGS OF SICE ANNUAL CONFERENCE, VOLS 1-7, IEEE, CD-ROM, 9-+, 2008, The spoken communication between human and a machine is difficult and challenging task. Under the noisy background, it is more difficult as the speech collecting microphone collects noisy signal. In this paper we describe a PVDF based microphone that collects bone conducted sound of the speaker Mile discriminating the background noise. The PVDF microphone is placed on the forehead of the speaker. Since the proposed microphone collects bone conducted sound, it contains high frequency components in feeble or little amount as the human bone acts like a low pass filter with upper cut off frequency ranging from 1kHz to 1.5 kHz.
International conference proceedings, English

Measurement of Threshold of Hearing Using Tone Trains
Rajkishore Prasad; Takuji Koike; Fumitoshi Matsuno
2008 PROCEEDINGS OF SICE ANNUAL CONFERENCE, VOLS 1-7, IEEE, CD-ROM, 2615-+, 2008, This paper presents a now method of measuring relative threshold of hearing using tone-trains of different frequencies. The conventional methods of measurement of hearing threshold in tonic audiometry are trail and error method and thus take handsome amount of time. Such methods are not suitable for the situations where ample amount of time for the measurement is not available. The proposed tone-train method is faster and can, be used to measure hearing threshold tip to precision of 1dB within multiple of minutes.
International conference proceedings, English

Modeling of the Human Cochlea using the Finite Element Method, Proceedings of the Ninth International Conference on Computational Structures Technology
T. Koike; T. Yamamoto; S. Murakami; K. Homma
Proceedings of the Ninth International Conference on Computational Structures Technology, paper 85, 2008, Peer-reviwed
International conference proceedings, English

Effect of Ferric Ions on the Mechanical Strength of Marine Mussel Adhesive Proteins
Michihito Aoki; Yoshihiro Takeda; Hajime Fukunaga; Takuji Koike; Sayuri Murakami; Kyoji Homma
Journal of Biomechanical Science and Engineering, 3, 2, 188-199, 2008, Peer-reviwed, Mussel adhesive protein (MAP) is expected to be used as a new bioadhesive. However, the mechanical properties of MAP have not been reported, despite the potential importance of MAP in medical applications. The study aims to estimate the mechanical strength of MAP, and describe the influence of ferric ions present in MAP on the mechanical strength. Fe3+ incorporated in MAP is regarded as having an important role in the mechanical properties. Mussels were classified into two groups in order to compare the effect of Fe3+ on both the tensile and peel properties of MAP. One group was exposed to artificial seawater with a high concentration of ferric ions, and the other group is exposed to natural seawater as a control. The results revealed that the deterioration of the adhesive strength over time was different between the two groups, although significant differences in the tensile properties were not observed. While the adhesive strength in the control group decreased with elapsed time, it was increased for the iron-enriched group over the first 17 days. This suggested that ferric ions may improve the magnitude of the adhesive strength for MAP. © 2008, The Japan Society of Mechanical Engineers. All rights reserved.
Scientific journal, English

Adhesive strength of plaque to soda-lime glass in marine mussel
Michihito Aoki; Kyoji Homma; Takuji Koike; Sayuri Murakami
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A, Japan Society of Mechanical Engineers, 73, 2, 307-312, 2007, Mussels living in the ocean adhere to shore reef and each other with byssus formed by insolubilization of a bonding protein, whose application to the new bio-adhesion material has been expected. Their adhesive strength has not been accurately measured because peeling test method is not established since the contact areas between a plaque and the substrate are less than 1 mm2. Present paper attempts to measure adhesive strength of the plaque using original simple peeling test method and investigates the influence of environmental change on the adhesive strength and the change of the adhesive strength in the lapse of time. The results show that the-adhesive strength of the plaque decreases with the change in the environment by moving mussels from the beach to an experimental environment and the adhesive strength changes along with the elapsed time after the plaque is formed.
Scientific journal, Japanese

1016 Effect of Adhesive Strength of Plaque on Temperature Hysteresis in Marine Mussel
AOKI Michihito; ISHIMARU Masaki; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2007, 233-234, 2007, The adhesive protein of the mussel is expected as an ingredient of the new adhesive, there are few studies about the mechanical characteristic of the protein. In this study, curing temperature dependence of the adhesive strength was investigated from the viewpoint of mechanical strength. The original peel test method by spatula-shaped probe was used for the measurement of the adhesive strength. The effect of a temperature hysteresis in curing on the adhesive strength to substratum of the protein by changing curing temperature was examined. The results show that the adhesive strength depended on curing temperature in a range of 20-70℃.
Japanese

1020 Mechanical Property of Mussel Byssus
TAKEDA Yoshihiro; AOKI Michihito; FUKUNAGA Hajime; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2007, 241-242, 2007, The byssus secreted by marine mussels has renowned for their adhesive and mechanical characteristics. Dopa contained in their byssal protein can form catechol complexes with exceptional stability in the presence of metal ions such as Fe^<3+> while mussels take up particulate or soluble iron from seawater. Iron may be the key reagent in protein cross-linking for adhesive synthesis, but the implications for byssal mechanical properties have not been known. Therefore, the effect of iron for mechanical properties of byssuses was examined by the tensile test. We have performed the tensile test for byssuses which secreted by the mussels exposed in Fe^<3+> supplemented seawater for 24 hours. The tensile test showed that mechanical properties of byssus kept in the high iron seawater didn't show significant change as contrasted with that kept in artificial seawater manipulated its pH same as the other level.
Japanese

ムラサキイガイ付着盤のガラス基盤への接着強度について
青木 路人; 本間 恭二; 小池 卓二; 村上 小百合
日本機械学会論文集(A編), 73, 726, 307-312, 2007, Peer-reviwed
Scientific journal, Japanese

A NEW DIAGNOSTIC APPARATUS FOR OSSICULAR FIXATION: EVALUATION OF USABILITY THROUGH MEASUREMENTS IN HUMAN TEMPORAL BONES AND IN PATIENTS
Takuji Koike; Shinji Hamanish; Yu Yuasa; Ryo Yuasa; Toshimitsu Kobayashi; Hideko H. Nakajima; Wade Chien; Michael E. Ravicz; Saumil N. Merchant; John J. Rosowski; Richard L. Goode; Hiroshi Wada
MIDDLE EAR MECHANICS IN RESEARCH AND OTOLOGY, WORLD SCIENTIFIC PUBL CO PTE LTD, 69-+, 2007, Peer-reviwed, To evaluate ossicular mobility in surgery, an apparatus that quasi-statically measures the load and displacement of the ossicles has been developed. This apparatus was used to measure the ossicular mobility in human temporal bones before and after the ossicles were artificially fixed. These results were compared with simultaneous estimates of ossicular mobility obtained with a laser Doppler velocimeter (LDV). In addition, the ossicular mobility of three patients with otosclerosis or chronic otitis media was also measured to evaluate the usability of the apparatus. The apparatus could make estimating the change of mobility between pre and post-treatments for ossicular fixation possible, and positive correlation was seen between ossicular mobility and hearing level. These results suggest that our apparatus has the ability to detect the difference in ossicular mobility quantitatively between fixed and normal ears, and shows that our apparatus could be a useful tool in the surgical estimate of ossicular disorders.
International conference proceedings, English

Effect of the stiffness of the round window membrane of the inner ear on auditory activity
Takuji Koike; Shinichi Gomita; Sayuri Murakami; Kyoji Homma
Proceedings of the Third Asian Pacific Conference on Biomechanics, S163, 2007, Peer-reviwed
International conference proceedings, English

Autophony in patients with patulous eustachian tube: Experimental investigation using an artificial middle ear
Tetsuaki Kawase; Shigeyuki Kano; Ttoshihiko Otsuka; Shinji Hamanishi; Takuji Koike; Toshimitsu Kobayashi; Hiroshi Wada
OTOLOGY & NEUROTOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 27, 5, 600-603, Aug. 2006, Peer-reviwed, Objective: To investigate the contribution of anatomical factors, such as the caliber of the patent eustachian tube (ET) and the volume of the middle car cavity, on vocalized sound transmission to the inner ear.
Methods: Model experiment using artificial middle ear.
Results: In the present model experiment, sound transmission from the pharynx to the inner ear under patulous conditions was affected by the caliber of the ET and by the mastoid volume, especially in the low-frequency region, that is, a larger caliber of the ET and smaller mastoid volume resulted in greater sound transmission from the pharyngeal space to the inner ear.
Conclusion: Patulous symptoms may be more distressful in patients with poorly developed mastoid cavity than in those with well-aerated mastoid under similar conditions of patulous ET.
Scientific journal, English

An apparatus for diagnosis of ossicular chain mobility in humans
T Koike; M Murakoshi; S Hamanishi; Y Yuasa; R Yuasa; T Kobayashi; H Wada
INTERNATIONAL JOURNAL OF AUDIOLOGY, TAYLOR & FRANCIS LTD, 45, 2, 121-128, Feb. 2006, Peer-reviwed, Confirmation of the conditions of the ossicles is essential for tympanoplasty. However, at present, ossicular mobility is experimentally estimated with palpation by a surgeon, and the results depend on the surgeon's skill. In this study, a new apparatus for quantitatively measuring ossicular mobility was developed. With this apparatus, the ossicles were displaced and the reaction force from the ossicles, (i.e. the load applied to the ossicles) was simultaneously detected. Ossicular mobility of three patients with otosclerosis or chronic otitis media was measured to evaluate the usability of the apparatus. The apparatus can distinguish the differences in ossicular mobility between normal and fixed ossicles, and it makes estimating the change of mobility between pre- and post-treatments for ossicular fixation possible. Positive correlation was seen between ossicular mobility and hearing level.
Scientific journal, English

An apparatus for diagnosis of ossicular chain mobility in humans
T Koike; M Murakoshi; S Hamanishi; Y Yuasa; R Yuasa; T Kobayashi; H Wada
INTERNATIONAL JOURNAL OF AUDIOLOGY, TAYLOR & FRANCIS LTD, 45, 2, 121-128, Feb. 2006, Peer-reviwed, Confirmation of the conditions of the ossicles is essential for tympanoplasty. However, at present, ossicular mobility is experimentally estimated with palpation by a surgeon, and the results depend on the surgeon's skill. In this study, a new apparatus for quantitatively measuring ossicular mobility was developed. With this apparatus, the ossicles were displaced and the reaction force from the ossicles, (i.e. the load applied to the ossicles) was simultaneously detected. Ossicular mobility of three patients with otosclerosis or chronic otitis media was measured to evaluate the usability of the apparatus. The apparatus can distinguish the differences in ossicular mobility between normal and fixed ossicles, and it makes estimating the change of mobility between pre- and post-treatments for ossicular fixation possible. Positive correlation was seen between ossicular mobility and hearing level.
Scientific journal, English

Simplified adhesive strength measurement of adhesive protein in marine mussel
Michihito Aoki; Kyoji Homma; Takuji Koike; Sayuri Murakami
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A, Japan Society of Mechanical Engineers, 72, 4, 487-492, 2006, The adhesive protein of the mussel widely living in the ocean is expected as an ingredient of the adhesive. Adhesive strength of the protein to substratum has not been clarified because a method of measuring the strength does not exist. In this research, the plaque consisted of adhesive protein was peeled using the spatula-shaped jig inclined at the angle of 45 degrees to substratum. Adhesive strength was determined from the peeling load obtained by the jig with a strain gauge. To investigate the effect of the thickness of the plaque on the peeling load, based on linear fracture mechanics, peeling simulations of plaque from substratum were conducted using the finite element method. The simulation suggested that adhesive strength of the plaque to substratum is quantitatively evaluated by averaging the peeling load fluctuations.
Scientific journal, Japanese

703 Adhesive Strength of Plaques to Soda-lime Glass in Mussel under the Environment of High Iron Seawater
FUKUNAGA Hajime; TAKEDA Yoshihiro; AOKI Michihito; MURAKAMI Sayuri; KOIKE Takuji; HOMMA Kyoji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2006, 209-210, 2006, The byssus secreted by marine mussels have adhesive plaques renowned for their great adhesive characteristics. Dopa contained in the byssal protein can form catechol complexes with exceptional stability in the presence of metal ions such as Fe3+ while mussels take up particulate or soluble iron from seawater. Iron may be the key reagent in protein cross-linking for adhesive synthesis, but the implications for their adhesive strength have not been clarified. The peeling strength of adhesive plaques deposited onto glass surface, which secreted by the mussels exposed in Fe3+ supplemented seawater for 24 hours, has been investigated by peeling apparatus exclusively for the mussel plaques. The peeling test showed that keeping plaques in the high iron seawater altered its tenacity as contrasted with that kept in artificial seawater manipulated its pH same as the other level.
Japanese

638 Frequency Dependence of the Sound Conduction Path of the Vibration Directly Applied to the Skull : from Low Frequency to Ultra Sound Frequency
SUZUKI Akira; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2006, Vol.5, 197-198, 2006, When a skull is vibrated by a vibrator, we can perceive a sound. The applied vibration is supposed to be transmitted to the cochlea through the temporal bone, and this sound path is called bone-conduction. However, our preliminary experiments showed that sound pressure is generated in the external auditory meatus when a skull is vibrated, and the sound pressure strongly influences perception of sound at low frequencies. In this study, the sound pressure in the external auditory meatus generated by the vibration of 0.2〜40kHz applied to a skull was measured. The results showed that the influence of the sound pressure generated in external auditory meatus on perception of the sound decreases with increasing the frequency.
Japanese

Development of a non-implantable electromagnetic hearing aid using coils to vibrate the ossicles
Shinji Hamanishi; Takuji Koike; Wade Chien; Michael E. Ravicz; Saumil N. Merchant; John J. Rosowski; Toshimitsu Kobayashi; Hiroshi Wada
FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS, WORLD SCIENTIFIC PUBL CO PTE LTD, 85-+, 2006, Peer-reviwed, We constructed a prototype of a non-implantable hearing aid which does not require an earphone. In this hearing aid, a coil is adhered to the tympanic membrane and excited by the electromagnetic force. This paper describes evaluation of excitation force in this hearing aid by experiments using human temporal bone. The experiments indicate that the newly developed hearing aid can generate an excitation force of more than 80 dB SPL in terms of sound pressure at frequencies between 0.8 and 3.2 kHz.
International conference proceedings, English

ムラサキイガイの持つ接着タンパク質の簡易接着強度測定について
青木 路人; 本間 恭二; 小池 卓二; 村上 小百合
日本機械学会論文集A, 72, 716, 487-492, 2006, Peer-reviwed
Scientific journal, Japanese

Effects of individual differences in size and mobility of the middle ear on hearing
T Koike; M Shinozaki; S Murakami; K Homma; T Kobayashi; H Wada
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, JAPAN SOC MECHANICAL ENGINEERS, 48, 4, 521-528, Dec. 2005, Peer-reviwed, The size of the tympanic membrane and ossicles and the stiffness of the middle-ear ligaments and joint are different between individuals, and the effects of these differences on middle-ear transfer function have not been clarified. In this study, using finite-element middle-ear models, the effects of individual differences in the size and mobility of the middle ear on its transmission characteristics were analyzed. The individual differences in the size of the normal middle ear were found to affect the transfer function by up to 10 dB. The effects of the Young's moduli of the stapedial annular ligaments and the incudostapedial joint on the transfer function were large compared to the effects of the Young's moduli of the other parts of the middle ear.
Scientific journal, English

Experimental assessment of the performance of an electromagnetic hearing aid in human temporal bones
S Hamanishi; T Koike; W Chien; ME Ravicz; JJ Rosowski; SN Merchant; T Kobayashi; H Wada
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, JAPAN SOC MECHANICAL ENGINEERS, 48, 4, 529-536, Dec. 2005, Peer-reviwed, To circumvent some of the problems inherent in conventional hearing aids such as low gain at high frequencies due to acoustic feedback, discomfort in occlusion of the external ear canal and so on, implantable hearing aids have been developed over the past two decades. The most prominent feature of implantable hearing aids is that a transducer is directly coupled to the one of the middle-ear ossicles. However, since invasive surgery is necessary for implantation of these hearing aids, they have not as yet been widely employed. We therefore constructed a prototype of a non-implantable hearing aid which is mainly composed of a microphone amplifier system and an electromagnetic transducer developed in our previous study. It can generate an excitation force to vibrate the ossicles by a coil adhered to the tympanic membrane. In this study, the excitation force generated by this hearing aid was evaluated using human temporal bones. The best result of experiments using three bones indicates that the newly developed hearing aid can generate an excitation force of more than 80 dB SPL in terms of sound pressure at frequencies between 0.8 and 3.2 kHz.
Scientific journal, English

Experimental assessment of the performance of an electromagnetic hearing aid in human temporal bones
S Hamanishi; T Koike; W Chien; ME Ravicz; JJ Rosowski; SN Merchant; T Kobayashi; H Wada
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, JAPAN SOC MECHANICAL ENGINEERS, 48, 4, 529-536, Dec. 2005, Peer-reviwed, To circumvent some of the problems inherent in conventional hearing aids such as low gain at high frequencies due to acoustic feedback, discomfort in occlusion of the external ear canal and so on, implantable hearing aids have been developed over the past two decades. The most prominent feature of implantable hearing aids is that a transducer is directly coupled to the one of the middle-ear ossicles. However, since invasive surgery is necessary for implantation of these hearing aids, they have not as yet been widely employed. We therefore constructed a prototype of a non-implantable hearing aid which is mainly composed of a microphone amplifier system and an electromagnetic transducer developed in our previous study. It can generate an excitation force to vibrate the ossicles by a coil adhered to the tympanic membrane. In this study, the excitation force generated by this hearing aid was evaluated using human temporal bones. The best result of experiments using three bones indicates that the newly developed hearing aid can generate an excitation force of more than 80 dB SPL in terms of sound pressure at frequencies between 0.8 and 3.2 kHz.
Scientific journal, English

Evaluation of the excitation force generated by a new electromagnetic hearing aid using human temporal bones
Shinji Hamanishi; Takuji Koike; Toshimitsu Kobayashi; Hiroshi Wada
12th International Congress on Sound and Vibration 2005, ICSV 2005, 5, 4113-4120, 2005, Sensorineural hearing loss, resulting from a dysfunction of cochlear amplification, is observed in a steadily increasing number of younger patients as well as in aged patients. The majority of these hearing-impaired individuals use conventional hearing aids, which are mainly composed of an earphone, a microphone and an amplifier. However, some patients who use conventional hearing aids remain unsatisfied owing to various problems such as sound distortion, feedback and so on. To circumvent some of the problems inherent in conventional hearing aids, implantable hearing aids have been developed. The most prominent feature of implantable hearing aids is that a transducer is directly coupled to the one of the middle-ear ossicles. However, since invasive surgery is necessary for implantation of these hearing aids, they have not as yet been widely employed. We therefore constructed a new non-implantable hearing aid which can generate an excitation force to vibrate the ossicles by a coil adhered to the tympanic membrane. In this study, the excitation force generated by this hearing aid was evaluated using human temporal bones. The best result of experiments using three bones indicates that the newly developed hearing aid can generate an excitation force of more than 80 dB SPL in terms of sound pressure at frequencies between 0.8 and 3.2 kHz.
International conference proceedings, English

Corrosion source location in plate of steel using neural network
Aiko Inaba; Kyoji Homma; Sayuri Murakami; Takuji Koike; Minoru Yamada
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A, Japan Society of Mechanical Engineers, 71, 7, 1046-1050, 2005, A new technique to locate a defect, combining acoustic emission and neural network, is proposed to assess the condition of the storage tank floor. Artificial acoustic emission source by means of a pencil lead break and acoustic emission source cause of corrosion in steel plate is located using neural network trained by time lag of artificial acoustic emission, P- wave, S-wave and Rayleigh wave. It turned out that artificial acoustic emission arrived at sensor is P-wave and acoustic emission course of corrosion is S-wave or Rayleigh wave. Same experiment is made on a specimen of bottom plate of real tank. As a result, corrosion source location using neural network is possible steel plate extended corrosion.
Scientific journal, Japanese

Acoustic analysis of adhesive surface in granular inhomogeneous structural material using neural network
Toshiyuki Iemoto; Kyoji Homma; Sayuri Murakami; Takuji Koike
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A, Japan Society of Mechanical Engineers, 71, 6, 976-981, 2005, Difficulty in quality assessment of adhesive interface between granular inhornogeneous materials and a disk plate has been pointed out in nondestructive ultrasonic inspection because of the effect of multiple-reflection at the contact point of each granular particle. A simulation technique is presented in this paper for estimating the adhesion quality of a CBN grinding wheel at the interface between the granular material and the disk plate. The grinding wheel was transposed to one dimensional serial model consisted of each segment of particle with random acoustic impedances at the interface. The propagation of incident ultrasonic waves in the grinding wheel was calculated and echoes from adhesive interface were analyzed. The domestic echo waveform from the adhesive interface was specified and learned by a neural network corresponding adhesion quality and the characteristic of the echo waveform. The effect of the grinding wheel structure to the accuracy of presumption was investigated by using the network. It was revealed that the neural network is effective to assess the adhesive quality of such inhomogeneous structural materials.
Scientific journal, Japanese

1103 Influence of the sound pressure generated in the external auditory meatus on sound perception when the skull is vibrated by an actuator
SUZUKI Akira; KOIKE Takuji; HOMMA Kyoji; MURAKAMI Sayuri
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2005, 79-80, 2005, When a bone is vibrated by a vibrator, we can perceive a sound even if conductive hearing loss exists. The applied vibrationis supposed to be transmitted to the cochlea through the temporal bone, and this sound path is called bone-conduction. However, the real sound paths of the vibration applied to the bone have not been clarified. In this study, the subjective sound pressure perceived by subjects and the sound pressure generated in the external auditory meatus (EAM) were measured when the zygomatic process of temporal bone was vibrated by a piezoelectric vibrator. The level of sound pressure in EAM was nearly equal to the subjective sound pressure level at 1kHz. This result suggests that subjects with normal middle ear perceive not only bone-conducted sound but also air-conducted sound through the middle ear when the zygomatic process was vibrated at 1kHz.
Japanese

1105 Development of a minimally invasive implantable hearing aid using an electromagnetic coil to vibrate the stapes and the round window
SOETA Akihiro; KOIKE Takuji; HOMMA Kyoji; MURAKAMI Sayuri; WADA Hitosi
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2005, 83-84, 2005, In this study, minimally invasive electromagnetic hearing aids (EMHA) which directly vibrate both the stapes and the round window were proposed, and a prototype of the EMHA was constructed. The EMHA consists of vibration coils, a chamber, and a magnet. To estimate the power of the EMHA, an artificial stapes-cochlea model was made, and the vibration of the stapes head of the model generated by the EMHA was measured. The results suggested that the EMHA generated an excitation force of 90dB SPL in terms of sound pressure in the wide frequency range of 250-10,000Hz.
Japanese

414 Removal Simulation of Mussel's Plaque from Substratum
AOKI Michihito; HOMMA Kyoji; KOIKE Takuji; MURAKAMI Sayuri
Proceedings of the JSME Bioengineering Conference and Seminar, The Japan Society of Mechanical Engineers, 2004, 159-160, 2005
Japanese

505 Development of a diagnostic apparatus for ossicular mobility and simulation of clinical inspection
KOIKE Takuji; SHINOZAKI Masaki; HOMMA Kyoji; Merchant Saumil N.; WADA Hiroshi
Proceedings of the JSME Bioengineering Conference and Seminar, The Japan Society of Mechanical Engineers, 2004, 185-186, 2005
Japanese

ニューラルネットワークを利用した鋼板の腐食位置標定
稲葉藍子; 本間恭二; 村上小百合; 小池卓二; 山田實
日本機械学会論文集A, 1046-1050, 2005, Peer-reviwed
Scientific journal, Japanese

ニューラルネットワークを用いた粒状不均質材の接着面における音響解析
家元利幸; 本間恭二; 村上小百合; 小池卓二
日本機械学会論文集A, 976-981, 2005, Peer-reviwed
Scientific journal, Japanese

ニューラルネットワークを利用した鋼板の腐食位置標定
稲葉藍子; 本間恭二; 村上小百合; 小池卓二; 山田實
日本機械学会論文集A, 1046-1050, 2005, Peer-reviwed
Scientific journal, Japanese

ニューラルネットワークを用いた粒状不均質材の接着面における音響解析
家元利幸; 本間恭二; 村上小百合; 小池卓二
日本機械学会論文集A, 976-981, 2005, Peer-reviwed
Scientific journal, Japanese

長期間水ストレスを与えた植物で発生するアコースティックエミッションについて
村上小百合; 矢作陽一; 本間恭二; 小池卓二
日本機械学会論文集C, The Japan Society of Mechanical Engineers, 71, 712, 200-205, 2005, The influence to ecosystem of plant by global warming is investigated. However, few diagnostic technologies by non-destructive inspection to environmental stress are established. Acoustic emission (AE) is applied to the measurement of damage under the water stress of plants. Cavitation phenomena are known by negative pressure under the lack of water in the vessel. Since shock wave due to cavitations issues AE, water stress state of plant can be monitored on real time by measuring AE. In this paper, AE events by the cavitation were measured in drought-treated Ginkgo biloba L, Ficus spp. and Lycopersicon es. In all plant, AE events are increased during drought and stopped by supplying water. In Ginkgo and Ficus, a temporary decrease of AE events was observed during drought. It is presumed that plant adjust internal water balance for self-defense by a certain procedure. Stoma closing of the leaf considered being the most effective physiology, however, was not the cause.
Scientific journal, Japanese

Evaluation of a new diagnostic apparatus for ossicular fixation using human temporal bones: Comparison with vibration measurements by a laser-Doppler velocimeter
Takuji Koike; Shinji Hamanishi; Toshimitsu Kobayashi; Hideko H. Nakajima; Michael E. Ravicz; Saumil N. Merchant; John J. Rosowski; Hiroshi Wada
Association for Research in Otolaryngology Midwinter Meeting, 323-324, 2005, Peer-reviwed
International conference proceedings, English

An Electromagnetic Hearing Aid Using Coils to Vibrate the Ossicles -Evaluation of Excitation Force and Distortion-
Shinji HAMANISHI; Takuji KOIKE; Hidetoshi MATSUKI; Toshimitsu KOBAYASHI; Hiroshi WADA
Proceedings of the 2005 IEEE International Magnetics Conference, FC-08, 2005, Peer-reviwed
International conference proceedings, English

Detection of small pests on vegetable leaves using GLCM
Sayuri Murakami; Kyoji Homma; Takuji Koike
Proceedings of American Society of Agriculture Engineer Annual International Conference, 053136, 2005, Peer-reviwed
International conference proceedings, English

Development of a hand-guided apparatus for measuring ossicular mobility
Takuji Koike; Shinji Hamanishi; Toshimitsu Kobayashi; Saumil N. Merchant; Hiroshi Wada
Twelfth International Congress on Sound and Vibration, 326, 2005, Peer-reviwed
International conference proceedings, English

A Hand-Guided Apparatus for Measuring Ossicular Mobility
Takuji Koike; Masaki Shinozaki; Shinji Hamanishi; Toshimitsu Kobayashi; Saumil N. Merchant; Hiroshi Wada
Proceedings of The 2nd Asian Pacific Conference on Biomechanics, D-23-10075, 2005, Peer-reviwed
International conference proceedings, English

耳小骨靱帯・筋腱の剛性変化が中耳伝音特性に及ぼす影響 : コンピュータシミュレーションによる解析
小池 卓二; 小林 俊光; 和田 仁
Audiology Japan, Japan Audiological Society, 47, 5, 413-414, 15 Sep. 2004
Japanese

A new electromagnetic hearing aid using lightweight coils to vibrate the ossicles
S Hamanishi; T Koike; H Matsuki; H Wada
IEEE TRANSACTIONS ON MAGNETICS, IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 40, 5, 3387-3393, Sep. 2004, As the first stage in the development of a noninvasive electromagnetic hearing aid, we made a new transducer that gencrates a high-excitation force to vibrate ossicles via the tympanic membrane. This transducer consists of a core, driving and induction coils, a rare-earth magnet, and a vibrator coil. We designed the core, the driving and induction coils, and the magnet so as to generate the greatest excitation force possible when installed in the external ear canal of humans. With regard to the vibrator coil, which was attached to the center of the tympanic membrane to vibrate the ossicles, we determined its optimal mass, position, and shape both by finite-element method (FEM) analysis and by experiments using an artificial middle ear. A prototype of the optimally designed transducer can generate an excitation force of more than 95 dB sound pressure level (SPL) in terms of sound pressure at frequencies between 0.1 and 10 kHz. This result indicates that the transducer developed in this study can be used to treat patients with a hearing loss up to 70 dB hearing level (HL).
Scientific journal, English

Sound localization of bone-conducted signals generated by two transducers attached to teeth
SOETA Akihiro; KOIKE Takuji; HONMA Kyouji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2004, 47-48, 2004, The efficiency of the sound transmission of a bone-conduction hearing aid is improved when tooth is excited by a transducer because the vibration generated by the transducer is not attenuated by the damping of skin and directly transmits to the skull. In addition, if sound localization is established by a binaural bone-conduction hearing aid, speech articulation is also improved. In this study, the sound localization was tested by applying sinusoidal signals to two transducers attached to right and left teeth. The pattern of the sound localization according to the phase difference between the two signals depended on individuals, and this sound localization seemed to be caused by the change of the amplitude of the vibration transmitted to the cochleae from the transducers.
Japanese

中耳stiffnessと聴力の関係(K05 バイオエンジニアリング部門企画)
小池 卓二; 和田 仁; 小林 俊光
年次大会講演資料集, 一般社団法人日本機械学会, 2004, 9-10, 2004
Japanese

Effects of individual differences in size and stiffness of the middle ear on its sound transmission
T Koike; H Wada; T Kobayashi
PROCEEDINGS OF THE 3RD SYMPOSIUM ON MIDDLE EAR MECHANICS IN RESEARCH AND OTOLOGY, WORLD SCIENTIFIC PUBL CO PTE LTD, 68-74, 2004, Peer-reviwed, The size and stiffness of the middle ear are different between individuals, and the effects of these differences on middle ear transfer function have not been clarified. In this study, using finite-element middle-car models, the effects of individual differences in the size and stiffness of the middle ear on its transmission characteristics were analyzed. The individual differences in the size on the middle ear were found to slightly affect the transfer function. The effects of Young's modulus of the ligaments and incudostapedial joint on the transfer function were significantly large compared to those of the other parts of the middle ear.
International conference proceedings, English

Development of an apparatus for diagnosis of ossicular chain mobility
H Wada; T Koike; M Murakoshi; R Yuasa; Y Yuasa; N Honda; RL Goode
PROCEEDINGS OF THE 3RD SYMPOSIUM ON MIDDLE EAR MECHANICS IN RESEARCH AND OTOLOGY, WORLD SCIENTIFIC PUBL CO PTE LTD, 333-339, 2004, Peer-reviwed, Confirmation of the conditions of the ossicles is essential for tympanoplasty. Although several methods to measure ossicular mobility have been reported, the quantitative evaluation of ossicular mobility has been difficult to date. We have therefore developed a new system with which it is possible to quantitatively evaluate ossicular mobility during surgery. The apparatus enables us to simultaneously obtain the reaction force from the ossicles and its displacement. Force-displacement curves obtained from otosclerotic ears were clearly different from these obtained from normal subjects. Furthermore, pre- and post-treatment results showed significant differences. With this new apparatus, it is possible to distinguish the differences in mobility of the ossicles between normal and fixed ossicles, as well as estimate the change of the mobility between pre- and post-treatment for ossicular fixation.
International conference proceedings, English

Development of a non-implantable electromagnetic hearing aid
S Hamanishi; H Wada; T Koike; T Kobayashi; N Honda; RL Goode
PROCEEDINGS OF THE 3RD SYMPOSIUM ON MIDDLE EAR MECHANICS IN RESEARCH AND OTOLOGY, WORLD SCIENTIFIC PUBL CO PTE LTD, 362-369, 2004, Peer-reviwed, Research and development over the past two decades has shown that implantable hearing aids can circumvent some of the problems found in conventional hearing aids, such as feedback, cosmetic problems and so on. However, these hearing aids have not as yet been widely used, because invasive surgery has to be performed to implant them and applying them in children, who are still growing, is difficult.
In this study, a prototype of the non-implantable electromagnetic hearing aid, which can generate a high-excitation force to vibrate the ossicles via the tympanic membrane, was constructed. The hearing aid consists of an electromagnetic transducer and an amplifier. To determine fundamental properties of the hearing aid, excitation force and acoustical gain were evaluated using an artificial middle ear and a human temporal bone, respectively. The experiments showed that the hearing aid was able to generate the maximum excitation force, which is equivalent to a sound pressure of 100 dB SPL at high frequencies.
International conference proceedings, English

Development of a New Electromagnetic Hearing Aid
Shinji Hamanishi; Takuji Koike; Hideko H. Nakajima; Saumil N. Merchant, Richard; L. Goode; Toshimitsu Kobayashi; Hiroshi Wada
XXVIIth International Congress of Audiology, 29, 2004, Peer-reviwed
International conference proceedings, English

Effects of ossicular fixation on ear transmission
Takuji Koike; Toshimitsu Kobayashi; Hiroshi Wada
XXVIIth International Congress of Audiology, 30, 2004, Peer-reviwed
International conference proceedings, English

Intraoperative measurement of ossicular mobility
Michio Murakoshi; Takuji Koike; Yu Yuasa; Ryo Yuasa; Toshimitsu Kobayashi; Hiroshi Wada
XXVIIth International Congress of Audiology, 31, 2004, Peer-reviwed
International conference proceedings, English

Efficiency of a New Electromagnetic Hearing Aid: Evaluated by Measurement of the Stapes-footplate Motion using Human Temporal Bones
Shinji Hamanishi; Takuji Koike; Toshimitsu Kobayashi, Richard; L. Goode; Hiroshi Wada
The 18th International Congress on Acoustics, 1517-1518, 2004, Peer-reviwed
International conference proceedings, English

Development of a minimally invasive implantable hearing aid using an electromagnetic coil to vibrate the stapes
Takuji Koike; Satoshi Aoki; Kyouji Homma; Hiroshi Wada
Eleventh International Congress on Sound and Vibration, 1637-1642, 2004, Peer-reviwed
International conference proceedings, English

High-speed video observation of tympanic membrane rupture in guinea pigs
T Koike; H Wada; F Ito; K Takayama; T Kobayashi
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, JAPAN SOC MECHANICAL ENGINEERS, 46, 4, 1434-1440, Dec. 2003, Peer-reviwed, In this study, the tympanic membrane (TM) of the guinea pig was exposed to a blast wave generated by micro-explosion of 10 mg silver azide, and the time history of TM rupture was recorded using a high-speed video camera. The relationship between the process of TM rupture and the peak pressure of the blast wave was then examined. The critical value which caused the TM rupture was found to be 192 dB SPL (79.6 kPa), and when this level of pressure was applied to the TM, tears were immediately caused in the radial direction, although they did not subsequently expand. When pressures above 195 dB SPL (112 kPa) were applied to the TM, it suffered a perforation, and this perforation. continued to expand for several milliseconds, even after disappearance of the pressure change caused by the blast wave.
Scientific journal, English

Transient evoked otoacoustic emissions in patients with middle ear disorders
F Zhao; H Wada; T Koike; K Ohyama; T Kawase; D Stephens
INTERNATIONAL JOURNAL OF AUDIOLOGY, INFORMA HEALTHCARE, 42, 3, 117-131, Apr. 2003, Peer-reviwed, The aim of this study is to investigate the middle ear dynamic characteristics and their influence on TEOAEs in patients with middle ear disorders. The middle ear dynamic characteristics and TEOAE findings were investigated in 89 patients with middle ear disorders using the sweep frequency impedance (SFI) meter and the ILO88 system, respectively. These patients were divided into six subcategories: tympanic membrane aberrations, otitis media with effusion, chronic otitis media, tympanic membrane perforation, otosclerosis, and ossicular chain dislocation. Details of the TEOAE frequency characteristics were compared with the individual's middle ear dynamic characteristics. TEOAE status as a function of hearing threshold and middle ear dynamic characteristics was also examined. The results showed that the middle ear dynamic characteristics in patients with middle ear disorders correlated with the TEOAE frequency characteristics and amplitudes. The hearing level and middle ear mobility were the controlling factors affecting TEOAE status. Using both non-linear and linear stimulus modes, larger TEOAE responses were obtained when the hearing level was better than 20 dB HL, and there was moderately good middle ear mobility. Moreover, TEOAEs were absent using the non-linear mode when the hearing level was worse than 30 dB HL, whereas with the linear mode, TEOAEs were recordable even with hearing losses of up to 40 dB HL in patients with middle ear disorders. A higher incidence of recordable TEOAEs was found in the subgroups with tympanic membrane abnormalities and secretory otitis media when compared with the other subgroups. No TEOAEs were recordable in patients with chronic otitis media.
Scientific journal, English

Fixation of the anterior mallear ligament: Diagnosis and consequences for hearing results in stapes surgery
A Huber; T Koike; H Wada; Nandapalan, V; U Fisch
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, ANNALS PUBL CO, 112, 4, 348-355, Apr. 2003, Peer-reviwed, In the search for possible causes of unfavorable results after stapes surgery, the study reported here focused on the anterior mallear ligament, since it has been previously reported that partial mallear fixation (PMF) leads to functional failure in 38% of cases of stapes revision surgery. The aims of the study were to identify effective methods for the diagnosis of PMF and experimentally assess the conductive hearing loss that results from PMF. The study included vibration amplitude measurements of the ossicles by laser Doppler interferometry (LDI) in 19 patients and 5 fresh human temporal bone (TB) specimens. Analysis of their dynamic behavior was performed by finite element modeling (FEM). Similar, significant changes of manubrium vibration patterns for PMF were found by FEM calculations, in TB experiments, and in patients. We could identify PMF either before operation, using LDI, or during operation, by manual palpation. In the TB experiments and FEM calculations, the attenuation of the stapes displacement due to an isolated PMF was approximately 10 dB and frequency-dependent. Untreated anterior mallear ligament fixation produced a persistent air-bone gap of approximately 10 dB after stapedioplasty.
Scientific journal, English

A new electromagnetic hearing aid using coils to vibrate the ossicles
Shinji Hamanishi; Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi
Association for Research in Otolaryngology Midwinter Meeting, 169, Feb. 2003, Peer-reviwed
International conference proceedings, English

Simulation of measurement of ossicular mobility: Effect of the direction of applied displacement on mobility of the ossicles
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi
Association for Research in Otolaryngology Midwinter Meeting, 247, Feb. 2003, Peer-reviwed
International conference proceedings, English

鼓膜面に留置した軽量コイルにより加振する新駆動方式補聴システムの開発
小池 卓二; 和田 仁; 小林 俊光
AUDIOLOGY JAPAN, Japan Audiological Society, 46, 5, 345-346, 2003
Japanese

Individual differences in sound transmission characteristics of the middle ear and the construction of a database of the differences : FEM analysis
KOIKE Takuji; KONNO Kazuaki; WADA Hiroshi
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2003, 45-46, 2003, The size and mobility of the middle ear are different between individuals, and the effects of these differences on the middle ear transfer function have not been clarified. In this study, using finite-element middle-ear models, the effects of individual differences in size and mechanical properties of the middle ear on its transmission characteristics were analyzed. The individual differences in size of the middle ear were found to affect the transfer function, and the effects of size of the tympanic membrane were more remarkable than those of the ossicles. The effects of Young's modulus of the ligaments and tendons on the transfer function were significantly large compared to that of the size. It was suggested that the differences of each part of the middle ear independently affects the transfer function.
Japanese

ティンパノグラムの理論的考察 : 外耳道内静圧変化による中耳変形に着目して
小池 卓二; 和田 仁; 小林 俊光
Audiology Japan, Japan Audiological Society, 45, 5, 617-618, 30 Sep. 2002
Japanese

Vibration measurement of the tympanic membrane of guinea pig temporal bones using time-averaged speckle pattern interferometry
H Wada; M Ando; M Takeuchi; H Sugawara; T Koike; T Kobayashi; K Hozawa; R Gemma
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, ACOUSTICAL SOC AMER AMER INST PHYSICS, 111, 5, 2189-2199, May 2002, Peer-reviwed, "Time-averaged holography" and "holographic interferometry" enable recording of the complete vibration pattern of a surface within several seconds. The results appear in the form of fringes. Vibration amplitudes smaller than 100 nm are not readily measurable by these techniques, because such small amplitudes produce variations in gray level, but not fringes. In practice, to obtain clear fringes in these measurements, stimulus sound pressures higher than 100 dB SPL must be used. The phase of motion is also not obtainable from such fringe techniques. In this study, a sinusoidal phase modulation technique is described, which allows detection of both small amplitudes of motion and their phase from time-averaged speckle pattern interferometry. In this technique, the laser injection current is modulated and digital image processing is used to analyze the measured patterns. When the sound-pressure level of stimuli is between 70 and 85 dB SPL, this system is applied to measure the vibratory response of the tympanic membrane (TM) of guinea pig temporal bones at frequencies up to 4 kHz where complicated vibration modes are observed. The effect of the bulla on TM displacements is also quantified. Results indicate that this system is capable of measuring the nanometer displacements of the TM, produced by stimuli of 70 d13 SPL. (C) 2002 Acoustical Society of America.
Scientific journal, English

Middle ear dynamic characteristics in patients with otosclerosis
F Zhao; H Wada; T Koike; K Ohyama; T Kawase; D Stephens
EAR AND HEARING, LIPPINCOTT WILLIAMS & WILKINS, 23, 2, 150-158, Apr. 2002, Peer-reviwed, Objective: To investigate the middle ear dynamic characteristics in patients with otosclerosis using the sweep frequency impedance meter (SFI test) and conventional tympanometry, and also to evaluate the diagnostic efficiency of the SFI test for otosclerosis.
Design: The study was designed to collect a total of 25 (36 ears) consecutive patients with otosclerosis. All subjects followed a clinical protocol, which consisted of a hearing problem questionnaire, otoscopic examination, and audiometric measurements. These included pure tone audiometry, conventional tympanometry, and SFI test.
Results: In the SFI test, the middle ear dynamic characteristics were measured in terms of the resonance frequency and middle ear mobility. Three distinct categories of middle ear dynamic characteristics were found in patients with otosclerosis, i.e., high stiffness, normal stiffness, and low stiffness middle ear status. On comparison of the results of SFI with conventional tympanometry, a significantly higher percentage of abnormal stiffness was found when using the SFI test than that when using conventional tympanometry.
Conclusions: The present findings confirm the advantage of the SFI test over conventional tympanometry in detecting middle ear status and mechanics in patients with otosclerosis. Moreover, different middle ear dynamic characteristics in patients with otosclerosis are most likely to be related to the different stages of the pathological changes.
Scientific journal, English

Development of a hand-guided diagnostic apparatus for ossicular fixation
KOIKE Takuji; WADA Hiroshi; YUASA Yu; YUASA Ryou; KAWASE Tetsuaki; KOBAYASHI Toshimitsu
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2002, 129-130, 2002, It is important to evaluate stapes mobility in tympanoplasty surgery, because it affects the prognosis of improvement of the hearing level. In this study, a new hand-guided apparatus was developed by assembling a small-sized force sensor and a hydraulic micromanipulator. Then, the mobility of stapes in humans was measured. In addition, the nobilities of incus and malleus in guinea pigs are also measured under the condition that the stapes was artificially fixed with glue being applied to the annular ligament to simulate otosclerosis. The load-displacement curve obtained from the normal stapes was different from that obtained from the fixed stapes. This result suggests that a surgeon can quantitatively analyze stapes mobility with this apparatus during surgery.
Japanese

モルモット中耳の振動挙動－有限要素法による理論解析－
小池卓二; 和田 仁; 小林俊光
Audiology Japan, Japan Audiological Society, 45, 4, 289-297, 2002, Peer-reviwed, A guinea pig is usually used for a study of auditory mechanics. However, the dynamic characteristics of guinea pig middle ear have not been fully understood. In this study, a finite-element model of the middle ear of a guinea pig was established, and the sound-transfer mechanism of the middle ear was analyzed. Unknown mechanical properties of middle-ear parts were determined so that the tympanic membrane vibration obtained from the FEM resembled that obtained by using the electronic speckle pattern interferometry. The validity of this model was confirmed by comparing the ossicular vibration and the middle-ear sound transmission obtained by this model with those by measurements.
The guinea pig's middle ear was found to keep a flat sound transfer function in the frequency range from 1kHz to 5kHz by changing its vibration mode gradually.
Scientific journal, Japanese

Development of a Diagnostic Apparatus for Stapes Fixation
Takuji Koike; Hiroshi Wada; Yu Yuasa; Ryo Yuasa; Tetsuaki Kawase; Toshimitsu Kobayashi
2002, Peer-reviwed
International conference proceedings, English

Hand-guided diagnostic apparatus for stapes fixation
Takuji Koike; Hiroshi Wada
110, 2002
International conference proceedings, English

Observation of tympanic membrane rupture by a high-speed video system
Takuji Koike; Hiroshi Wada; Fumiaki Ito; Kazuyoshi Takayama
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 1, 113-114, 2002, Tympanic membrane (TM) rupture due to overpressure results from a slap in the face and sports such as diving. The level of overpressure that causes TM rupture and the location of the rupture have been estimated in various animals under various experimental conditions. However, the process of TM rupture due to dynamic pressure has not been observed. In this study, the process of TM rupture in the guinea pig caused by a shock wave was recorded using a high-speed video system, and the time history of the pressure was simultaneously measured by a pressure gauge. Based on our findings, the reason for the existence of different TM rupture mechanisms, and the relationship between the rupture process and the peak pressure are here in discussed.
International conference proceedings, English

Modeling of human middle ear using the finite-element method
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi
J. Acoust. Soc. Am., 111, 1306-1616, 2002, Peer-reviwed
Scientific journal, English

Effect of depth of conical-shaped tympanic membrane on middle-ear sound transmission
T Koike; H Wada; T Kobayashi
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, JAPAN SOC MECHANICAL ENGINEERS, 44, 4, 1097-1102, Dec. 2001, Peer-reviwed, The shape of the tympanic membrane (TM) is often changed due to middle-ear diseases or middle-ear surgery. Although it is assumed that this change ill shape affects the sound transmission of the middle ear, the degree of this effect remains unclear. In this study, three-dimensional finite-element models of the middle ear with different depths of the conical-shaped portion of the TM were established, and the effects of the depth, Young's modulus and thickness of the TM on middle-ear sound transmission were analyzed. The efficiency of sound transmission was found to decrease when the depth of the conical-shaped portion of the TM decreased because of a decline in the efficiency of transmission of the vibration of the TM to the ossicles. The transfer function was also influenced by the Young's modulus and thickness of the TM. Thus, when substitutional materials, whose Young's modulus or thickness was appropriately greater than those of the normal TM, were used in TM reconstruction, the efficiency improved, even if its shape was flat.
Scientific journal, English

Effect of depth of conical-shaped tympanic membrane on middle-ear sound transmission
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Hiroshi Wada
JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing, 44, 4, 1097-1102, Dec. 2001, The shape of the tympanic membrane (TM) is often changed due to middle-ear diseases or middle-ear surgery. Although it is assumed that this change in shape affects the sound transmission of the middle-ear, the degree of this effect remains unclear. In this study, three-dimensional finite-element models of the middle-ear with different depths of the conical-shaped portion of the TM were established, and the effects of the depth. Young's modulus and thickness of the TM on middle-ear sound transmission were analyzed. The efficiency of sound transmission was found to decrease when the depth of the conical-shaped portion of the TM decreased because of a decline in the efficiency of transmission of the vibration of the TM to the ossicles. The transfer function was also influenced by the Young's modulus and thickness of the TM. Thus, when substitutional materials, whose Young's modulus or thickness was appropriately greater than those of the normal TM, were used in TM reconstruction, the efficiency improved, even if its shape was flat.
Scientific journal, English

耳小骨可動性計測装置の開発
小池 卓二; 和田 仁; 湯浅 有; 湯浅 涼; 川瀬 哲明; 小林 俊光
Audiology Japan, Japan Audiological Society, 44, 5, 343-344, 30 Sep. 2001
Japanese

Measurement of stapes mobility in guinea pigs and rabbits
H Wada; T Koike; Y Yuasa; T Kawase; H Fujii
HEARING RESEARCH, ELSEVIER SCIENCE BV, 154, 1-2, 158-164, Apr. 2001, Peer-reviwed, In tympanoplasty, it is essential to know the condition of the stapes. However, it has been difficult to evaluate stapes mobility in routine measurement. With the eve on improving future clinical practice, in this study we developed a new, easy system of measuring stapes mobility quantitatively and, as a first step, applied it to measurement of the relationship between the load and displacement of the stapes in guinea pigs and rabbits. The stapes displacement increased linearly with an increase in load in the small displacement region, and increased nonlinearly in the large displacement region. The slope of the regression line of this stiffness curve in the small displacement region was used as an index of the stapes mobility. The values in the guinea pigs and rabbits were 16 +/- 7 N/m and 115 +/- 25 N/m. respectively. A significant difference between the two species was observed. (C) 2001 Elsevier Science B.V. All rights reserved.
Scientific journal, English

F-0803 Dynamic Characteristics of the Middle Ear with Partial Fixation of Anterior Malleal Ligament
KOIKE Takuji; WADA Hiroshi; KOBAYASHI Toshimitsu; Huber Alexander M.
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 1, 5-6, 2001, The middle ear plays an important role in auditory mechanics, transmitting sound signals efficiently from the ear canal to the cochlea. If ligaments, which support ossicles, become fixed, conductive hearing loss occurs. A diagnosis of these fixations of the ligaments is difficult. Especially, as the anterior malleal ligament (AML) is a tiny ligament, its fixation is often overlooked. In this study, the effect of the AML fixation on the middle-ear vibration was analyzed by using a finite-element model of the middle ear and by measuring vibrations of temporal bones with a laser Doppler interferometer. Then, based on our findings, a diagnostic method for detecting the AML fixation was suggested.
Japanese

Finite-element method analysis of transfer function of middle ear reconstructed using stapes prosthesis
Takuji Koike; Hiroshi Wada; Manabu Munakata
2001, Peer-reviwed
International conference proceedings, English

アブミ骨可動性の計測(第2報)
湯浅有; 川瀬哲明; 湯浅涼; 小池卓二; 和田仁
Audiology Japan, 43, 5, 445-446, Sep. 2000
Scientific journal, Japanese

The influence of middle ear disorders on otoacoustic emissions
F Zhao; H Wada; T Koike; D Stephens
CLINICAL OTOLARYNGOLOGY, BLACKWELL SCIENCE LTD, 25, 1, 3-8, Feb. 2000, Peer-reviwed
Scientific journal, English

Transfer Function of the Middle Ear Reconstructed by the Stapes Prosthesis : FEM Analysis
KOIKE Takuji; WADA Hiroshi; MUNAKATA Manabu; KOBAYASHI Toshimitsu
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2000, 499-500, 2000, Various kinds of prostheses have been used for stapes surgery in cases of otosclerosis. However, the factors, which improve the acoustic performance of the prostheses, have not been clarified, because it is difficult to compare the different types of prosthesis under the same middle ear condition. In this study, three-dimensional models of wire-piston stapes prostheses made of Teflon, titanium or gold were established using finite element method. Then, the effects of the piston diameter and materials on the middle car transfer function were analyzed. Also, the effect of the stiffness of the tissue, which filled the gap between the piston and footplate, on the transfer function was examined.
Japanese

Vibration of the Spiral Shaped Cochlea : FEM Analysis
SEKINE Masanao; WADA Hiroshi; KOIKE Takuji
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2000, 501-502, 2000, To clarify the mechanism of the cochlea, simulations using a mathematical or electrical circuital cochlear model have been performed by many researchers. However, in most of their models, the cochlea was assumed to be straight to simplify their simulations, although the mammalian cochlea is a spiral-shaped duct. A few researchers have already established the spiral cochlear models, but the effects of spiral shape of cochlea are still unclear. In this study, a three-dimensional model of the guinea pig cochlea was established, and numerical simulations were performed using the finite element method (FEM). To examine the effect of the spiral shape of cochlea on its mechanics, the numerical results obtained from the spiral-shaped model were compared with those from the straight model. It was found that the basilar membrane (BM) velocity amplitude and the vibration mode of the BM along the transverse direction in the spiral model were different from those of the straight model.
Japanese

Development of Diagnosis Method of Stapes Fixation
FUJII Hiroaki; WADA Hiroshi; KOIKE Takuji; YUASA Yu
The proceedings of the JSME annual meeting, The Japan Society of Mechanical Engineers, 2000, 215-216, 2000, In tympanoplasty, it is essential to understand the condition of the stapes. However, it has been difficult to evaluate stapes mobility in routine measurement. In this study, aiming at the clinical usage in the future, a new measuring system, which enables to measure the stapes mobility quantitatively and easily, has been developed, and the relationships between the load and displacement of the normal and artificially fixed stapes in the guinea pigs and rabbits were examined.
Japanese

Analysis of the finite-element method of transfer function of reconstructed middle ears and their postoperative changes
T Koike; H Wada; T Kobayashi
FUNCTION AND MECHANICS OF NORMAL, DISEASED AND RECONSTRUCTED MIDDLE EARS, KUGLER PUBLICATIONS BV, 309-320, 2000, Peer-reviwed, Many middle ear prostheses are available for the reconstruction of missing or damaged ossicles. However, there are few studies that investigate the acoustic properties of these prostheses, and there is no information available that could lead to the design and development of better ossicular replacement prostheses. In this study, three-dimensional finite-element models of a human intact middle ear and reconstructed middle ears using different types of incus replacement prosthesis are established, and an attempt is made to clarify the optimum method for reconstructing the middle ear. Prostheses with a high degree of stiffness, connecting the stapes head to either the malleus manubrium or near to the center of the tympanic membrane, give the best acoustic performance.
International conference proceedings, English

電子式スペックル干渉法による鼓膜の振動挙動計測
和田 仁; 竹内正孝; 菅原広格; 小池卓二; 小林俊光; 朴沢孝治; 玄間隆史; 奈良 誠
日本音響学会誌, 56, 379-383, 2000, Peer-reviwed
Scientific journal, Japanese

Theoretical analysis of sound transmission in human middle ear and its effects on otoacoustic emissions
T Koike; H Wada; T Kobayashi; K Ohyama; T Takasaka
PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON RECENT DEVELOPMENTS IN AUDITORY MECHANICS, WORLD SCIENTIFIC PUBL CO PTE LTD, 71-77, 2000, Peer-reviwed, In this study, a three-dimensional FEM model of a human middle ear was established, and the antorograde and retrograde pressure gains of the normal and pathologic middle ears were analyzed. Then, the levels of otoacoustic emissions (OAEs) in pathologic ears such as secretory otitis media, otosclerosis and incudo-stapedial joint separation were estimated based on the obtained pressure gains. The OAE frequency characteristics showed distinctive patterns depending on the kind of disorder and its degree.
International conference proceedings, English

Analysis of the finite-element method of transfer function of reconstructed middle ears and their postoperative changes
T Koike; H Wada; T Kobayashi
FUNCTION AND MECHANICS OF NORMAL, DISEASED AND RECONSTRUCTED MIDDLE EARS, KUGLER PUBLICATIONS BV, 309-320, 2000, Peer-reviwed, Many middle ear prostheses are available for the reconstruction of missing or damaged ossicles. However, there are few studies that investigate the acoustic properties of these prostheses, and there is no information available that could lead to the design and development of better ossicular replacement prostheses. In this study, three-dimensional finite-element models of a human intact middle ear and reconstructed middle ears using different types of incus replacement prosthesis are established, and an attempt is made to clarify the optimum method for reconstructing the middle ear. Prostheses with a high degree of stiffness, connecting the stapes head to either the malleus manubrium or near to the center of the tympanic membrane, give the best acoustic performance.
International conference proceedings, English

Development of measurement device of the stapes mobility
Takuji Koike; Hiroshi Wada; Yu Yuasa; Tomoniri Takasaka; Ryo Yuasa
2000, Peer-reviwed
International conference proceedings, English

Design of stapes prosthesis from the standpoint of dynamics
Takuji Koike; Hiroshi Wada; Manabu Munakata; Toshimitsu Kobayashi
Ear Symposium, 2000
International conference proceedings, English

Middle ear reconstruction using stapes prosthesis -theoretical analysis-
Takuji Koike; Hiroshi Wada; Richard; L. Good; Manabu Munakata; Toshimitsu Kobayashi
2000, Peer-reviwed
International conference proceedings, English

有限要素法によるモルモット中耳の振動挙動解析
小池 卓二; 和田 仁; 小林 俊光; 高坂 知節
Audiology Japan, Japan Audiological Society, 42, 5, 353-354, 16 Sep. 1999
Japanese

Measurement of dynamic frequency characteristics of guinea pig middle ear by a laser Doppler velocimeter
H Wada; M Takeda; T Koike; Y Suzaki; T Kobayashi; K Ohyama
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING, JAPAN SOC MECHANICAL ENGINEERS, 42, 3, 753-758, Sep. 1999, Peer-reviwed, The objective of the present study is to clarify the dynamic behavior of the middle ear by measuring the middle ear vibration directly. The velocity amplitudes of the tympanic membrane and ossicles of guinea pigs are measured before and after the manipulation of the cochlea and bulla using a laser Doppler velocimeter coupled to a compound microscope. The frequency characteristics of the middle ear vibration after the manipulation are different from those before it. These differences are explained by considering mass and damping components of the cochlear impedance and mass and stiffness components of the bulla's impedance.
Scientific journal, English

耳小骨筋反射が耳小骨振動に及す影響
和田 仁; 湯浅 有; 小池卓二; 川瀬哲明; 高坂知節
Audiology Japan, Japan Audiological Society, 42, 4, 237-242, 1999, Peer-reviwed, The effect of the middle ear reflex (MER) on cochlear microphonics (CM) and middle ear impedance has been reported. However, its effect on ossicular vibrations has not been clarified. In this study, using Laser Doppler Velocimeter (LDV), ossicular vibrations of guinea pigs and rabbits were measured directly when contralateral stimuli were presented to induce the MER. The measured results revealed that the amplitude of ossicular vibrations decreased with an increase in the stimulus intensity, and that the attenuation of ossicular vibrations at low frequencies was larger than at high frequencies. Also, from these results, the mode change of the ossicular vibrations before and after stimulation was speculated.
Scientific journal, Japanese

Effects of ventilation tube on sound transmission in the middle ear: finite-element method (fem) analysis
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Tomoniri Takasaka
1999, Peer-reviwed
International conference proceedings, English

鐙骨の可動性の計測
湯浅有; 川瀬哲明; 高坂知節; 小池卓二; 和田仁; 湯浅涼
Audiology Japan, 41, 5, 345-346, Sep. 1998
Scientific journal, Japanese

Clinical applicability of the sweep frequency measuring apparatus for diagnosis of middle ear diseases
H Wada; T Koike; T Kobayashi
EAR AND HEARING, LIPPINCOTT WILLIAMS & WILKINS, 19, 3, 240-249, Jun. 1998, Peer-reviwed, Objective: To develop a measuring apparatus that has the ability to sweep both frequency and external auditory meatus static pressure and can display measurement results in a three-dimensional expression. To measure the middle ear dynamic characteristics of normal-hearing subjects and of patients with this apparatus.
Design: Investigate 275 ears of 153 normal-hearing subjects and 72 ears with middle ear diseases.
Results: The measurement results show fairly distinctive patterns depending on the middle ear conditions, i.e., normal, ossicular chain separation, ossicular chain fixation, secretory otitis media, tympanic membrane perforation, and tympanic membrane atelectasis. The evaluation of patients with ossicular diseases revealed that the rate of correct diagnosis of ossicular chain separation is 84% and that of ossicular chain fixation is 74%. These diagnoses were confirmed by surgery.
Conclusion: Displaying the measurement results in a three-dimensional expression is helpful to make correct diagnosis in clinical practice. It is especially easy to make a distinction between the ossicular chain separation and ossicular chain fixation. Therefore, it is concluded that this apparatus has a high degree of clinical applicability to the diagnosis of these diseases.
Scientific journal, English

コルメラを用いた最適鼓室形成法の検討 ―有限要素法による理論解析―
小池卓二; 和田 仁; 小林俊光; 髙坂知節
Otology Japan, 8, 87-92, 1998, Peer-reviwed
Scientific journal, Japanese

スペックル干渉法を応用した新しい計測システムによるモルモット鼓膜の振動モード解析
和田 仁; 小林俊光; 朴沢孝治; 小池卓二; 髙坂知節
Audiology Japan, Japan Audiological Society, 41, 4, 296-303, 1998, Peer-reviwed, As middle ear diseases affect the vibration mode of the tympanic membrane, it is necessary for a correct diagnosis to measure the tympanic membrane vibration precisely. Although some techniques for the measurement of the tympanic membrane vibration has already been developed, they need high SPL for measurement, and the phase information is not obtainable by those techniques. Therefore, in this study, using the time-averaged electronic speckle pattern interferometry and sinusoidal phase modulation technique, an attempt is made to develop a system for measuring a small vibration sensitively. Then, the vibratory responses of guinea pigs' tympanic membranes are measured by this system. The results of this study indicate that the vibration amplitude is detectable in nanometer order even when the stimulus level is small, e. g. 70dB SPL and phase information is also obtainable. Consequently, the system developed in this study has a potential for clinical application.
Scientific journal, Japanese

最適中耳換気チューブ留置法の検討 ―理論的考察―
小池卓二; 和田 仁; 小林俊光; 髙坂知節
Audiology Japan, Japan Audiological Society, 41, 6, 740-745, 1998, Peer-reviwed, In order to treat secretory otitis media (SOM), numerous types of ventilation tube have been used. The ventilation tubes were designed with the aim of long-term ventilation of the middle ear. However, there are few studies which investigate the effect of tube insertion on the transmission characteristics of the middle ear.
In this study, three-dimensional finite-element method (FEM) model of a human middle ear is established by applying the FEM program developed by our group. Then, the effects of the materials and the site of placement of the ventilation tube on the transmission characteristics of the middle ear are analyzed. The following conclusions were obtained: (1) Low density materials such as silicone are suitable for ventilation tube. (2) When a light-weighed ventilation tube is used, the effect of the site of placement is small. When a relative heavy ventilation tube is used, the best site of placement is the antero-inferior quadrano.
Scientific journal, Japanese

SOUND TRANSMISSION CHARACTERISTICS OF THE RECONSTRUCTED HUMAN MIDDLE EAR
Takuji Koike; Hiroshi Wada; Takasaka. Kobayashi
154-155, 1998
International conference proceedings, English

Effects of middle ear on measurement of otoacoustic emissions: a finite-element method (FEM) analysis
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Kenji Ohyama; Tomoniri Takasaka
1998, Peer-reviwed
International conference proceedings, English

Middle ear effects on otoacoustic emissions: Theoretical consideration
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Kenji Ohyama; Tomoniri Takasaka
1998
International conference proceedings, English

Effects of middle ear sound transfer function on otoacoustic emissions (OAEs): A finite-element method (FEM) analysis
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Kenji Ohyama; Tomoniri Takasaka
1998
International conference proceedings, English

Dynamic Animation of the Human Middle and Inner Ear
Hiroshi Wada; Takuji Koike; Shu-ichi Noguchi; Toshimitsu Kobayashi; Kenji Ohyama
Proceedings of ASVA, 241-244, 1997

鼓膜穿孔を有する中耳の挙動解析 ―有限要素法による理論的考察―
和田 仁; 小池卓二; 松谷幸子; 小林俊光; 髙坂知節
Audiology Japan, 40, 1, 46-51, 1997, Peer-reviwed
Scientific journal, Japanese

モルモット中耳の振動挙動計測
和田 仁; 武田道弘; 小池卓二; 洲崎 洋; 小林俊光; 大山健二
日本機械学会論文集（C編, The Japan Society of Mechanical Engineers, 63, 607, 649-653, 1997, Peer-reviwed, The middle ear transmits sound signals from the external auditory meatus to the cochlea through the mechanical linkage of the tympanic membrane and the ossicular chain. However, the dynamic behavior of the middle ear has not been well analyzed. Therefore, in order to clarify its dynamic behavior, the velocity amplitudes of the tympanic membrane and ossicles of guinea pigs are measured before and after the manipulation of the middle and inner ear using a laser doppler vibrometer coupled to a compound microscope.
Scientific journal, Japanese

有限要素法によるヒト末梢聴覚系のモデル化
小池卓二; 和田 仁; 小林俊光
日本機械学会論文集（C編）, 63, 654-660, 1997, Peer-reviwed
Scientific journal, Japanese

Finite-element method analysis of a middle ear reconstructed by incus replacement prosthesis
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Tomonori Takasaka
7, 29-32, 1997
International conference proceedings, English

FINITE- ELEMENT METHOD ANALYSIS OF THE NORMAL AND RECONSTRUCTED MIDDLE EAR
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi
1231-1237, 1997
International conference proceedings, English

Finite-element method analysis of reconstructed middle ear
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Tomonori Takasaka
1997, Peer-reviwed
International conference proceedings, English

Measurement of isolated outer hair cell motility using high speed video system
Hiroshi Wada; Takuji Koike; Toshimitsu Kobayashi; Kenji Ohyama; Tomonori Takasaka
Third Joint Meeting, 719-720, 1996

鼓膜に生ずるRetraction Pocket発生機序の解明（理論的考察）
和田 仁; 竹内正孝; 小池卓二; 小林俊光
日本機械学会論文集（A編）, 62, 1951-1954, 1996, Peer-reviwed
Scientific journal, Japanese

ヒト中耳の伝音特性 ―有限要素法による理論解析―
小池卓二; 和田 仁; 小林俊光
日本音響学会誌, 52, 695-702, 1996, Peer-reviwed
Scientific journal, Japanese

Three- Dimensional Finite-Element Method (FEM) Analysis of the Human Middle Ear
Hiroshi Wada; Takuji Koike; Toshimitsu Kobayashi
76*81, 1996
International conference proceedings, English

Dynamic behavior of the human middle ear: A finite‐element method (FEM) analysis
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Tomonori Takasaka
Journal of the Acoustical Society of America, 100, 4, 2785-718, 1996, Peer-reviwed, A few investigations of finite‐element method (FEM) application to the analysis of the middle ear have already been reported [Funnell et al., J. Acoust. Soc. Am. 81, 1851–1859 (1987)
K. R. Williams and T. H. J. Lesser, Br. J. Audiol. 24, 319–327 (1990)]. However, in the models of these studies, ossicles and middle ear cavities were neglected, and their effects on the dynamic behavior of the middle ear have not been analyzed. In this study, first, applying the authors’ own FEM program, a three‐dimensional FEM model of a human auditory periphery was established. Then, vibration modes and transfer functions of the middle ear were obtained. The following conclusions can be drawn. (1) The vibration mode of the tympanic membrane and ossicles changes considerably due to the elastic ligament support of the ossicles. (2) This change enables the transfer function of the middle ear to keep flat. (3) The effect of the cavities on the dynamic behavior of the middle ear is large
the amplitude of the tympanic membrane vibration after opening the cavities is nearly two times larger than that before opening them. © 1996, Acoustical Society of America. All rights reserved.
Scientific journal, English

MIDDLE EAR EFFECT ON OTOACOUSTIC EMISSIONS (OAEs): A FINITE-ELEMENT METHOD (FEM) ANALYSIS
Hiroshi Wada; Takuji Koike; Toshimitsu Kobayashi; Kenji Ohyama; Tomonori Takasaka
Proceedings of the International Symposium on Diversity in Auditory Mechanics, 1996, World Scientific, 719-720, 1996, Peer-reviwed
International conference proceedings, English

Finite-element method (FEM) analysis of human middle ear
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi; Tomonori Takasaka
1996, Peer-reviwed
International conference proceedings, English

Effect of middle ear on otoacoustic emissions
H Wada; K Ohyama; T Kobayashi; T Koike; S Noguchi
AUDIOLOGY, B C DECKER INC, 34, 4, 161-176, Jul. 1995, Peer-reviwed, Otoacoustic emissions (OAEs) are believed to originate from outer hair cell movement and are considered to be transmitted to the external auditory meatus through the middle ear in a retrograde fashion. Therefore, the effect of the middle-ear on OAEs seems to be large. However, few investigations of middle-ear effects on OAEs have been published because no apparatus that can measure the middle-ear dynamic characteristics is easily available except a conventional impedance meter. We developed a sweep frequency impedance meter (SFI) which gives us much more information on middle-ear dynamic characteristics than a conventional impedance meter, In this paper, applying SFI and 3 OAE measuring apparatuses, middle-ear dynamic characteristics and different sorts of OAEs of human subjects and guinea pigs were measured, and an attempt was made to examine the relationship between OAEs and middle-ear dynamic characteristics from various aspects. It is concluded that frequency characteristics of OAEs correlate well with middle-ear frequency characteristics; and middle-ear effect on OAEs must be taken into account when OAE data are analyzed.
Scientific journal, English

Effect of middle ear on otoacoustic emissions
Hiroshi Wada; Kenji Ohyama; Toshimitsu Kobayashi; Takuji Koike; Shu-Ichi Noguchi
International Journal of Audiology, Informa Healthcare, 34, 4, 161-176, 1995, Peer-reviwed, Otoacoustic emissions (OAEs) are believed to originate from outer hair cell movement and are considered to be transmitted to the external auditory meatus through the middle ear in a retrograde fashion. Therefore, the effect of the middle-ear on OAEs seems to be large. However, few investigations of middle-ear effects on OAEs have been published because no apparatus that can measure the middle-ear dynamic characteristics is easily available except a conventional impedance meter. We developed a sweep frequency impedance meter (SFI) which gives us much more information on middle-ear dynamic characteristics than a conventional impedance meter. In this paper, applying SFI and 3 OAE measuring apparatuses, middle-ear dynamic characteristics and different sorts of OAEs of human subjects and guinea pigs were measured, and an attempt was made to examine the relationship between OAEs and middle-ear dynamic characteristics from various aspects. It is concluded that frequency characteristics of OAEs correlate well with middle-ear frequency characteristics
and middle-ear effect on OAEs must be taken into account when OAE data are analyzed. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Scientific journal, English

Development of a Three-Dimensional Impedance Meter and its Clinical Applicability to Diagnosing Middle Ear Diseases
Hiroshi Wada; Takuji Koike; Toshimitsu Kobayashi
Journal of Otolaryngology of Japan, 97, 8, 1443-1455, 1994, Peer-reviwed
Scientific journal, English

The effect of aging on middle ear dynamic characteristics
Hiroshi Wada; Takuji Koike; Toshimitsu Kobayashi
Nippon Jibiinkoka Gakkai Kaiho, 97, 5, 898-904, 1994, Peer-reviwed, The effect of aging on middle ear function has not been investigated thoroughly, as there is no simple measuring apparatus except for the conventional impedance meter (IM). However, the reliability of the IM is insufficient, because the stimulus frequency is fixed and the information provided by the IM is minimal. We have developed a sweep frequency middle ear analyzer (MEA), which provides much more information on middle ear dynamic characteristics than a conventional IM, and have obtained various measurements with this device. In this paper, middle ear dynamic characteristics of 187 normal subjects (309 ears) ranging from a 4-year-old child to an elderly person, 79 years old, were measured with the MEA in the middle ear resonance frequency region where dynamic characteristics can be seen clearly, and the effect of aging on middle ear dynamic characteristics was examined. The main results obtained were as follows: Middle ear mobilities tend to increase up to the twenties, then decrease up to the forties. Subsequently, a clear difference between those of males and females is observed. The middle ear mobilities of males decrease gradually with an increase in age. In contrast, although the standard deviation values are large, those for females tend to rise with increasing age. © 1994, The Oto-Rhino-Laryngological Society of Japan, Inc. All rights reserved.
Scientific journal, English

中耳動特性に及ぼす年齢の影響
和田 仁; 小池卓二; 小林俊光
日本耳鼻咽喉科学会会報, 97, 898-904, 1994, Peer-reviwed
Scientific journal, Japanese

3次元インピーダンスメーターの開発とその診断的意義
和田 仁; 小池卓二; 小林俊光
日本耳鼻咽喉科学会会報, 97, 1443-1455, 1994, Peer-reviwed
Scientific journal, Japanese

RELATIONSHIP BETWEEN EVOKED OTOACOUSTIC EMISSIONS AND MIDDLE-EAR DYNAMIC CHARACTERISTICS
H WADA; K OHYAMA; T KOBAYASHI; N SUNAGA; T KOIKE
AUDIOLOGY, DECKER PERIODICALS INC, 32, 5, 282-292, Sep. 1993, Peer-reviwed, Evoked otoacoustic emissions (EOAEs) are considered to originate from outer hair cell movement and to be transmitted to the external auditory meatus through the ossicular chain and eardrum in a retrograde fashion. Therefore, the effect of the middle ear on EOAEs seems to be large. A sweep frequency middle-ear analyzer (MEA) has been developed that gives much more information on middle-ear dynamic characteristics than a conventional impedance meter. In this paper, applying our own EOAE measuring system and the MEA, EOAEs and middle-ear dynamic characteristics of normal subjects were measured, and an attempt was made to clarify the relationship between EOAEs and middle-ear dynamic characteristics. It is concluded that EOAEs are detected most distinctly at the middle-ear resonance frequency and that EOAEs are most detectable in normal subjects whose middle-ear mobility is moderate.
Scientific journal, English

Relationship between evoked otoacoustic emissions and middle-ear dynamic characteristics
Hiroshi Wada; Kenji Ohyama; Toshimitsu Kobayashi; Naohisa Sunag; Takuji Koike
International Journal of Audiology, Informa Healthcare, 32, 5, 282-292, 1993, Peer-reviwed, Evoked otoacoustic emissions (EOAEs) are considered to originate from outer hair cell movement and to be transmitted to the external auditory meatus through the ossicular chain and eardrum in a retrograde fashion. Therefore, the effect of the middle ear on EOAEs seems to be large. A sweep frequency middle-ear analyzer (MEA) has been developed that gives much more information on middle-ear dynamic characteristics than a conventional impedance meter. In this paper, applying our own EOAE measuring system and the MEA, EOAEs and middle-ear dynamic characteristics of normal subjects were measured, and an attempt was made to clarify the relationship between EOAEs and middle-ear dynamic characteristics. It is concluded that EOAEs are detected most distinctly at the middle-ear resonance frequency and that EOAEs are most detectable in normal subjects whose middle-ear mobility is moderate. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Scientific journal, English

AGING EFFECT ON MIDDLE EAR DYNAMIC CHARACTERISTICS
H WADA; T KOIKE; T KOBAYASHI
14TH INTERNATIONAL CONGRESS ON ACOUSTICS, PROCEEDINGS, VOLS 1-4, ACADEMIA SINICA INST ACOUSTICS, H4-5, 1251-1252, 1992
International conference proceedings, English

近赤外蛍光を利用した嚥下評価機器の開発
小池卓二; 小池卓二; 若松海門; 中川量晴; 吉見佳那子; 西村吾朗; 山田幸生; 丹羽治樹
2023, リハビリテーション・エンジニアリング, 38, 2, 1342-3444, 202302238756748613

高齢難聴者のQOLを改善する革新的骨導補聴デバイスの開発
羽藤直人; 小池卓二; 神崎晶; 鈴木克佳
2023, 日本耳鼻咽喉科頭頚部外科学会会報, 126, 4, 2436-5793, 202302250824484504

Development of Vibrational Technologies for Pest Management and Sustainable Cultivation-Toward Practical Application in Tomatoes and Shiitake Mushrooms-
高梨琢磨; 向井裕美; 関根崇行; 立田晴記; 小池卓二
2023, 農業食料工学会誌, 85, 5, 2188-224X, 202302235961547329

IPMの普及 第1部 トピックス 期待されるIPM関連最新技術情報 振動を利用した害虫防除技術
高梨琢磨; 関根崇行; 大江高穂; 小池卓二
2022, 技術と普及, 59, 1, 0285-2950, 202202255471288491

Modeling of peripheral auditory system and medical applications
小池卓二; LEE Sinyoung
2022, 日本音響学会研究発表会講演論文集(CD-ROM), 2022, 1880-7658, 202202238591845402

Measurement of Swallowing-related Signals using PVDF film and Swallowing Event Extraction of based on SVM
飯田美月; 橋本卓弥; 菊池貴博; 道脇幸博; 小池卓二
2022, LIFE講演概要集(CD-ROM), 2022, 202202237664868170

Development of swallowing function test method using near-infrared fluorescence
小池卓二; 若松海門; 飯野裕二; 中川量晴; 吉見佳那子; 西村吾朗; 山田幸生; 丹羽治樹; 道脇幸博
2022, LIFE講演概要集(CD-ROM), 2022, 202202252908929124

超磁歪素子を用いた埋め込み補聴器の基礎的研究-動物への長期埋め込み試験とご遺体での解析-
神崎晶; 神崎晶; 鈴木克佳; 入江優花; 高柳良太; 小池卓二; 羽藤直人
2022, 日本耳科学会総会・学術講演会(Web), 32nd, 202202234658919405

中耳数理モデルの解析データの機械学習による耳小骨固着部位判別法の検討
李信英; 神崎晶; 小池卓二; 池上元
2022, 日本耳科学会総会・学術講演会(Web), 32nd, 202202250271382422

先生!その耳小骨操作は適切ですか?(2)-耳小骨可動性の判断における術者間のばらつきに関する検証-
神崎晶; 神崎晶; 小池卓二; 入江優花; 徐世傑; 肥後武展; 林正晃; 池上元
2022, 日本耳科学会総会・学術講演会(Web), 32nd, 202202255384468989

加振して育苗したトマト苗に対してタバココナジラミは密度抑制効果を示す
大矢武志; 浜田泰子; 小野寺隆一; 高梨琢磨; 小池卓二
2022, 関東東山病害虫研究会報, 69, 1347-1899, 202302246618988428

Relationship between Hearing and the Operating Point of Auditory Sensory Cells in the Endolymphatic Hydrops
LEE Sinyoung; 小池卓二
2022, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 32nd, 1348-2939, 202302241205175574

Residual Food and Dynamic Measurement in the Nasopharynx with Near-infrared Fluorescence
若松海門; 飯野裕二; 西村吾朗; 中川量晴; 吉見佳那子; 齋木章乃; 山田幸生; 丹羽治樹; 道脇幸博; 小池卓二
2022, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 33rd, 1348-2939, 202302267883706539

Measurement of Vibration Propagation Characteristics in Tomato Plants for Artificial Pollination by Drone
岡部昌優; 東海林篤; 大矢武志; 小池卓二
2022, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 33rd, 1348-2939, 202302283868480454

上半規管裂隙症候群による基底板振動の変化:ヒト蝸牛有限要素モデルを用いた数値解析
李信英; 鈴木光也; 小池卓二
2021, 日本耳科学会総会・学術講演会(Web), 31st, 202102246911457940

先生!その耳小骨操作は適切ですか?-ばね模型を用いた耳小骨の可動性確認操作の術者間のばらつきの検証-
神崎晶; 小池卓二; 入江優花; 肥後武展; 徐世傑; 林正晃; 池上元
2021, 日本耳科学会総会・学術講演会(Web), 31st, 202102273023293706

人工中耳振動子の留置位置による基底板振動の変化 : ヒト蝸牛有限要素モデルによる数値解析
李信英; 茂木雅臣; 小池卓二
2021, Audiology Japan, 64, 5, 0303-8106, 202102257607208827

コンピュータシミュレーションによる上半規管裂隙症候群
小池卓二
2021, Equilibrium Research, 80, 5, 0385-5716, 202202236974923407

Dynamic measurement of food in pharynx and larynx using near-infrared fluorescence
若松海門; 田代剛大; 山田幸生; 丹羽治樹; 牧昌次郎; 牧昌次郎; 小池卓二; 小池卓二; 道脇幸博; 西村吾朗; 山内大輔; 川村善宣; 香取幸夫
2021, Optics & Photonics Japan講演予稿集(CD-ROM), 2021, 202202277286867791

嚥下の筋骨格モデル
橋本卓弥; 菊地貴博; 道脇幸博; 小池卓二
2021, 日本嚥下医学会抄録(Web), 44th, 202202287751809032

騒音環境での音楽聴取における雑音抑制機能イヤホンの効果
保科卓成; 小池卓二; 池田勝久
2020, 日本耳鼻咽喉科学会会報, 123, 4, 0030-6622, 202002254002913491

Investigation of factors causing fluctuations in DPOAEs
白井愛理; 小池卓二; 小池卓二; 根木裕次郎
2020, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 31st, 1348-2939, 202102214560998190

Non-invasive detection of pharyngeal residue using near-infrared fluorescence-Evaluation of the detectability by phantom experiments-
田代剛大; 山田幸生; 丹羽治樹; 牧昌次郎; 牧昌次郎; 北田昇雄; 斉藤亮平; 小池卓二; 小池卓二; 道脇幸博; 西村吾朗
2020, Optics & Photonics Japan講演予稿集(CD-ROM), 2020, 202102274483914423

Simulation of middle ear disorders and establishment of diagnostic criteria for ossicular fixation
森田陽士; LEE Sinyoung; 神崎晶; 小池卓二
2020, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 31st, 1348-2939, 202102219239836995

Imptovement of hand probe for better stability of intraoperative measurement
清水悠貴; 入江優花; KEAT Chee Sze; 肥後武展; 大山健二; 池上元; 林正晃; 神崎晶; 小池卓二
2020, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 31st, 1348-2939, 202102227858939088

Development of measuring method of distortion product otoacoustic emissions (DPOAEs) in noisy environment
根木裕次郎; 小池卓二; 小池卓二
2020, 日本機械学会年次大会講演論文集(CD-ROM), 2020, 2424-2667, 202202210251562326

Evaluation of non-invasive detection for pharyngeal residue in human using near-infrared fluorescence
田代剛大; 鈴木嵩弘; 山田幸生; 丹羽治樹; 牧昌次郎; 牧昌次郎; 北田昇雄; 齊藤亮平; 小池卓二; 小池卓二; 道脇幸博; 西村吾朗
2020, 日本機械学会年次大会講演論文集(CD-ROM), 2020, 2424-2667, 202202221715279029

Development of Pest Control Technologies Using Substrate Vibration
SHIBATA Kengo; TKANASHI Takuma; KOIKE Takuji; ABE Shota; HOSOKAWA Akira; ONO Toshifumi; ONODERA Ryuichi; TAYAMA Tsuyoki; OE Takaho; SEKINE Takayuki
The Japan Society of Mechanical Engineers, 2019, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2019.32, 2B32, Japanese, 2424-2829, 130007864582

嚥下筋骨格モデルを用いた異なる食塊による筋活動変化の推定
占部麻里子; 菊地貴博; 道脇幸博; 小池卓二; 橋本卓弥
2019, 日本摂食嚥下リハビリテーション学会学術大会抄録集(Web), 25th, 202002275707473299

Development of a detection system of pharyngeal residue using near-infrared fluorescence for aspiration test
田代剛大; 鈴木崇弘; 山田幸生; 丹羽治樹; 牧昌次郎; 牧昌次郎; 北田昇雄; 斉藤亮平; 小池卓二; 小池卓二; 道脇幸博; 西村吾朗
2019, Optics & Photonics Japan講演予稿集(CD-ROM), 2019, 202002289348370842

内視鏡下副鼻腔手術(ESS)における微小眼球・眼窩振動測定
伊藤伸; 中村真浩; 藤山大輝; 小池卓二; 池田勝久
2019, 日本鼻科学会会誌(Web), 58, 3, 1883-7077, 202002239060403075

胎児聴性誘発電位と心拍数変化に基づく胎児聴力検査の試み
松岡理奈; 日比谷怜美; 板倉敦夫; 小池卓二; 池田勝久
2018, 耳鼻咽喉科ニューロサイエンス, 32, 202102257601226078

内視鏡下副鼻腔手術(ESS)における微小眼球・眼窩振動測定
伊藤伸; 藤山大輝; 中村真浩; 小池卓二; 池田勝久
2018, 日本鼻科学会会誌(Web), 57, 3, 1883-7077, 201902252156913928

Simulation of Mechano-Electrical Transduction and Frequency Selectivity in the Human Cochlea
LEE Sinyoung; 小池卓二
2018, 日本音響学会聴覚研究会資料, 48, 4, 1346-1109, 202002230999298136

1F41 Simulation of endolymphatic hydrops : Analysis using the finite element cochlear model considering activity of outer hair cells
LEE Sinyoung; HASHIMOTO Takuya; KOIKE Takuji
Endolymphatic hydrops is a disorder of inner ear and is associated with abnormal fluctuations in the endolymph fluid. These fluctuations cause an increase of pressure in scala media of the cochlea. The symptoms of endolymphatic hydrops include hearing loss especially at low frequencies and balance problems. To investigate the reason of hearing loss at low frequencies, we aim to analyze endolymphatic hydrops with the finite element cochlear model which is considered activity of outer hair cells. At first, we developed models of endolymphatic hydrops by loading static pressure in scala media. Each pressure of model is 10, 100, 500 Pa. Next, we analyzed the normal cochlear model and the endolymphatic models with loading sound pressure at frequency of 125 Hz to 2 kHz. As the results, the displacement of the basilar membrane of the endolymphatic hydrops model was smaller than the numerical result obtained from the normal cochlear model at low frequencies under 500 Hz. Also, characteristic frequency of the endolymphatic model was not matched with characteristic frequency of the normal cochlear model at low frequencies. These results show that increase of pressure in scala media might cause hearing loss at low frequencies., The Japan Society of Mechanical Engineers, 09 Jan. 2016, バイオエンジニアリング講演会講演論文集, 2016, 28, "1F41-1"-"1F41-5", Japanese, 110010052102, AA11903175

内視鏡下副鼻腔手術におけるPVDFフィルムを用いた微小眼球振動測定
矢部鮎美; 伊藤伸; 黒田亨太; 小池卓二; 池田勝久
2016, 日本鼻科学会会誌(Web), 55, 3, 1883-7077, 201802265749887369

B206 Safety assessment of the cochlea during measuring ossicular mobility : Analysis by the finite element cochlear model
LEE Sinyoung; HASHIMOTO Takuya; KOIKE Takuji
The Japan Society of Mechanical Engineers, 01 Oct. 2015, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2015, 26, 111-112, Japanese, 1348-2939, 110010051943, AA11902434

2E23 Study of fetus hearing test system based on auditory evoked response
LEE Sinyoung; MATSUOKA Rina; IKEDA Katsuhisa; HASHIMOTO Takuya; KOIKE Takuji
The Japan Society of Mechanical Engineers, 08 Jan. 2015, バイオエンジニアリング講演会講演論文集, 2015, 27, 493-494, Japanese, 110009965457, AA11903175

2G36 Vibration measurement of trees using PVDF films
SUGAYA Akihiro; TAKANASHI Takuma; KOIKE Takuji
The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014, 26, 543-544, Japanese, 110009956235, AA11903175

1G32 Numerical simulation of cochlear amplification mechanism caused by activity of the outer hair cell
MOCHIZUKI Hideyuki; KOIKE Takuji
The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014, 26, 233-234, Japanese, 110009956080, AA11903175

2D13 Multiple simultaneous measurements of volume of middle ear cavities and behavior characteristics of eustachian tube
SANO Takuma; KOIKE Takuji; SHINNABE Akihiro
The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014, 26, 393-394, Japanese, 110009956160, AA11903175

蝸牛内イオン流動を解析可能な蝸牛モデルの開発
大瀧直也; 横井大介; 橋本卓弥; 小池卓二
2014, 日本機械学会バイオフロンティア講演会講演論文集, 25th, 1348-2939, 201402205114803971

非接触型中耳可動性測定装置の開発と実用化
小池卓二
2014, 中谷医工計測技術振興財団年報, 28, 0914-2487, 201402298438411209

C215 Clinical measurement with equipment for evaluating function of middle-ear ventilation
SANO Takuma; KOIKE Takuji; SHINNABE Akihiro
The Japan Society of Mechanical Engineers, 31 Oct. 2013, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2013, 24, 187-188, Japanese, 1348-2939, 201402228614659184, 110009954790, AA11902434

C211 Development of hearing test system for fetus
OTAKI Naoya; KOIKE Takuji; MATSUOKA Rina; IKEDA Katsuhisa
The Japan Society of Mechanical Engineers, 31 Oct. 2013, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2013, 24, 179-180, Japanese, 1348-2939, 110009954786, AA11902434

J024016 Development of detecting system for approaching object mimicking bat's echolocation
OKAYASU Maia; YABE Shinichirou; KOIKE Takuji
Bats can receive the detailed information of velocity of objects by using echolocation without depending on visual. Bat's ears sensitively respond to particular frequency, and this is an important factor for bats to use echolocation. In this study, by mimicking bat's echolocation, a detecting system for approaching objects by using ultrasound was developed. This system will assist daily life of visually-impaired peoples in place of white cane. This system consists of a speaker, a microphone and a feedback program including lock-in amplifier program. Sound is emitted from the speaker, and the reflected sound from an object is detected by the microphone. When the distance between the speaker and the object decreases and relative velocity is generated, the frequency of the reflected sound increases. In order to keep the frequency of the reflected sound detected by the microphone constant, the system adjusts the frequency of emitted sound from the speaker. The relative velocity between the speaker and the object can be known by checking the frequency of the emitted sound. When the motion a pendulum was measured by this system, the approaching velocity and the cycle of the pendulum were accurately evaluated., The Japan Society of Mechanical Engineers, 08 Sep. 2013, Mechanical Engineering Congress, Japan, 2013, "J024016-1"-"J024016-5", Japanese, 110009934607, AA12588255

J024022 Preliminary study for development of sound stimulation system with piezoelectric vibrator for auditory test of fetus
OTAKI Naoya; KOIKE Takuji; MATSUOKA Rina; IKEDA Katsuhisa
Congenital deafness of human has possibilities to progress during embryonic life, and it becomes to be serious after birth in many cases. However, if causal factors of congenital deafness are identified, its progress may be prevented, and new cures may be introduced. As preliminary study for auditory test of fetus, the maternal abdomen was modeled, and sound pressure level near the auditory organ of fetus in the model was measured when the abdomen wall was vibrated with a piezo electric vibrator. The relationship between sound stimulation level applied to fetus and input voltage to the piezoelectric vibrator was investigated. The result showed the sound pressure level near the auditory organ of fetus was controlled by the input voltage regardless of the amount of amniotic fluid. The sound pressure levels were measured with changing the position of the vibrator. The result suggests that the vibrator should be placed on the abdomen wall just above the auditory organ of fetus to stabilize the stimulus level applied to the fetus., The Japan Society of Mechanical Engineers, 08 Sep. 2013, Mechanical Engineering Congress, Japan, 2013, "J024022-1"-"J024022-5", Japanese, 110009935152, AA12588255

J024023 Study of transcutaneous signal transmission system for bone conduction hearing aid
TANAKA Eri; TACHI Ryosuke; KOIKE Takuji; KANZAKI Sho; HATO Naohito
In the preliminary research, a new partially implantable bone conduction hearing aid using giant magnetostrictive material (GMM) for transducer has been proposed. The hearing aid is implanted under the skin of a patient's temporal bone. The hearing aid consists of an external unit, i.e., a microphone, a sound processor and a transmitting coil, and of an internal unit i.e., a receiving coil and a transducer (bone vibrator). The internal unit and the external unit are completely separated, and sound signals are transmitted from the external unit to the internal unit by percutaneously using mutual induction. GMM is a metal material which changes its length according to change of magnetic field. However, the powers of the hearing aid at low frequencies are inadequate. In this paper, amplitude modulation (AM) was introduced to the signal transmission to improve the performance of the hearing aid. The excitation force of the hearing aid generated by AM wave was higher than that by sine wave particularly at low frequencies. This result suggests that efficiency of transducer can be more improved by AM using high-frequency carrier waves., The Japan Society of Mechanical Engineers, 08 Sep. 2013, Mechanical Engineering Congress, Japan, 2013, "J024023-1"-"J024023-4", Japanese, 110009935153, AA12588255

ドップラーエコーにおける胎児聴力測定の試み
松岡 理奈; 池田 勝久; 西村 将彦; 笠井 美里; 竹田 省; 牧野 真太郎; 稲垣 徹訓; 小池 卓二; 大瀧 直也
(一社)日本耳鼻咽喉科学会, Apr. 2013, 日本耳鼻咽喉科学会会報, 116, 4, 496-496, Japanese, 0030-6622, 2013309964

2B03 Development of implantable hearing aid using giant magnetostrictive material : Evaluation of vibration characteristics of the hearing aid in semi-practical condition
TACHI Ryosuke; TANAKA Eri; KOIKE Takuji; KANZAKI Syo; HATO Naohito
The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013, 25, 277-278, Japanese, 110009920016, AA11903175

2F03 Simulation of effects of cochlear-implant electrode insertion on vibration of basilar membrane
HANAWA Shintaro; SAKASHITA Tasuku; KOIKE Takuji; KUMAKAWA Kozo
The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013, 25, 429-430, Japanese, 110009920093, AA11903175

2F04 Evaluation of excitation force generated by an apparatus for non-contact measurement of ossicular mobility
YAMANAKA Ryota; SASAKI Koji; KOIKE Takuji; KANZAKI Sho; IKEDA Katsuhisa
The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013, 25, 431-432, Japanese, 110009920094, AA11903175

MEMS/NEMS人工聴覚器による感音難聴治療法開発 人工感覚上皮電極挿入による蝸牛基底板振動変化
小池卓二
2013, MEMS/NEMS人工聴覚器による感音難聴治療法開発 平成24年度 総括・分担研究報告書, 201302231305897180

B112 Analysis of conchlear vibration considering activity of the outer hair cell
Mochizuki Hideyuki; Sakashita Tasuku; Koike Takuji
The Japan Society of Mechanical Engineers, 04 Oct. 2012, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2012, 23, 55-56, Japanese, 1348-2939, 110009920339, AA11902434

B115 Development of implantable hearing aid using giant magnetostrictive material : Performance evaluation of transducer by measuring auditory brainstem responses (ABR) in guinea pigs
Tachi Ryosuke; Tanaka Eri; Koike Takuji; Kanzaki Syo; Hato Naohito
The Japan Society of Mechanical Engineers, 04 Oct. 2012, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2012, 23, 61-62, Japanese, 1348-2939, 110009920342, AA11902434

B113 Effects of cochlear-implant electrode insertion on vibration of the basilar membrane
Hanawa Shintaro; Sakashita Tasuku; Koike Takuji; Kumakawa Kozo
The Japan Society of Mechanical Engineers, 04 Oct. 2012, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2012, 23, 57-58, Japanese, 1348-2939, 110009920340, AA11902434

J241012 Development of a hybrid implantable hearing aid using giant magnetostrictive material and magnetic vibrators
TACHI Ryosuke; Oshiro Kosumi; IKEJIRI Kyosuke; KOIKE Takuji; KANZAKI Syo; HATO Naoto
In this study, a new subcutaneously implanted bone-conduction hearing aid with an external unit and an internal unit is proposed In the preliminary research, although the transducer using giant magnetostrictive material (GMM transducer) was developed, the power in lower frequency range was inadequate In this study, to improve the performance the implanted magnet used for fixing the external unit was utilized as a transducer for lower frequency range (magnet transducer), and its performance was investigated The frequency response of the amplitude of the artificial model of the temporal bone generated by the magnet transducer was higher than that by the GMM transducer in lower frequencies The frequency response of the amplitude of the cadaver head generated by the magnet transducer was lower than that of the temporal bone model These results suggest that although the magnet transducer has the potential of compensating for deficiencies of the GMM transducer in lower frequency range, it needs to be improved to generate bigger excitation force, The Japan Society of Mechanical Engineers, 09 Sep. 2012, Mechanical Engineering Congress, Japan, 2012, "J241012-1"-"J241012-4", Japanese, 110009995069, AA12588255

J022013 Simulation of the effects of cochlear-implant electrode insertion on vibration of the cochlea
HANAWA Shintaro; SAKASHITA Tasuku; KOIKE Takuji; KUMAKAWA Kozo
Cochlear implant is a device that provides electrical stimulation directly to the cochlea. Stimulation pulses emitted from the inserted electrode is transmitted to the brain through the auditory nerves in the cochlea. Some patients with significant hearin g loss still have residual hearing for low frequencies. An attempt has been made to amplify acoustic sound at low frequencies with a conventional hearing aid and to apply electrical stimulation for the middle and high frequencies with the cochlear implant. This device is called the electric-acoustic stimulation (EAS). In this study, the electrode for the electric-acoustic stimulation was optimized by using a three dimensional finite-element model of the human cochlea. Dynamic behavior of the basilar membrane (BM) and the cochlear fluid caused by the vibration of the stapes footplate were analyzed. The effect of the Young's modulus of the electrode on the vibration of the BM was examined by modeling the electrode in the cochlea model. The results suggest that BM has large amplitude at low frequencies and the residual hearing is preserved by reducing the stiffness of the base of the electrode., The Japan Society of Mechanical Engineers, 09 Sep. 2012, Mechanical Engineering Congress, Japan, 2012, "J022013-1"-"J022013-4", Japanese, 110009993270, AA12588255

G020033 Effects of the shape of the basilar membrane on mechanical frequency discrimination in the cochlea
SANO Takuma; KOIKE Takuji
The basilar membrane (BM) plays an important role for sound reception in the cochlea because the BM has frequency discrimination characteristics. Echolocating bats can perceive objects in the environment by emitting ultrasonic sound. Therefore, the frequency discrimination of the echolocating bats is presumably more highly accurate than that of humans. The shape of the BM of the echolocating bats is different from that of humans, and its thickness changes remarkably at the base. To clarify the effects of the shape of the BM with respect to frequency discrimination performance, two types of finite-element models of the cochlea were created, i, e, the human model (H model) and the modified human model (MH model). The shape of the BM of MH model was modified considering the aspect ratio of the BM (thickness/width) of a horseshoe bat which is a species of echolocating bat. The traveling wave on the BM was found to have only one peak at the input frequencies in the H model. By contrast, two peaks were observed in the MH model around 3 kHz or 9 kHz The maximum amplitude position of the BM shifted greatly in the MH model because the amplitude ratio of the two peaks was reversed. This result suggests that the shape of the BM can affect frequency discrimination performance., The Japan Society of Mechanical Engineers, 09 Sep. 2012, Mechanical Engineering Congress, Japan, 2012, "G020033-1"-"G020033-4", Japanese, 2424-2667, 201402283175023554, 110009994112, AA12588255

8H11 Development of an implantable hearing aid : Improvement of the efficiency of the transcutaneous signal transmission system
OSHIRO Kosumi; TACHI Ryosuke; KOIKE Takuji; KANZAKI Sho; HATO Naohito
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012, 24, "8H11-1"-"8H11-2", Japanese, 110009689225, AA11903175

8H16 Simulation of the cochlear vibration: Theoretical analysis of distortion product otoacoutic emissions
SAKASHITA Tasuku; KOIKE Takuji
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012, 24, "8H16-1"-"8H16-2", Japanese, 110009689230, AA11903175

8H15 Construction of intercellular ion transport network model of the inner ear
Yokoi Daisuke; Koike Takuji
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012, 24, "8H15-1"-"8H15-2", Japanese, 1348-2920, 201202271171188912, 110009689229, AA11903175

8H23 Measurement of ossicular mobility in human
FUJII Makiko; YAMANAKA Ryota; KOIKE Takuji; KANZAKI Sho
The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012, 24, "8H23-1"-"8H23-2", Japanese, 110009689233, AA11903175

B202 Simulation of the cochlear vibration : Optimum insert position of the electrode of the cochlear implant
HANAWA Shintaro; SAKASHITA Tasuku; KOIKE Takuji; KUMAKAWA Kozo
The Japan Society of Mechanical Engineers, 06 Oct. 2011, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2011, 22, 129-130, Japanese, 1348-2939, 110009663365, AA11902434

B203 Development of implantable hearing aid using giant magnetostrictive material : Experimental investigation on the acoustic characteristics depending on the difference of the direction of vibration
TACHI Ryosuke; OSHIRO Kosumi; KOIKE Takuji; KANZAKI Sho; HATO Naohito
The Japan Society of Mechanical Engineers, 06 Oct. 2011, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2011, 22, 131-132, Japanese, 1348-2939, 110009663366, AA11902434

B204 Development of an apparatus for non-contact measurement of ossicular mobility
YAMANAKA Ryota; FUJII Makiko; KOIKE Takuji; IKEDA Katsuhisa; KANZAKI Sho
The Japan Society of Mechanical Engineers, 06 Oct. 2011, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2011, 22, 133-134, Japanese, 1348-2939, 110009663367, AA11902434

MP-41 Development of an implantable hearing aid using giant magnetostrictive material : Vibration characteristics of a vibrator installed on the surface of a temporal bone
OSHIRO Kosumi; TACHI Ryosuke; KOIKE Takuji; KANZAKI Sho; HATO Naohito
Bone-conduction hearing aids have better sound quality and higher sound pressure than air-conduction hearing aids. In this study, a new subcutaneously implanted bone-conduction hearing aid is proposed and evaluated. A vibrator of the hearing aid is composed of giant magnetostrictive material (GMM). The vibrator is implanted into the temporal bone of patients with hearing loss and generates the bone conduction sound. In this study, the vibrator was implanted into the temporal bone of the cadavers and its fundamental properties were examined. Nano order vibration generated on the skull was measured by a 3D scanning vibrometer., The Japan Society of Mechanical Engineers, 25 Sep. 2011, マイクロ・ナノ工学シンポジウム, 2011, 3, 149-150, Japanese, 110009664183, AA12456946

6-1 Development of a device for measuring the ossicular mobility : A compact force sensor using a PVDF film
FUJII Makiko; YAMANAKA Ryota; KOIKE Takuji; KANZAKI Sho
When ligaments and tendons which support the ossicles in middle ear are fixed due to increasing age or pathological abnormality, conductive hearing loss occurs. To treat the conductive hearing loss, the ossicular mobility should be recovered by surgery. However, specification of the region of fixation and evaluation of the extent of fixation are difficult, because available measurement instruments for the ossicular mobilities are big and expensive and are not suitable for use during surgery. In this study, a force sensor in the measurement probe was downsized and improved. Simultaneously, the drive mechanism of the force sensor was developed and evaluated., The Japan Society of Mechanical Engineers, 25 Sep. 2011, マイクロ・ナノ工学シンポジウム, 2011, 3, 59-60, Japanese, 110009664138, AA12456946

9D-19 Analysis of the dynamic behavior of the auditory organ using a 3D fmite-element model including the ear canal and the middle ear
FUJIWARA Yasuhiro; KOIKE Takuji; ZHAO Fei
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 525-526, Japanese, 110008744254, AA11903175

8E-17 Development of a device for measurement of the ossicular mobility : Development of the force sensor with a piezoelectric material
FUJII Makiko; KOIKE Takuji; KANZAKI Sho
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 245-246, Japanese, 110008744114, AA11903175

9F-05 Transient response simulation of the basilar membrane in the cochlea
Yokoi Daisuke; Acosta Isaac Juarez; Koike Takuji
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 401-402, Japanese, 110008744192, AA11903175

9F-02 Development of implantable hearing aid using giant magnetostrictive material : Investigation of the characteristic of the transducer attached to the cadaver temporal bone under the skin
HARASHIMA Tatsunari; OSHIRO Kosumi; KOIKE Takuji; HATO Naohito; KANZAKI Syo
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 395-396, Japanese, 110008744189, AA11903175

8H-19 Simulation of the cochlea vibration considering activity of the outer hair cell
SAKASHITA Tasuku; SAKAMOTO Chiaki; KOIKE Takuji
The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010, 23, 285-286, Japanese, 110008744134, AA11903175

MNM-P9-5 Measurement of ossicular mobility in patients with otosclerosis
FUJII Makiko; KOIKE Takuji; KANZAKI Sho
When ligaments and tendons which support the ossicles are fixed due to increasing age or pathological abnormality, conductive hearing loss occurs. To treat the conductive hearing loss, ossicular mobility should be recovered by surgery. However, specification of the region of fixation and evaluation of the extent of fixation are difficult, because the measurement instruments for the ossicular mobilities are big and expensive and are not suitable for use during surgery. In this study, a hand-held apparatus for measuring ossicular mobility was developed and applied in a clinical setting. Then, air bone gap and ossicular mobility in patients with otosclerosis were compared., The Japan Society of Mechanical Engineers, 12 Oct. 2010, マイクロ・ナノ工学シンポジウム, 2010, 2, 131-132, Japanese, 110008743253, AA12456946

507 Pipe Corrosion Diagnosis using AE
SAKASHITA Tasuku; KOIKE Hitoshi; HOMMA Kyoji; AOKI Michihito; KOIKE Takuji; YAMADA Minoru; YUYAMA Shigenori
The Japan Society of Mechanical Engineers, 05 Mar. 2010, 講演論文集, 2010, 47, 167-168, Japanese, 110008744740, AN00360648

幼弱期のGjb2変異マウスの歪耳音響放射(DOPAE)の測定及び外有毛細胞の機能評価
峯川 明; 成井 裕弥; 井下 綾子; 飯塚 崇; 阿部 尚央; 欠畑 誠治; 木谷 令; 長岐 孝彦; 新川 秀一; 小池 卓二; 池田 勝久
生後14日前後のGjb2優性阻害変異の遺伝子改変マウス(R75Wトランスジェニックマウス)に対し、耳音響反射(DPOAE)測定を行い、電子顕微鏡像等と合わせて、非トランスジェニックマウスとの比較検討を行った。更に、コルチ器のプレスチン免疫染色や急速単離した外有毛細胞(OHC)の機能・形態の比較検討を行った。R75WトランスジェニックマウスのOHCは生後正常の成長を示し、単離したOHCからも運動能は正常であることを確認した。OHCの機能を反映するDPOAEは出現していなかった。R75WトランスジェニックマウスのEPは正常マウスとほぼ同じであった。支持細胞の不完全な発達によると考えられるコルチトンネル、Nuel腔、OHC周囲のスペースの欠如を認めた。Gjb2変異によるOHCを囲む支持細胞の発達の障害がOHCの機能欠如に影響をおよぼした事が示唆された。, 耳鼻咽喉科ニューロサイエンス研究会, Mar. 2010, 頭頸部自律神経, 24, 10-14, Japanese, 2010189302

0512 Simulation of the inner ear vibration : Effects of the Reissner's membrane on the vibration of the basilar membrane
SAKAMOTO Chiaki; KOIKE Takuji; AOKI Michihito; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 269-269, Japanese, 110008064648, AA11903175

1121 Effect of Mussel Plaque Configuration on Peeling Resistance Force Using a Probe
SHIMAZAKI Kenichi; AOKI Michihito; KOIKE Takuji; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 378-378, Japanese, 110008064755, AA11903175

0912 Development of implantable hearing aid using giant magnetostrictive material : Investigation of excitation force with human cadaver
HARASHIMA Tatsunari; KOIKE Takuji; HOMMA Kyoji; AOKI Michihito; HATO Naoto; KANZAKI Syo
The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009, 22, 154-154, Japanese, 110008064534, AA11903175

耳小骨はなぜ3つ？
小池卓二
2010, JOHNS, 26, 7, 981-984, Japanese, Introduction other

106 Modeling of the human ear using the finite element method and its clinical application
YAMAMOTO Takahiro; KOIKE Takuji; Aoki Mitihito; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 22 Jan. 2009, バイオエンジニアリング講演会講演論文集, 2008, 21, 11-12, Japanese, 110007706267, AA11903175

613 Time Dependence of Adhesive Strength of Marine Mussel Plaque Containing Ferric Ions
AOKI Michihito; TAKEDA Yoshihiro; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 22 Jan. 2009, バイオエンジニアリング講演会講演論文集, 2008, 21, 257-258, Japanese, 110007706394, AA11903175

B214 Relation between plaque configuration in mussel and pealing strength of plaque-glass interface by using probe
SHIMAZAKI Kenichi; AOKI Michihito; MURAKAMI Sayuri; KOIKE Takuji; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 22 Sep. 2008, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2008, 19, 65-66, Japanese, 1348-2939, 110007705759, AA11902434

幼若期のGjb2変異マウスの歪耳音響放射の測定および外有毛細胞の機能評価について
峯川 明; 成井 裕弥; 井下 綾子; 飯塚 崇; 阿部 尚央; 欠畑 誠治; 木谷 令; 長岐 孝彦; 新川 秀一; 小池 卓二; 池田 勝久
(一社)日本耳科学会, 16 Sep. 2008, Otology Japan, 18, 4, 324-324, Japanese, 0917-2025, 2009030298, 10025821748

幼若期のGjb2変異マウスの歪耳音響放射の測定
峯川 明; 成井 裕弥; 井下 綾子; 飯塚 崇; 小池 卓二; 池田 勝久
(一社)日本耳鼻咽喉科学会, Apr. 2008, 日本耳鼻咽喉科学会会報, 111, 4, 343-343, Japanese, 0030-6622, 2008234672

302 Analysis of the vibration of the basilar membrane using a stapes-cochlea coupled vibration model : Effects of perilymph fistula on the vibration of the basilar membrane
YAMAMOTO Takahiro; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007, 20, 81-82, Japanese, 110007085251, AA11903175

聴覚検査に必要な音響学の基礎知識
小池卓二
2008, JOHNS, 24, 5, 697-701, Japanese, Introduction other

517 Elemental Study for Development of an Implantable Hearing Aid Using Compact Piezo-Electric Device
SUZUKI Akira; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 06 Jan. 2007, バイオエンジニアリング講演会講演論文集, 2006, 19, 180-181, Japanese, 110006640258, AA11903175

430 Clarification of the vibration of the auditory system using a stapes-cochlea coupled vibration model
GOMITA Shinichi; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 06 Jan. 2007, バイオエンジニアリング講演会講演論文集, 2006, 19, 360-361, Japanese, 110006640348, AA11903175

AE Source Location Using Neural Network on AE Evaluation of Floor conditions in Above-Ground Tank
MURAKAMI Sayuri; HOMMA Kyoji; KOIKE Takuji; YAMADA Minoru; YUYAMA Shigenori
Present study reports acoustic emission (AE) technique to evaluate corrosion damages of bottom plates (floor conditions) in above-ground tanks. Artificial AE signals were generated by pencil lead breaks at arbitrary locations on the bottom of a tank (300 kL in capacity) to investigate accuracy of AE source location. Attenuation of AE waves was shown to be very small in liquid. AE source location analysis was conducted, using a neural network (NN). Input and output units of the NN were arrival time differences between four AE sensors and coordinate of the AE source location, respectively. Arrival time differences of AE waves were determined by visual observation of the first signal arrivals and threshold crossing times of the AE signal normalized by its peak amplitude. It was concluded that accurate AE source location can be obtained by the decision process resulted from automated readings of threshold crossing time, based on the NN trained method by theoretical calculation., The Japan Society of Mechanical Engineers, 2007, Jarnal of Solid Mechanics and Materials Engineering, 1, 7, 919-930, English, 1880-9871, 130000078893

特集「生物に見るハイパーセンサのメカニズム」に寄せて
小池卓二
バイオメカニズム学会, 2007, バイオメカニズム学会誌, 31, 3, 118-149, Japanese, Introduction other, 0285-0885, 40015652069, AN00334047

ヒトの聴覚器官における振動伝達
小池卓二
2007, 比較生理生化学, 24, 3, 122-125, Japanese, Introduction other

中耳伝音系モデルによる最適鼓室形成術の検討
小池卓二
THE JAPAN OTOLOGICAL SOCIETY, 2007, Otology Japan, 17, 1, 40-43, Japanese, Introduction other, 0917-2025, 10021298015, AN10358085

A207 Modeling of the patulous Eustachian tube with surrounding tissue : FEM analysis
INOUE Hirofumi; KOIKE Takuji; HOMMA Kyoji; MURAKAMI Sayuri
The Japan Society of Mechanical Engineers, 10 Nov. 2006, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2006, 17, 91-92, Japanese, 1348-2939, 110006639140, AA11902434

304 Development of a hand-guided apparaturs for measuring ossicular mobility : Verification and improvement of a prototype of apparaturs
SHINOZAKI Masaki; KOIKE Takuji; MURAKAMI Sayuri; HOMMA Kyoji; MERCHAN Saumil; WADA Hiroshi
The Japan Society of Mechanical Engineers, 12 Jan. 2006, バイオエンジニアリング講演会講演論文集, 2005, 18, 145-146, Japanese, 110006205493, AA11903175

B105 Frequency dependence of the sound conduction path when vibration was directly applied to the skull
SUZUKI Akira; KOIKE Takuji; HOMMA Kyoji; MURAKAMI Sayuri
The Japan Society of Mechanical Engineers, 08 Nov. 2005, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2005, 16, 53-54, Japanese, 1348-2939, 110006205913, AA11902434

B104 Individual differences in deformation of the patulous Eustachian tube : FEM analysis
GOMITA Shinichi; KOIKE Takuji; HOMMA Kyoji; MURAKAMI Sayuri; KOBAYASHI Toshimitsu
The Japan Society of Mechanical Engineers, 08 Nov. 2005, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2005, 16, 51-52, Japanese, 1348-2939, 110006205912, AA11902434

鼓室形成術後の鼓膜形状および厚さの変化が中耳伝音特性に及ぼす影響 : 振動様式のアニメーション表示
小池 卓二; 小林 俊光; 和田 仁
22 Sep. 2005, Otology Japan, 15, 4, 313-313, Japanese, 0917-2025, 10024564454, AN10358085

104 Measurement of the Vibration at the Ossicles Excited by a New Electromagnetic Hearing Aid Using Human Temporal Bones
HAMANISHI Shinji; KOIKE Takuji; KOBAYASHI Toshimitsu; WADA Hiroshi
The Japan Society of Mechanical Engineers, 09 Sep. 2005, 日本機械学会東北支部秋季講演会講演論文集, 2005, 41, 11-12, Japanese, 110006206257, AA11902660

20603 Conduction path of the sound directly applied to a bone
SUZUKI Akira; KOIKE Takuji; HOMMA Kyoji
When a bone is vibrated by a vibrator, we can perceive a sound even if conductive hearing loss exists. The applied vibration is supposed to be transmitted to the cochlea through the temporal bone, and this path is called bone-conduction. However, the real paths of the vibration have not been clarified. In this study, loudness of the sound perceived by a subject and the sound pressure generated in the external ear canal were measured when the mastoid was vibrated by a piezoelectric vibrator. The vibration applied to the mastoid was found to generate sound pressure in the external ear canal, the level of which was nearly equal to the perceived sound level. This result suggests that a subject with normal middle ear perceives the airconducted sound through the middle ear particularly at low frequency., The Japan Society of Mechanical Engineers, 17 Mar. 2005, 日本機械学会関東支部総会講演会講演論文集, 2005, 11, 149-150, Japanese, 110006205719, AA11902161

有限要素法による中耳振動シミュレーション
小池卓二; 和田仁
2005, シミュレーション, 24, 1, 3-8, Japanese, Introduction other

有限要素法による中耳シミュレーション
小池卓二; 和田 仁
2005, シミュレーション, 24, 1, 3-8, Japanese, Introduction other

耳小骨可動性計測装置を用いた耳小骨固着状態の定量化
小池 卓二; 湯浅 有; 湯浅 涼; 小林 俊光; 和田 仁
22 Sep. 2004, Otology Japan, 14, 4, 570-570, Japanese, 0917-2025, 10020400689, AN10358085

Acoustic Impedance Analysis of Adhesive Surface in Inhomogeneous Structural Material using Neural Network
IEMOTO Toshiyuki; HOMMA Kyoji; MURAKAMI Sayuri; KOIKE Takuji
The Japan Society of Mechanical Engineers, 06 Mar. 2004, 講演論文集, 2004, 42, 61-62, Japanese, 110004074631, AN00360626

Simulation of clinical inspection of the stiffness of ossicular ligaments
KOIKE Takuji; HUBER Alexander M.; WADA Hiroshi
The Japan Society of Mechanical Engineers, 21 Jan. 2004, バイオエンジニアリング講演会講演論文集, 2004, 16, 71-72, Japanese, 110002484097, AA11903175

Sound transmission in human middle ear with tympanic membrane perforation
MURAKAMI Sayuri; KOIKE Takuji; HOMMA Kyoji; WADA Hiroshi
The Japan Society of Mechanical Engineers, 21 Jan. 2004, バイオエンジニアリング講演会講演論文集, 2004, 16, 73-74, Japanese, 110002484098, AA11903175

Fundamental Properties of a New Electromagnetic Hearing Aid Determined by Experiments using Human Temporal Bones
HAMANISHI Shinji; KOIKE Takuji; GOODE Richard L.; WADA Hiroshi
The Japan Society of Mechanical Engineers, 21 Jan. 2004, バイオエンジニアリング講演会講演論文集, 2004, 16, 97-98, Japanese, 110002484110, AA11903175

聴覚器のモデリングとその臨床応用
小池卓二; 和田 仁
2004, バイオメカニズム学会誌, 28, 4, 179-183, Japanese, Introduction other

Time Dependence of Adhesive Strength of Plaque to Soda-Lime Glass in Marine Mussel
AOKI Michihito; MURAKAMI Sayuri; KOIKE Takuji; HOMMA Kyoji
The Japan Society of Mechanical Engineers, 17 Sep. 2003, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2003, 14, 171-172, Japanese, 1348-2939, 110002479271, AA11902434

Development of a minimally-invasive implantable hearing aid : Designing of the transducer of the hearing aid by numerical analysis
Aoki Satoshi; KOIKE Takuji; HOMMA Kyouji; WADA Hiroshi
The Japan Society of Mechanical Engineers, 17 Sep. 2003, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2003, 14, 77-78, Japanese, 1348-2939, 110002479224, AA11902434

鼓膜と耳小骨形状および靱帯・筋腱剛性の個人差が伝音特性に及ぼす影響
小池 卓二; 和田 仁; 小林 俊光
12 Sep. 2003, Otology Japan, 13, 4, 275-275, Japanese, 0917-2025, 10020400955, AN10358085

Development of a Surgical Simulation System for Analyzing Dynamic Characteristics of Individual Middle Ears
KONNO Kazuaki; KOIKE Takuji; OHYAMA Kenji; WADA Hiroshi
The Japan Society of Mechanical Engineers, 20 Jan. 2003, バイオエンジニアリング講演会講演論文集, 2003, 15, 157-158, Japanese, 110002483927, AA11903175

耳小骨可動性計測手法
小池卓二; 和田 仁
2003, 日本音響学会誌, 59, 1, 36-39, Japanese, Introduction other

耳小骨可動性計測手法
小池卓二; 和田 仁
2003, 日本音響学会誌, 59, 1, 36-39, Japanese, Introduction other

Development of a hand-guided diagnostic apparatus for ossicular fixation
小池 卓二; 和田 仁; 湯浅 有
日本音響学会, 15 Nov. 2002, 聴覚研究会資料 = Proceedings of the auditory research meeting, 32, 9, 509-513, Japanese, 1346-1109, 40020278397, AN00227138

耳小骨固着診断装置の開発 : ヒトおよびモルモットの耳小骨可動性術中計測
小池 卓二; 和田 仁; 湯浅 有; 湯浅 涼; 河瀬 哲明; 小林 俊光
12 Sep. 2002, Otology Japan, 12, 4, 511-511, Japanese, 0917-2025, 10010706160, AN10358085

Development of a New Electromagnetic Hearing Device : New Method for Vibrating the Tympanic Membrane Using a Light Weight Coil
HAMANISHI Shinji; KOIKE Takuji; WADA Hiroshi; KAWASE Tetsuaki; KOBAYASHI Toshimitsu
The Japan Society of Mechanical Engineers, 01 Mar. 2002, バイオエンジニアリング講演会講演論文集, 2002, 14, 159-160, Japanese, 110002483753, AA11903175

中耳疾患例のTEOAE(Transiently evoked otoacoustic emissions)
和田 仁; 小池 卓二; 大山 健二; 川瀬 哲明; 小林 俊光
30 Sep. 2001, Audiology Japan, 44, 5, 553-554, Japanese, 0303-8106, 10008449983, AN00000347

Development of measurement apparatus for diagnosis of stapes fixation
IGARASHI Junji; WADA Hiroshi; KOIKE Takuji; YUASA Yu
The Japan Society of Mechanical Engineers, 15 Jan. 2001, バイオエンジニアリング講演会講演論文集, 2001, 13, 58-59, Japanese, 110002483555, AA11903175

Effect of the conical shape of the tympanic membrane on the middle ear sound transmission
KOIKE Takuji; WADA Hiroshi; KOBAYASHI Toshimitsu
The Japan Society of Mechanical Engineers, 15 Jan. 2001, バイオエンジニアリング講演会講演論文集, 2001, 13, 92-93, Japanese, 110002483572, AA11903175

より豊かな生活に貢献する医療技術に関する研究 マイクロマシン技術を応用した術中使用可能な耳小骨可動性測定装置の開発
小池卓二; 和田仁; 湯浅涼; 小林俊光
2001, 医科学応用研究財団研究報告, 18, 43-46

有限要素法による中耳伝音特性解析
小池卓二
2001, 日本ME学会誌, 14, 63-68, Japanese, Introduction other

モルモットおよびウサギのアブミ骨可動性計測 : 新たな計測手法を用いて
小池 卓二; 和田 仁; 湯浅 有; 湯浅 涼; 川瀬 哲明
20 Sep. 2000, Otology Japan, 10, 4, 447-447, Japanese, 0917-2025, 10013204101, AN10358085

Dynamic Behavior of the Basilar Membrane in the Cochlea : FEM Analysis Using Spiral Shaped Cochlea Model
SEKINE Masanao; WADA Hiroshi; KOIKE Takuji
To clarify the mechanism of the cochlea, simulations using a mathematical or electrical circuital cochlear model have been performed by many researchers. However, in the most of their models, the cochlea was assumed to be straight to simplify their simulations, although the mammalian cochlea has a spiral-shaped duct. A few researchers have already established the spiral cochlear models, but the effects of spiral shape of cochlea are still unclear. In this study, a three-dimensional model of the guinea pig cochlea was established, and numerical simulations were performed using the finite element method(FEM). To examine the effect of the spiral shape of the cochlea on its dynamic behavior, the numerical results obtained from the spiral-shaped model were compared with those from the straight model. It was found that the basilar membrane(BM) velocity amplitude and the vibration mode of the BM along the transverse direction in the spiral model were different from those of the straight model., The Institute of Electronics, Information and Communication Engineers, 16 Aug. 2000, Technical report of IEICE. EA, 100, 255, 21-24, Japanese, 0913-5685, 110003284654, AN10164817

THE MIDDLE EAR DYANMIC CHARACTERISTICS AND TEOAES IN PATIENTS WITH MIDDLE EAR DISORDERS
ZHAO Fei; WADA Hiroshi; KOIKE Takuji; OHYAMA Kenji; KAWASE Tetsuaki
Within the present study, the influence of changes in the middle ear dynamic characteristics on transient evoked otoacoustic emissions(TEOAEs)was investigated in 88 subjects(126 ears)with common middle ear disorders using a sweep frequency impedance meter(SFI). Certain type and degree of middle ear pathologies resulted in dramatic changes of the middle ear dynamic characteristics showing in the SFI test. Moreover, TEOAE furequency spectrum characteristics and their amplitudes were closely related to the middle ear dynamic characteristics., The Institute of Electronics, Information and Communication Engineers, 15 Aug. 2000, Technical report of IEICE. EA, 100, 254, 75-81, English, 0913-5685, 110003284650, AN10164817

Measurement of Stapes Mobility
KOIKE Takuji; WADA Hiroshi; YUASA Yu; KAWASE Tetsuaki; FUJII Hiroaki
In tympanoplasty, it is essential to understand the condition of the stapes. However, it has been difficult to evaluate stapes mobility in routine measurement. In this study, aiming at the clinical usage in the future, a new measuring system, which enables to measure the stapes mobility quantitatively and easily, has been developed, and the relationships between the load and displacement of the normal and artificially fixed stapes in the guinea pigs and rabbits were examined., The Institute of Electronics, Information and Communication Engineers, 15 Aug. 2000, Technical report of IEICE. EA, 100, 254, 71-74, Japanese, 0913-5685, 110003284649, AN10164817

代用アブミ骨を用いた連鎖再建中耳の伝音特性 理論的考察
小池卓二; 和田仁; 小林俊光; 湯浅涼
2000, Audiology Japan, 43, 5, 447-448, 0303-8106, 10008449090

Vibration measurement of the tympanic membrane using the electronic speckle pattern interferometry
Hiroshi Wada; Masataka Takeuchi; Hironori Sugawara; Takuji Koike; Toshimitsu Kobayashi; Koji Hozawa; Takashi Gemma; Makoto Nara
2000, Acoustical Society of Japan, 56, 379-383

コルチ器の振動挙動解明 : 有限要素法による理論解析
小池 卓二; 和田 仁; 高坂 知節
10 Aug. 1999, Otology Japan, 9, 4, 484-484, Japanese, 0917-2025, 10024563820, AN10358085

OAEsに及ぼす中耳順方向及び逆方向の伝音特性の影響 理論的考察
小池卓二; 和田仁; 小林俊光; 大山健二; 高坂知節
1998, Audiology Japan, 41, 5, 349-350, 0303-8106, 10008447390

warble tone による術中聴力検査の有用性と問題点
湯浅 有; 片橋 立秋; 湯浅 涼; 川瀬 哲明; 高坂 知節; 小岩 哲夫; 小池 卓二
20 Sep. 1997, Otology Japan, 7, 4, 407-407, Japanese, 0917-2025, 10024562003, AN10358085

コルメラを用いた最適鼓室形成術の開発 : 有限要素法による理論解析
小池 卓二; 和田 仁; 小林 俊光; 高坂 知節
20 Sep. 1997, Otology Japan, 7, 4, 314-314, Japanese, 0917-2025, 10024561877, AN10358085

中耳振動挙動と伝音特性 : 有限要素法によるアニメーション表示
小池 卓二; 和田 仁; 小林 俊光; 高坂 知節
05 Sep. 1996, Otology Japan, 6, 4, 296-296, Japanese, 0917-2025, 10024561371, AN10358085

Transfer function of human middle ear -Theoretical Analysis using Finite-Element Method-
Takuji Koike; Hiroshi Wada; Toshimitsu Kobayashi
1996, The Journal of the Acoustical Society of Japan, 52, 9, 695-702

コンピューターを使って耳の機能を理解する―直接計測が難しい生体挙動の推定―
小池卓二
Textbook, Japanese, Contributor, 共立出版, 2015

Middle ear mechanics in research and otology
Kiyofumi Gyo; Hiroshi Wada; Naohito Hato; Takuji Koike
English, World Scientific, 2003

Recent Developments in Auditory Mechanics
Hiroshi Wada; Tomonori Takasaka; Katsuhisa Ikeda; Kenji Ohyama; Takuji Koike
English, Editor, World Scientific, 2000

音声言語医療のための音に関する基礎知識
小池卓二
Invited oral presentation, Japanese, 第69回日本音声言語医学会学術講演会, Invited
17 Oct. 2024

対側刺激がDPOAEレベルに及ぼす影響
原 佑太; 李 信英; 小池 卓二
Poster presentation, Japanese, 日本機械学会2024年度年次大会
09 Sep. 2024

受粉促進のためのトマト株の機械インピーダンス計測
東海林 篤; 岡部 昌優; 小池 卓二
Oral presentation, Japanese, 日本機械学会2024年度年次大会
09 Sep. 2024

Nearinfrared fluorescence detection for assessment of aspiration risk
G. Nishimura; T. Suzuki; K. Tashiro; K. Wakamatsu; T. Koike; Y. Yamada; H. Niwa; Y. Michiwaki
Oral presentation, English, The 3rd Britton Chance International Symposium on Metabolic Imaging and Spectroscopy, Peer-reviewed
18 Jun. 2024

臨床使用に向けた耳小骨可動性計測装置の計測安定性向上
筥﨑 智弘; 入江 優花; 神崎 晶; 李 信英; 徐 世傑; 肥後 武展; 林 正晃; 池上 元; 小池 卓二
Oral presentation, Japanese
11 May 2024

聴覚と振動触覚におけるクロスモダリティ効果
白井 穂乃香; 小池 卓二
Oral presentation, Japanese, 第36回バイオエンジニアリング講演会
11 May 2024

理論と実機計測による骨導補聴器の性能評価
沼澤 睦; 仁科 翔平; 鈴木 克佳; 小池 卓二
Oral presentation, Japanese, 第36回バイオエンジニアリング講演会
11 May 2024

聴覚器の個人差とアブソーバンスパターンの関係－数値解析による検討－
入江 佑理花; 小池 卓二
Oral presentation, Japanese, 第36回バイオエンジニアリング講演会
11 May 2024

人工授粉のための植物体各部のインピーダンス計測
岡部昌優; 東海林 篤; 小池卓二
Oral presentation, Japanese, 日本機械学会第34回バイオフロンティア講演会
16 Dec. 2023

眼球振動計測による内視鏡下副鼻腔手術時の眼窩副損傷危険性判定法の検討
飯田 和眞; 伊藤 伸; 小池 卓二
Oral presentation, Japanese, 日本機械学会第34回バイオフロンティア講演会
16 Dec. 2023

Contralateral Suppression of Input/Output Function of Distortion-Product Otoacoustic Emissions in Young Adults
Sinyoung Lee; Yuta Hara; Takuji Koike
Poster presentation, English, Acoustics 2023
04 Dec. 2023

Measurement of Distortion-Product Otoacoustic Emissions at Low Frequency and Effect of Contralateral Acoustic Stimulation on Its Level
Takuji Koike; Yuta Hara; Sinyoung Lee
Poster presentation, English, Acoustics 2023
04 Dec. 2023

鼓膜臍可動性計測による耳小骨固着部位判別法の検討：数理モデル解析データの機械学習
李 信英; 神﨑 晶; 小池 卓二
Oral presentation, Japanese, 日本耳科学会学術講演会
03 Nov. 2023

先生！その耳小骨操作は適切ですか？（3）―アブミ骨固着と正常耳小骨モデルを用いた耳小骨可動測定の検討―
神﨑 晶; 小池卓二; 入江優花; 徐世傑; 肥後武展; 林正晃; 池上元
Oral presentation, Japanese, 日本耳科学会学術講演会
03 Nov. 2023

ガウス頻度二相性パルス電気刺激による嚥下反応の変化
森本 韻; フリーザ マイケル; ピッツ テレサ; 小池 卓二
Oral presentation, Japanese, 日本機械学会 2023年度 年次大会
04 Sep. 2023
03 Sep. 2023- 06 Sep. 2023

Swallowing response to electrical stimulation of the back or neck at gaussian frequency
In Morimoto; Michael Frazure; Teresa Pitts; Takuji Koike
Poster presentation, English, 6th Japan-Switzerland Workshop on Biomechanics
30 Aug. 2023
29 Aug. 2023- 01 Sep. 2023

イチゴの受粉促進周波数の検討と空気を媒介とした受粉装置の開発
東海林篤; 岡部昌優; 小池卓二
Oral presentation, Japanese, 日本機械学会第35回バイオエンジニアリング講演会
03 Jun. 2023
03 Jun. 2023- 04 Jun. 2023

対側刺激による低周波数域 DPOAE の計測と聴力検査への応用
原佑太; 李信英; 小池卓二
Oral presentation, Japanese
03 Jun. 2023
03 Jun. 2023- 04 Jun. 2023

聴覚感覚細胞の I/O ファンクションの変化を用いた難聴早期診断法の検討
李信英; 原佑太; 小池卓二
Oral presentation, Japanese, 日本機械学会第35回バイオエンジニアリング講演会
03 Jun. 2023
03 Jun. 2023- 04 Jun. 2023

ガウス頻度での背部電気刺激による嚥下反応の性差
森本 韻; Michael Frazure; Teresa Pitts; 小池 卓二
Oral presentation, Japanese, 日本機械学会第35回バイオエンジニアリング講演会
03 Jun. 2023
04 Jun. 2023

固着部位診断のための耳小骨可動性計測方法の開発：有限要素中耳モデルによる検討
YOU HYEONSIK; 入江優花; 李 信英; 神﨑 晶; Chee Sze Kea; 肥後武展; 大山健二; 清水義智; 池上 元; 小池卓二
Oral presentation, Japanese, 日本機械学会第33回バイオフロンティア講演会
18 Dec. 2022
17 Dec. 2022- 18 Dec. 2022

近赤外蛍光計測による下咽頭における食物残留および動態計測
若松海門; 山田幸生; 丹羽治樹; 飯野裕二; 西村吾朗; 道脇幸博; 中川量晴; 吉見佳那子; 齋木章乃; 小池卓二
Oral presentation, Japanese, 日本機械学会第33回バイオフロンティア講演会
18 Dec. 2022
17 Dec. 2022- 18 Dec. 2022

Appropriate procedure of palpating ossicules model
Sho Kanzaki; Takuji Koike; Yuuka Irie
Nominated symposium, English, 4th World Congress on Endoscopic Ear Surgery
06 Dec. 2022
05 Dec. 2022- 08 Dec. 2022

Development of measurement device for ossicular mobility
Takuji Koike
Nominated symposium, English, 4th World Congress on Endoscopic Ear Surgery
06 Dec. 2022
05 Dec. 2022- 08 Dec. 2022

An influence of probes over ossicular mobility measurements
Ahn Jiwon; Yuka Irie; Takuji Koike; Sho Kanzaki; Chee Sze Kea; Takenobu Higo; Kenji Ohoyama; Hajime Ikegami
Oral presentation, English, Joint meeting of 9th Annual meeting of the Society for Bioacoustics and 18th meeting of Inner ear distortion research group of Japan Audiological Society
04 Dec. 2022

中耳数理モデルの解析データの機械学習による耳小骨固着部位判別法の検討
李信英; 神﨑晶; 小池卓二; 池上 元
Oral presentation, Japanese, 日本耳科学会第32回学術講演会
21 Oct. 2022
19 Oct. 2022- 21 Oct. 2022

先生！その耳小骨操作は適切ですか？（2） ―耳小骨可動性の判断における術者間のばらつきに関する検証―
神崎 晶; 小池卓二; 入江優花; 徐 世傑; 肥後武展; 清水義智; 林 正晃; 池上 元
Oral presentation, Japanese, 第32回日本耳科学会学術講演会
20 Oct. 2022
19 Oct. 2022- 21 Oct. 2022

近赤外蛍光を用いた非侵襲咽頭残留検出装置のヒトにおける検出性評価
小池卓二; 若松海門; 飯野裕二; 中川量晴; 吉見佳那子; 西村吾朗; 山田幸生; 丹羽治樹; 道脇幸博
Nominated symposium, Japanese, LIFE2022
22 Aug. 2022
19 Aug. 2022- 22 Aug. 2022

振動によるトマトの着果への影響
徳永 絢子; 小池 卓二; 高梨 琢磨; 大矢 武志; 柴 智徳; 小野寺 隆一
Oral presentation, Japanese, 第33回バイオエンジニアリング講演会, Domestic conference
25 Jun. 2021

Formulation of nonlinear force of the outer hair cells based on measurement and numerical analysis of distortion product otoacoustic emissions
Sinyoung Lee; Takuji Koike
Oral presentation, English, Association for Research in Otolaryngology 44th Annual Midwinter Meeting, 24 February, International conference
24 Feb. 2021

近赤外蛍光を用いた咽頭残留の非侵襲検出法の開発：ファントムを用いた検出能評価
田代剛大; 山田幸生; 丹羽治樹; 牧昌次郎; 北田昇雄; 斉藤亮平; 小池卓二; 道脇幸博; 西村吾朗
Oral presentation, Japanese, 日本光学会年次学術講演会2020, Domestic conference
Nov. 2020

近赤外蛍光を用いた非侵襲咽頭残留検出装置のヒトにおける検出性評価
田代剛大; 鈴木崇弘; 山田幸生; 丹羽治樹; 牧昌次郎; 北田昇雄; 斉藤亮平; 小池卓二; 道脇幸博; 西村吾朗
Oral presentation, Japanese, 日本機械学会 2020年度年次大会, Domestic conference
Sep. 2020

騒音環境下における歪成分耳音響放射検査法の開発
根木裕次郎; 小池 卓二
Oral presentation, Japanese, 日本機械学会 2020年度年次大会, Domestic conference
Sep. 2020

Intra-operative assessment of middle ear transfer function using cochlear microphonic
Takuji Koike; Yuuka Irie; Ryo Ebine; Takaaki Fujishiro; Sho Kanzaki; Chee Sze Keat; Takenobu Higo; Kenji Ohoyama; Masaaki Hayashi; Hajime Ikegami
Oral presentation, English, The 6th Annual Meeting of the Society for Bioacoustics, International conference
Nov. 2019

Development of Technology for Control of the Greenhouse Whitefly Using Substrate Vibration
Kengo Shibata; Takuma Takanashi; Takuji Koike; Shota Abe; Akira Hosokawa; Toshifumi Ono; Ryuichi Onodera; Tsuyoki Tayama; Takaho Ohe; Takayuki Sekine
Oral presentation, English, The 6th Annual Meeting of the Society for Bioacoustics, International conference
Nov. 2019

Simulation of stapedial mobility in ossicular fixation using finite-element model of human middle ear
Sinyoung Lee; Sho Kanzaki; Takuji Koike
Oral presentation, English, The 6th Annual Meeting of the Society for Bioacoustics, International conference
Nov. 2019

Noise-resistant method for measuring distortion product otoacoustic emissions (DPOAEs)
Yujiro Motoki; Takuji Koike
Oral presentation, English, The 6th Annual Meeting of the Society for Bioacoustics, International conference
Nov. 2019

Relationship between Stimulus Frequency Ratios and Area of OHCs Contributing Generation of DPOAEs: Simulation Using Finite-Element Model of Human Cochlea
Sinyoung Lee; Takuji Koike
Poster presentation, English, Association for Research in Otolaryngology 43rd Annual Midwinter Meeting, International conference
25 Jan. 2019

Intra-operative assessment of ossicular mobility: Measurements in cadavers and numerical analysis
Takuji Koike; Yuuka Irie; Takaaki Fujishiro; Chee Sze Keat; Takenobu Higo; Kenji Ohoyama; Masaaki Hayashi; Hajime Ikegami
Oral presentation, English, Association for Research in Otolaryngology 43rd Annual Midwinter Meeting, International conference
25 Jan. 2019

The effects of an active noise control technology applied to earphones on preferred listening levels in noisy environments
Takunari Hoshina; Daiki Fujiyama; Takuji Koike; Katsuhisa Ikeda
Oral presentation, English, Association for Research in Otolaryngology 43rd Annual Midwinter Meeting, International conference
25 Jan. 2019

Development of Intra-operative Assessment System for Ossicular Mobility
Takuji Koike; Yuuka Irie; Ryo Ebine; Takaaki Fujishiro; Sho Kanzaki; Chee Sze Keat; Takenobu Higo; Kenji Ohoyama; Masaaki Hayashi; Hajime Ikegami
Oral presentation, English, The 8th International Symposium on Middle-Ear Mechanics in Research and Otology
Jul. 2018

Compliance change caused by ossicular fixation: Simulation of intra-operative assessment of ossicular mobility
Sinyoung Lee; Takuji Koike; Sho Kanzaki
Oral presentation, English, The 8th International Symposium on Middle-Ear Mechanics in Research and Otology, International conference
Jul. 2018

胎児の聴力検査を目指した心拍数変動計測：妊娠20週から29週における計測
佐藤 美帆; 李 信英; 日比谷 怜美; 松岡 理奈; 池田 勝久; 小池 卓二
Oral presentation, Japanese, 日本機械学会関東支部第24期講演会, Domestic conference
17 Mar. 2018

Development of an efficient method for behavioral disruption using vibration against pest insects in greenhouses
Kengo Shibata; Takuma Takanashi; Takuji Koike; Tsuyoki Tayama; Ryuichi Onodera; TOshifumi Ono; Shouta Abe; Takahiro Sekine; Yasuyuki Komagata
Oral presentation, English, The 5th Annual Meeting of the Society for Bioacoustics, International conference
2018

Relationship between active area on the basilar membrane and hearing level: Simulation using human cochlear finite-element model
Sinyoung Lee; Takuji Koike
Oral presentation, English, The 5th Annual Meeting of the Society for Bioacoustics, International conference
2018

近赤外蛍光色素を用いた咽頭腔残留食物の非侵襲検出法の開発:食肉を用いた予備実験
鈴木崇弘; 山田幸生; 丹羽治樹; 牧昌次郎; 北田昇雄; 斉藤亮平; 小池卓二; 西村吾朗; 道脇幸博
Poster presentation, Japanese, 第30回バイオエンジニアリング講演会, Domestic conference
14 Dec. 2017

聴力損失と歪成分耳音響放射(DPOAEs)の関係:ヒト蝸牛有限要素モデルを用いたシミュレーション
李信英; 小池卓二
Poster presentation, Japanese, 第30回バイオエンジニアリング講演会, Domestic conference
14 Dec. 2017

二音抑制時の基底板振動挙動解析
水戸健太; 李信英; 小池卓二
Poster presentation, Japanese, 第30回バイオエンジニアリング講演会, Domestic conference
14 Dec. 2017

嚥下筋骨格モデルを用いた異なる食塊による筋活動の変化の推定
占部麻里子; 菊地貴博; 道脇幸博; 小池卓二; 橋本卓弥
Poster presentation, Japanese, 第30回バイオエンジニアリング講演会, Domestic conference
14 Dec. 2017

耳科用探針を用いた耳小骨可動性計測装置の開発と性能評価
海老根崚; 神崎晶; 小池卓二
Poster presentation, Japanese, 第30回バイオエンジニアリング講演会, Domestic conference
14 Dec. 2017

植込み型骨導補聴器の伝送コイル周辺の磁界計測
和賀井洋平; 神崎晶; 羽藤直人; 小池卓二
Poster presentation, Japanese, 第30回バイオエンジニアリング講演会, Domestic conference
14 Dec. 2017

Simulation of electrical changes in the inner hair cells derived from the basilar membrane vibration
Sinyoung Lee; Takuji Koike
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Simulation of two-tone suppression using human cochlear model considering activity of outer hair cells
Kenta Mito; Sinyoung Lee; Takuji Koike
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Measurement system for mobility of auditory ossicles using ear pick
Ryo Ebine; Sho Kanzaki; Takuji Koike
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Examination of a method for risk detection in endoscopic sinus surgery
Kota Kuroda; Sinyoung Lee; Shin Ito; Kastuhisa Ikeda; Takuji Koike
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Measurement of fetal heart rate variance for fetal hearing screening
Miho Sato; Sinyoung Lee; Remi Hibiya; Rina Matsuoka; Katsuhisa Ikeda; Takuji Koike
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Simultaneous vibration measurement of hyoid muscle activity and swallowing sound
Takahiro Suzuki; Takuji Koike
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Vibration sensitivity in longicorn beetles and its potential for pest management
Takuma Takanashi; Shuji Fukui; Takuji Koike; Hiroshi Nishino
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

Development of a new method for behavioral control of an agricultural insect pest by vibration
Yuta Yoshimura; Takuji Koike; Takuma Takanashi
Poster presentation, English, The 4th Annual Meeting of the Society for Bioacoustics, International conference
09 Dec. 2017

耳科用探針を用いた耳小骨可動性計測装置の開発
小池 卓二; 神崎晶
Oral presentation, Japanese, 第27回日本耳科学会学術講演会, Domestic conference
22 Nov. 2017

基底板における OHC の機能低下領域と歪成分耳音響放射レベルの関係：蝸牛有限要素モデルによる数値解析
李信英; 小池卓二
Poster presentation, Japanese, 第27回日本耳科学会学術講演会, Domestic conference
22 Nov. 2017

コンピュータシミュレーションによる蝸牛振動の可視化
小池卓二
Invited oral presentation, Japanese, 日本聴覚医学会第65回聴覚生理研究会, Invited, Domestic conference
19 Oct. 2017

携帯型音楽プレイヤーによる無意識下の過大音刺激による蝸牛障害危険性の定量的評
保科卓成; 小池卓二; 池田勝久
Oral presentation, Japanese, 第62回日本聴覚医学会学術講演会, Domestic conference
18 Oct. 2017

胎児心拍計測法による胎児聴力検査の開発
日比谷怜美; 松岡理奈; 佐藤美帆; 小池卓二; 池田勝久
Oral presentation, Japanese, 第62回日本聴覚医学会学術講演会, Domestic conference
18 Oct. 2017

Aspiration Risk Detection Using Oral Administration of Fluorescent Food: Preliminary Experiments Using Meat Phantoms
Takahiro SUZUKI; Ryohei SAITO; Nobuo KITADA; Takuji KOIKE; Shojiro MAKI; Yukihiro MICHIWAKI; Goro NISHIMURA; Haruki NIWA; Yukio YAMADA
Oral presentation, English, 2017 IEEE International Conference on Cyborg and Bionic Systems, Beijing, China, International conference
17 Oct. 2017

HAND-HELD PROBE FOR OBJECTIVE INTRA-OPERATIVE ASSESSMENT OF OSSICULAR MOBILITY
Takuji Koike; Kai Takakuwa; Yuuka Irie; Sinyoung Lee; Sho Kanzaki
Oral presentation, English, the XXVI Congress of the International Society of Biomechanics, International conference
23 Jul. 2017

RELATIONSHIP BETWEEN INCREASE IN ENDOLYMPHATIC PRESSURE AND LEVEL OF DPOAES: FINITE-ELEMENT ANALYSIS OF HUMAN ACTIVE COCHLEA
Sinyoung Lee; Takuji Koike
Oral presentation, English, the XXVI Congress of the International Society of Biomechanics, Brisbane, Australia, International conference
23 Jul. 2017

MEASUREMENT OF PIEZOELECTRIC VIBRATOR-STIMULATED POTENTIAL FOR FETAL HEARING SCREENING
Miho Sato; Sinyoung Lee; Rina Matsuoka; Remi Hibiya; Katsuhisa Ikeda; Takuji Koike
Oral presentation, English, the XXVI Congress of the International Society of Biomechanics, Brisbane, Australia, International conference
23 Jul. 2017

Quantitative Assessment of Swallowing Activity by MMG measurement with PVDF film
Hashimoto Takuya; Tsukagoshi Keita; Koike Takuji
Oral presentation, English, 15th IEEE International Conference on Rehabilitation Robotics, International conference
17 Jul. 2017

Relationship between the levels of DP components and non-active portions of the basilar membrane: Simulation using human cochlear finite-element model
Takuji KOIKE; Sinyoung LEE
Invited oral presentation, English, Mechanics of Hearing 2017, Canada, International conference
19 Jun. 2017

数値モデルによる蝸牛の振動解析
小池卓二
Invited oral presentation, Japanese, 日本聴覚医学会第14回内耳ひずみ研究会, Invited, Domestic conference
17 Jun. 2017

しいたけ原木の害虫ハラアカコブカミキリに対する振動を用いた防除の試み
高梨琢磨; 福井修二; 舟木宏; 松井康浩; 小池卓二
Oral presentation, Japanese, 第61回日本応用動物昆虫学会大会, Domestic conference
27 Mar. 2017

筋音計測による嚥下運動の定量的評価に関する研究
橋本卓弥; 塚越恵太; 鈴木崇弘; 小池 卓二
Oral presentation, Japanese, 日本機械学会第23回関東支部講演会, Domestic conference
16 Mar. 2017

Vibration sensitivity in longicorn beetles and biomimetic potential for insect pest control
TAKANASHI Takuma; SAKAMOTO Hironori; SKALS Niels; FUKUI Shuji; MATSUI Yasuhiro; KOIKE Takuji; NISHINO Hiroshi
Invited oral presentation, English, International Symposium on Engineering Neo-Biomimeteics VII, Invited, International conference
17 Feb. 2017

耳小骨可動性の定量的評価：等価ばね定数の計測
高桑加以; 神崎晶; 入江優香; 小池卓二
Oral presentation, Japanese, 第29回バイオエンジニアリング講演会, Domestic conference
19 Jan. 2017

外有毛細胞の伸縮運動を考慮したヒト蝸牛有限要素モデル：歪成分耳音響放射(DPOAEs)のシミュレーション
李信英; 小池卓二
Oral presentation, Japanese, 第29回バイオエンジニアリング講演会, Domestic conference
19 Jan. 2017

耳鼻咽喉科領域における医工連携研究
小池卓二
Public discourse, Japanese, 愛媛ヒアリング研究会, Invited, Domestic conference
06 Mar. 2016

耳鼻咽喉科領域における医工連携研究
小池卓二
Public discourse, Japanese, 愛媛ヒアリング研究会, Invited, 愛媛大学(松山市), Domestic conference
06 Mar. 2016

内リンパ水腫の基底板振動シミュレーション：外有毛細胞のactivityを考慮した蝸牛有限要素モデルによる解析
李信英; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第28回バイオエンジニアリング講演会，, Domestic conference
09 Jan. 2016

埋め込み型骨導補聴器用振動子の駆方法の検討
林直輝; 橋本卓弥; 神崎晶; 羽藤直人; 小池卓二
Oral presentation, Japanese, 第28回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2016

術中使用を考慮した耳小骨可動性計測装置の開発
高桑加以; 橋本卓弥; 神崎晶; 小池卓二
Oral presentation, Japanese, 第28回バイオエンジニアリング講演会，, Domestic conference
09 Jan. 2016

Nonlinear Time-Domain Cochlear Model Using Finite-Element Method: Simulation of DPOAEs
Takuji Koike; Hideyuki Mochizuki; Sinyoung Lee
Oral presentation, English, IUTAM Symposium on Advances in Biomechanics of Hearing, International conference
2016

Simulation of the Basilar Membrane Vibration of the Endolymphatic Hydrops
Sinyoung Lee; Takuya Hashimoto; Takuji Koike
Oral presentation, English, IUTAM Symposium on Advances in Biomechanics of Hearing, International conference
2016

Vibration sensitivity in cerambycid beetles and its potential for insect pest control
TAKANASHI Takuma; SAKAMOTO Hironori; SKALS Niels; FUKUI Shuji; MATSUI Yasuhiro; KOIKE Takuji; NISHINO Hiroshi
Oral presentation, English, The 22nd International Congress of Zoology，The 87th meeting of Zoological Society of Japan，Joint events, The 22nd International Congress of Zoology，The 87th meeting of Zoological Society of Japan，Joint events, Okinawa, International conference
2016

Finite-element model of human active cochlea: Short-time variation of DP components on the BM
Sinyoung Lee; Takuji Koike
Poster presentation, English, The 3rd Annual Meeting of the Society for Bioacoustics, International conference
2016

Measurement and evaluation of vibration characteristics of mushroom logs aimed at insect pest control
Yuta Yoshimura; Yuncong Ma; Takuji Koike
Poster presentation, English, The 3rd Annual Meeting of the Society for Bioacoustics, International conference
2016

超磁歪素子を用いた埋め込み型骨導補聴器の振動子の改良と振動の可視化
小池卓二; 羽藤直人; 神崎晶
Oral presentation, Japanese, 第25回日本耳科学会総会学術講演会, Domestic conference
07 Oct. 2015

耳小骨可動性計測時の蝸牛安全評価：蝸牛有限要素モデルによる解析
李信英; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第26回バイオフロンティア講演会, Domestic conference
02 Oct. 2015

嚥下時における舌骨及び甲状軟の筋格モデル開発
村越温子; 菊地 貴博; 道脇幸博; 小池卓二; 橋本卓弥
Oral presentation, Japanese, 第26回バイオフロンティア講演会
02 Oct. 2015

埋め込み型骨導補聴器の経皮伝送法最適化および音質評価
林直輝; 田中絵里; 金子渥; 橋本卓弥; 神崎晶; 羽藤直人; 小池卓二
Oral presentation, Japanese, 第26回バイオフロンティア講演会
02 Oct. 2015

Effect of Insertion of Cochlear Implant Electrode on Bashilar Membrane Vibration: An Analysis Using Finite-Element Cochlear Models
Takuji Koike; Kozo Kumakawa; Tasuku Sakashita; Shintaro Hanawa
Oral presentation, English, 8th Asian-Pacific Conference on Biomechanics, International conference
16 Sep. 2015

Evaluation of Transcutaneous Signal Transmission System Used for Implantable Bone Conduction Hearing Aid
Naoki Hayashi; Eri Tanaka; Atsushi Kaneko; Takuya Hashimoto; Sho Kanzaki; Naohito Hato; Takuji Koike
Oral presentation, English, 8th Asian-Pacific Conference on Biomechanics, International conference
16 Sep. 2015

Study of Fetus Hearing Screening Based on Change in Heart Rate and Auditory Revoked Response
Sinyoung Lee; Rina Matsuoka; Katsuhisa Ikeda; Takuya Hashimoto; Takuji Koike
Oral presentation, English, 8th Asian-Pacific Conference on Biomechanics, Sapporo, International conference
16 Sep. 2015

耳科用探針を用いた耳小骨可動性計測装置の開発
高桑加以; 橋本卓弥; 神崎晶; 小池卓二
Oral presentation, Japanese, 日本機械学会2015年度年次大会
14 Sep. 2015

Enhancement of excitation force of new implantable bone-conduction hearing device in low-frequency range
Takuji Koike; Eri Tanaka; Naoki Hayashi; Naohito Hato; Sho Kanzaki
Oral presentation, English, The 7th International Symposium on Middle Ear Mechanics in Research and Otology
01 Jul. 2015

Audiological evaluation of bone-anchored hearing device using giant-magnetostrictive material
Kiyofumi Gyo; Kenji Ikeda; Naohito Hato; Takuji Koike
Oral presentation, English, The 7th International Symposium on Middle Ear Mechanics in Research and Otology, Aalborg
01 Jul. 2015

基底板振動と内有毛細胞膜電位モデルによる蝸牛内機械-電気変換機構の解析
大瀧直也; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第27回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2015

ヒトとコウモリの蝸牛形状の違いが聴覚に及ぼす影響
岡安 真偉雅; 橋本 卓弥; 小池 卓二
Oral presentation, Japanese, 第27回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2015

埋め込み型骨導補聴器の信号伝送効率の改善
田中絵里; 林直輝; 金子渥; 神埼晶; 羽藤直人; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第27回バイオエンジニアリング講演会
09 Jan. 2015

聴性誘発反応を用いた胎児の聴覚検査システムの検討
李信英; 松岡里奈; 池田勝久; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第27回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2015

Simulation of distortion-product optoacoustic emissions (DPOAEs) using finite-element model of human cochlea
Takuji Koike; Hideyuki Mochizuki; Sinyoung Lee
Keynote oral presentation, English, The 2nd Annual Meeting of the Society for Bioacoustics, International conference
2015

Vibration analysis of standing trees using finite element models for insect pest control
Yuncong Ma; Takuji Koike
Poster presentation, English, The 2nd Annual Meeting of the Society for Bioacoustics, International conference
2015

Effects of characteristic cochlear configuration in bats on vibration of basilar membrane
Maia Okayasu; Takuji Koike
Oral presentation, English, The 19th Auditory Research Forum, International conference
13 Dec. 2014

Modeling of Human Active Cochlea Using Finite-Element Method: Simulation of DPOAEs
Nominated symposium, English, Koike T, Mochizuki H, Sakashita T, Inner Ear Biology Workshop, Kyoto, Japan, International conference
04 Nov. 2014

Modeling of Human Active Cochlea Using Finite-Element Method: Simulation of DPOAEs
Koike T; Mochizuki H; Sakashita T
Keynote oral presentation, English, Inner Ear Biology Workshop, International conference
01 Nov. 2014

蝸牛内イオン流動を解析可能な蝸牛モデルの開発
大瀧直也; 横井大介; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第25回バイオフロンティア講演会
03 Oct. 2014

コウモリの特徴的な蝸牛形状が聴覚に及ぼす影響
岡安 真偉雅; 橋本 卓弥; 小池 卓二
Oral presentation, Japanese, 第25回バイオフロンティア講演会, Domestic conference
03 Oct. 2014

骨導補聴器用トランスデューサーにより発生する振動の三次元計測
田中絵里; 林直輝; 神埼晶; 羽藤直人; 橋本卓弥; 小池卓二
Oral presentation, Japanese, 第25回バイオフロンティア講演会, Domestic conference
03 Oct. 2014

Development of semi-implantable bone-conduction hearing aid using giant magnetostrictive material
Takuji Koike; Eri Tanaka; Naoki Hayashi; Takuya Hashimoto; Sho Kanzaki; Naohito Hato
Invited oral presentation, English, The 4th Japan-Switzerland Workshop on Biomechanics, Invited, The 4th Japan-Switzerland Workshop on Biomechanics, The 4th Japan-Switzerland Workshop on Biomechanics, International conference
04 Sep. 2014

Development of semi-implantable bone-conduction hearing aid using giant magnetostrictive material
Takuji Koike; Eri Tanaka; Naoki Hayashi; Takuya Hashimoto; Sho Kanzaki; Naohito Hato
Oral presentation, English, The 4th Japan-Switzerland Workshop on Biomechanics
01 Sep. 2014

外有毛細胞のactivityによる蝸牛増幅機構の数値シミュレーション
望月秀行; 小池卓二
Oral presentation, Japanese, 第26回バイオエンジニアリング講演会, Domestic conference
11 Jan. 2014

中耳腔容積と耳管挙動特性に関する多角的同時計測
佐野拓真; 小池卓二; 新鍋晶浩
Oral presentation, Japanese, 第26回バイオエンジニアリング講演会, Domestic conference
11 Jan. 2014

PVDFフィルムを用いた樹木の振動計測
菅谷章洋; 高梨琢磨; 小池卓二
Oral presentation, Japanese, 第26回バイオエンジニアリング講演会, Domestic conference
11 Jan. 2014

超磁歪素子を用いた埋め込み型骨導補聴器の性能評価～ Bonebridgeとの振動特性比較～
小池卓二; 羽藤直人; 神崎晶
Oral presentation, Japanese, 第23回日本耳科学会学術講演会, Domestic conference
24 Nov. 2013

胎児の聴覚検査システムの開発
大瀧直也; 小池卓二; 松岡理奈; 池田勝久
Oral presentation, Japanese, 第24回バイオフロンティア講演会, Domestic conference
01 Nov. 2013

中耳換気能評価装置を用いた臨床計測
佐野拓真; 小池卓二; 新鍋晶浩
Oral presentation, Japanese, 第24回バイオフロンティア講演会, Domestic conference
01 Nov. 2013

外有毛細胞の能動性を考慮した蝸牛モデルによるDPOAE発生源の推定～DP-gramは何を表しているのか～
小池卓二
Oral presentation, Japanese, 第58回日本聴覚医学会学術講演会, Domestic conference
24 Oct. 2013

コウモリのエコロケーションを模倣した物体接近検知システムの開発
岡安真偉雅; 小池卓二
Oral presentation, Japanese, 日本機械学会2013年度年次大会, Domestic conference
09 Sep. 2013

鼓室換気能評価装置の開発
佐野拓真; 小池卓二; 新鍋晶浩
Oral presentation, Japanese, 日本機械学会2013年度年次大会, Domestic conference
09 Sep. 2013

胎児の聴覚検査を目指した圧電素子による音刺激システム開発のための基礎研究
大瀧直也; 小池卓二; 松岡理奈; 池田勝久
Oral presentation, Japanese, 日本機械学会2013年度年次大会, Domestic conference
09 Sep. 2013

埋め込み型骨導補聴器用経皮信号伝送方法の検討
田中絵里; 田地良輔; 小池卓二; 神崎晶; 羽藤直人
Oral presentation, Japanese, 日本機械学会2013年度年次大会, Domestic conference
09 Sep. 2013

Intraoperative Measurement of Skull Bone Vibration during Mastoidectomy Using an Ultrasonic Bone Curette
Tsukasa Ito; Hideyuki Mochizuki; Tomoo Watanabe; Toshinori Kubota; Takatoshi Furukawa; Takuji Koike; Seiji Kakehata
Oral presentation, English, 146th Annual Meeting AMERICAN OTOLOGICAL SOCIETY, International conference
12 Apr. 2013

Transfer functions of normal and pathologic middle ears - theoretical analysis -
Takuji Koike
Invited oral presentation, English, International Symposium on Middle-Ear Mechanics in Research and Minimally Invasive Otology, Beijing, China, International conference
Apr. 2013

超磁歪素子を利用した埋め込み型骨導補聴器の開発：実使用に近い状態における補聴性能評価
田地良輔; 田中絵里; 小池卓二; 神崎晶; 羽藤直人
Oral presentation, Japanese, 第24回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2013

人工内耳電極挿入時における基底板振動挙動解析
塙慎太郎; 坂下輔; 小池卓二; 熊川孝三
Oral presentation, Japanese, 第24回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2013

非接触型耳小骨可動性計測装置の加振能力評価
山中亮太; 小池卓二
Oral presentation, Japanese, 第24回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2013

PVDFフィルムを用いた中耳手術における体表振動計測
望月秀行; 坂下輔; 小池卓二
Oral presentation, Japanese, 第24回バイオエンジニアリング講演会, Domestic conference
09 Jan. 2013

埋め込み型骨導補聴器の開発：補聴システムの高効率化
大城越美; 田地良輔; 小池卓二; 神崎晶; 羽藤直人
Oral presentation, Japanese, 日本機械学会,第24回バイオエンジニアリング講演会
Jan. 2012

蝸牛の振動挙動シミュレーション：歪成分耳音響放射発生機序の理論的考察
坂下輔; 小池卓二
Oral presentation, Japanese, 日本機械学会,第24回バイオエンジニアリング講演
Jan. 2012

両眼球振動差に着目した内視鏡下副鼻腔手術におけるリスク検知システムの開発
田地良輔; 藤井麻起子; 望月秀行; 小池卓二; 小野倫嗣; 池田勝久
Oral presentation, Japanese, 日本機械学会,第24回バイオエンジニアリング講演会
Jan. 2012

ヒト耳小骨の可動性計測
藤井麻起子; 山中亮太; 小池卓二; 神崎晶v
Oral presentation, Japanese, 日本機械学会,第24回バイオエンジニアリング講演会
Jan. 2012

内耳細胞間イオン流動ネットワークモデルの構築
横井大介; 小池卓二
Oral presentation, Japanese, 日本機械学会,第24回バイオエンジニアリング講演会
Jan. 2012

Modeling of the human cochlea using the finite element method
Takuji Koike; Tasuku Sakashita
Oral presentation, English, Neurosensing and Bionavigation
Dec. 2011

Effects of the shape of the basilar membrane on mechanical frequency discrimination in the cochlea
Takuma Sano; Takuji Koike
Oral presentation, English, The 16th Auditory Research Forum
Dec. 2011

超磁歪素子を用いた埋め込み型骨導補聴器の開発：骨加振方法の違いによる補聴特性比較
田地良輔; 大城越美; 小池卓二; 神埼晶; 羽藤直人
Oral presentation, Japanese, 日本機械学会,第22回バイオフロンティア講演会
Oct. 2011

内耳の振動挙動シミュレーション：人工内耳電極最適挿入位置の検討
塙慎太郎; 坂下輔; 小池卓二; 熊川孝三
Oral presentation, Japanese, 日本機械学会,第22回バイオフロンティア講演会
Oct. 2011

非接触型耳小骨可動性計測装置の開発
山中亮太; 藤井麻起子; 小池卓二; 池田勝久; 神崎晶
Oral presentation, Japanese, 日本機械学会,第22回バイオフロンティア講演会
Oct. 2011

人工内耳電極挿入時の基底板振動シミュレーション：残存聴力の保存を目指して
小池卓二; 熊川孝三
Oral presentation, Japanese, 日本聴覚医学会,第56回日本聴覚医学会
Oct. 2011

体表振動を利用した内視鏡手術リスク低減装置の開発
田地良輔; 藤井麻起子; 小池卓二; 小野倫嗣; 池田勝久
Oral presentation, Japanese, 日本機械学会,日本機械学会2011年度年次大会
Sep. 2011

超磁歪素子を用いた埋め込み型骨導補聴器の開発：遺体加振時における骨表面の振動特性
大城越美; 田地良輔; 小池卓二; 神崎晶; 羽藤直人
Oral presentation, Japanese, 日本機械学会,第3回マイクロ・ナノ工学シンポジウム
Sep. 2011

耳小骨可動性計測装置の開発：PVDFフィルムを用いた小型力センサの開発
藤井麻起子; 山中亮太; 小池卓二; 神崎晶
Oral presentation, Japanese, 日本機械学会,第3回マイクロ・ナノ工学シンポジウム
Sep. 2011

耳小骨可動性計測装置の開発:圧電材料を用いた力センサの開発
藤井麻起子; 小池卓二; 神崎晶
Oral presentation, Japanese, 日本機械学会,第23回バイオエンジニアリング講演会
Jan. 2011

埋め込み型骨導補聴器の開発と評価:経皮伝送コイルの高効率化
大城越美; Dewanda Fadia; 原島立成; 小池卓二
Oral presentation, Japanese, 日本機械学会,第23回バイオエンジニアリング講演会
Jan. 2011

外有毛細胞のactivityを考慮した蝸牛の振動挙動シミュレーション
坂下 輔; 坂本智明; 小池卓二
Oral presentation, Japanese, 日本機械学会,第23回バイオエンジニアリング講演会
Jan. 2011

超磁歪素子を用いた埋め込み型骨導補聴器の開発:遺体埋め込み時における振動子の特性評価
原島立成; 大城越美; 小池卓二; 羽藤直人; 神崎 晶
Oral presentation, Japanese, 日本機械学会,第23回バイオエンジニアリング講演会
Jan. 2011

蝸牛内基底板の過渡応答シミュレーション
横井大介; Isaac Juarez Acosta; 小池卓二
Oral presentation, Japanese, 日本機械学会,第23回バイオエンジニアリング講演会
Jan. 2011

ヒトの外耳・中耳を統合した 3 次元有限要素モデルによる挙動解析
藤原康弘; 小池卓二; Fei Zhao
Oral presentation, Japanese, 日本機械学会,第23回バイオエンジニアリング講演会
Jan. 2011

Effects of a cochlear fistula on the vibration of the basilar membrane: Theoretical analysis
Tasuku Sakashita; Chiaki Sakamoto; Takuji Koike
Oral presentation, English, The 15th Auditory Research Forum
Dec. 2010

超磁歪素子を用いた埋め込み型骨導補聴器の開発
原島立成; 大城越美; 小池卓二; 羽藤直人; 神崎晶
Oral presentation, Japanese, 東京農工大学・電気通信大学合同シンポジウム,第7回東京農工大学・電気通信大学合同シンポジウム
Dec. 2010

残存聴力の保存を目指す人工内耳電極挿入術：ヒト蝸牛モデルを用いた基底板振動シミュレーション
熊川孝三; 武田英彦; 射場恵; 熊谷文愛; 小池卓二
Oral presentation, Japanese, 日本聴覚医学会,第55回日本聴覚医学会学術講演会
Nov. 2010

超磁歪素子を用いた埋め込み型骨導補聴器の開発：埋め込み時における振動子の特性評価
小池卓二; 羽藤直人; 神崎晶
Oral presentation, Japanese, 日本耳科学会,第21回日本耳科学会学術講演会
Nov. 2010

超磁歪素子を用いた埋め込み型骨導補聴器の開発：献体による振動子加振特性評価
小池卓二; 羽藤直人; 神崎晶
Oral presentation, Japanese, 日本耳科学会,第20回日本耳科学会学術講演会
Oct. 2010

埋め込み型骨導補聴器の加振力評価： 頭蓋骨に発生するナノメートルスケール振動の計測
大城 越美; 小池 卓二; 神崎 晶; 羽藤 直人
Oral presentation, Japanese, マイクロ・ナノシンポジウム,第2回マイクロ・ナノシンポジウム
Oct. 2010

内耳の振動挙動シミュレーション：人工内耳装用方法の最適化
坂下 輔; 坂本 智明; 小池 卓二
Oral presentation, Japanese, マイクロ・ナノシンポジウム,第2回マイクロ・ナノシンポジウム
Oct. 2010

耳硬化症患者における耳小骨可動性計測
藤井 麻起子; 小池 卓二; 神崎 晶
Oral presentation, Japanese, マイクロ・ナノシンポジウム,第2回マイクロ・ナノシンポジウム
Oct. 2010

内耳の振動挙動シミュレーション：人工内耳電極最適挿入位置の検討
塙慎太郎; 坂下輔; 小池卓二; 熊川孝三
Oral presentation, Japanese, 日本機械学会,第22回バイオフロンティア講演会
Oct. 2010

超磁歪素子を用いた埋め込み型骨導補聴器の開発：遺体加振時における振動子の周波数特性評価
原島 立成; 小池 卓二; 本間 恭二; 青木 路人; 羽藤 直人; 神崎 晶
Oral presentation, Japanese, 日本機械学会,日本機械学会2010年度年次大会学術講演会
Sep. 2010

有限要素法によるヒト外耳･中耳結合モデルの構築
藤原 康弘; Fei Zhao; 小池 卓二
Oral presentation, Japanese, 日本機械学会,日本機械学会2010年度年次大会学術講演会
Sep. 2010

Comparison of round window and cochleostomy approaches for hearing preservation: Analysis using computational structures technology
Kozo Kumakawa; Chiaki Sakamoto; Takuji Koike
Oral presentation, English, Joint Meeting - IV Consensus in Auditory Implants & VEAONO Instructional Workshop
Jun. 2010

超磁歪素子を利用した埋め込み型骨導補聴器の開発：人体を用いた加振力評価
原島立成; 小池卓二; 本間恭二; 青木路人; 羽藤直人; 神埼 晶
Oral presentation, Japanese, 日本機械学会,第21回バイオエンジニアリング講演会
Jan. 2010

内耳の振動挙動シミュレーション：ライスネル膜が基底板振動に及ぼす影響
坂本智明; 小池卓二; 青木路人; 本間恭二
Oral presentation, Japanese, 日本機械学会,第21回バイオエンジニアリング講演会
Jan. 2010

ムラサキイガイ付着盤形状がプローブによる対物はく離抵抗力に与える影響
島崎賢一; 青木路人; 本間恭二; 小池卓二
Oral presentation, Japanese, 日本機械学会,第21回バイオエンジニアリング講演会
Jan. 2010

Effects of a perilymphatic fistula on the vibration of the basilar membrane
Ken Hayashi; Takuji Koike; Sho Kanzaki; Kaoru Ogawa
Oral presentation, English, Sixth International Symposium on Meniere's Disease and Inner Ear Disorders,Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
2010

異なる再建材料を用いた両側性先天性耳小骨連鎖離断の1例
羽藤直人; 暁清文; 小池卓二
Oral presentation, Japanese, 日本耳科学会,第19回日本耳科学会学術講演会
Oct. 2009

耳硬化症のアブミ骨可動性に関する検討 ―耳小骨可動装置を用いた解析―
神崎晶; 小池卓二; 鈴木隆史; 水足邦雄; 岡本康秀; 大石直樹; 南秀司郎; 渡部高久; 斉藤秀行; 井上泰宏; 湯浅有; 湯浅涼; 和田仁; 小川郁
Oral presentation, Japanese, 日本耳科学会,第19回日本耳科学会学術講演会
Oct. 2009

局所噴霧液の鼻腔内分布
小池卓二; 原島立成; 大城越美
Invited oral presentation, Japanese, 第33回日本医用エアロゾル研究会, 日本医用エアロゾル研究会
Sep. 2009

超磁歪素子を利用した埋め込み型骨導補聴器の加振力評価
小池卓二; 山本顕生; 原島立成; 青木路人; 本間恭二; 羽藤直人; 神崎晶
Oral presentation, Japanese, 日本機械学会,2009年度日本機械学会全国大会
Sep. 2009

ムラサキイガイ付着盤の接着強度の長期的時間変化
青木 路人; 早田 真梨子; 小池 卓二; 本間 恭二
Oral presentation, Japanese, 日本機械学会,2009年度日本機械学会全国大会
Sep. 2009

PVDF フィルムを用いた内視鏡下副鼻腔手術における生体振動情報計測システムの開発
高橋 裕太郎; 原島 立成; 小池 卓二; 青木 路人; 本間 恭二
Oral presentation, Japanese, 日本機械学会,2009年度日本機械学会全国大会
Sep. 2009

アブミ骨－蝸牛連成振動モデルによる基底板振動解析 －骨形成不全症による基底板振動変化－
小池卓二; 林 賢; 小川 郁
Oral presentation, Japanese, 日本聴覚医学会,日本聴覚医学会第６回内耳ひずみ研究会
Jul. 2009

超磁歪素子を利用した埋め込み型骨導補聴器の開発
山本顕生; 小池卓二; 本間恭二; 青木路人; 羽藤直人; 神崎晶
Oral presentation, Japanese, 日本機械学会,第20回バイオエンジニアリング講演会
Jan. 2009

鼓膜加振用軽量コイルを用いた術中聴力検査法の検討
福田康一; 小池卓二; 須納瀬弘; 森川敬之; 村上小百合; 本間恭二
Oral presentation, Japanese, 日本機械学会,第20回バイオエンジニアリング講演会
Jan. 2009

耳小骨可動性計測装置の臨床応用 －患者アブミ骨の可動性計測－
吉田圭祐; 小池卓二; 池田勝久; 小川郁; 村上小百合; 本間恭二; 和田仁
Oral presentation, Japanese, 日本機械学会,第20回バイオエンジニアリング講演会
Jan. 2009

Private Whispering: Moths Produce Quiet Ultrasonic Courtship Songs
Takuma Takanashi; Ryo Nakano; Niels Skals; Takuji Koike; Keisuke Yoshida; Hirotaka Maruyama; Haruki Tatsuta; Jun Tabata; Sadahiro Tatsuki; Annemarie Surlykke; Yukio Ishikawa
Invited oral presentation, English, The 5th Animal Sonar Symposium, Animal Sonar Symposium, International conference
2009

内リンパ水腫による低音障害型難聴の発生機序に関する一考察
小池卓二; 羽藤直人; 暁 清文
Oral presentation, Japanese, 日本耳科学会,2008年度日本耳科学会学術講演会
Oct. 2008

外リンパ瘻の基底板振動シミュレーション
小池卓二; 林 賢; 神崎 晶; 小川 郁
Oral presentation, Japanese, 日本聴覚医学会,第５回内耳ひずみ研究会
Jul. 2008

耳小骨の可動性と聴力の関係 －計測とシミュレーションによる中耳伝音特性の評価－
小池卓二
Invited oral presentation, Japanese, 日本耳鼻咽喉科学会青森県地方部会, 日本耳鼻咽喉科学会
Jun. 2008

アブミ骨－蝸牛連成振動モデルによる基底板振動解析：外リンパ瘻による基底板振動解析
山本宇紘; 小池卓二; 村上小百合; 本間恭二
Oral presentation, Japanese, 日本機械学会,第19回バイオエンジニアリング講演会
Jan. 2008

鼓膜加振用軽量コイルを用いた術中聴力検査法の検討
福田康一; 小池卓二; 須納瀬弘; 森川敬之; 村上小百合; 本間恭二
Oral presentation, Japanese, 日本機械学会,バイオエンジニアリング講演会
Jan. 2008

耳小骨可動性計測装置の臨床応用 －患者アブミ骨の可動性計測－
吉田圭祐; 小池卓二; 池田勝久; 小川郁; 村上小百合; 本間恭二; 和田仁
Oral presentation, Japanese, 日本機械学会,バイオエンジニアリング講演会
Jan. 2008

正円窓の可動性が聴力に及ぼす影響：ヒト蝸牛モデルによる基底板振動シミュレーション
小池卓二
Oral presentation, Japanese, 日本聴覚医学会,2007年度日本聴覚医学会学術講演会
Oct. 2007

アブミ骨振動様式が聴力に及ぼす影響：アブミ骨―蝸牛連成振動モデルによる基底板振動シミュレーション
小池卓二
Oral presentation, Japanese, 日本耳科学会,2007年度日本耳科学会学術講演会
Oct. 2007

騒音環境下で使用可能な情報通信デバイスの開発～騒音環境再現システムの構築と騒音環境下の外耳道内音圧計測～
高橋紀成; 高橋裕太郎; 小池卓二; 村上小百合; 本間恭二
Oral presentation, Japanese, 日本機械学会,2007年度年次大会
Sep. 2007

小型圧電素子埋め込み型補聴器開発のための基礎研究
鈴木晃; 小池卓二; 村上小百合; 本間恭二
Oral presentation, Japanese, 日本機械学会,バイオエンジニアリング講演会
Jan. 2007

アブミ骨‐蝸牛連成振動モデルによる聴覚器微小振動様式の解明
五味田愼一; 小池卓二; 村上小百合; 本間恭二
Oral presentation, Japanese, 日本機械学会,バイオエンジニアリング講演会
Jan. 2007

骨入力音が蝸牛に到達する経路の周波数依存性
鈴木 晃; 小池 卓二; 本間 恭二; 村上小百合
Oral presentation, Japanese, 日本機械学会,第16回バイオフロンティア講演会
Nov. 2005

開放耳管の変形挙動における個人差の影響 －有限要素法モデルによる解析－
五味田愼一; 小池卓二; 本間恭二; 村上小百合; 小林俊光
Oral presentation, Japanese, 日本機械学会,第16回バイオフロンティア講演会
Nov. 2005

耳小骨可動性計測装置の開発―レーザードップラ振動計による計測結果との比較評価―
篠崎真希; 小池卓二; 本間恭二
Oral presentation, Japanese, 日本機械学会,2005年度日本機械学会全国大会
Sep. 2005

電磁力を利用した低侵襲植え込み型補聴器の開発
添田晃弘; 小池卓二; 本間恭二
Oral presentation, Japanese, 日本機械学会,日本機械学会 2005年度年次大会
Sep. 2005

骨加振時に発生する外耳道内音圧が音の知覚に及ぼす影響
鈴木 晃; 小池 卓二; 本間 恭二
Oral presentation, Japanese, 日本機械学会,2005年度日本機械学会全国大会
Sep. 2005

咽頭圧変化による開放耳管の変形挙動解析
五味田愼一; 小池卓二; 本間恭二; 村上小百合; 小林俊光
Oral presentation, Japanese, 日本機械学会,2005年度日本機械学会全国大会
Sep. 2005

骨導入力音の伝達経路の解明
鈴木 晃; 小池 卓二; 本間 恭二
Oral presentation, Japanese, 日本機械学会,日本機械学会関東支部第11期総会講演会
Mar. 2005

耳小骨可動性診断装置の開発と臨床検査シミュレーション
小池卓二; 篠崎真希; 本間恭二; Saumil N. Merchant; 和田 仁
Oral presentation, Japanese, 日本機械学会,第17回バイオエンジニアリング講演会
2005

Development of an Electromagnetic Hearing Aid using Lightweight Coils to Vibrat the Ossicles
Takuji Koike; Shinji Hamanishi; Toshimitsu Kobayashi, Richard; L. Goode; Hiroshi Wada
Invited oral presentation, English, The 18th International Congress on Acoustics, Kyoto, Japan, International conference
2004

臨床医学基礎Ⅱ
農工大

臨床医学基礎Ⅱ
農工大

大学院技術英語
The University of Electro-Communications

生体計測工学特論
The University of Electro-Communications

物理学概論第二
The University of Electro-Communications

機械力学および演習
The University of Electro-Communications

生体システム工学
The University of Electro-Communications

Advanced Bioinstrumentation Engineering
The University of Electro-Communications

Dynamics of Machinery, Theory and Practice
The University of Electro-Communications

Bio-Systems Engineering
The University of Electro-Communications

Physics Ⅰ
The University of Electro-Communications

物理学概論第一
電気通信大学

機械力学および演習
The University of Electro-Communications

機械力学および演習
電気通信大学

物理学概論第二
The University of Electro-Communications

物理学概論第二
電気通信大学

生体システム工学
The University of Electro-Communications

生体システム工学
電気通信大学

生体計測工学特論
The University of Electro-Communications

生体計測工学特論
電気通信大学

大学院技術英語
The University of Electro-Communications

大学院技術英語
電気通信大学

The Japanese Rhinologic Society

Society of Biomechanisms Japan

Association for Research in Otolaryngology

Japan Audiology Society

The Japan Otological Society

Japanese Society of Otorhinolaryngology Head and Neck Surgery

Acoustical Society of Japan

The Japan Society of Mechanical Engineers

近赤外蛍光検査システムを応用した新しい嚥下機能評価に関する基礎的研究
吉見 佳那子; 小池 卓二; 道脇 幸博; 西村 吾朗; 戸原 玄; 中川 量晴
日本学術振興会, 科学研究費助成事業, 東京医科歯科大学, 基盤研究(C), 本年度は、まず、蛍光計測法の有用性評価のための予備実験を実施した。 牛肉ブロックとバルーンカテテールを用いてヒトの咽頭の梨状窩を再現し作成したファントムと、ヤギの頭頸部標本を使用した。実験項目は、①近赤外線ファイバおよび蛍光検出ファイバを取り付けたプローブの頚部への照射角の設定、②咽頭通過する食物中の蛍光を計測可能な蛍光強度積算時間の設定、③咽頭残留を計測する最適スパンの検討、である。その結果、①光プローブと頚部の接触角度が蛍光強度可否に大きく影響すること、②嚥下時に食塊が咽頭を通過する速度での蛍光検出は深さ25mmまでは可能であること、③最適スパンは10mmから20mmであること、がわかった。 また、人を対象とした計測では蛍光計測と嚥下造影検査を同時に実施する予定であったため、ICG入り検査食に硫酸バリウムやとろみ剤を混和した場合に、蛍光強度に影響するか調査した。その結果、混和前と比較し混和後は蛍光強度が大きくなる傾向が見られたが、検査自体には支障はないことがわかった。 予備実験終了後、実際に嚥下障害患者を対象とし計測を実施した。対象は、東京医科歯科大学病院摂食嚥下リハビリテーション外来を受診する嚥下障害患者4名である。嚥下時の蛍光計測および嚥下造影検査を同時に実施し、得られた蛍光強度と検査画像を対応させた。その結果、咽頭残留、咽頭通過の蛍光検出が可能であった。一方で、プローブの接触位置や接触強さが検出精度に影響するため、プローブ形態やセンサの感度を改良し、検査手技の簡易化と検出精度向上を検討する必要があることが示唆された。, 20K12741
01 Apr. 2020 - 31 Mar. 2023

Development of technologies for pest management and crop cultivation based on vibrational responses in pest insects and crops
Takanashi Takuma
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Forest Research and Management Organization, Grant-in-Aid for Scientific Research (C), Vibrational technologies applied to crop protection and cultivation are presented. Because vibrations modify behaviors in insect pests of tomatoes and mushrooms, vibrations can be exploited for physical pest management. In addition, vibrations promote pollination in tomatoes. Indeed, we revealed that vibrations decreased infestation of whitefly pests and increased yields of tomatoes in greenhouses installed with vibration exciters., 19KT0040
17 Jul. 2019 - 31 Mar. 2022

Hair bundle formation and tonotopy in genetic hearing loss models and the iPS cells
kamiya kazusaku
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Juntendo University, Grant-in-Aid for Scientific Research (B), Recently, abnormalities in frequency discrimination have been observed in some patients with abnormal sound perception, but the cause of these abnormalities is unknown and there are no objective diagnostic criteria. We reported the mice with abnormal frequency discrimination and confirmed the predicted abnormal propagation of basal menbrane vibration from basal (high frequency) to apical (low frequency) rotation. We further elucidated the possible causes of this abnormality by simulating the cochlear model and suggested the possiblity that high frequency hearing loss model abnormally recognize the sound as a low frequency sound. Furthermore, by developing a technology to generate cochlear cells from iPS cells, they were able to reproduce the pathophysiology of hearing loss and succeeded in generating hair cells using the same method, which is expected to lead to clinical applications of inner ear cell therapy in the future., 18H02953
01 Apr. 2018 - 31 Mar. 2022

Study of noninvasive aspiration detection using fluorescence food
YAMADA YUKIO
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, The University of Electro-Communications, Grant-in-Aid for Challenging Research (Exploratory), For the purpose of evaluating pulmonary aspiration, we have developed a technology to inspect food residue in the piriform sinus noninvasively and easily. When fluorescence food is remained in the piriform sinus, it can be detected by an optical probe attached to the skin for measuring fluorescence emitted from the food. Selection of fluorescence agent emitting near-infrared light with high penetration depth, development of an instrument having high sensitivity to near-infrared fluorescence as well as an optical probe, preliminary experiments using phantoms, and measurements for healthy elderly subjects were conducted. It was confirmed that fluorescence from the depth of about 25 mm was detectable, and fluorescence from fluorescence food remained in the piriform sinus of healthy elderly subjects were detected. Consequently, we have established the fundamental technology for inspecting food residue in the piriform sinus noninvasively and easily., 18K18448
29 Jun. 2018 - 31 Mar. 2021

生物の振動応答性を活用した害虫防除ならびに作物栽培促進法の開発
積水化学財団, 積水化学 自然に学ぶものづくり
Oct. 2019 - Oct. 2020

蝸牛詳細構造モデルによる音響振動および電気現象の解明と臨床へのフィードバック
小池卓二
Principal investigator
01 Apr. 2017 - 31 Mar. 2020

磁歪クラッド鋼による新しいアクチュエータデバイスの開発
東北特殊鋼株式会社
Jul. 2019 - Mar. 2020

基質伝導音を利用した害虫防除および受粉技術の開発
小池卓二
一般財団法人カワイサウンド技術・音楽振興財団, 研究助成, Principal investigator
10 Apr. 2018 - 31 Mar. 2019

術中計測デバイスと新医療データ群に基づく聴覚障害の診断・治療支援システムの開発
中小企業庁, 中小企業経営支援等対策補助金
2017 - 2018

持続可能な農業生産のための新たな総合的植物保護技術の開発
2014 - 2018

携帯型音楽プレーヤーによる無意識下の過大音刺激による蝸牛障害危険性の定量的評価
伊藤麻美
01 Apr. 2015 - 31 Mar. 2017

Measurement of Doppler blood flow velocity in middle cerebral artery induced by sound stimulation in human fetuses
KASAI Misato; MATSUOKA Rina; KOIKE Takuji
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Juntendo University, Grant-in-Aid for Young Scientists (B), We developed a device for fetal auditory stimulus. Auditory signals generated by the function generator are amplified by the piezo-driver, and are input into the piezo-electric vibrator. The piezo-electric vibrator is placed on a pregnant-woman's abdominal surface facing towards the fetal head, and the vibration stimulus produced by the system reaches the fetus though the amniotic fluid. Prenatal Hearing Screening was applied to 30 healthy women in the period of 27 to 33 weeks gestational age. Burst tones were delivered though the piezo-electric device at an intensity of 75dB, frequency of 1000Hz, 2000Hz and 4000Hz. Brain circulation changes caused by the sound stimulation are registered in the middle cerebral artery. The changes in the pulsatility index (PI) of the fetal middle cerebral artery before and after sound exposure were measured by a Doppler ultrasound device. PI gradually decreased a time progressed. The change of the PI- induced sound stimulation was marked at 2000Hz., 26750167
01 Apr. 2014 - 31 Mar. 2017

中高度難聴者への超磁歪素子を用いた埋め込み型骨導人工中耳の開発
羽藤直人
2013 - 2016

中高度難聴者への超磁歪素子を用いた埋め込み型骨導人工中耳の開発
羽藤直人
2013 - 2016

能動的基底板振動と蝸牛内イオン流動の相互作用を解析可能な蝸牛モデル開発と臨床応用
小池卓二
Principal investigator
01 Apr. 2013 - 31 Mar. 2015

カミキリムシにおける基質付着の制御機構の解明
2014 - 2015

Development of air-bone hybrid typed hearing aids
KOMIYA Hisashi; KOIKE Takuji; IKEDA Katuhisa
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Juntendo University, Grant-in-Aid for Young Scientists (B), 骨加振デバイスのみを用いて,低域では外耳道内に発生する音波による気導補聴を,高域では骨導による補聴を行なうハイブリッド補聴器を開発した。試作した気導骨導ハイブリッド型補聴器を用いて,健聴者を被験者とした性能評価実験を行った.気導骨導ハイブリッド型補聴器のプロトタイプを複数作成し,難聴患者に日常生活の中で試用させ,問題点の発見および改良を行った., 19791236
2007 - 2008

神経栄養因子分泌細胞の蝸牛内導入による老人性難聴の治療・予防戦略
東海林 史; 千葉 敏彦; 小池 卓二; 池田 勝久; 吉田 尚弘
日本学術振興会, 科学研究費助成事業, 東北大学, 基盤研究(C), 従来、積極的な治療法がなく、その聴覚障害に対しては補聴器などにたよらざるをえなかった老人性難聴に対する新たな治療戦略の可能性1つとして、加齢による聴覚系の変性の神経栄養因子遺伝子導入による軽減が考えられる。今回は、モルモットを用い、線維芽細胞に神経栄養因子を永久的に発現させることができるか、また、遺伝子導入された細胞の蝸牛内への移植により老化変性を防止するかができるか否かを検討する目的で、以下の研究を実施した。 1 モルモット線維芽細胞への遺伝子永久発現の試み 臨床の老人性難聴の治療を考慮すると、遺伝子の永久発現が必須となる。今回は、ベクターとしてクロンテック社のpIREShrGFPをもちい、これにネオマイシン耐性遺伝子を選択マーカーとして導入し、個々のモルモットより採取した繊維芽細胞に永久的に遺伝子発現させるよう試みた。 2 レポータージーンを用いた細胞移植実験 さらに、老人性難聴の退行変性に対し、遺伝子を長期に安定的に発現させるため、蝸牛内に移植した線維芽細胞を長期に生存させる方法、すなわち、外リンバ内移植、あるいは内リンパ内移植をGFPによる蛍光をレポーターとして検討した。 現在までのところ、上記条件下の実験では、恒常的に永久的遺伝子発現を認めるには至らなかった。臨床応用を考えた治療戦略上、確実な遺伝子発現が必要となるであろう。, 14571604
2002 - 2003

Development of the program for analysis of the dynamic behavior of the organ of Corti
WADA Hiroshi; KOIKE Takuji; KAWASE Tetsuaki
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Tohoku University, Grant-in-Aid for Scientific Research (B), The organ of Corti (OC) in the cochlea transforms sounds into action potentials in auditory nerve fibers. As the extreme vulnerability to trauma exhibited by the cochlea prevents the experimental observation that could confirm the inherence in this process, the two-dimensional finite-element model of the OC was constructed. Using this model, the dynamic behavior of the OC was analyzed. As the DC is immersed in lymph fluid, the interaction between the OC and the lymph fluid must be taken into account when the dynamic behavior of the OC and fluid pressure distribution are numerically analyzed. However, the complex structure of the OC and the large difference in material properties between the fluid and the structure of the OC complicate modeling of the lymph-OC interaction using commercially available FEN applications. Therefore, the original program was developed to consider the fluid-structure interaction. When a fluid pressure fluctuation is induced by vibration of the stapes, two types of pressure waves occur in the cochlea. As the OC is driven by these pressure waves, it is important to understand their frequency characteristics. However, there have been no reports on empirical observations of these waves, because of the difficulty of measuring them independently. Using the model, the magnitude and phase of the fast and slow waves were predicted so as to fit the numerically obtained pressure distribution in the scala tympani with that of the intracochlea pressure measurement. Next, the dynamic behavior of the OC was analyzed when these predicted pressures were applied to the OC. The following conclusions can be drawn: 1. The magnitude of the fast wave increases with increasing frequency for the entire frequency range. The magnitude of the slow wave increases gradually with increasing frequency until it reaches a maximum at the characteristic frequency (CF), and it then falls sharply. 2. The OC shows a rotational movement around the end of the modiolus side of the basilar membrane., 13557142
2001 - 2002

可動性評価システム
Patent right, 特願2017-135735, Date applied: 11 Jul. 2017, The University of Electro-Communications, 特許7036309, Date issued: 07 Mar. 2022

振動を用いた害虫の行動制御により植物を保護する方法
Patent right, 高梨 琢磨, 向井 裕美, スカルス ニールス, 小池 卓二, 松井 康浩, 上地 奈美, 福井 修二, 舟木 宏, 立田 晴記, 栗山 賢門, 特願2016-244162, Date applied: 16 Dec. 2016, 森林総合研究所, 特許第6849186号, Date issued: 08 Mar. 2021

検出装置、検出方法、及び検出器
Patent right, 山田 幸生, 西村 吾朗, 丹羽 治樹, 牧 昌次郎, 道脇 幸博, 小池 卓二, 鈴木 祟弘, 田代 剛大, 特願2020-123183, Date applied: 17 Jul. 2020

中耳伝音特性評価システム、中耳伝音特性評価方法、および計測プローブ
Patent right, 小池 卓二, 入江 優花, 神崎 晶, 徐 世傑, 肥後 武展, 林 正晃, 特願2018-142976, Date applied: 30 Jul. 2018, 国立大学法人電気通信大学，第一医科株式会社，学校法人慶應義塾，有限会社メカノトランスフォーマ，株式会社リーデンス, 特許第6596141, Date issued: 04 Oct. 2019

中耳伝音特性評価システムおよび中耳伝音特性評価方法
Patent right, 特願2018-142976, Date applied: 30 Jul. 2018

可動性評価システムおよび可動性評価方法
Patent right, 小池卓二, PP01166PCT, Date applied: 31 Jan. 2017

振動を用いた害虫の行動制御により植物を保護する方法
Patent right, 高梨琢磨, 小池卓二, 松井康浩, 上地奈美, 立田晴記, 栗山賢門, 福井修二, 舟木宏, 向井裕美, スカルスニールス, 宇賀博之, 特願2016-244162, Date applied: 16 Dec. 2016, 森林総合研究所

マイクロホン装置
Patent right, プラサドラジキショール, 小池卓二, 高橋紀成, 松野文俊, 特願2008-025379, Date applied: 2008, 特許第5391374号, Date issued: 25 Oct. 2013

EMBEDDED AUDIPHONE
Patent right, 小池 卓二, 山本 顕生, 羽藤 直人, PCT/JP2009/066709, Date applied: 2009, 米国特許8,520,867号, Date issued: 27 Aug. 2013

埋込み型骨導補聴器
Patent right, 小池 卓二, 山本 顕生, 羽藤 直人, 特願2008-246342, Date applied: 2008, 特許第5219037号, Date issued: 15 Mar. 2013

振動により害虫を防除する方法
Patent right, 高梨 琢磨, 大村 和香子, 大谷 英児, 久保島 吉貴, 森 輝夫, 小池 卓二, 西野 浩史, 13/394,892, Date applied: 08 Sep. 2010, US2012/167826A1, Date announced: 05 Jul. 2012

振動により害虫を防除する方法
Patent right, 高梨 琢磨, 大村 和香子, 大谷 英児, 久保島 吉貴, 森 輝夫, 小池 卓二, 西野 浩史, 2010293497, Date applied: 08 Sep. 2010, AU2010293497, Date announced: 22 Mar. 2012

振動により害虫を防除する方法
Patent right, 高梨 琢磨, 大村 和香子, 大谷 英児, 久保島 吉貴, 森 輝夫, 小池 卓二, 西野 浩史, PCT/JP2010/065398, Date applied: 08 Sep. 2010, WO2011/030783A1, Date announced: 17 Mar. 2011

振動により害虫を防除する方法
Patent right, 高梨琢磨, 小池卓二, 西野浩史, 特願 2009-208413, Date applied: 2009, 森林総合研究所，電気通信大学，北海道大学

埋め込み型骨導補聴器
Patent right, 小池卓二, 羽藤直人, 山本顕生, PCT/JP2009/066709, Date applied: 2009, The University of Electro-Communications

狭い空間で使用可能な力-変位計測システム
Patent right, 小池卓二, 和田 仁, 小林俊光, 湯浅 涼, 特願2004-326931, Date applied: 10 Nov. 2004, The University of Electro-Communications

微量薬品の温度調整および注入機構
Patent right, 小池卓二, 特願2004-326925, Date applied: 10 Nov. 2004, The University of Electro-Communications

補聴システム及び補聴方法
Patent right, 小池卓二, 和田 仁, 小林俊光, -, Date applied: 24 Jul. 2002, 東北大学長, 特開2004-064141

耳科領域における診断・治療に関する医工連携研究：工学的視点から見た聴覚器の仕組みと医療機器開発
Lecturer, 東京理科大学, 第 9 回パラレル脳研究部門勉強会・セミナー, Seminar
30 Jan. 2023

振動でトマトの害虫防除！？～安心・安全な農業生産につながる農業技術の開発～
Other than myself, 生研支援センターBRAINChannel, 生研支援センターBRAINChannel, Internet
Sep. 2023

イヤホン難聴を防ぐには？ 騒音抑制機能付き 奨励
Other than myself, 読売新聞, Paper
Apr. 2023

イヤホン難聴 全世界で１１億人の若者にリスク…防ぐにはどうする？
読売新聞, 読売新聞オンライン
Apr. 2023

振動によるトマトの害虫防除
日経BP, 日経トレンディ, Paper
Jan. 2023

農林水産省「2022年農業技術10大ニュース」振動でトマト害虫を防除－コナジラミ類の発生抑制・トマトの授粉促進による安定生産へ－
農林水産省, Internet
Dec. 2022

難聴リスクにノイズキャンセリング機能が有用、地下鉄騒音下のイヤホン音楽聴取で実験
大学ジャーナル ON LINE, Internet
Apr. 2022

Middle ear measurement and AI-based diagnosis
Competition etc, Panel chair etc, EES 2022 4th World Congress on Endoscopic Ear Surgery, 06 Dec. 2022