Makiko TANAKA
| Department of Engineering Science | Associate Professor |
| Cluster III (Fundamental Science and Engineering) | Associate Professor |
Researcher Information
Research Keyword
Career
- Feb. 2021 - Present
電気通信大学大学院情報理工学研究科, 准教授 - Feb. 2016 - Jan. 2021
電気通信大学大学院情報理工学研究科, 助教 - Apr. 2013 - Jan. 2016
日本学術振興会特別研究員（RPD） - Jul. 2012 - Mar. 2013
筑波大学, 博士研究員 - Apr. 2010 - Jun. 2012
日本大学工学部, 博士研究員 - Apr. 2007 - Mar. 2010
日本学術振興会特別研究員（PD） - Sep. 2007 - Mar. 2009
カリフォルニア工科大学, 博士研究員（学振海外渡航） - Apr. 2005 - Mar. 2007
日本学術振興会特別研究員（DC2）
Research Activity Information
Award
- Sep. 2024
第18回バイオ関連化学シンポジウム
Organic & Biomolecular Chemistry 賞, 牧野 哲直;田仲 真紀子 - Jul. 2024
第35回 生体機能関連化学部会若手の会
Chemistry Letters Young Scientist Award, 牧野 哲直;田仲 真紀子 - Oct. 2023
第13回CSJ化学フェスタ2023
優秀ポスター発表賞, 牧野 哲直;田仲 真紀子 - Mar. 2006
日本化学会第86春季年会学生講演賞 - Jan. 2005
The 5th International 21 Century COE Symposium on Integrated EcoChemistry ポスタープレゼンテーション賞
Paper
- Fibers and Double‐Layered Tubes Formed From a Single Self‐Complementary DNA Oligonucleotide
So Shirai; Tetsunao Makino; Takashi Kajitani; Makiko Tanaka
Last, Angewandte Chemie International Edition, Wiley, e6741643, 23 Jun. 2026, Peer-reviwed, ABSTRACT
This study reports the first observation that a short self‐complementary DNA oligonucleotide can self‐assemble into two distinct liquid‐crystalline architectures—long fibers and double‐layered molecular tubes—upon thermal annealing. These two morphologies are determined by depletion forces tuned by the concentration of poly(ethylene glycol) (PEG) in solution. At lower PEG concentrations (25–30 w/v %), the depletion forces between duplexes are relatively weak. Under these conditions, nucleation occurs only at lower temperatures after sufficient duplex DNA has formed, leading to predominantly longitudinal growth and the formation of elongated DNA fibers. Small‐angle X‐ray scattering (SAXS) revealed a single columnar hexagonal packing structure within these fibers. At higher PEG concentrations (35–40 w/v %), the depletion forces become stronger. Under these conditions, nucleation occurs even at elevated temperatures, where the amount of duplex is still limited, leading to the formation of tubular assemblies. SAXS measurements conducted on the tubular DNA assemblies revealed two separate hexagonal lattice constants, suggesting differences in packing density between the inner core and the outer framework. This work establishes a new direction in DNA‐based materials design, demonstrating that hierarchical liquid‐crystalline architectures can emerge from a single short DNA oligonucleotide simply by tuning molecular crowding conditions.
Scientific journal - Hierarchical assembly of short double-stranded DNA in a molecularly crowded environment
Makiko Tanaka; Tetsunao Makino
Lead, Chemistry Letters, Oxford University Press (OUP), 54, 7, upaf128, 01 Jul. 2025, Peer-reviwed, Invited, Abstract
Double-stranded DNA (dsDNA) formed a liquid crystalline phase under molecularly crowded conditions. A single type of short dsDNA having 2-base overhangs spontaneously self-assembled into microsized hexagonal platelets in a solution containing poly(ethylene glycol) and salt. Remarkably, combining 2 dsDNAs of different lengths resulted in stepwise assembly formation, with the overhangs modulating the overall morphology by altering the growth direction.
Scientific journal - Controlling the Hierarchical Assembly of DNA-Based Hexagonal Microstructures.
Tetsunao Makino; Takashi Kajitani; Makiko Tanaka
Last, Small (Weinheim an der Bergstrasse, Germany), e2410243, 23 Dec. 2024, Peer-reviwed, True, This paper discusses the controlled morphology of hierarchical liquid crystalline DNA assemblies. Through a process of heating and slow cooling, double-stranded DNAs (dsDNAs) having 23 complementary bases and two base overhangs (a pair of 25mer oligonucleotides) spontaneously assemble into micro-sized hexagonal platelets in a solution containing poly(ethylene glycol) (PEG) and salt. Remarkably, the addition of a shorter dsDNA with AA/TT overhangs (a pair of 18mer oligonucleotides) to a PEG-salt solution of 25mer DNA with AA/TT overhangs results in the formation of molecular tubes, each with a central blockage. In contrast, the addition of 18mer DNA with GG/CC overhangs leads to the formation of hexagonal frames from hexagonal platelets. In the assemblies, 18mer DNA is more predominant at the edges, while the central nuclei are composed of 25mer DNA. X-ray scattering measurements reveal that both molecular tubes and hexagonal frames form hexagonal columnar liquid crystalline assemblies. These self-assemblies are thought to result from depletion attraction due to PEG and end-to-end stacking between dsDNA overhangs. Differences in the melting temperatures between longer and shorter dsDNAs enable the stepwise formation of hierarchical assemblies, while variations in overhang sequences modulate the overall morphology by altering the growth direction of the assemblies.
Scientific journal, English - Various Forms of Self-Assembled DNA and Their Properties
Tetsunao Makino; Makiko Tanaka
Last, Accounts of Materials & Surface Research, 8, 2, 107-115, Jun. 2023, Peer-reviwed, Invited - Self-assembled micro-sized hexagons built from short DNA in a crowded environment
Tetsunao Makino; Daisuke Nakane; Makiko Tanaka
Last, ChemBioChem, Wiley-VCH, 23, e202200360, Oct. 2022, Peer-reviwed
Scientific journal, English - Evaluation of DNA-mediated electron transfer using a hole-trapping nucleobase under crowded conditions
Yuuki Taketomi; Yuuki Yamaguchi; Shunsuke Sakurai; Makiko Tanaka
Last, Organic & Biomolecular Chemistry, 20, 2043-2047, 10 Mar. 2022, Peer-reviwed
Scientific journal, English - Guanine damage by singlet oxygen from SYBR Green I in liquid crystalline DNA
Sakurai, S; Jo, K; Kinoshita, H; Esumi, M; Tanaka, M
Last, Organic & Biomolecular Chemistry, Royal Society of Chemistry, 18, 7183-7187, 04 Sep. 2020, Peer-reviwed
Scientific journal, English - Effect of spermidine on guanine decomposition via photoinduced electron transfer in DNA
Mayu Esumi; Shunsuke Sakurai; Makiko Tanaka
Last, Organic & Biomolecular Chemistry, Royal Society of Chemistry, 18, 47-51, Jan. 2020, Peer-reviwed
Scientific journal, English - Drastic promotion of guanine oxidation via electron transfer in Ψ-type DNA
Shunsuke Sakurai; Mayu Esumi; Makiko Tanaka
Last, Chemical Communications, 55, 7695-7698, Jun. 2019, Peer-reviwed
Scientific journal, English - Attenuation of guanine oxidation via DNA-mediated electron transfer in crowded environment using small cosolutes
Makiko Tanaka; Takayuki Matsumoto; Hiroki Iida
Lead, Organic & Biomolecular Chemistry, Royal Society of Chemistry, 16, 6695-6702, Sep. 2018, Peer-reviwed
Scientific journal, English - Effects of molecular-crowding on electron transfer and oxidative damage in pyrene-modified oligonucleotides
Makiko Tanaka; Hiroki Iida; Takayuki Matsumoto
Lead, Chemistry Letters, Chemical Society of Japan, 47, 1, 62-64, 2018, Peer-reviwed
Scientific journal, English - Ribonuclease A as Effective Promoter for Unimolecular Invasion of Peptide Nucleic Acid to Double-stranded DNA
Makiko Tanaka; Narumi Shigi; Makoto Komiyama
Lead, CHEMISTRY LETTERS, 45, 7, 767-769, Jul. 2016, Peer-reviwed
Scientific journal, English - Thiazole orange-conjugated peptide nucleic acid for fluorescent detection of specific DNA sequences and site-selective photodamage
Makiko Tanaka; Narumi Shigi; Jun Sumaoka; Makoto Komiyama
Lead, RSC ADVANCES, 4, 108, 63533-63538, 2014, Peer-reviwed
Scientific journal, English - Fluorometric detection of adenine in target DNA by exciplex formation with fluorescent 8-arylethynylated deoxyguanosine
Yoshio Saito; Kenji Kugenuma; Makiko Tanaka; Azusa Suzuki; Isao Saito
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 11, 3723-3726, Jun. 2012, Peer-reviwed
Scientific journal, English - Enhancement of fluorescence quenching and exciplex formation in DNA major groove by double incorporation of modified fluorescent deoxyuridines
Makiko Tanaka; Kazuhiro Oguma; Yoshio Saito; Isao Saito
Lead, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 12, 4103-4105, Jun. 2012, Peer-reviwed
Scientific journal, English - Drastic enhancement of excess electron-transfer efficiency through DNA by inserting consecutive 5-phenylethynyl-2 '-deoxyuridines as a modulator
Makiko Tanaka; Kazuhiro Oguma; Yoshio Saito; Isao Saito
Lead, CHEMICAL COMMUNICATIONS, 48, 75, 9394-9396, 2012, Peer-reviwed
Scientific journal, English - Stabilization of DNA duplex by 2-substituted adenine as a minor groove modifier
Makiko Tanaka; Ryota Kozakai; Yoshio Saito; Isao Saito
Lead, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 23, 7021-7024, Dec. 2011, Peer-reviwed
Scientific journal, English - Synthesis of environmentally sensitive 2 '-deoxyguanosine containing solvatochromic pyrene fluorophore
Yoshio Saito; Yuta Shinohara; Shinya Ishioroshi; Azusa Suzuki; Makiko Tanaka; Isao Saito
TETRAHEDRON LETTERS, 52, 18, 2359-2361, May 2011, Peer-reviwed
Scientific journal, English - Design and application of novel nucleobase analogs as an environmentally sensitive probe.
Tanaka, M; Oguma, K; Kozakai, R; Kugenuma, K; Saito, Y; Saito, I
Lead, The 33th Annual Meeting of the Japanese Society for Photomedicine and Photobiology, 33, 47-48, 2011
Symposium, English - DNA-Mediated Electron Transfer in Naphthalene-Modified Oligonucleotides
Makiko Tanaka; Benjamin Elias; Jacqueline K. Barton
Lead, JOURNAL OF ORGANIC CHEMISTRY, 75, 8, 2423-2428, Apr. 2010, Peer-reviwed
Scientific journal, English - Intermolecular vs. intramolecular photoinduced electron transfer from nucleotides in DNA to acridinium ion derivatives in relation with DNA cleavage
Makiko Tanaka; Kazusa Yukimoto; Kei Ohkubo; Shunichi Fukuzumi
Lead, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 197, 2-3, 206-212, Jun. 2008, Peer-reviwed
Scientific journal, English - DNA cleavage induced by photoiffadiation of coenzyme B-12 and organocobaloximes without dioxygen
Makiko Tanaka; Kei Ohkubo; Shunichi Fukuzumi
Lead, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 197, 1, 94-100, Jun. 2008, Peer-reviwed
Scientific journal, English - π-complex formation between a bisporphyrin and acridinium ion and the photodynamics
Makiko Tanaka; Kei Ohkubo; Claude P. Gros; Roger Guilard; Shunichi Fukuzumi
Lead, ECS Transactions, 2, 12, 167-176, 2007, Peer-reviwed
International conference proceedings, English - Persistent electron-transfer state of a pi-complex of acridinium ion inserted between porphyrin rings of cofacial bisporphyrins
Makiko Tanaka; Kei Ohkubo; Claude P. Gros; Roger Guilard; Shunichi Fukuzumi
Lead, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128, 45, 14625-14633, Nov. 2006, Peer-reviwed
Scientific journal, English - Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen
Makiko Tanaka; Kei Ohkubo; Shunichi Fukuzumi
Lead, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128, 38, 12372-12373, Sep. 2006, Peer-reviwed
Scientific journal, English - DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes
Makiko Tanaka; Kei Ohkubo; Shunichi Fukuzumi
Lead, JOURNAL OF PHYSICAL CHEMISTRY A, 110, 38, 11214-11218, Sep. 2006, Peer-reviwed
Scientific journal, English - Photodynamics in Various Complexes between Acridinium Ion and Freebase, Monozinc and Zinc Bisporphyrins.
Tanaka, M; Ohkubo, K; Gros, C. P; Guilard, R; Fukuzumi, S
Lead, Journal of Porphyrins and Phthalocyanines, 10, 892-892, 2006
Symposium, English - Effects of DNA on driving force dependence of photoinduced electron transfer from the excited state of tris(2,2-bipyridine)ruthenium(II) to intercalators in DNA distinction between intra- and inter-DNA pathways
S Fukuzumi; M Tanaka; M Nishimine; K Ohkubo
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 175, 2-3, 79-88, Oct. 2005, Peer-reviwed
Scientific journal, English - Phase transition in photo-absorbing single microemulsion droplets during the laser photophoretic migration
Hideaki Monjushiro; Makiko Tanaka; Hitoshi Watarai
Proceedings of SPIE - The International Society for Optical Engineering, 5930, 1-11, 2005
International conference proceedings, English - Laser photophoretic migration with periodic expansion-contraction motion of photo-absorbing microemulsion droplets in water
M Tanaka; H Monjushiro; H Watarai
Lead, LANGMUIR, 20, 25, 10791-10797, Dec. 2004, Peer-reviwed
Scientific journal, English - Periodic expansion-contraction motion of photoabsorbing organic droplets during laser pbotophoretic migration in water
H Monjushiro; M Tanaka; H Watarai
CHEMISTRY LETTERS, 32, 3, 254-255, Mar. 2003, Peer-reviwed
Scientific journal, English
MISC
- Electron transfer and guanine photodamage in DNA condensate
MAKIKO TANAKA
光化学協会, 19 Aug. 2020, PHOTOCHEMISTRY, 51, 2, 92-95, Japanese, Invited, Introduction scientific journal - Charge transfer and damage in DNA by oxidizing DNA with light
Makiko Tanaka
09 Mar. 2018, UEC e-Bulletin, 17, English, Introduction research institution - 人工核酸を用いたDNA内電荷移動とDNA光損傷
田仲真紀子
日本生化学会, Aug. 2015, 生化学, 187, 4, 463-466, Japanese, Introduction scientific journal, 0037-1017, 40020571874, AN00126072
Books and other publications
Lectures, oral presentations, etc.
- AFM observation and systematic investigation of structural formation factors in hexagonal platelet DNA liquid crystals
Tetsunao Makino; Kenta Sawada; Keisuke Miyazawa; Takeshi Fukuma; Makiko Tanaka
English, 日本化学会第106春季年会
18 Mar. 2026 - Self-assembled DNA Microfibers from a Single Oligonucleotide via Depletion Interactions
So Shirai; Tetsunao Makino; Takashi Kajitani; Makiko Tanaka
Poster presentation, The 52th International Symposium on Nucleic Acid Chemistry (ISNAC2025)
12 Nov. 2025 - Sequence dependence in the formation of hexagonal liquid crystals composed of short DNA
Tetsunao Makino; Keisuke Miyazawa; Kenta Sawada; Takeshi Fukuma; Makiko Tanaka
Poster presentation, The 52th International Symposium on Nucleic Acid Chemistry (ISNAC2025)
12 Nov. 2025 - ポリエチレングリコール共存下におけるDNA液晶形成の塩基配列依存性と階層的自己集合による形状制御
黒木 英介; 牧野 哲直; 田仲 真紀子
Poster presentation, 第15回 CSJ化学フェスタ2025
23 Oct. 2025 - 二本鎖DNAの自己集合による六角形型液晶形成への共存イオンと混雑剤の分子量の影響
牧野 哲直; 田仲 真紀子
Oral presentation, 第19回バイオ関連化学シンポジウム
02 Sep. 2025 - 2種類の短鎖DNAをビルディングブロックとした階層的な集合体の形成
牧野 哲直; 梶谷 孝; 田仲 真紀子
Oral presentation, 日本化学会 第105春季年会
26 Mar. 2025 - ２種類の短鎖 DNA を活用した分子集合体の階層構造の構築
牧野 哲直; 田仲 真紀子
Oral presentation, 第15回分子サイバネティクス/第59回分子ロボティクス定例研究会
06 Dec. 2024 - 分子混雑環境下における自己相補 DNA 鎖の集合によるファイバー状液晶の形成
白井 想; 牧野 哲直; 田仲 真紀子
Oral presentation, 第15回分子サイバネティクス/第59回分子ロボティクス定例研究会
06 Dec. 2024 - 2種類の短鎖DNAを用いた六角形構造に基づく階層的な自己集合
牧野 哲直; 田仲 真紀子
分子サイバネティクス第４回領域会議, Invited
29 Nov. 2024 - 2種類の短鎖DNAをビルディングブロックとしたDNA集合体の形態制御
牧野 哲直; 田仲真紀子
Poster presentation, 第18回バイオ関連化学シンポジウム
13 Sep. 2024 - Controlling Morphology of Hexagonal Liquid Crystalline DNA
Makiko Tanaka
Poster presentation, 10th Japan-Italian Joint Workshop on Liquid Crystal (JILCW2024)
05 Sep. 2024 - Hierarchically self-assembled liquid crystal built from short DNA
Makiko Tanaka
Invited oral presentation, International Congress on Pure & Applied Chemistry (ICPAC) Mongolia 2024, Invited
29 Aug. 2024 - ２種類の短鎖DNAによって成長方向を制御した六角形型集合体
牧野 哲直; 田仲真紀子
Poster presentation, 第35回生体機能関連化学部会若手の会サマースクール
09 Jul. 2024 - 短鎖DNAの集合とその機能
田仲 真紀子
Oral presentation, 研究会「宇宙線学」の共創, Invited
09 May 2024 - Self-assembly of Short Double-stranded DNA into Micro-sized H-shaped and Hexagonal Ring Structures
Tetsunao Makino, Makiko Tanaka
Poster presentation, The 3rd International Symposium on Biofunctional Chemistry (ISBC2024)
24 Apr. 2024 - 二本鎖DNAのマイクロメートルサイズのH型構造体への自己集合
牧野哲直; 田仲真紀子
日本化学会第104春季年会
20 Mar. 2024 - 分子混雑環境下で形成する六角形DNA集合体の形成メカニズムの探索
牧野 哲直; 田仲 真紀子
第13回 CSJ化学フェスタ2023
17 Oct. 2023 - Self-assembly of double-stranded DNA into hexagonal liquid crystal
Makiko Tanaka
Invited oral presentation, International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023, Invited
13 Sep. 2023 - Micro-sized liquid crystals composed of short double-stranded DNA
Makiko Tanaka
Invited oral presentation, The 6th Asian Chemical Biology Conference (ACBC2023), Invited
22 Aug. 2023 - 六角形型DNA集合体の形成におけるDNA配列と共溶質の影響
牧野哲直; 田仲真紀子
Oral presentation, 日本化学会 第103回 春季年会
23 Mar. 2023 - Formation and Properties of DNA Liquid Crystalline Phase in Crowded Environment
Makiko Tanaka
Invited oral presentation, English, International Congress on Pure & Applied Chemistry (ICPAC KK 2022), Invited, International conference
25 Nov. 2022 - Formation of micro-sized hexagonal DNA assemblies in aqueous-salt PEG solution
Tetsunao Makino; Daisuke Nakane; Makiko Tanaka
Poster presentation, English, The 49th International Symposium on Nucleic Acid Chemistry, International conference
02 Nov. 2022 - 光学顕微鏡観察可能なマイクロメートルサイズの六角形型DNA構造体の形成
牧野 哲直; 田仲 真紀子
Poster presentation, Japanese, 第１２回CSJ化学フェスタ
20 Oct. 2022 - 光照射によるDNA集合体の形態変化
木下 晴弥; 山口 湧暉; 田仲 真紀子
Poster presentation, Japanese, 第１２回CSJ化学フェスタ
19 Oct. 2022 - Formation of double-stranded DNA assemblies and their properties under crowded conditions
牧野哲直; 山口湧暉; 田仲真紀子
Oral presentation, Japanese, 第１６回バイオ関連化学シンポジウム, Domestic conference
12 Sep. 2022 - 光を用いたDNA集合状態の機能探索 ～化学の視点からのDNA研究～
田仲 真紀子
Public discourse, Japanese, 奈良県⽴医科⼤学V-iCliniX講座, Invited, オンライン
28 Sep. 2021 - ホールトラップ核酸塩基を用いた分子混雑環境におけるDNA内電子移動効率の評価
武富 祐樹; 山口 湧暉; 櫻井 俊亮; 田仲 真紀子
Poster presentation, Japanese, 第15回バイオ関連化学シンポジウム, オンライン, Domestic conference
09 Sep. 2021 - 光増感剤とホール捕捉塩基を含む液晶 DNA の形成と液晶内電子移動特性の検討
山口 湧暉; 武富 祐樹; 櫻井 俊亮; 田仲 真紀子
Poster presentation, Japanese, 第8回バイオ関連化学シンポジウム若手フォーラム, オンライン, Domestic conference
03 Sep. 2021 - Electron transfer and oxidative base damage in DNA condensed phase
Makiko Tanaka
Public symposium, English, MBSJ2020 Online, Invited, Domestic conference
03 Dec. 2020 - 光を用いたDNAの機能と特性の探索
田仲 真紀子
2020年度UECパスポートセミナー第１回, Invited
15 Oct. 2020 - Guanine damage in DNA condensate by singlet oxygen generated from photosensitizer
SAKURAI, Shunsuke; JO, Kento; KINOSHITA, Hikari; ESUMI, Mayu; TANAKA, Makiko
Oral presentation, Japanese, 第１4回バイオ関連化学シンポジウム
07 Sep. 2020 - Effects of polyamines on DNA structural changes and guanine photodamage
〇Mayu Esumi; Shunsuke Sakurai; Makiko Tanaka
Oral presentation, Japanese, The 100th CSJ Annual Meeting
22 Mar. 2020 - Promotion of Interduplex Electron Transfer in Ψ-type DNA
○Shunsuke Sakurai; Mayu Esumi; Makiko Tanaka
Oral presentation, Japanese, The 100th CSJ Annual Meeting
22 Mar. 2020 - Promotion of guanine damage by singlet oxygen generated from SYBR Green I in DNA condensation
Jo Kento; Shunsuke Sakurai; ○Makiko Tanaka
Oral presentation, Japanese, The 100th CSJ Annual Meeting
22 Mar. 2020 - DNA凝縮体中の電子移動およびグアニン光酸化損傷特性の研究
櫻井 俊亮; 江角 茉結; 城 健斗; 田仲 真紀子
Poster presentation, Japanese, 第４回LLPS研究会・ASUKA若手交流会2019, Domestic conference
09 Dec. 2019 - DNAの多様な形態とその機能 –化学の視点からのDNA研究–
田仲 真紀子
スマートテクノロジーフォーラム(STF)2019 医療用テクノロジーの進歩と可能性, Invited
26 Sep. 2019 - ψ型DNA中での光誘起電子移動によるグアニン酸化損傷の促進
櫻井俊亮; 江角茉結; 田仲真紀子
Poster presentation, Japanese, 第９２回日本生化学会大会
20 Sep. 2019 - スペルミジンによるDNAの高次構造変化とDNA内電子移動への影響
江角茉結; 櫻井俊亮; 田仲真紀子
Poster presentation, Japanese, 第９２回日本生化学会大会
20 Sep. 2019 - 凝縮DNA中での電子移動によるグアニン酸化損傷の促進
櫻井 俊亮; 江角 茉結; 田仲 真紀子
Oral presentation, Japanese, 第１３回バイオ関連化学シンポジウム
04 Sep. 2019 - Effect of DNA Condensation on Guanine Photooxidative Damage via Electron Transfer
Makiko Tanaka
Invited oral presentation, English, International Congress on Pure & Applied Chemistry (ICPAC) Yangon 2019, Invited, International conference
07 Aug. 2019 - Effects of surrounding environments on guanine photooxidation via DNA-mediated electron transfer
○Makiko Tanaka; Shunsuke Sakurai; Mayu Esumi
Oral presentation, Japanese, 日本化学会第99回春季年会, 甲南大学 岡本キャンパス
16 Mar. 2019 - Effects of Molecular Crowding on DNA-mediated Electron Transfer and Guanine Oxidation in Pyrene-modified Oligonucleotides
H. Iida; T. Matsumoto; M. Tanaka
Poster presentation, English, The Irago Conference 2018, International conference
01 Nov. 2018 - Molecular crowding effect on DNA charge transfer and guanine photodamage
TANAKA, Makiko; ESUMI, Mayu; SAKUEAI, Shunsuke; IIDA, Hiroki
Oral presentation, Japanese, 第12回バイオ関連化学シンポジウム, Domestic conference
09 Sep. 2018 - Effects of Molecular-crowding on Electron Transfer and Oxidative Damage in Pyrene-modified Oligonucleotides
Makiko Tanaka; Hiroki Iida; Takayuki Matsumoto
Oral presentation, Japanese, 日本化学会第98春季年会, 日本化学会, 日本大学船橋キャンパス, Domestic conference
20 Mar. 2018 - Photoinduced Electron Transfer in Pyrene-modified Oligonucleotides under Crowding Conditions
Makiko Tanaka; Hiroki Iida; Takayuki Matsumoto
Poster presentation, English, The 44th International Symposium on Nucleic Acid Chemistry, International conference
Nov. 2017 - 光でDNAを調べる、操作する －超スマート社会における個別化医療にむけて－
田仲 真紀子
創立100周年記念公開講座 －超スマート社会の実現を目指す最先端の科学・技術研究 第３回, Invited
05 Aug. 2017 - Ribonuclease A as Effective Promoter for Unimolecular Invasion of Peptide Nucleic Acid to Double-stranded DNA
TANAKA, Makiko; SHIGI, Narumi; KOMIYAMA, Makoto
Oral presentation, Japanese, The 96th CSJ Annual Meeting, Domestic conference
25 Mar. 2016 - Promotion of peptide nucleic acid invasion into double-stranded DNA by RNase A
田仲真紀子; 鴫成実; 小宮山眞
Poster presentation, Japanese, BMB2015(第３８回 日本分子生物学会年会、第８８回日本生化学大会 合同大会)
03 Dec. 2015 - チアゾールオレンジ修飾ペプチド核酸による二本鎖DNA中での特定配列の蛍光検出と位置選択的光損傷
田仲真紀子; 鴫 成実; 須磨岡 淳; 小宮山 眞
Oral presentation, Japanese, 日本化学会第95春季年会, Domestic conference
Mar. 2015 - Efficient excess electron transfer through modified DNA using 2’-deoxyuridine derivatives
Makiko Tanaka; Kazuhiro Oguma; Yoshio Saito; Isao Saito
Poster presentation, English, The 39th International Symposium on Nucleic Acid Chemistry, International conference
Nov. 2012 - フェニルエチニル基を有するデオキシウリジン誘導体を電子メディエーターとする修飾DNA内の高効率過剰電子移動
田仲真紀子; 小熊一裕; 齋藤義雄; 齋藤烈
Poster presentation, Japanese, 2012年光化学討論会, 東工大, Domestic conference
Sep. 2012 - DNA二本鎖に複数導入した修飾核酸塩基の光物性
田仲真紀子; 小熊一裕; 齋藤義雄; 齋藤烈
Oral presentation, Japanese, 日本化学会第92春季年会, 日本大学, Domestic conference
Mar. 2012 - Synthesis and properties of oligodeoxynucleotides containing 2-substituted adenine
Tanaka, M; Kozakai, R; Oguma, K; Saito, Y; Saito, I
Poster presentation, English, The 38th International Symposium on Nucleic Acid Chemistry, Sapporo, Japan, International conference
Nov. 2011 - 環境感応型蛍光プローブとなる新規核酸塩基誘導体の開発とその応用
田仲真紀子; 小熊一裕; 小坂井亮太; 久下沼賢志; 齋藤義雄; 齋藤烈
Oral presentation, Japanese, 第33回光医学光生物学会, 大阪大学, Domestic conference
Jul. 2011 - 芳香族化合物をエチニルリンカーで連結した核酸塩基誘導体の光物性
田仲真紀子; 小熊一裕; 小坂井亮太; 齋藤義雄; 齋藤烈
Oral presentation, Japanese, 日本化学会第91春季年会, 神奈川大学, Domestic conference
Mar. 2011 - 新規な発色団修飾塩基を光誘起電子供与体として含むDNA内の過剰電子移動特性
田仲真紀子; Benjamin Elias; Jacqueline K. Barton
Oral presentation, Japanese, 2009年光化学討論会, 群馬県桐生市, Domestic conference
Sep. 2009 - DNA中の核酸塩基とアクリジニウムイオンの分子間および分子内光誘起電子移動
田仲真紀子; 行本和紗; 大久保敬; 福住俊一
Poster presentation, Japanese, ２００７年光化学討論会, Domestic conference
Sep. 2007 - 補酵素類縁体を用いたDNA光損傷とその光ダイナミクス
田仲真紀子; 大久保 敬; 福住俊一
Oral presentation, Japanese, 日本化学会第86春季年会, 関西大, Domestic conference
Mar. 2007 - Photoreductive DNA Cleavage Induced by UVA Irradiation of Coenzyme
Tanaka, M; Ohkubo, K; Fukuzumi, S
Oral presentation, English, The International Symposium on Advanced Science and Biotechnology 2007, Osaka, International conference
Mar. 2007 - 酵素およびそのモデル化合物の光励起によって発生させた活性ラジカル種によるDNA切断
田仲真紀子; 大久保 敬; 福住俊一
Oral presentation, Japanese, 生体機能関連化学シンポジウム, 京都大学, Domestic conference
Sep. 2006 - NADHによるDNAの光電子移動還元と切断機構
田仲真紀子; 大久保 敬; 福住俊一
Poster presentation, Japanese, 2006年光化学討論会, 東北大, Domestic conference
Sep. 2006 - π−Complex Formation between Various Bisporphyrins and Acceptor ion and the Photodynamics
Tanaka, M; Amasaki, I; Ohkubo, K; Gros, C. P; Guilard, R; Fukuzumi, S
Oral presentation, English, The 209th Meeting of the Electrochemical Society, Denver, Colorado, International conference
May 2006 - Generation of Triplet Excited State of NADH by UVA Irradiation and DNA Cleavage Mechanism
Tanaka, M; Ohkubo, K; Fukuzumi, S
Poster presentation, English, XXIst IUPAC Symposium on Photochemistry, Kyoto, International conference
Apr. 2006 - NADHのUVA照射による活性酸素種発生機構とDNA損傷
田仲真紀子; 大久保 敬; 福住俊一
Oral presentation, Japanese, 日本化学会第86春季年会, 日本大学, Domestic conference
Mar. 2006 - Formation of Supramolecular Complex between Porphyrin and NAD+ Analogs by π−π Interaction and Photoinduced Electron Transfer
Tanaka, M; Ohkubo, K; Gros, C. P; Guilard, R; Fukuzumi, S
Poster presentation, English, The 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005), Hawaii, USA, International conference
Dec. 2005 - Extremely Long-Lived Charge Separated State in π-Complex of Bisporphyrins with Acridinium Ion
Tanaka, M; Ohkubo, K; Gros, C. P; Guilard, R; Fukuzumi, S
Oral presentation, English, 2005 Korea-Japan Symposium on Frontier Photoscience, International conference
Oct. 2005 - NADHおよびそのモデル化合物によるDNA光損傷
田仲真紀子; 大久保 敬; 福住俊一
Oral presentation, Japanese, 2005年光化学討論会, 福岡, Domestic conference
Sep. 2005 - NADHによる活性酸素種発生と光DNA切断
田仲真紀子; 大久保 敬; 福住俊一
Poster presentation, Japanese, 第20回生体機能関連化学シンポジウム, 名古屋市大, Domestic conference
Sep. 2005 - Phase transition in photo-absorbing single microemulsion droplets during the laser photophoretic migration
Hideaki Monjushiro; Makiko Tanaka; Hitoshi Watarai
Oral presentation, English, SPIE 5930, Optical Trapping and Optical Micromanipulation II, San Diego, California, USA, International conference
26 Aug. 2005 - Photodynamics of Supramolecular Complexes of Bisporphyrins with NAD+ Analogs by π−π Interaction
Tanaka, M; Ohkubo, K; Gros, C. P; Guilard, R; Fukuzumi, S
Oral presentation, English, The 207th Meeting of the Electrochemical Society, Quebec City, Canada, International conference
May 2005 - ポルフィリン多量体とNAD+類縁体のπ−π相互作用による超分子錯体形成と光電子移動
田仲真紀子; 大久保 敬; Claude P. Gros、Roger Guilard; 福住俊一
Oral presentation, Japanese, 日本化学会第８５春季年会, 神奈川大学, Domestic conference
Mar. 2005 - π-Complex Formation and Photoinduced Electron Transfer between Acridinium Ion and a Cofacial Bisporphyrin
Tanaka, M; Ohkubo, K; Gros, C. P; Guilard, R; Fukuzumi, S
Poster presentation, English, The 5th International 21 Century COE Symposium on Integrated EcoChemistry, Osaka, International conference
Jan. 2005 - フリーベースビスポルフィリン-アクリジニウムイオン超分子錯体のフォトダイナミクス
田仲真紀子; 大久保 敬; C; P. Gros; R. Guilard; 福住俊一
Oral presentation, Japanese, ２００４年光化学討論会, つくば国際会議場, Domestic conference
Nov. 2004 - DNA中におけるトリスビピリジンルテニウム(II)錯体からNAD+類縁体への光誘起電子移動反応のドライビングフォース依存性
田仲真紀子; 西峯麻里; 大久保 敬; 福住俊一
Poster presentation, Japanese, 2004年光化学討論会, つくば国際会議場, Domestic conference
Nov. 2004 - NAD+ 類縁体の電子移動還元反応におけるスタッキング効果
田仲真紀子; 西峯麻里; 大久保 敬; 福住俊一
Poster presentation, Japanese, 第19回生体機能関連シンポジウム, 東京大学, Domestic conference
Oct. 2004 - Photoinduced Electron Transfer in Free-base Bisporphyrin-Acridinium Ion Supramolecular Complexes
Tanaka, M; Ohkubo, K; Gros, C. P; Burdet, F; Barbe, J.-M; Guilard, R; Fukuzumi, S
Poster presentation, English, CREST International Symposium on Radical Ion Reactivity, Hyogo, International conference
Jun. 2004 - Co(III)-par錯体を抽出した微小液滴のレーザー光泳動の解析
田仲 真紀子; 文珠四郎; 秀昭; 渡會 仁
Oral presentation, Japanese, 日本化学会第84春季年会, 関西学院大学(西宮市), Domestic conference
Mar. 2004 - Co(III)-par 錯体を抽出した微小液滴のレーザー光泳動の解析
田仲 真紀子; 文珠四郎; 秀昭; 渡會 仁
Poster presentation, Japanese, 特定領域研究(B)「液液界面ナノ領域の化学」 第5回公開シンポジウム, グランキューブ大阪(大阪国際会議場)(大阪市), Domestic conference
Dec. 2003 - Co(III)-par錯体を抽出した微小液滴のレーザー光泳動の解析
田仲 真紀子; 文殊四郎; 秀昭; 渡會 仁
Oral presentation, Japanese, 日本分析化学会第52年会, 宮城教育大学(仙台市), Domestic conference
Sep. 2003 - Periodic Expansion and Contraction of Photo-Absorbing Organic Droplets during Laser Photophoresis in Water
Hideaki Monjushiro; Makiko Tanaka; Hitoshi Watarai
Poster presentation, English, XXIst International Conference on Photochemistry, Nara, International conference
Jul. 2003 - O/Wエマルション液滴のレーザー光泳動における周期的膨張現象
田仲 真紀子; 文珠四郎; 秀昭; 渡會 仁
Oral presentation, Japanese, 日本分析化学会第51年会, 北海道大学(札幌市), Domestic conference
Sep. 2002
Courses
- システム生物学
Present
The University of Electro-Communications - 化学概論第一
Present
The University of Electro-Communications - 生命分子化学特論
Present
The University of Electro-Communications - 現代化学
Present
The University of Electro-Communications - 化学生命工学実験第二
Present
The University of Electro-Communications - システム生物学
電気通信大学 - 化学概論第一
電気通信大学 - 生命分子化学特論
電気通信大学 - 機器分析学
The University of Electro-Communications - 機器分析学
電気通信大学 - 現代化学
電気通信大学 - 化学生命工学実験第二
電気通信大学 - 生体機能システム実験第二
The University of Electro-Communications - 現代化学 第４回
The University of Electro-Communications - 現代化学 第４回
The University of Electro-Communications - 現代化学 第４回
電気通信大学 - 生体機能システム実験第二
The University of Electro-Communications - 生体機能システム実験第二
電気通信大学
Research Themes
- DNAの階層的自己集合による超分子ポリマーの構築と制御
田仲 真紀子
日本学術振興会, 科学研究費助成事業, 電気通信大学, 基盤研究(C), 25K08740
01 Apr. 2025 - 31 Mar. 2028 - 短鎖DNAの集合制御による高効率電子シグナル伝達システムの創出
田仲 真紀子
日本学術振興会, 科学研究費助成事業 学術変革領域研究(A), 電気通信大学, 学術変革領域研究(A), Principal investigator, 23H04409
Apr. 2023 - Mar. 2025 - 光を用いたDNAメゾスコピック凝縮反応場の機能分析
田仲真紀子(庄司真紀子)
日本学術振興会, 科学研究費助成事業 基盤研究(C), 電気通信大学, 基盤研究(C), Principal investigator, 本研究では、種々の分子夾雑・混雑環境でのDNA凝縮体の形成条件を検討し、メゾスコピックスケールの可逆的な微小凝縮場の形成がDNAに与える機能の解明を目指した。具体的には相分離凝縮場でのDNAの電子移動と核酸塩基損傷特性に着目し、光を用いて化学的アプローチにより解析を行うことで生体分子の微小反応場としての凝縮体の性質を調べた。DNA凝縮場でグアニン塩基、またその連続配列が電子移動により酸化損傷を受ける効率およびその特性については、まだほとんどが未解明である。そこで当該年度の研究ではまずホール捕捉により開環反応を起こすグアニン類縁体を含むDNA鎖を固相合成により合成し、光増感剤を含むDNA鎖とアニーリングにより相補鎖とした。この修飾DNAについてポリエチレングリコールを用いて人工的に作製した分子混雑環境下で液晶とした。修飾DNAを含む液晶について、光照射による電子移動をスタートさせグアニン酸化損傷を誘発する手法により、電子移動特性を評価した。高速液体クロマトグラフィーによる損傷塩基の定量を行い、それぞれの凝縮場での電子移動効率の評価を行った。その結果、凝縮場における電子移動効率の大幅な増大が観測された。解析の結果、液晶中でスタッキングした異なるDNA鎖間での電子移動が起こったことが示唆された。
当初は購入を予定していた備品の凍結乾燥機については消耗品代その他の研究費用がかさみ、購入できなかったため、デモ機の使用とあわせ、時間とサンプルおよび消耗品であるカラム代のロスがあるが、遠心濃縮とカラムを用いてDNAの精製をおこなった。その他、実験に使用する小型機器、試薬、合成DNA、HPLCカラム、チップやチューブ等を購入した。, 21K05108
Apr. 2021 - Mar. 2024 - グアニン損傷を誘発するDNA電荷移動シグナルの生体内条件での経路探索
田仲真紀子
戸部眞紀財団, 研究助成, Principal investigator
Sep. 2018 - Aug. 2019 - Creation of new genome science using chemical tools to precisely detect modification and damage of human genome
Komiyama Makoto; SHIGI Narumi; Tanaka Makiko; Rajendran Arivazhagan
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), National Institute for Materials Science, Grant-in-Aid for Scientific Research (A), Coinvestigator not use grants, We already developed super artificial restriction enzyme. In this research, we added affinity separating ability to this tool, and constructed the second- generation super artificial restriction enzyme. By modifying biotin to PNA which is a constituent of super restriction enzyme, we successfully extracted desired DNA fragments of several thousand base pairs in high purity and high yield from the human genome with 3 billion base pairs. Furthermore, by combining this biotin-modified PNA with S1 nuclease, we also succeeded in extracting desired DNA fragments from the human genome in one pot., 15H02189
Apr. 2015 - Mar. 2018 - 高効率DNA内シグナル伝達システムの構築とDNA光切断を用いた遺伝子操作法の開発
田仲真紀子(庄司真紀子)
日本学術振興会・特別研究員奨励費RPD, Principal investigator
2013 - 2015 - Design of Environmentally Sensitive Fluorescent Nucleosides and Their Application to Innovative Fluorescence Probe for Gene Analysis
SAITO Isao; SAITO Yoshio
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Nihon University, Grant-in-Aid for Scientific Research (B), Coinvestigator, We have designed a novel type of base-discriminating fluorescent (BDF) nucleosides which are used for SNP genotyping and gene detection. We also succeeded to design environmentally sensitive fluorescent (ESF) nucleosides that emit strong fluorescence at different wavelengths depending upon a difference of local environment near the ESF base. The newly designed ESF nucleosides may discriminate structural changes such as single strands, matches, mismatches and deletions when incorporated in DNA by a significant change of emission wavelengths as well as their intensities. Quencher and end free molecular beacons (MB) were discovered for the first time by using newly designed ESF nucleosides. These low cost MB were used for the gene detection in a cell. ESF nucleosides that are sensitive to pH were also designed. Such pH sensor ESF nucleoside that emits strong fluorescence only at bellow pH 5.5 was used for the detection of cancer cell., 23350082
Apr. 2011 - Mar. 2014 - 新規π拡張核酸塩基の開発によるDNA内過剰電子移動特性の解明とその応用展開
田仲真紀子(庄司真紀子)
公益信託山村富美記念女性自然科学者研究助成基金, Principal investigator
2011 - 2012 - 光誘起電子移動による各種DNA損傷の検討と新規DNA光操作法の開発
田仲真紀子
日本学術振興会・特別研究員奨励費PD, Principal investigator
2007 - 2009 - メゾスコピック生体系レーザー光誘起電子移動過程の解析と応用
田仲真紀子
日本学術振興会・特別研究員奨励費DC2, Principal investigator
2005 - 2006
Media Coverage
Academic Contribution Activities
- 第15回分子サイバネティクス/第59回分子ロボティクス定例研究会
Academic society etc, Others, 06 Dec. 2024 - 調査・研究会などの実績 文部科学省 科学技術予測センター専門調査員
Academic society etc, Academic research planning, 01 Apr. 2020 - 31 Mar. 2022 - 第４回LLPS研究会・ASUKA若手交流会2019
Academic society etc, Others, 09 Dec. 2019 - カリフォルニア工科大学（日本学術振興会特別研究員 海外渡航制度）
Others, Others, Sep. 2007 - Mar. 2009
